Basic Principle of Cell Injury and Cellular Adaptation multiple choice question subject : Pathophysiology (Sem -II) as per the PCI Syllabus

1. Basic Principle of Cell Injury and Cellular
Adaptation
MCQ
subject : Pathophysiology (Sem -II)
By
Mr. Satish Shamrao Meshram
Assistant professor
Kamla Nehru college of Pharmacy ,Butibori
Email.id : satish.meshram@gmail.com
Contacted on: 8975866806

2. MCQ on
Basic Principle of Cell Injury and
Cellular adaptation
1. Inflammation is the dynamic process by which living tissue
react to injury
a) True
b) False
2. Physical agent responsible for inflammation
a) Trauma
b) Heat or Cold
c) Radiation
d) All of these
3. An altered state of Immunological responsiveness causes an in
appropriate or excessive immune reaction which damage of
tissue known as hypersensitivity
a) True
b) False

3. 4.Match the following of clinical sign of Inflammation and Latin
words .
a) Redness i) Calor
b) Heat ii) Rabor
c) Swelling iii) Dolar
d) Pain iv) Tumor
Ans-(a)-ii (b)-i (c) iv (d) iii
5. Cell death
a) Swelling of endoplasmic reticulum
b) Loss of Ribosome or Lysosome Rupture
c) Swollen mitochondrial or membrane blebs
d) All of these
6.Component of feedback and types of feedback system
a) Sensory Mechanism
b) Integrating or Control Center
c) Effective Mechanism

4. 7. The chromosomal abnormalities are concerned abnormalities
of chromosome ,it may be numbered or structural
a) Developmental Defect
b) Cytogenic Defect
c) Single gene defect
d) Disorder with multifactorial inheritance
8. Programmed cell death is known as
a) apoptosis
b) Necrosis
c) both a and b
d) none of the above
09. Irreversible cell injury in cell is
a) Deposition of Ca++ in mitochondria
b)Swelling
c)Mitotic figure
d)Ribosomal detachment

5. 10. An example of hypertrophy would be
(a) liver regeneration after partial hepatectomy
(b) breast development at puberty
(c) the uterus during pregnancy
(d) the uterus during menstruation
11. Hyperplasia
(a) increase in the size of cells
(b) increase in the number of cells
(c) increase in the number of cellular organelles
(d) increase in the size of the organ
12. Pinocytosis
(a) adds to the cell membrane
(b) is the uptake of small particulate matter
(c) involves the uptake of soluble macromolecules
(d) involves the uptake of opsinised bacteria

6. 13.Match the following of cellular adaptation and changes occurs
during adaptation
a) Atrophy i ) Increase cell size
b) Hypertrophy ii) Increase cell number
c) Hyperplasia iii) Disorderedly Growth
d) Dysplasia iv) Decreased cell size
Ans (a)–iv (b)-i (c)-ii (d)-iii
14.Regarding apoptosis which of the following is False
a) It is responsible fro programmed destruction of cell during
embryogenesis
b) Occurs in pathological atrophy in parenchymal organs after
duct destruction
c) Cell death by cytotoxic T Cell and Chromatin condensation
d) Associated with inflammation

7. 15. In Hypoxic cell injury , cell Swelling occurs because of increased
intracellularlly
a) Lipid
b) Protein
c) Glycogen
d) Water
16.Which of the following is NOT a feature of reversible cell injury
a) Cellular swelling
b) Reduction of ATP Synthesis
c) Clumping of Nuclear chromatin
d) Defects in cell membrane
17.Fatty changes occurs
a) Does not impaired cellular function
b) It most commonly due diabetes mellitus
c) It caused by alcohol by an increase in intracellular alpha
glycerophosphate
d) Only occurs in the liver

8. 18.Metastatic calcification
a) Is encountered in areas of necrosis
b) Commonly developed in ageing of damaged heart valve
c) Can occur with normal serum level of calcium
d) Can be associated with metastatic malignancy
19. The defect follows classic mendelian patterns of inheritance
and are called mendelian syndrome or disorder it is due to
mutation of a single gene
a) True
b) False
20. Cellular swelling due to disturbance of Sodium Potassium
ATPase Pumps
a) Influx of Calcium
b) Water and sodium Retention
c) Efflux of Potassium
d) All of these

9. 21.Reactive Oxygen Species (ROS) to generate free radicals include
a) Superoxide anion (O2)
b) Hydrogen Peroxide (H2O2)
c) Hydroxyl radical (OH)
d) All of these
22. Reactive Nitrogen Species (RNS) include which generates free
radical
a) Nitric Oxide (NO)
b) Peroxynitrite (NO3)
c) Nitroso- thiols
d) All of the above
23.Lipofucin endogenous pigments seen in which organs
a) Liver
b) Heart
c) Both a and b
d) Lung

10. 24. Cathepsins plays a vital role in
a) Bone remodeling
b) Epidermal Homeostasis
c) Prohormone Processing
d) All of these
25. Apoptotic factors such as cytochrome-C AND caspases are
released or activated and execute apoptosis
a) True
b) False
26. Electrolyte have maintained
a) Osmotic Pressure
b) Body Fluids for nerve function
c) Acid-base balanced
d) All of these