This document provides guidance for completing research proposals for the Centre for Defence Enterprise (CDE). It outlines key factors to address, such as clarity, innovation, low technology readiness levels, defence users, and benefits. It emphasizes that proposals should demonstrate game-changing potential, strong outputs, a logical approach, and clear deliverables. The guidance stresses that proposals should prove operational relevance and likelihood of exploitation, while building critical science and technology for the UK. It provides reminders to consider proposal format and attachments, as well as submission through the online portal.