Chemo mcq's

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Chemo mcq's

  1. 1. <ul><li>A 25 years old boy having oropharyngeal infection for one week. He is taking penicillin’s. Which statement about the bio disposition of penicillin’s and cephlosporins is not accurate?
  2. 2. Oral bioavailability is affected by liability in gastric acid
  3. 3. Most third generation cephlosporins cross the blood brain barrier
  4. 4. Nafcillin and ceftriaxone are eliminated by mainly via biliary secreation
  5. 5. Procaine penicillin G is used via intra muscular injection
  6. 6. Renal tubular reabsorption of beta- Lactams is inhibited by probenecid
  7. 7. A young female having a urinary tract infection on urine C/S there is E.Coli sensitive to cephalosporin. The primary mechanism of antibacterial action of cephlosporins involves
  8. 8. Production of Beta- Lactamases
  9. 9. Inhibition of Cell membrane synthesis
  10. 10. Inhibition of Reaction involving transpeptidation
  11. 11. Decreasing Synthesis of N- acetyl muramic acid
  12. 12. Preventing Trans glycosylation
  13. 13. A 40years old man having an infection involving enterobacter spp. Which of the drug is drug of choice now a days?
  14. 14. Penicillin
  15. 15. Cephalosporin
  16. 16. Tetracycline
  17. 17. Imipenem
  18. 18. Clavilanic acid
  19. 19. An elderly male has a fever believed to be due to an infection. He has skin lesions scrapings of which reveal the presence of large number of gram positive cocci. The drug to use for the treatment of this patient is?
  20. 20. Amoxicillin
  21. 21. Aztreonam
  22. 22. Cefoxitin
  23. 23. Nafcillin
  24. 24. Penicillin G
  25. 25. A 40 years old female treated for Leukemia two month back. She is admitted to the hospital with malaise, chills and high fever. Gram stain of blood reveals the presence of gram negative bacilli. The initial diagnosis is bacteremia and the parenteral antibiotics are indicated. The records of the patients reveal that she had a severe urticarial rash, hypotension and respiratory difficulty after oral penicillin V about 6 month ago. The drug regimen for empiric treatment is?
  26. 26. Ampicillin plus sulbactam
  27. 27. Aztreonam
  28. 28. Cefazolin
  29. 29. Imipenem plus cilastatio
  30. 30. Ticarcillin plus clavulanic
  31. 31. A female patient needs antibiotic treatment prophylaxis before going for a tooth extraction. Her medical history includes a severe anaphylactic reaction to penicillin G during the past year. The best approach would be treatment with:
  32. 32. Amoxicillin clavcilanate
  33. 33. Aztreonam
  34. 34. Cefazolin plus gentamycin
  35. 35. Meropenem
  36. 36. vancomycin
  37. 37. A man is on vancomycin for one week. Which statement about vancomycin is accurate
  38. 38. It is bacteriostatic
  39. 39. It is binds to PBPs
  40. 40. It is not susceptible to penicillinase
  41. 41. It has good oral bioavailability
  42. 42. Staphylococcal enterocolitis occurs commonly with its use
  43. 43. A 10 years old child is taking Ampicillin for upper respiratory tract infection. Which of the following statements about ampicillin is not accurate?
  44. 44. Antibacterial activity is Enhanced by sulbactam
  45. 45. Causes maculopapular rashes
  46. 46. Drug of choice for L monocytogenes infection
  47. 47. Eradicates most strains of MRSA
  48. 48. May cause pseudomembranous colitis
  49. 49. A 25 years old female has primary syphilis. She has a history of penicillin hypersensitivity, so tetracycline will be used to treat the infection. Which statement about the proposed drug treatment of this patient is accurate?
  50. 50. Antacids will not affect absorption of the drug
  51. 51. Azithromycin would not be effective in treatment of this patient
  52. 52. For full effectiveness tetracycline must be taken for 15 days
  53. 53. She should eat plenty of yogurt to prevent vaginal candidiasis
  54. 54. Tetracycline is potent inhibitor of hepatic drug metabolizing enzymes
  55. 55. A patient having culture positive enterococcal bacteremia. Who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is?
  56. 56. Claritheomycin
  57. 57. Erythromycin
  58. 58. Linezolid
  59. 59. Minocycline
  60. 60. Ticarcillin
  61. 61. A 28 years old man having a degenerative joint disease is to undergo insertion of hip prosthesis. To avoid complication due to postoperative infection, the surgeon will pretreat this patient with an antibiotic. This hospital has a significant problem with methicillin resistant staphylococcus aureus. Which of the following antibiotics should the surgeon select?
  62. 62. Ampicillin
  63. 63. Imipenem
  64. 64. Gentamycin
  65. 65. Vancomycin
  66. 66. Cefazolin
  67. 67. A 28 years old male returns home from a holiday in the far days east and complains of three days of dysuria and a purulent urethral discharge. You diagnose this to gonorrhea. Which of the following is appropriate treatment?
  68. 68. Ceftriaxone intra muscular
  69. 69. Penicillin G intra muscular
  70. 70. Gentamycin intra muscular
  71. 71. Piperacillin intra Venus
  72. 72. Vancomycin intra Venus
  73. 73. 19 years old beautiful, fair skinned girl visits her dermatologist at a local clinic because of a rash that appeared after she spent the sunny weekend kite flying with her friends. She was put on a drug for two months to prevent acne flare ups. The drug responsible for her recent concerns may be:
  74. 74. Amoxicillin
  75. 75. Cepheradine
  76. 76. Minocycline
  77. 77. Oxacillin
  78. 78. Erythromycin
  79. 79. 40 years old bus driver presents to the clinic with severe headache and tinnitus. Upon investigations he is found to have an increased intracranial pressure but the CSF composition is normal. No hydrocephalus, mass, or structural or vascular lesion. No obvious cause is identified except a history of antibiotic therapy. Which of the following drug may be responsible for this condition?
  80. 80. Azithromycin
  81. 81. Imipenem
  82. 82. Mezlocillin
  83. 83. Tetracycline
  84. 84. Methicillin
  85. 85. Drug of first choice for MRSA is:
  86. 86. Clindamycin
  87. 87. Erythromycin
  88. 88. Vancomycin
  89. 89. Oxytetracycline
  90. 90. Meropenem
  91. 91. Medical students are discussing the clinical uses of antimicrobials when they come across a beta lactam antibiotic named methacillin. After considerable arguments they approach their instructor. The instructor wouyld tell:
  92. 92. It is used to treat gram positive infection
  93. 93. It is used to treat Methacillin Sensitive Staphylococcus Aureus (MSSA)
  94. 94. It is used to treat Vancomycin Resistant Staphylococcus Aureus (VRSA)
  95. 95. It is used to treat Vancomycin Resistant Enterococci (VRE)
  96. 96. It is not used therapeutically
  97. 97. After taking a macrolide the girl develops severe diarrhea and colitis, which of the following drugs may be of use in antimicrobial associated diarrhea?
  98. 98. Apmicillin
  99. 99. Vancomycin
  100. 100. Ceftriaxone
  101. 101. Cefamendol
  102. 102. Oxytetracycline
  103. 103. 49 years school teacher has been regularly taking warfarin, an anti-coagulant for his long standing coagulation disorder. He develops upper respiratory tract infection and goes to a quack who prescribes an antibacterial without bothering about his drug history. After a couple of doses he develops frank bleeding from gums. Which antimicrobial may have been wrongly prescribed?
  104. 104. Gentamycin
  105. 105. Clarithromycin
  106. 106. Linezolid
  107. 107. Amoxicillin
  108. 108. Cephradine
  109. 109. Drug of choice for treatment of mycobacterium avium complex in AIDS patient is:
  110. 110. a) Tetracycline
  111. 111. b) Azithromycine
  112. 112. c) Penicillin G
  113. 113. d) Amoxicillin
  114. 114. e) Chloramphenicol
  115. 115. Which of the following groups of antibiotics demonstrates a bacteriostatic effect?
  116. 116. a) Carbapenems
  117. 117. b) Erythromycin
  118. 118. c) Penicillin G
  119. 119. d) Cephradine
  120. 120. e) Amoxicillin
  121. 121. Mr. Smith is a patient of chronic renal failure and has regular dialysis. The tetracycline antibiotic that does not require dose reduction to treat his skin lesions is:
  122. 122. Doxycycline
  123. 123. Demeclocycline
  124. 124. Minocycline
  125. 125. Oxytetracycline
  126. 126. Chlortetracycline
  127. 127. A 61 years old male smoker presents with headache, weakness, fatigue and decreased urinary output, he has hyponateremia and urine osmolality is markedly increased. He might be suffering from a condition that may be treated with:
  128. 128. Doxycycline
  129. 129. Demeclocycline
  130. 130. Minocycline
  131. 131. Oxytetracycline
  132. 132. Chlortetracycline
  133. 133. Vancomycin resistant staphylococci may be given a trail of:
  134. 134. Aztreonam
  135. 135. A thirg generation cephalosporin
  136. 136. Streptogramins
  137. 137. Rifampin
  138. 138. Azithromycin
  139. 139. The term MIC refers to:
  140. 140. Minimum Inhibitory Concentration of an anti microbial in blood
  141. 141. Minimum Inhibitory Concentration of an anti microbial in a confined medium
  142. 142. Minimum Inhibitory Concentration of an anti microbial in a diseased tissue or organ
  143. 143. Minimum Inhibitory Concentration of an anti microbial against bacterial in a population
  144. 144. Minimum concentration required to kill the bacteria in the body
  145. 145. After an antimicrobial overdosage little Johnny developed irregular and rapid respiration, abdominal distention, periods of cyanosis, and passage of loose, green stools occur. He was severely ill by the end of the first day. Over the next 24 hours, he turned an ashen-gray color and became flaccid and hypothermic. The most likely antimicrobial he has taken is:
  146. 146. Amoxicillin
  147. 147. Chloramphenicol
  148. 148. Erythromycin
  149. 149. Doxicycline
  150. 150. Bacitracin </li></ul>1e<br />2c<br />3d<br />4d<br />5b<br />6e<br />7c<br />8d<br />9c<br />10c<br />11d<br />12a<br />13c<br />14d<br />15c<br />16e<br />17b<br />18b<br />19b<br />20b<br />21a<br />22b<br />23c<br />24b<br />25b<br />

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