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Product Information                                                                                                                              Novel Kinase Inhibitors
                                                                                                                                                 for cell signaling & oncology research


                                                                                                                                                 Toll Free:
  S4002 Sitagliptin                                                                                                                              (877)796-6397
                                                                                                                                                 -- USA and Canada only --
                    » DPP-4
                                                                                                                                                 Fax:
                                                                                                                                                 +1-713-796-9816
Technical Data:
                                                                                                                     CF 3                        Orders
M.Wt:                      407.31
                                                                                                                                                 +1-713-922-4115
                                                                              F                                N
Formula:                   C16H15F6N5O                                                                                  N                        enquiry@selleckchem.com
                                                                                                       N            N
Solubility:                DMSO
Purity:                    99%                                                            NH 2 O                                                 Tech Support
                                                                      F
                                                                                                                                                 tech@selleckchem.com
Storage:                   at -20℃ 2 years                                    F
                                                                                                                                                 (chemistry support)
CAS No.:                   486460-32-6                                Synonyms: MK-0431,                      Januvia                            techbio@selleckchem.com
                                                                                                                                                 (bio support)


                                                                                                                                                 Web
Biological Activity
                                                                                                                                                 www.selleckchem.com
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are
important incretin hormones contributing to 50-70% of the stimulation of insulin secretion after
a meal.Dipeptidyl-peptidase IV(DPP-4) inhibitors inhibit the degradation of GLP-1 and GIP as
well as that of other regulatory peptides.[1] Sitagliptin abolished sDPP-IV effects on splenic CD4+
T-cell migration whereas incretins decreased migration of lymph node, but not splenic, CD4+
T-cells. Sitagliptin decreases migration of splenic CD4 + T-cells through a pathway involving
                                                                                                                                                 Selleck Overnight Delivery Service
Rac1/VASP, whereas its inhibitory effects on the migration of lymph node CD4+ T-cells involve
incretin-activation of the NF-κB pathway.[2]It is eliminated renally, with a terminal half-life of
11.8-14.4 hours. [3]


References                                                                                                                                       Return Policy
                                                                                                                                                 Please inspect packages immediately upon
[1] Gallwitz B. Drugs Today (Barc). 2007 Nov; 43(11):801-14
                                                                                                                                                 receipt and notify customer service within
[2] Su-Jin Kim et al. Diabetes, 2010 July; 59(7):1739-1750                                                                                       3 days of delivery of any damage or

                                                                                                                                                 discrepancies.Our team will take quick and
[3] Shannon A Miller et al. The Annals of Pharmacotherapy. 40(7):1336-1343
                                                                                                                                                 appropriate action to correct any problem.


MSDS & CoA                                                                                                                                       Goods ordered in error can only be accepted

Please visit www.selleckchem.com to download MSDS and CoA.                                                                                       for return if made within 3 days of delivery,

                                                                                                                                                 are unopened,have been stored correctly and

                                                                                                                                                 are in good condition. Should you wish to

                                                                                                                                                 return any item(s), prior authorization must

Notes                                                                                                                                            be received from our customer service team.

                                                                                                                                                 Returns accepted will be subject to a 30%

                                                                                                                                                 restocking charge.
   PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.

   NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.                                                                                    For all product returns and product replace-

                                                                                                                                                 ments,please contact Selleck directly by
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under        info@selleckchem.com or
the recommended conditions, are stable for two year. Products are sometimes shipped at a temperature that differs from the recommended           +1-713-922-4115.
storage temperature,most are recommended stored at -20℃.Many products are stable in the short-term at temperatures that differ from that         Please have on hand, the invoice number,
required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save   purchase order number,air bill number and
you shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage   approximate date of shipment/receipt.
recommendations on the product data sheet.



                                                                                                                                                 © Copyright 2010 Selleck chemicals

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S4002 sitagliptin

  • 1. Product Information Novel Kinase Inhibitors for cell signaling & oncology research Toll Free: S4002 Sitagliptin (877)796-6397 -- USA and Canada only -- » DPP-4 Fax: +1-713-796-9816 Technical Data: CF 3 Orders M.Wt: 407.31 +1-713-922-4115 F N Formula: C16H15F6N5O N enquiry@selleckchem.com N N Solubility: DMSO Purity: 99% NH 2 O Tech Support F tech@selleckchem.com Storage: at -20℃ 2 years F (chemistry support) CAS No.: 486460-32-6 Synonyms: MK-0431, Januvia techbio@selleckchem.com (bio support) Web Biological Activity www.selleckchem.com Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are important incretin hormones contributing to 50-70% of the stimulation of insulin secretion after a meal.Dipeptidyl-peptidase IV(DPP-4) inhibitors inhibit the degradation of GLP-1 and GIP as well as that of other regulatory peptides.[1] Sitagliptin abolished sDPP-IV effects on splenic CD4+ T-cell migration whereas incretins decreased migration of lymph node, but not splenic, CD4+ T-cells. Sitagliptin decreases migration of splenic CD4 + T-cells through a pathway involving Selleck Overnight Delivery Service Rac1/VASP, whereas its inhibitory effects on the migration of lymph node CD4+ T-cells involve incretin-activation of the NF-κB pathway.[2]It is eliminated renally, with a terminal half-life of 11.8-14.4 hours. [3] References Return Policy Please inspect packages immediately upon [1] Gallwitz B. Drugs Today (Barc). 2007 Nov; 43(11):801-14 receipt and notify customer service within [2] Su-Jin Kim et al. Diabetes, 2010 July; 59(7):1739-1750 3 days of delivery of any damage or discrepancies.Our team will take quick and [3] Shannon A Miller et al. The Annals of Pharmacotherapy. 40(7):1336-1343 appropriate action to correct any problem. MSDS & CoA Goods ordered in error can only be accepted Please visit www.selleckchem.com to download MSDS and CoA. for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must Notes be received from our customer service team. Returns accepted will be subject to a 30% restocking charge. PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. For all product returns and product replace- ments,please contact Selleck directly by Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under info@selleckchem.com or the recommended conditions, are stable for two year. Products are sometimes shipped at a temperature that differs from the recommended +1-713-922-4115. storage temperature,most are recommended stored at -20℃.Many products are stable in the short-term at temperatures that differ from that Please have on hand, the invoice number, required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save purchase order number,air bill number and you shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage approximate date of shipment/receipt. recommendations on the product data sheet. © Copyright 2010 Selleck chemicals