Presented by Karen Hytteballe Ibanez (DTU)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_Dietmar Lampert _ New indicators for Open ScieneOpenAIRE
Presented by Dietmar Lampert (ZSI Research Policy and Development)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
Presented by Paolo Manghi (OpenAIRE)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_Brecht Wyns & Christophe Bahim _ FAIR data maturity modelOpenAIRE
Presented by Brecht Wyns & Christophe Bahim (RDA)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
Supporting a national funders open access policy (Portugal)OpenAIRE
Presented by Vasco Vaz (Foundation for Science and Technology)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_Diego Chialva_ Research evaluation: the unseized opportunities ...OpenAIRE
Presented by Diego-Valerio Chialva (ERC)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_David Osimo_The Open Science MonitorOpenAIRE
Presented by David Osimo (Lisbon Council)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_Marc Vanholsbeeck_Open Science monitoring and the notion of research...OpenAIRE
Presented by Marc Vanholsbeeck, Fédération Wallonie-Bruxelles
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
Presented by Helena Cousijn (FREYA)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_Dietmar Lampert _ New indicators for Open ScieneOpenAIRE
Presented by Dietmar Lampert (ZSI Research Policy and Development)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
Presented by Paolo Manghi (OpenAIRE)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_Brecht Wyns & Christophe Bahim _ FAIR data maturity modelOpenAIRE
Presented by Brecht Wyns & Christophe Bahim (RDA)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
Supporting a national funders open access policy (Portugal)OpenAIRE
Presented by Vasco Vaz (Foundation for Science and Technology)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_Diego Chialva_ Research evaluation: the unseized opportunities ...OpenAIRE
Presented by Diego-Valerio Chialva (ERC)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_David Osimo_The Open Science MonitorOpenAIRE
Presented by David Osimo (Lisbon Council)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
20190527_Marc Vanholsbeeck_Open Science monitoring and the notion of research...OpenAIRE
Presented by Marc Vanholsbeeck, Fédération Wallonie-Bruxelles
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
Presented by Helena Cousijn (FREYA)
during the OpenAIRE workshop "Research policy monitoring in the era of Open Science and Big Data" taking place in Ghent, Belgium on May 27th and 28th 2019
Day 1: Monitoring and Infrastructure for Open Science
https://www.openaire.eu/research-policy-monitoring-in-the-era-of-open-science-and-big-data-the-what-indicators-and-the-how-infrastructures
HESA data, describing research activity and #REF2021Jisc RDM
Research Data Network
Dan Cook, Head of Data Policy & Development at HESA;
An update on the work Hesa is doing in relation to research data, especially in the context of the forthcoming REF.
OpenAIRE content in support of Open Science monitoring (Presentation by Paolo...OpenAIRE
"OpenAIRE content in support of Open Science monitoring".
Presentation by Paolo Manghi from Institute of Information Science and Technologies - CNR, at the Digital Infrastructures Conference 2018, Lisbon - OpenAIRE session: The Who and the How of Open Science: A user journey in Open Science through the lens of OpenAIRE (Oct. 10, 2018)
As part of a webinar series on Open Research in Ireland, the National Open Research Forum (NORF) presented a webinar focused on Infrastructures to support Open Research on 30 March 2021. This presentation on the European Open Science Cloud (EOSC) was delivered by Sarah Jones (GÉANT).
The future of scholarly communications professionalsNancy Pontika
The scholarly communications profession is constantly changing, and a wide range of skills are required in the advertised job descriptions. In an effort to investigate what kind of skills future information professionals need, during the period March 2015 to September 2017 job postings advertising positions relating to Open Access were collected. The total number of the collected job postings was 72.
The collection was done manually throughout this whole period from job advertising sites, such as Jobs.ac.uk, CILIP Lisjobnet and the Times of Higher Education. In addition, the author is subscribing to open listserves, such as the Jisc-Repositories, OAGoodPractice and a closed one, the UKCoRR-Discussion list, and managed to collect job descriptions from those list servers as well.
The aim of this work is to identify the most important skills required in the jobs advertised in our field, educate the new comers in the field and identify how our profession is evolving.
Dimensions of open research: critical reflections on openness in the ROER4D p...ROER4D
Dimensions of open research: critical reflections on openness in the ROER4D project
Thomas King, Cheryl Hodgkinson-Williams, Michelle Willmers, Sukaina Walji
University of Cape Town
OE Global Conference 2016, 14-16 April, Krakow, Poland
HESA data, describing research activity and #REF2021Jisc RDM
Research Data Network
Dan Cook, Head of Data Policy & Development at HESA;
An update on the work Hesa is doing in relation to research data, especially in the context of the forthcoming REF.
OpenAIRE content in support of Open Science monitoring (Presentation by Paolo...OpenAIRE
"OpenAIRE content in support of Open Science monitoring".
Presentation by Paolo Manghi from Institute of Information Science and Technologies - CNR, at the Digital Infrastructures Conference 2018, Lisbon - OpenAIRE session: The Who and the How of Open Science: A user journey in Open Science through the lens of OpenAIRE (Oct. 10, 2018)
As part of a webinar series on Open Research in Ireland, the National Open Research Forum (NORF) presented a webinar focused on Infrastructures to support Open Research on 30 March 2021. This presentation on the European Open Science Cloud (EOSC) was delivered by Sarah Jones (GÉANT).
The future of scholarly communications professionalsNancy Pontika
The scholarly communications profession is constantly changing, and a wide range of skills are required in the advertised job descriptions. In an effort to investigate what kind of skills future information professionals need, during the period March 2015 to September 2017 job postings advertising positions relating to Open Access were collected. The total number of the collected job postings was 72.
The collection was done manually throughout this whole period from job advertising sites, such as Jobs.ac.uk, CILIP Lisjobnet and the Times of Higher Education. In addition, the author is subscribing to open listserves, such as the Jisc-Repositories, OAGoodPractice and a closed one, the UKCoRR-Discussion list, and managed to collect job descriptions from those list servers as well.
The aim of this work is to identify the most important skills required in the jobs advertised in our field, educate the new comers in the field and identify how our profession is evolving.
Dimensions of open research: critical reflections on openness in the ROER4D p...ROER4D
Dimensions of open research: critical reflections on openness in the ROER4D project
Thomas King, Cheryl Hodgkinson-Williams, Michelle Willmers, Sukaina Walji
University of Cape Town
OE Global Conference 2016, 14-16 April, Krakow, Poland
Presentació a càrrec de Mireia Alcalá, tècnica de Recursos d'Informació al CSUC, duta a terme al workshop en línia "Research Data Management & Open Science" organitzat per l'IDIBELL el 2 de novembre de 2020.
Research data discovery in OpenAIRE (Presentation by Paolo Manghi at DI4R2018)OpenAIRE
"Research data discovery in OpenAIRE".
Presentation by Paolo Manghi from CNR-ISTI, at the Digital Infrastructures Conference 2018, Lisbon. Session: Building better collaborative national networks to support Open Science (Oct. 11, 2018)
Presentation investigating the state of FAIR practice and what is needed to turn FAIR data into reality given at the Danish FAIR conference in Copenhagen on 20th November 2018. https://vidensportal.deic.dk/en/Programme/FAIR_Toolbox_Nov2018 The presentation reflect on recent FAIR studies and international initiatives and outlines the recommendations emerging from the European Commission's FAIR Data Expert Group report - http://tinyurl.com/FAIR-EG
IFLA ARL Webinar Series: Research Ethics in an Open Research EnvironmentIFLAAcademicandResea
IFLA ARL Webinar Series | Held online on June 16/17, 2022
Research ethics guide the production of scholarly inquiry the world over. This webinar focuses on Institutional Data Support in Open Research Environment; toolkit for diversity scholarship data guidance; and Research, Ethics and CARE Principles presented by:
* Su-Nee, GOH, Deputy Director and Lead, Open Science & Research Services - Nanyang Technological University (NTU), Singapore;
* Rachel Woodbrook, Data Curation Librarian, University of Michigan;
* Zehra Taşkın, Associate Professor, Hacettepe University, Turkey; and
* Spencer Lilley, Associate Professor, School of Information Management Victoria University of Wellington Te Herenga Waka Aotearoa, New Zealand.
OpenAIRE Content Providers Community Call, November 4th, 2020
This call was focused on the PROVIDE future developments, functionalities wishlist and PROVIDE service in EOSC.
Was also an opportunity to share the most recent updates and novelties in the OpenAIRE Content Provider Dashboard, and to get feedback from community.
Recordings: https://youtu.be/wY4fOS767Us
Follow the Community activities at https://www.openaire.eu/provide-community-calls
OpenAIRE in the European Open Science Cloud (EOSC)OpenAIRE
Openness is the success factor for EOSC. OpenAIRE has been working in delivering an open access scholarly communication in Europe for the past 10 years and we now present how our work fits into the EOSC core developments
OpenAIRE Content Providers Community Call, October 7th, 2020
This call was focused on the OpenAIRE Broker Service, specifying how the service works to deploy the enrichment events to the Content Providers managers.
Was also an opportunity to share the most recent updates and novelties in the OpenAIRE Content Provider Dashboard, and to get feedback from community.
Recording: https://youtu.be/3sF4B58EGcs
Follow the Community activities at https://www.openaire.eu/provide-community-calls
OpenAIRE Content Providers Community Call, July 1st, 2020
This call was focused on Data Repositories namely the OpenAIRE Research Graph and Data Repositories, the OpenAIRE Content Acquisition Policy, and the Guidelines for Data Archive Managers.
Was also an opportunity to share the most recent updates and novelties in the OpenAIRE Content Provider Dashboard, and to get feedback from community.
Follow the Community activities at https://www.openaire.eu/provide-community-calls
OpenAIRE Content Providers Community Call. May 6th, 2020.
This Call focused the presentation of the new User Interface of Provide Dashboard and the presentation of 4 use cases using the Provide service.
Was also an opportunity to share the most recent updates and novelties in the OpenAIRE Content Provider Dashboard, and to get feedback from community.
Recording available here: https://youtu.be/J4m_ryRxtnY
20200504_OpenAIRE Legal Policy Webinar: GDPR and Sharing DataOpenAIRE
Presentation by Jacques Flores Dourojeanni (Research Data Management Consultant Utrecht University Library), as delivered during the OpenAIRE Legal Policy Webinar series on May 4th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200504_Research Data & the GDPR: How Open is Open?OpenAIRE
Presentation by Prodromos Tsiavos (Senior Legal Advisor - ARC/ Director - Onassis Group) as delivered during the OpenAIRE Legal Policy Webinar series on May 4th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200504_Data, Data Ownership and Open ScienceOpenAIRE
Presentation by Thomas Margoni (Senior Lecturer in Intellectual Property and Internet Law, Co-director, CREATe, University of Glasgow) as delivered during the OpenAIRE Legal Policy Webinar series on May 4th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200429_Research Data & the GDPR: How Open is Open? (updated version)OpenAIRE
Presentation by Prodromos Tsiavos (Senior Legal Advisor - ARC/ Director - Onassis Group) as delivered during the OpenAIRE Legal Policy Webinar series on April 29th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200429_Data, Data Ownership and Open ScienceOpenAIRE
Presentation by Thomas Margoni (Senior Lecturer in Intellectual Property and Internet Law, Co-director, CREATe, University of Glasgow) as delivered during the OpenAIRE Legal Policy Webinar series on April 29th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
20200429_OpenAIRE Legal Policy Webinar: GDPR and Sharing DataOpenAIRE
Presentation by Jacques Flores Dourojeanni (Research Data Management Consultant Utrecht University Library), as delivered during the OpenAIRE Legal Policy Webinar series on April 29th 2020.
More information and recordings: https://www.openaire.eu/item/openaire-legal-policy-webinars
COVID-19: Activities, tools, best practice and contact points in GreeceOpenAIRE
Presentation from the webinar organized by the Greek OpenAIRE and RDA Nodes (Athena RC) and Elixir-GR to inform participants of EU and national efforts, in collaboration with the following research organizations: Flemming, CERTH, HEAL-Link, Demokritos, Univ. of Athens (Medical School).
Presentation of the 2nd Content Providers Community Call, targeting the following topics: 1) OpenAIRE Content provider dashboard updates; Main topic: DSpace-CRIS for OpenAIRE: implementation of the CRIS guidelines and beyond; 3) Community questions & comments.
Presentation of the 2nd Content Providers Community Call, targeting the following topics: 1) OpenAIRE Content provider dashboard updates;
2) OpenAIRE aggregation and enrichment processes: specifications and good practices;
3) Community questions & comments.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
20190527_Karen Hytteballe Ibanez _ The OPERA project
1. DTUDate Title
The OPERA project
Exploring Open Research Analytics
Karen Hytteballe Ibanez
Senior Officer & Project Manager
DTU – Technical University of Denmark
kshi@dtu.dk
3. DTUDate Title 3
• Identify and evaluate approaches to
document the impact of open science
• practical experience and knowledge
building in handling FAIR principles with
respect to research analytics practises
• Evaluate established, emerging, open
and supplementary data sets
• implement these data in the open
source semantic web application VIVO
• Explores how the Humanities and
Social Sciences can help expand current
methodologies and indicators for impact
assessment, and shape the future
availability of data and metrics.
• find the most relevant network
analytics and visualizations that may
support and complement both classical &
open research analytics
Analytics data and
systems
Network Analysis &
visualizations
Also Humanities
Open Science Support
Open
Research
Analytics
Work Packages
4. DTUDate Title
OPERA Dec. 2020
4
Exploring Open Research analytics in different
contexts
Experimenting with showcasing and
monitoring Open Science efforts at national
and university level, including as many Open
Science elements as possible
Selected project deliverables
4 reviews and reports to be published
June 2019 on https://deffopera.dk/
• Quantitative indicators for societal impact
• identifying tools for visualizing and
representing publication- and impact data
in SSH
• OS & Open Data in research analytics –
the most prominent and important
manifests and policy papers.
• Ontology report
Research analytics systems
5. DTUDate Title
Before we monitor Open Science
we need:
• Valid, robust and reliable data sources
• Open data sources (no black boxes) Registry of Scientometrics Data Sources
https://labs.tib.eu/rosi/index.php
• Comprehensive data coverage
• 100% transparency
• To understand the scope, coverage and limitations of the sources
• Therefore we need to analyze the data in the OPERA project we are
spending a substantial amount of time conducting data analyses – comparing
sources on an overall level and on article level as well
• Collaboration and joint initiatives
• And open systems/platform
5
7. DTUDate Title
What is VIVO?
• Member-supported, open source software
• An ontology for representing scholarship
Ongoing development of the ontology – new
is the Contributor Role Ontology, a
structured representation of contribution
roles, built on the CRedIT taxonomy
The VIVO ontology is extendable in order to
accommodate local needs
• Open shared platform
• Integrates multiple data sources
• Linked Open Data (LOD)
• Visualizations
Why did we choose VIVO?
• An alternative to the commercial products
• Freedom to customize without being
dependent on the agenda of big companies
• No vendor lock-in effect
• Powerfull and flexible ontology
• An Open, dedicated and helpful community
7
8. DTUDate Title
VIVO for different purposes
8
Expert finder system
CRIS
Res. Analytics platform
9. DTUDate Title
A test platform for several universities
(in casu from Denmark) – For inter-
university analytics and visualisations
OPERA Systems Overview – 2 VIVOs
9
A single university (in casu DTU)
Research Analytics Platform – RAP
For in-depth (internal) analyses
10. DTUDate Title
National Dimensions VIVO test platform –
combining global and national data with supplementary sources for OS elements
10
National VIVO test
platform - with data
from the Danish
Universities
11. DTUDate Title
Potential analyses and visualizations to be added
11
National VIVO
test platform -
with data from
the Danish
Universities
12. DTUDate Title 12
Dec 2020
Monitoring:
• OA publications
• Open dataset
• Open peer review
contributions
• Open citations
&
• Open Science
impact?
13. DTUDate Title
Open Science monitoring
13
Open
Science
monitoring
Open
source
Open
Methods
Open
Data
Open
Code
Open
Systems
Open
Tools
Open
Platform
In the OPERA project we
work to make the results
open & open for discussion
14. DTUDate Title
Thank you for your attention
More info on the OPERA project
https://deffopera.dk
&
@deffopera / #deffopera
14