Biological Activity of Bendamustine Hydrochloride: Bendamustine is a nitrogen mustard used in the treatment of chronic lymphocytic leukemias (CLL) and lymphomas. It is also being studied for the treatment of sarcoma. [1] Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators. [2] This agent inhibited SU-DHL-1 cell proliferation with IC50 at 50 μm. [3] -------------------------------------------------------------------------------- References on Bendamustine Hydrochloride: [1] http://en.wikipedia.org/wiki/Bendamustine [2] http://www.cancer.gov/drugdictionary/?CdrID=350251 [3] Lorenzo M. Leoni et al. Clin Cancer Res.2008 January 1;14:309-317 [4] http://www.rxlist.com/treanda-drug.htm

1. Product Information Novel Kinase Inhibitors
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Formula: C21H18NO4.HCl O
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Chelerythrine is a benzophenanthridine alkaloid extracted from the plant Greater celandine
(Chelidonium majus). It is a potent, selective, and cell-permeable PKC inhibitor (IC50 = 660 nM).
It has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial
and antitumor effects. [1,2]
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[2] Herbert JM et al. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9
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