1. Vicriviroc malate is a novel kinase inhibitor developed for cell signaling and oncology research that acts as a CCR5 receptor antagonist. 2. Studies showed that vicriviroc potently inhibited chemokine-induced migration, calcium release, and GTPS exchange in CCR5-expressing cells with IC50 values below 4.2 nM, demonstrating its ability to block CCR5 receptor signaling. 3. Selleck Chemicals produces vicriviroc malate and provides information on its product details, storage conditions, references, and ordering procedures.

1. Product Information Novel Kinase Inhibitors
for cell signaling & oncology research
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Technical Data:
Orders
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Formula: C32H44F3N5O7 enquiry@selleckchem.com
N
Solubility: DMSO N N
Purity: 99%
CF 3
Tech Support
N N
tech@selleckchem.com
Storage: at -20℃ 2 years O
C 4H 6O 5
(chemistry support)
CAS No.: 541503-81-5 Synonyms: SCH417690, SCH-D techbio@selleckchem.com
(bio support)
Web
Biological Activity
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In order to determine if vicriviroc is a receptor agonist or antagonist, three functional assays were
employed to measure the ability of the compound to block b-chemokine signaling in CCR5-expressing
cells. A chemotaxis assay was first employed to determine the ability of vicriviroc to inhibit
chemokine-mediated migration of a mouse Ba/F3 cell line stably expressing recombinant human
CCR5. In this assay,vicriviroc showed equally potent inhibition of the chemotactic response to MIP-1
with IC50 values below 1 nM. The ability of vicriviroc to inhibit intracellular calcium release
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induced by receptor stimulation was also assessed. A assay utilized to demonstrate the ability of
vicriviroc to inhibit CCR5 receptor signaling was a GTPS exchange assay. GTPS binding induced
by RANTES. vicriviroc potently inhibited RANTES-induced signaling with mean IC50s of
4.2 nM. [1]
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References Please inspect packages immediately upon
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[1] Julie M. Strizki et al. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9
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