This document summarizes a proposed study to evaluate vitamin C as a potential anti-tuberculosis drug. The study would first test vitamin C in vitro against drug-susceptible and drug-resistant strains of M. tuberculosis, alone and in combination with existing drugs, to determine minimum inhibitory concentrations. It would then evaluate vitamin C pharmacokinetics in guinea pigs at different doses. Finally, it would test vitamin C alone and in combination with other drugs in guinea pig models of acute and chronic tuberculosis infection to assess efficacy. The goal is to explore whether vitamin C's ability to generate oxidative damage could make it useful for treating tuberculosis, including multi-drug resistant forms.