Upgrading from older versions of Exchange Server to Exchange Server 2010 requires planning and testing. Supported upgrade paths include upgrading from Exchange Server 2003 or 2007. Key steps involve preparing Active Directory, deploying Exchange 2010 servers in a specific order, and implementing coexistence of client access and messaging during the transition. Considerations for administration, messaging transport, and Outlook clients ensure a smooth upgrade process. Removing legacy servers after validating the migration is complete finalizes the upgrade.