More Related Content
Similar to S1470 tsu 68 (12)
S1470 tsu 68
- 1. Product Information Novel Kinase Inhibitors
for cell signaling & oncology research
Toll Free:
S1470 TSU-68 (877)796-6397
-- USA and Canada only --
» VEGFR-PDGFR
Fax:
+1-713-796-9816
Technical Data:
Orders
M.Wt: 310.35 O
+1-713-922-4115
Formula: C18H18N2O3 OH
enquiry@selleckchem.com
Solubility: DMSO N
Purity: 99%
H
Tech Support
O
tech@selleckchem.com
Storage: at -20℃ 2 years N
H (chemistry support)
CAS No.: 252916-29-3 Synonyms: SU6668 techbio@selleckchem.com
(bio support)
Web
Biological Activity
www.selleckchem.com
TSU-68 has significant antitumor activity against many types of tumor xenograft explants in
athymic mice. TSU-68 inhibits angiogenesis through several mechanisms, including the induction
of apoptosis in vascular endothelial cells and tumor cells, resulting in perturbing existing tumor
vascular function and also inhibiting newly synthesis angiogenesis for the tumor growth.[1] TSU-68,
a molecular-targeting drug, has the effect on blocking the tyrosine kinase phosphorylation of the
receptors not only for VEGF but also for PDGF and bFGF, and inhibiting angiogenesis. Studies
Selleck Overnight Delivery Service
using in vivo experimental models of cancers such as colon cancer have reported that TSU-68
has the effect on inhibiting tumor proliferation and metastasis through the inhibition of tumor
angiogenesis. In vitro TSU-68 does not influence the proliferation of ovarian cancer cells.[2] The
administration of TSU-68 does not influence the concentration of VEGF or PDGF in the ascetic
fluid of mice with peritoneal dissemination of ovarian cancer. TSU-68 does not act directly on Return Policy
VEGF or PDGF, but binds to their receptors, thereby inhibiting their phosphorylation. [2] Please inspect packages immediately upon
receipt and notify customer service within
References 3 days of delivery of any damage or
discrepancies.Our team will take quick and
[1] Ueda Y et al. Cancer Chemother Pharmacol. 2010 Jul 30 appropriate action to correct any problem.
[2] Machida S et al. Int J Cancer. 2005 Mar 20; 114 (2): 224-9
Goods ordered in error can only be accepted
for return if made within 3 days of delivery,
MSDS & CoA are unopened,have been stored correctly and
Please visit www.selleckchem.com to download MSDS and CoA. are in good condition. Should you wish to
return any item(s), prior authorization must
Notes be received from our customer service team.
Returns accepted will be subject to a 30%
restocking charge.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. For all product returns and product replace-
ments,please contact Selleck directly by
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under info@selleckchem.com or
the recommended conditions, are stable for two year. Products are sometimes shipped at a temperature that differs from the recommended +1-713-922-4115.
storage temperature,most are recommended stored at -20℃.Many products are stable in the short-term at temperatures that differ from that Please have on hand, the invoice number,
required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save purchase order number,air bill number and
you shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage approximate date of shipment/receipt.
recommendations on the product data sheet.
© Copyright 2010 Selleck chemicals