Dinoprostone is a naturally occurring prostaglandin. It has important effect in labour. Also it stimulates osteoblasts to release factors which stimulates bone. As a prescription, it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.

1. DRUG
PRESENTATION
“DINOPROSTONE”
Presented By:
Sandhya Kumari
MSc Nursing, 3rd Sem
ACON, AUH

2. INTRODUCTION-
 Dinoprostone is a naturally occurring
prostaglandin E2 (PGE2). It has important
effects in labour. It also stimulates
osteoblasts to release factors which
stimulates bone re-absorption by osteoclasts.
As a prescription drug it is used as a vaginal
suppository, to prepare the cervix for labour
and to induce labour.

3. PHARMACODYNAMICS
Dinoprostone is equivalent to prostaglandin E2
(PGE2). It stimulates labor and delivery by
stimulating the uterine, and thus terminates
pregnancy. Dinoprostone is also capable of
stimulating the smooth muscle of the
gastrointestinal tract. This activity may be
responsible for the vomiting and/or diarrhea that
is not uncommon when dinoprostone is used to
terminate pregnancy.

4. MECHANISM OF ACTION:-
Dinoprostone administered intravaginally stimulates the
myometrium of the gravid uterus to contract in a manner that is
similar to the contractions seen in the term uterus during labor,
resulting in the evacuation of the products of conception from the
uterus. Dinoprostone exerts its uterine effects via direct
myometrial stimulation. Other suggested mechanisms include the
regulation of cellular membrane calcium transport and of
intracellular concentrations of cyclic 3',5'-adenosine
monophosphate. Dinoprostone also appears to produce local
cervical effects including softening, effacement, and dilation. The
exact mechanism of action for this effect is also unknown, but it
has been suggested that this effect may be associated with
collagen degradation caused by secretion of the enzyme
collagenase as a partial response to locally administered
dinoprostone.

5. SIDE EFFECT OF DRUG “DINOPROSTONE
 Upset stomach.
 Vomiting.
 Diarrhea.
 Dizziness.
 Flushing of the skin.
 Headache.
 Fever

6. INDICATION OF DRUG “DINOPROSTONE”.:-
 Evacuation of the uterine contents.
 Amniotic fluid embolism
 Termination of pregnancy
 Labor induction/cervical ripening

7. CONTRA INDICATION OF DRUG“DINOPROSTONE”
 Acute pelvic inflammatory disease (PID)
 Placenta previa
 Unexplained vaginal bleeding
 Vasaprevia or genital herpes infection.
 Pregnancy termination
 Breast-feeding
 Hypersensitivity reactions

8. MANAGEMENT OF DRUG ‘DINOPROSTONE’:-
CERVIPRIME GEL - is commonly used for cervical ripening is available in a 2.5-mL
syringe for an intracervical application of 0.5 mg of dinoprostone.
With the woman supine, the tip of a pre-filled syringe is placed intracervically, and
the gel is deposited just below the internal cervical os.
After application she remains reclined for at least 30 minutes. Doses may be
repeated every 6 hours, with a maximum of three doses recommended in 24
hours.
Dinoprostone should only be administered at hospital.Continuous Uterine activity &
FHR monitoring.
If optimal response is not achieved by 6 hours, another dose can be administered.
The maximum allowed dose is 3 doses be administered per 24 hours.
Oxytocin should not be initiated until 6 to12 hours after the last dose because of the
potential for uterine hyperstimulation with concurrent oxytocin and prostaglandin
administration.
Vaginal insert containing 10 mg of dinoprostone in a timed-release formulation. The
vaginal insert administers the medication at 0.3 mg/h and may be left in place for
up to 12 hours.

9. SUMMARY:-
 Introduction of Drug “Dinoprostone”
 Pharmaceutical action of Drug
“Dinoprostone”.
 Mechanism of Action.
 Side Effect of Drug “Dinoprostone”
 Indication of drug “Dinoprostone”
 Contra-indication of drug “Dinoprostone”
 Management of Drug “Dinoprostone”

10. CONCLUSION:-
Dinoprostone is a naturally occurring
prostaglandin E2 (PGE2). It has important
effects in labour. It also stimulates
osteoblasts to release factors which
stimulates bone re-absorption by osteoclasts.
As a prescription drug it is used as a vaginal
suppository, to prepare the cervix for labour
and to induce labour.

11. BIBLIOGRAPHY:-
 https://www.google.com/search?q=dinoprostone+ma
nagement&sxsrf=ALeKk03HpcpEuo_XsiAJdig43y
wdnR7iw:1600519533036&source=lnms&tbm=isch
&sa=X&ved=2ahUKEwioyuPxn_XrAhVD63MBHc
NhBAEQ_AUoAXoECA0QAw&biw=1366&bih=65
7#imgrc=h53LlWRHOAgRRM
 https://www.slideshare.net/sravanthi_1786/cervical-
ripening-and-labour-induction
 https://www.pdr.net/drug-summary/Cervidil-
dinoprostone-2192

12. THANK
YOU