This document provides information about Alfuzosin hydrochloride, an alpha1 receptor antagonist used to treat benign prostatic hyperplasia. It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. Technical data on the compound such as molecular weight, formula, solubility, and purity are listed. References and related products targeting other pathways are also included. The company, Selleck Chemicals, provides samples and rewards for customers who provide scientific data on products and confirms customer satisfaction with products and service.
Global Trends & Development in Biopharmaceutical Contract Manufacturingmikechan088
This document summarizes a presentation on global biopharmaceutical contract manufacturing trends and developments. It discusses market trends such as slowing growth rates in mature markets and higher growth expected in emerging markets. It also covers threats to the industry like lack of capital and increasing regulatory scrutiny. The presentation provides an overview of top biologics companies and contract manufacturing organizations (CMOs) globally. It discusses why customers may choose to work with Indian CMOs due to competitive pricing, quality capabilities, and services offered.
EFFICACY OF AN INACTIVATED BTV-8 VACCINE AGAINST A VIRULENT BTV-8 CHALLENGE I...Merial EMEA
This document summarizes a study on the efficacy of an inactivated bluetongue virus serotype 8 (BTV-8) vaccine in sheep and cattle. The study found that:
1) Vaccination induced production of neutralizing antibodies against BTV-8.
2) Vaccinated sheep and cattle had strong clinical protection against challenge with virulent BTV-8 as measured by reduced fever and clinical signs compared to unvaccinated controls.
3) Vaccination completely prevented detectable virus in the blood (viremia) following challenge, unlike unvaccinated controls which all developed viremia.
21 quantitative lc-msms analysis of 15 estrogens and estrogen metabolites in ...CPSA-2012_5-Minutes-Fame
Primera Analytical Solutions Corp. is an analytical chemistry contract research organization founded in 2002 that offers pharmaceutical and biotech companies a range of analytical services including GMP analytical testing, method development and validation, stability testing, bioanalysis of clinical samples, preformulation, and protein characterization. It has a team of PhD scientists, robust SOPs and quality systems, ICH-compliant stability chambers, and was FDA audited in 2008 and 2012 with no observations.
This document is a flyer from Bio Basic Inc advertising their products such as DNA/RNA modifying enzymes, bacterial culture medium, protein related products, and molecular biology kits. It announces a "Buy TWO, get ONE FREE" promotion running from April 1 to June 30, 2012, and offers additional extended discounts for larger orders. Terms and conditions of the sale are provided at the bottom.
This document discusses alpha blockers, which are drugs that inhibit the interaction of hormones like norepinephrine with alpha receptors. It describes their classification as selective or non-selective, their functions in relaxing smooth muscle and reducing vasoconstriction, and individual drugs like prazosin, terazosin, and doxazosin. These drugs are important in managing conditions like pheochromocytoma, benign prostatic hyperplasia, hypertension, and peripheral vascular disease, but can cause adverse effects like postural hypotension and reflex tachycardia.
Benign Prostatic Hyperplasia BPH [Dr. Edmond Wong]Edmond Wong
Here are the key points about the natural history and progression of BPH on watchful waiting:
- Most men with BPH will experience gradual worsening of symptoms over time if left untreated. However, the rate of progression varies between individuals.
- In the Ball et al study of 100 men on watchful waiting for 5 years, about 25% got better, 30% stayed the same, and 45% got worse.
- Other studies have found annual progression rates of symptoms and complications to be around 10-15% per year. However, many men have stable disease for many years as well.
- Risk factors for faster progression include larger prostate size, more bothersome initial symptoms, and older age at presentation
This document provides product information for Sitagliptin, a DPP-4 inhibitor used for research into cell signaling and oncology. It inhibits the degradation of important incretin hormones that stimulate insulin secretion after meals. Studies show it decreases migration of CD4+ T-cells through different pathways depending on their location. It is eliminated renally with a half-life of 11.8-14.4 hours. The document provides references, storage and handling guidelines, and return policies.
Global Trends & Development in Biopharmaceutical Contract Manufacturingmikechan088
This document summarizes a presentation on global biopharmaceutical contract manufacturing trends and developments. It discusses market trends such as slowing growth rates in mature markets and higher growth expected in emerging markets. It also covers threats to the industry like lack of capital and increasing regulatory scrutiny. The presentation provides an overview of top biologics companies and contract manufacturing organizations (CMOs) globally. It discusses why customers may choose to work with Indian CMOs due to competitive pricing, quality capabilities, and services offered.
EFFICACY OF AN INACTIVATED BTV-8 VACCINE AGAINST A VIRULENT BTV-8 CHALLENGE I...Merial EMEA
This document summarizes a study on the efficacy of an inactivated bluetongue virus serotype 8 (BTV-8) vaccine in sheep and cattle. The study found that:
1) Vaccination induced production of neutralizing antibodies against BTV-8.
2) Vaccinated sheep and cattle had strong clinical protection against challenge with virulent BTV-8 as measured by reduced fever and clinical signs compared to unvaccinated controls.
3) Vaccination completely prevented detectable virus in the blood (viremia) following challenge, unlike unvaccinated controls which all developed viremia.
21 quantitative lc-msms analysis of 15 estrogens and estrogen metabolites in ...CPSA-2012_5-Minutes-Fame
Primera Analytical Solutions Corp. is an analytical chemistry contract research organization founded in 2002 that offers pharmaceutical and biotech companies a range of analytical services including GMP analytical testing, method development and validation, stability testing, bioanalysis of clinical samples, preformulation, and protein characterization. It has a team of PhD scientists, robust SOPs and quality systems, ICH-compliant stability chambers, and was FDA audited in 2008 and 2012 with no observations.
This document is a flyer from Bio Basic Inc advertising their products such as DNA/RNA modifying enzymes, bacterial culture medium, protein related products, and molecular biology kits. It announces a "Buy TWO, get ONE FREE" promotion running from April 1 to June 30, 2012, and offers additional extended discounts for larger orders. Terms and conditions of the sale are provided at the bottom.
This document discusses alpha blockers, which are drugs that inhibit the interaction of hormones like norepinephrine with alpha receptors. It describes their classification as selective or non-selective, their functions in relaxing smooth muscle and reducing vasoconstriction, and individual drugs like prazosin, terazosin, and doxazosin. These drugs are important in managing conditions like pheochromocytoma, benign prostatic hyperplasia, hypertension, and peripheral vascular disease, but can cause adverse effects like postural hypotension and reflex tachycardia.
Benign Prostatic Hyperplasia BPH [Dr. Edmond Wong]Edmond Wong
Here are the key points about the natural history and progression of BPH on watchful waiting:
- Most men with BPH will experience gradual worsening of symptoms over time if left untreated. However, the rate of progression varies between individuals.
- In the Ball et al study of 100 men on watchful waiting for 5 years, about 25% got better, 30% stayed the same, and 45% got worse.
- Other studies have found annual progression rates of symptoms and complications to be around 10-15% per year. However, many men have stable disease for many years as well.
- Risk factors for faster progression include larger prostate size, more bothersome initial symptoms, and older age at presentation
This document provides product information for Sitagliptin, a DPP-4 inhibitor used for research into cell signaling and oncology. It inhibits the degradation of important incretin hormones that stimulate insulin secretion after meals. Studies show it decreases migration of CD4+ T-cells through different pathways depending on their location. It is eliminated renally with a half-life of 11.8-14.4 hours. The document provides references, storage and handling guidelines, and return policies.
1. Vicriviroc malate is a novel kinase inhibitor developed for cell signaling and oncology research that acts as a CCR5 receptor antagonist.
2. Studies showed that vicriviroc potently inhibited chemokine-induced migration, calcium release, and GTPS exchange in CCR5-expressing cells with IC50 values below 4.2 nM, demonstrating its ability to block CCR5 receptor signaling.
3. Selleck Chemicals produces vicriviroc malate and provides information on its product details, storage conditions, references, and ordering procedures.
1. AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor being studied for its effects on human multiple myeloma (MM) and cell signaling.
2. In studies, AS703026 inhibited the growth and survival of MM cells and cytokine-induced osteoclast differentiation more potently than AZD6244.
3. The inhibition was mediated by cell cycle arrest and reduction of the MAF oncogene, and AS703026 sensitized MM cells to a variety of anti-MM therapies.
TSU-68 is a novel kinase inhibitor developed for cell signaling and oncology research. It has significant antitumor activity against many types of tumors by inducing apoptosis in vascular and tumor cells, perturbing tumor vasculature and inhibiting angiogenesis. TSU-68 inhibits the tyrosine kinase phosphorylation of VEGF, PDGF and bFGF receptors to block angiogenesis. Studies show it inhibits tumor proliferation and metastasis in colon cancer models by blocking tumor angiogenesis, but does not affect ovarian cancer cell proliferation directly. TSU-68 binds to VEGF and PDGF receptors to inhibit their phosphorylation rather than acting directly on the growth factors.
This document provides product information for Cilomilast, a novel kinase inhibitor for cell signaling and oncology research. Specifically:
- Cilomilast is a PDE4 inhibitor with a molecular weight of 343.42 and formula of C20H25NO4. It has a purity of 99% and should be stored at -20°C.
- Cilomilast inhibits both HPDE4 and LPDE4 catalytic activity with equal potency of around 100nM. It is less potent against HPDE4 than rolipram, suggesting it retains anti-inflammatory effects but decreased side effects.
- The document provides supplier contact information, technical specifications, activity descriptions, references
Doripenem is an injectable antibiotic that is particularly active against Pseudomonas aeruginosa. It is an ultra-broad spectrum antibiotic that belongs to the subgroup of carbapenems. Doripenem is a beta-lactam antibiotic that works by inhibiting cell wall synthesis in bacteria. It should be stored at -20°C for long-term storage.
Ketoconazole is a synthetic antifungal drug used to treat fungal infections, especially in immunocompromised patients. It works by interfering with fungal cell membrane synthesis and certain enzymes. Ketoconazole is structurally similar to imidazole. It is a white to light yellow powder with a molecular weight of 531.43. It is soluble in DMSO and has a purity of 99%. It should be stored at -20°C for long term storage.
Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family that inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. It has a molecular weight of 375.39 and formula of C19H22FN3O4. Gatifloxacin is soluble in water and has a purity of 99%. It should be stored at -20°C for up to 2 years.
Doxazosin mesylate is an alpha-1 adrenergic receptor blocker used to treat high blood pressure and benign prostatic hyperplasia. It inhibits the binding of norepinephrine to alpha-1 receptors in vascular smooth muscle cells, relaxing the muscles and decreasing blood pressure. Doxazosin mesylate is provided by Selleck Chemicals for cell signaling and oncology research, with product information including molecular weight, formula, solubility, purity, storage conditions, and CAS number.
Biological Activity of Bendamustine Hydrochloride:
Bendamustine is a nitrogen mustard used in the treatment of chronic lymphocytic leukemias (CLL) and lymphomas. It is also being studied for the treatment of sarcoma. [1]
Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators. [2]
This agent inhibited SU-DHL-1 cell proliferation with IC50 at 50 μm. [3]
--------------------------------------------------------------------------------
References on Bendamustine Hydrochloride:
[1] http://en.wikipedia.org/wiki/Bendamustine
[2] http://www.cancer.gov/drugdictionary/?CdrID=350251
[3] Lorenzo M. Leoni et al. Clin Cancer Res.2008 January 1;14:309-317
[4] http://www.rxlist.com/treanda-drug.htm
1. Posaconazole is a triazole antifungal drug that works by inhibiting the enzyme lanosterol 14α-demethylase, blocking ergosterol synthesis and accumulating sterol precursors.
2. It is significantly more potent at inhibiting 14-alpha demethylase than itraconazole.
3. Posaconazole disrupts the packing of phospholipid acyl chains, impairing membrane-bound enzyme systems like ATPase and electron transport, inhibiting fungal growth.
Bendamustine hydrochloride is an alkylating agent used to treat chronic lymphocytic leukemias and lymphomas. It differs from other alkylators in that it may be more potent in activating stress pathways and inducing apoptosis. It causes DNA cross-linking and inhibits cell proliferation. Bendamustine hydrochloride should be stored at -20°C for long term storage to maintain stability and quality. It has a purity of 99% and molecular weight of 394.72.
Biological Activity of Cladribine:
Cladribine (Leustatin) is a drug used to treat hairy cell leukemia (leukemic reticuloendotheliosis) and multiple sclerosis. [1]As a purine analog, it is a synthetic anti-cancer agent that also suppresses the immune system. Chemically, it mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, which interferes with the cell's ability to process DNA. [1]It is easily destroyed by normal cells except for blood cells, with the result that it produces relatively few side effects and results in very little non-target cell loss. [1]
--------------------------------------------------------------------------------
References on Cladribine:
[1] http://en.wikipedia.org/wiki/Cladribine
[2] http://www.rxlist.com/leustatin-drug.htm
Biological Activity of 17-DMAG:
17-DMAG, a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG binds to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. 17-DMAG demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral bioavailability. [1]
--------------------------------------------------------------------------------
References on 17-DMAG:
[1] Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126-37
1. Vicriviroc malate is a novel kinase inhibitor developed for cell signaling and oncology research that acts as a CCR5 receptor antagonist.
2. Studies showed that vicriviroc potently inhibited chemokine-induced migration, calcium release, and GTPS exchange in CCR5-expressing cells with IC50 values below 4.2 nM, demonstrating its ability to block CCR5 receptor signaling.
3. Selleck Chemicals produces vicriviroc malate and provides information on its product details, storage conditions, references, and ordering procedures.
1. AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor being studied for its effects on human multiple myeloma (MM) and cell signaling.
2. In studies, AS703026 inhibited the growth and survival of MM cells and cytokine-induced osteoclast differentiation more potently than AZD6244.
3. The inhibition was mediated by cell cycle arrest and reduction of the MAF oncogene, and AS703026 sensitized MM cells to a variety of anti-MM therapies.
TSU-68 is a novel kinase inhibitor developed for cell signaling and oncology research. It has significant antitumor activity against many types of tumors by inducing apoptosis in vascular and tumor cells, perturbing tumor vasculature and inhibiting angiogenesis. TSU-68 inhibits the tyrosine kinase phosphorylation of VEGF, PDGF and bFGF receptors to block angiogenesis. Studies show it inhibits tumor proliferation and metastasis in colon cancer models by blocking tumor angiogenesis, but does not affect ovarian cancer cell proliferation directly. TSU-68 binds to VEGF and PDGF receptors to inhibit their phosphorylation rather than acting directly on the growth factors.
This document provides product information for Cilomilast, a novel kinase inhibitor for cell signaling and oncology research. Specifically:
- Cilomilast is a PDE4 inhibitor with a molecular weight of 343.42 and formula of C20H25NO4. It has a purity of 99% and should be stored at -20°C.
- Cilomilast inhibits both HPDE4 and LPDE4 catalytic activity with equal potency of around 100nM. It is less potent against HPDE4 than rolipram, suggesting it retains anti-inflammatory effects but decreased side effects.
- The document provides supplier contact information, technical specifications, activity descriptions, references
Doripenem is an injectable antibiotic that is particularly active against Pseudomonas aeruginosa. It is an ultra-broad spectrum antibiotic that belongs to the subgroup of carbapenems. Doripenem is a beta-lactam antibiotic that works by inhibiting cell wall synthesis in bacteria. It should be stored at -20°C for long-term storage.
Ketoconazole is a synthetic antifungal drug used to treat fungal infections, especially in immunocompromised patients. It works by interfering with fungal cell membrane synthesis and certain enzymes. Ketoconazole is structurally similar to imidazole. It is a white to light yellow powder with a molecular weight of 531.43. It is soluble in DMSO and has a purity of 99%. It should be stored at -20°C for long term storage.
Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family that inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. It has a molecular weight of 375.39 and formula of C19H22FN3O4. Gatifloxacin is soluble in water and has a purity of 99%. It should be stored at -20°C for up to 2 years.
Doxazosin mesylate is an alpha-1 adrenergic receptor blocker used to treat high blood pressure and benign prostatic hyperplasia. It inhibits the binding of norepinephrine to alpha-1 receptors in vascular smooth muscle cells, relaxing the muscles and decreasing blood pressure. Doxazosin mesylate is provided by Selleck Chemicals for cell signaling and oncology research, with product information including molecular weight, formula, solubility, purity, storage conditions, and CAS number.
Biological Activity of Bendamustine Hydrochloride:
Bendamustine is a nitrogen mustard used in the treatment of chronic lymphocytic leukemias (CLL) and lymphomas. It is also being studied for the treatment of sarcoma. [1]
Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators. [2]
This agent inhibited SU-DHL-1 cell proliferation with IC50 at 50 μm. [3]
--------------------------------------------------------------------------------
References on Bendamustine Hydrochloride:
[1] http://en.wikipedia.org/wiki/Bendamustine
[2] http://www.cancer.gov/drugdictionary/?CdrID=350251
[3] Lorenzo M. Leoni et al. Clin Cancer Res.2008 January 1;14:309-317
[4] http://www.rxlist.com/treanda-drug.htm
1. Posaconazole is a triazole antifungal drug that works by inhibiting the enzyme lanosterol 14α-demethylase, blocking ergosterol synthesis and accumulating sterol precursors.
2. It is significantly more potent at inhibiting 14-alpha demethylase than itraconazole.
3. Posaconazole disrupts the packing of phospholipid acyl chains, impairing membrane-bound enzyme systems like ATPase and electron transport, inhibiting fungal growth.
Bendamustine hydrochloride is an alkylating agent used to treat chronic lymphocytic leukemias and lymphomas. It differs from other alkylators in that it may be more potent in activating stress pathways and inducing apoptosis. It causes DNA cross-linking and inhibits cell proliferation. Bendamustine hydrochloride should be stored at -20°C for long term storage to maintain stability and quality. It has a purity of 99% and molecular weight of 394.72.
Biological Activity of Cladribine:
Cladribine (Leustatin) is a drug used to treat hairy cell leukemia (leukemic reticuloendotheliosis) and multiple sclerosis. [1]As a purine analog, it is a synthetic anti-cancer agent that also suppresses the immune system. Chemically, it mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, which interferes with the cell's ability to process DNA. [1]It is easily destroyed by normal cells except for blood cells, with the result that it produces relatively few side effects and results in very little non-target cell loss. [1]
--------------------------------------------------------------------------------
References on Cladribine:
[1] http://en.wikipedia.org/wiki/Cladribine
[2] http://www.rxlist.com/leustatin-drug.htm
Biological Activity of 17-DMAG:
17-DMAG, a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG binds to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. 17-DMAG demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral bioavailability. [1]
--------------------------------------------------------------------------------
References on 17-DMAG:
[1] Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126-37