21 quantitative lc-msms analysis of 15 estrogens and estrogen metabolites in human plasma using supported liquid extraction (sle) technique steve cines - primera analytical solutions
Primera Analytical Solutions Corp. is an analytical chemistry contract research organization founded in 2002 that offers pharmaceutical and biotech companies a range of analytical services including GMP analytical testing, method development and validation, stability testing, bioanalysis of clinical samples, preformulation, and protein characterization. It has a team of PhD scientists, robust SOPs and quality systems, ICH-compliant stability chambers, and was FDA audited in 2008 and 2012 with no observations.
Our team of 8 undergrads spent a summer conceiving, designing, constructing, and testing a new system for sensing and reporting alternative fuel source concentrations. We were lucky enough to be invited to the world championship jamboree at MIT in Cambridge, MA, and this was our presentation for our 20 minute talk. Let me just say, I absolutely love how these slides turned out. However, it definitely makes more sense with our explanations, so check the whole talk out at the iGEM results website: http://2011.igem.org/files/video/Wisconsin-Madison_Championship.mp4
Cell culture refers to the removal of cells from an animal or plant and their subsequent growth in a favorable artificial environment. The cells may be removed from the tissue directly and disaggregated by enzymatic or mechanical means before cultivation, or they may be derived from a cell line or cell strain that has already been established.
More cell culture techniques and best practices here. http://owl.li/dgS2Y
Over the past decade, there have been a growing number of mAb candidates entering the clinical pipeline. This results in a large increase on the demand for analytical characterization. This seminar discusses advances in analytical method development with analytical run times below 10 minutes for all routine methods with intelligent, integrated chromatography workflows. Orbitrap technology has been established as the most powerful MS technology for protein characterization. How this can be incorporated into a complete workflow for bio-pharma analysis is also discussed.
SPICE MODEL of D10SC4M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of D10SC4M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
Formulation and Stability Challenges for Virus TherapeuticsIntegrity Bio
Case Study from Vaccine Development Forum in 2009. Discussion of challenges of virus formulations vs. protein formulations. Includes a comparison of analytical methods and formulation solutions
SPICE MODEL of 5FWJ2CZ47M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of 5FWJ2CZ47M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
Enhancing food security through improved seed systems of appropriate cassava,...ILRI
Presented by Baguma Yona, Nuwamanya Ephraim, Magambo Stephen and Akoli Barbara at the First Bio-Innovate Regional Scientific Conference, Addis Ababa, Ethiopia, 25-27 February 2013
SPICE MODEL of SF20JC6 (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of SF20JC6 (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
SPICE MODEL of D5SC4M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of D5SC4M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
SPICE MODEL of S25SC6M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of S25SC6M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
Interphex2009 Advances In Bioreactor Modeling And ControlGregory McMillan
Presentation of kinetics, beta test results of wireless pH and temperature transmitters, and virtual plant study results on the effect of measurement resolution and time delay for bioreactor control
SPICE MODEL of DF10SC4M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of DF10SC4M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
SPICE MODEL of CRS04 (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of CRS04 (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
SPICE MODEL of DE10SC4 (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of DE10SC4 (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
SPICE MODEL of D5S9M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of D5S9M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is
http://www.spicepark.com by Bee Technologies.
Similar to 21 quantitative lc-msms analysis of 15 estrogens and estrogen metabolites in human plasma using supported liquid extraction (sle) technique steve cines - primera analytical solutions
Our team of 8 undergrads spent a summer conceiving, designing, constructing, and testing a new system for sensing and reporting alternative fuel source concentrations. We were lucky enough to be invited to the world championship jamboree at MIT in Cambridge, MA, and this was our presentation for our 20 minute talk. Let me just say, I absolutely love how these slides turned out. However, it definitely makes more sense with our explanations, so check the whole talk out at the iGEM results website: http://2011.igem.org/files/video/Wisconsin-Madison_Championship.mp4
Cell culture refers to the removal of cells from an animal or plant and their subsequent growth in a favorable artificial environment. The cells may be removed from the tissue directly and disaggregated by enzymatic or mechanical means before cultivation, or they may be derived from a cell line or cell strain that has already been established.
More cell culture techniques and best practices here. http://owl.li/dgS2Y
Over the past decade, there have been a growing number of mAb candidates entering the clinical pipeline. This results in a large increase on the demand for analytical characterization. This seminar discusses advances in analytical method development with analytical run times below 10 minutes for all routine methods with intelligent, integrated chromatography workflows. Orbitrap technology has been established as the most powerful MS technology for protein characterization. How this can be incorporated into a complete workflow for bio-pharma analysis is also discussed.
SPICE MODEL of D10SC4M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of D10SC4M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
Formulation and Stability Challenges for Virus TherapeuticsIntegrity Bio
Case Study from Vaccine Development Forum in 2009. Discussion of challenges of virus formulations vs. protein formulations. Includes a comparison of analytical methods and formulation solutions
SPICE MODEL of 5FWJ2CZ47M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of 5FWJ2CZ47M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
Enhancing food security through improved seed systems of appropriate cassava,...ILRI
Presented by Baguma Yona, Nuwamanya Ephraim, Magambo Stephen and Akoli Barbara at the First Bio-Innovate Regional Scientific Conference, Addis Ababa, Ethiopia, 25-27 February 2013
SPICE MODEL of SF20JC6 (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of SF20JC6 (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
SPICE MODEL of D5SC4M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of D5SC4M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
SPICE MODEL of S25SC6M (Standard Model) in SPICE PARKTsuyoshi Horigome
SPICE MODEL of S25SC6M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
Interphex2009 Advances In Bioreactor Modeling And ControlGregory McMillan
Presentation of kinetics, beta test results of wireless pH and temperature transmitters, and virtual plant study results on the effect of measurement resolution and time delay for bioreactor control
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SPICE MODEL of DF10SC4M (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
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SPICE MODEL of CRS04 (Standard Model) in SPICE PARK. English Version is http://www.spicepark.net. Japanese Version is http://www.spicepark.com by Bee Technologies.
SPICE MODEL of DE10SC4 (Standard Model) in SPICE PARKTsuyoshi Horigome
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UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
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1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Generating a custom Ruby SDK for your web service or Rails API using Smithyg2nightmarescribd
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https://alandix.com/academic/papers/synergy2024-epistemic/
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21 quantitative lc-msms analysis of 15 estrogens and estrogen metabolites in human plasma using supported liquid extraction (sle) technique steve cines - primera analytical solutions
2. Founded in 2002.
Strong, solid, steady
organic growth.
Strong base of PhD level
scientists heading our
groups.
Working relationships
with many international
and domestic
pharmaceutical
enterprises
Primera Analytical Solutions Corp.
3. GMP Analytical
Release Testing
Bioanalysis of Clinical
Samples
Formulation Development
GMP Analytical Method
Development, Validation
Stability Testing/Stability
Indicating Method
Development.
Method Transfer
Primera Analytical Solutions Corp.
4. 0.120
UPLC/HPLC Experience
30.010
0.110
SEC/GPC 0.100
Ion Exchange 0.090
Chiral Methods 0.080
Conventional Reverse Phase 0.070
AU
Conventional Normal Phase 0.060
0.050
0.040
SDS PAGE 0.030
0.020
25.705
34.683
GC/FID, GC/MS, GC
0.010
0.000
Headspace 0.00 10.00 20.00 30.00 40.00 50.00 60.00 70.00
Minutes
HPLC Detection Systems
CAD
ELSD
DAD
RI Primera Analytical Solutions Corp.
5. Mass Spectroscopy Laboratory
Bioanalysis of Clinical
Trial/BE Samples
Method Transfer
Method Development
Method Validation
Clinical Partners
Primera Analytical Solutions Corp
6. Characterization of Proteins
and Peptides
30.010
0.0045
0.0040
25.705
0.0035
0.0030
0.0025
SDS PAGE
AU
0.0020
0.0015 ELISA
34.683
0.0010 Protein Stability Studies
0.0005 Peptide Mapping with HPLC or LC/MS/MS
0.0000
Amino Acid Analysis
Chiral Edman Degradation
-0.0005
10.00 20.00 30.00 40.00 50.00 60.00
70.00
qPCR
Minutes
Cell Viability Assays.
Endotoxins…
Primera Analytical Solutions Corp.
7. Preformulation
Physicochemical Properties
Particle size analysis
Solubility profile
pH and pKa determination
Solid and solution state
stability
Drug-excipient compatibility
Drug-drug compatibility
(combination drugs)
Primera Analytical Solutions Corp.
8. Our Facilities Include:
ICH Stability Chambers
Photostability Chamber
Full Power Back Up
-70C, -20C Freezers.
24/7 Alarms: Cellphone/
Online Veriteq System
Unique Conditions Capability
Primera Analytical Solutions Corp.
9. Robust System of SOP’s
Full GLP/GMP Staff
Training Program
Secure Data Backup
FDA Audited 2008
and 2012
No 483’s
Primera Analytical Solutions Corp.
