ppt on dydrogesterone

1.  DYDROGESTERONE
Introduction-
 It is a progestin which is a female hormone.
 This works by regulating the healthy growth and normal
shedding of the womb lining.
 Firstly, introduced in 1961, now currently approves by
over 100 countries.

2. PHARMACODYNAMICS
1) INTERACTION –
It is highly selective progestogen.
Binds to Progesterone Receptor (PR)
PR-A, PR-B

3. 2) Active Metabolite
Non-sedative
20 α –
dihydrodydrogesterone
(20α-DHD)

4. 3) DOSAGE
Oral
dosage
• 5-40 mg/day
• On 5 days interval
Intramuscular
injection
• 100 mg/day
• As microcrystalline aqueous suspension.

5. PHARMACOKINETICS
(I) ABSORPTION-
Active
Cons.-
• 20α-DHD
Bio-Availability
• 28%
Peak - Availability
• 1.5 Hours after post dose

6. (II) DISTRIBUTION
Protein-Binding site
unknown
Probably - Albumin

7. (III) METABOLISM
In Liver • Completely
metabolised
Process • Hydrogenation
Complete
el. time
• 14-17
hours

8. (IV) EXCRETION
Through
Urine
Within 72
Hours
Complete
excretion

9. CHEMISTRY
 OVER-DOSE-
 No major side effects noted during clinical trails, as given 4,000 mg to mice.
 SYNTHESIS-
 Treatment of progesterone with UV light exposure.
 BRAND NAME-
 Marketed under Duphastone and Femoston.
 REFERNCE-
https://www.bing.com/search?q=dydrogesterone&cvid=60fefdc74d7646c39d35166ed2ad5788&aqs=edge.3.69i59i450l8...8.53
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10.  INDICATIONS OF DYDROGESTERONE-
 Menstrual disorders: it is used for treating menstrual disorders like absent or irregular
menstruation, painful menstruation, secondary amenorrhea and premenstrual symptoms.
 Prevent miscarriage: Since the drug helps in maintaining integrity of the endometrial
lining in a pregnant womb, it is used for preventing habitual and recurrent abortion.
 Endometriosis: Dydrogesterone relieves the pain during menstruation due to
endometriosis without inhibiting ovulation.
 Infertility: The drug is used during IVF (in-vitro fertilization) cycle to achieve successful
implantation.
 In combination with hormonal replacement therapy (HRT): Dydrogesterone prevents
thickening of the uterine lining in the patient taking HRT.

11. DOSAGE -
1. Dysfunctional bleeding – 10 mg twice daily for a week for stopping bleeding.
2. Painful menstruation and irregular Menstrual periods – 10 mg twice daily
starting from the 5th day of menstrual cycle to 25th day.
3. Abortion – In case of threatened abortion, 40mg immediately and then 10 mg dose
repeated every 8 hours till remission.
4. Infertility – 10mg once daily from the 14th day till 25th day of menstrual cycle.
What are the side effects of Dydrogesterone?
 Pulsating headache which can develop into a migraine
 Pain in breast and breast tenderness
 Occasional blood spotting
 Pain during periods
 Irregular period
 Heavy bleeding during periods
 Missed period
 Weight gain
 Depression
 Hypersensitivity