This study examines the relationship between Notch pathway activity, epithelial-mesenchymal transition (EMT) status, and chemoresistance in non-small cell lung cancer. The researchers found that cells with high Notch activity had increased invasiveness, overexpression of mesenchymal genes, and resistance to chemotherapy. Inhibiting the Notch pathway with a gamma secretase inhibitor (GSI) decreased invasiveness and the expression of mesenchymal genes, while increasing the expression of epithelial genes. It also rendered the resistant cells sensitive to chemotherapy. Combining GSI with docetaxel reduced tumor growth more than either treatment alone in mouse models. Therefore, blocking the Notch pathway inhibits EMT status