1. Two persons with the sickle cell trait marry and want to have chi.pdf

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1. Two persons with the sickle cell trait marry and want to have children, but concerned about them having sickle cell anemia. What is the probability of sickle cell anemia in their children? What proportion of their children would you expect to be carriers? 2. If a person with the sickle cell trait marries a person with a normal hemoglobin, what is the probability they will have a child with sickle cell anemia? What proportion of their children would you expect to be carriers? Solution Answer: 1) If both parents are having sickle cell anemia,then the out come is I = Normal gene, T: sickle cell trait TI (One parent ) x TI (Another parent) Possible genotypes: TT, TI, TI, II (TT)25% : not affected by sickle cell, (TI)50%: carriers (II)25%: affected by sickle cell 2) Person with the sickle cell trait marries a person with a normal hemoglobin TI (sickle cell trait person) x II (Normal ) Possible genotypes: TI, TI, II,II TI (50%) = carrier II (50%)= Unaffected by sickle cell..

1. Two persons with the sickle cell trait marry and want to have children, but concerned about
them having sickle cell anemia. What is the probability of sickle cell anemia in their children?
What proportion of their children would you expect to be carriers?
2. If a person with the sickle cell trait marries a person with a normal hemoglobin, what is the
probability they will have a child with sickle cell anemia? What proportion of their children
would you expect to be carriers?
Solution
Answer:
1)
If both parents are having sickle cell anemia,then the out come is
I = Normal gene, T: sickle cell trait
TI (One parent ) x TI (Another parent)
Possible genotypes: TT, TI, TI, II
(TT)25% : not affected by sickle cell,
(TI)50%: carriers
(II)25%: affected by sickle cell
2)
Person with the sickle cell trait marries a person with a normal hemoglobin
TI (sickle cell trait person) x II (Normal )
Possible genotypes: TI, TI, II,II
TI (50%) = carrier
II (50%)= Unaffected by sickle cell.

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1. Two persons with the sickle cell trait marry and want to have chi.pdf

1. 1. Two persons with the sickle cell trait marry and want to have children, but concerned about them having sickle cell anemia. What is the probability of sickle cell anemia in their children? What proportion of their children would you expect to be carriers? 2. If a person with the sickle cell trait marries a person with a normal hemoglobin, what is the probability they will have a child with sickle cell anemia? What proportion of their children would you expect to be carriers? Solution Answer: 1) If both parents are having sickle cell anemia,then the out come is I = Normal gene, T: sickle cell trait TI (One parent ) x TI (Another parent) Possible genotypes: TT, TI, TI, II (TT)25% : not affected by sickle cell, (TI)50%: carriers (II)25%: affected by sickle cell 2) Person with the sickle cell trait marries a person with a normal hemoglobin TI (sickle cell trait person) x II (Normal ) Possible genotypes: TI, TI, II,II TI (50%) = carrier II (50%)= Unaffected by sickle cell.