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S4002 sitagliptin
- 1. Product Information Novel Kinase Inhibitors
for cell signaling & oncology research
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Technical Data:
CF 3 Orders
M.Wt: 407.31
+1-713-922-4115
F N
Formula: C16H15F6N5O N enquiry@selleckchem.com
N N
Solubility: DMSO
Purity: 99% NH 2 O Tech Support
F
tech@selleckchem.com
Storage: at -20℃ 2 years F
(chemistry support)
CAS No.: 486460-32-6 Synonyms: MK-0431, Januvia techbio@selleckchem.com
(bio support)
Web
Biological Activity
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Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are
important incretin hormones contributing to 50-70% of the stimulation of insulin secretion after
a meal.Dipeptidyl-peptidase IV(DPP-4) inhibitors inhibit the degradation of GLP-1 and GIP as
well as that of other regulatory peptides.[1] Sitagliptin abolished sDPP-IV effects on splenic CD4+
T-cell migration whereas incretins decreased migration of lymph node, but not splenic, CD4+
T-cells. Sitagliptin decreases migration of splenic CD4 + T-cells through a pathway involving
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Rac1/VASP, whereas its inhibitory effects on the migration of lymph node CD4+ T-cells involve
incretin-activation of the NF-κB pathway.[2]It is eliminated renally, with a terminal half-life of
11.8-14.4 hours. [3]
References Return Policy
Please inspect packages immediately upon
[1] Gallwitz B. Drugs Today (Barc). 2007 Nov; 43(11):801-14
receipt and notify customer service within
[2] Su-Jin Kim et al. Diabetes, 2010 July; 59(7):1739-1750 3 days of delivery of any damage or
discrepancies.Our team will take quick and
[3] Shannon A Miller et al. The Annals of Pharmacotherapy. 40(7):1336-1343
appropriate action to correct any problem.
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the recommended conditions, are stable for two year. Products are sometimes shipped at a temperature that differs from the recommended +1-713-922-4115.
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