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SALIVARY
GLANDS
BY - D R . S A K S H I S H U K L A
1DR. SAKSHI SHUKLA
CONTENTS
• Introduction
• Definition
• Classification
• Development
• Structure
• Histology
• Saliva
• Clinical considerations
• conclusion
2DR. SAKSHI SHUKLA
INTRODUCTION
• Salivary glands are a group of organs secreting a watery substance that
is of utmost importance for several physiological functions ranging from
the protection of teeth and surrounding soft tissues to the lubrication of
the oral cavity, which is crucial for speech and perception of food taste.
• Salivary glands are complex networks of hollow tubes and secretory
units that are found in specific locations of the mouth and which,
although architecturally similar, exhibit individual specificities according
to their location.
3DR. SAKSHI SHUKLA
DEFINITIONS
• These are compound tubule acinar exocrine glands found in oral cavity
that secrete complex fluid known as saliva.
Or
• any of various glands that discharge a fluid secretion and especially
saliva into the mouth cavity and that in humans comprise large
compound racemose glands including the parotid glands, the sublingual
glands, and the submandibular gland
4DR. SAKSHI SHUKLA
CLASSIFICATION
OF SALIVARY
GLANDS
B A S E D O N S I Z E
B A S E D O N T Y P E O F S E C R E TO R Y C E L L S
5DR. SAKSHI SHUKLA
BASED ON
SIZE
 Major salivary glands
 Minor salivary glands
Major salivary glands -
Collection of secretory cells
aggregated into large
bilaterally paired extra oral
glands with extended duct
system through which the
gland secretions reach the
mouth.
• - Parotid
• -Submandibular
• - Sublingual
6DR. SAKSHI SHUKLA
M I N O R S A L I VA R Y
G L A N D S
2. Collection of secretory cells
scattered throughout the mucosa
& submucosa of the oral cavity
with short ducts opening directly
onto mucosal surface.
-Serous glands of Von Ebner.
-Anterior lingual glands.
- - Lingual, buccal, labial, palatal
glands, glossopalatine and
retromolar glands
7DR. SAKSHI SHUKLA
8DR. SAKSHI SHUKLA
BASED ON
TYPE OF
SECRETORY
CELLS
1. Serous : Parotid
2. Mixed
(seromucous):
Submandibular
3. Mucous: Minor
salivary glands
9DR. SAKSHI SHUKLA
PAROTID GLAND
10DR. SAKSHI SHUKLA
PAROTID
GL AND
Largest
Average Wt - 15gm
Irregular lobulated
mass lying mainly below
the external acoustic
meatus between
mandible and
sternomastoid.
On the surface of the
masseter, small detached
part lies b/w zygomatic
arch and parotid duct
accessory parotid gland
or ‘socia parotidis’
11DR. SAKSHI SHUKLA
PAROTID
CAPSULE
Derived from investing
layer of deep cervical
fascia.
Superficial lamina-thick,
closely adherent
Deep lamina-thin-
attached to styloid
process, mandible and
tympanic plate.
Stylomandibular
ligament
12DR. SAKSHI SHUKLA
REL ATIONS
Superficial
Temporal vessels.
Auriculotemporal
n.
Cartilaginous part
of External
Auditory Meatus.
Temporal branch of
Facial n
13DR. SAKSHI SHUKLA
14DR. SAKSHI SHUKLA
15DR. SAKSHI SHUKLA
P O S T E R O - M E D I A L
S U R FAC E
.Mastoid process
2.Sternocleidomastoid
3.Posterior belly of
Digastric
4.Styloid process and the
muscle & ligaments
attached to it.
5.Internal carotid artery
& Internal jugular vein.
16DR. SAKSHI SHUKLA
APEX
Cervical branch of Facial
n.
2.Retromandibular vein.
3.Posterior belly of
digastric.
4.External Carotid artery
SUPERFICIALLY
Skin and superficial
fascia.
2. Great Auricular nerve.
3. Parotid lymph nodes17DR. SAKSHI SHUKLA
A N T E R O M E D I A L
S U R FAC E
Zygomatic branch of Facial n.
• Transverse Facial artery.
• Buccal branch of Facial n.
• Accessory Parotid gland.
• Parotid duct.
• Mandibular branch of Facial n.
18DR. SAKSHI SHUKLA
PA R OT I D D U C T:
Stensons duct
Thick walled
5 cm long
Emerges from middle
of anterior border
It opens into the
vestibule of mouth
opposite to the 2nd
upper Molar.
19DR. SAKSHI SHUKLA
SURFACE
ANATOMY OF
PAROTID DUCT
Corresponds to middle
third of a line drawn from
lower border of tragus to
a point midway b/w
nasal ala and upperlabial
margin
20DR. SAKSHI SHUKLA
• BLOOD
SUPPLY
Arterial
Branches of Ext .
Carotid A
Venous
Into Ext. Jugular
Vein
• LYMPHATIC
DRAINAGE
Upper Deep
cervical nodes via
Parotid nodes
NERVE SUPPLY
Sensory: auriculotemporal n for
gland, great auricular nerve for the
capsule.
Sympathetic: plexus around the
middle meningeal artery.
Parasympathetic: reach the gland
through auriculotemporal nerve.
21DR. SAKSHI SHUKLA
SUBMANDIBULAR
GLANDS
22DR. SAKSHI SHUKLA
- Anterior part of digastric
triangle - J-shaped
- - Walnut size
- - 3- surfaces
- – lateral, medial, inferior
- - Covered by 2 layers of
deep cervical fascia.
23DR. SAKSHI SHUKLA
PA R T S
1.Superficial part
2.Deep part
3.Submandibular duct
24DR. SAKSHI SHUKLA
C A P S U L E
Derived from deep
cervical fascia
Superficial Layer is
attached to base of
mandible
Deep layer attached
to mylohyoid line of
mandible
25DR. SAKSHI SHUKLA
REL ATIONS
Inferior- covered by
• Skin
• Superficial fascia containing
platysma and cervical branches of
facial N
• Deep Fascia
• Facial Vein
• Submandibular Nodes
Lateral surface – Related to
submandibluar fossa on the mandible
• Madibular attachment of Medial
pterygoid
• Facial Artery
26DR. SAKSHI SHUKLA
Medial surface
Anterior part is related to
myelohyoid muscle,nerve
and vessles
Middle part
Hyoglossus,,lingual nerve,
submandibular
ganglion,hypoglossal nerve
and deep lingual vein.
Posterior Part-
Styloglossus,stylohyoid
ligament,9th nerve and wall
of pharynx
27DR. SAKSHI SHUKLA
Deep part
Small in size
Lies deep to mylohyoid
and superficial to
hyoglossus and
styloglossus
Posteriorly continuous
with superficial part
around the posterior
border of mylohyoid
28DR. SAKSHI SHUKLA
SUBMANDIBUL AR
DUCT
Whartons duct
5 cm long
Emerges at the anterior
end of deep part of the
gland
Runs forwards on
hyoglossus b/w lingual and
hypoglossal N
At the ant. Border of
hyoglossus it is crossed by
lingual nerve
Opens in the floor of
29DR. SAKSHI SHUKLA
BLOOD SUPPLY
Facial artery
VENOUS DRAINAGE
Common facial & lingual vein
LYMPHATIC DRAINAGE:
Submandibular lymph nodes
30DR. SAKSHI SHUKLA
N E R V E S U P P LY
Supplied by branches
of submandibular
ganglion
• sensory fibres from
lingual nerve.
secretomotor fibers.
vasomotor
sympathetic fibres
from the plexus on
the facial a
31DR. SAKSHI SHUKLA
SUBLINGUAL
GLAND
32DR. SAKSHI SHUKLA
SUBLINGUAL GL AND
smallest of the three glands
weighs nearly 3-4 gm
Lies beneath the oral
mucosa in contact with the
sublingual fossa on lingual
aspect of mandible
33DR. SAKSHI SHUKLA
REL ATIONS
Superiorly- Mucosa of oral
floor, raised as sublingual
fold
Inferiorly-Myelohyoid
Behind-Deep part of
Submandibular gland
Lateral -Mandible above
the anterior part of
mylohyoid line
Medial -Genioglossus and
separated from it by
lingual nerve and
34DR. SAKSHI SHUKLA
SUBLINGUAL
DUCT
Ducts of Rivinus
8-20 ducts
Open into oral cavity through
series of small ducts (duct of
Rivinus) opening along
sublingual fold and
open through large duct-
Bartholin’s duct, that opens with
submandibular duct at
sublingual caruncle
Few of them join the
submandibular duct
35DR. SAKSHI SHUKLA
Blood supply
Arterial from
sublingual and
submental arteries
Venous drainage
corresponds to the
arteries
Nerve Supply
Similar to that of
submandibular glands(
via lingual nerve ,
chorda tympani and
sympathetic fibers36DR. SAKSHI SHUKLA
MINOR
SALIVARY
GLANDS
37DR. SAKSHI SHUKLA
MINOR SALIVARY GLAND:
No. between 600 and 1000.
Exist as aggregates of secretory tissue present in submucosa throughout
most of the oral cavity.
Not seen in gingiva & anterior part of hard plate
38DR. SAKSHI SHUKLA
V O N E B N E R S ’ S
L I N G UA L S E R O U S
G L A N D
Located in tongue and open
into the troughs surrounding
circumvallate papillae on the
dorsum of tongue and at the
foliate papillae on the side of
tongue.
Secrete digestive enzymes &
proteins that are thought to
play role in taste process
Fluid of their secretion
cleanse the trough & prepare
the taste receptors for a new
stimulus.
39DR. SAKSHI SHUKLA
DISTINGUISHING CHARACTERISTICS OF
THE MINOR SALIVARY GLANDS:
• Produce serous & mucous secretions.
• Secretory activity appears to be continuous rather than in response to
specific stimuli.
• 10% of total salivary secretion.
• But approx 70% of mucous secretion.
• Empty the secretory products into oral cavity through numerous small
ducts. • Are polystomatic (multiple main excretory ducts). • Ducts of minor
salivary gland (lips), tend to form cysts(mucocele)
40DR. SAKSHI SHUKLA
DEVELOPMENT
41DR. SAKSHI SHUKLA
DEVELOPMENT OF SALIVARY GLANDS
Bud formation
Formation and growth of epithelial chord.
Initiation of branching in terminal parts of epithelial chord.
Branching of epithelial chord and lobule formation
Canalization Cytodifferentiation
42DR. SAKSHI SHUKLA
43DR. SAKSHI SHUKLA
STRUCTURES
44DR. SAKSHI SHUKLA
S T R U C T U R E S O F
S A L I VA R Y G L A N D S
Comprises of
-a series of secretory end piece
or acini.
-connected to the oral cavity
by a system of ducts.
45DR. SAKSHI SHUKLA
Secretory end piece or accini:
• Consists of secretory cells,
which are arranged in a roughly
spherical configuration around a
central lumen or cavity.
• Show a great diversity in size,
shape, and cell number.
46DR. SAKSHI SHUKLA
S E R O U S C E L L S
Secretory end piece
consisting of serous cells
are typically spherical
and consist of 8 to 12
cells surrounding a
central lumen.
The lumen of serous end
piece has small
extensions in the form of
intercellular canaliculi
(found between adjacent
serous cells).
47DR. SAKSHI SHUKLA
Serous Cells:
Parotid & submandibular
gland.
Serous cells are also
present in demilune
formations at the blind ends
of mucous secretory tubules
(submandibular and
sublingual glands).
Secretions of serous cells
are proteinaceous-usually
enzymatic, antimicrobial,
calcium-binding.
48DR. SAKSHI SHUKLA
49DR. SAKSHI SHUKLA
Plasma membrane exhibits several specializations:
The surface of the seromucous cell lining both the central lumen & canaliculi possess a
delicate microvilli that extend into luminar and canalicular spaces.
Space between basement membrane and basal plasma membrane may be increased
by complex foldings (0.5 microns) of the basal plasma membrane.
Canaliculus terminates in the form of a classic junctional complex consisting of a tight
junction (zona occludens), an adherent junction & a desmosome.
50DR. SAKSHI SHUKLA
M U CO U S C E L L S
Predominant secretory cell type of
the sublingual gland & most of
minor salivary glands.
Also occur in submandibular
gland.
Secretion consists of large
amount of mucins -lubrication,
effective barrier, aggregation of
microorganisms.
Secretory component of
mucous cell accini consists of
round or tubular configuration.
Larger lumen. Larger than
serous cells. Pyramidal in shape.
Broader luminal surface
51DR. SAKSHI SHUKLA
52DR. SAKSHI SHUKLA
Serous
Stain darkly (zymogen
granules)
Wedge shaped with
round nucleus, lying towards
the base
Mucous
Lightly stained
Appears empty
Polyhedral
Contain mucinogen
granules
Nucleus flattened ,close to53DR. SAKSHI SHUKLA
M YO E P I T H E L I A L
C E L L S ( B A S K E T
C E L L S ) :
Contractile cells located
around the terminal secretory
units and the first portion of
the duct system, intercalated
duct.
Located between basal
lamina and secretory or duct
cells and are joined by
desmosomes.
54DR. SAKSHI SHUKLA
DUCTS
Terminal secretory units opens
into a small duct called the
intercalated duct.
Secretions pass through a
system of ducts
Smallest – intercalated ducts
lined by flattened cells
Intercalated ducts open into
striated ducts lined by cuboidal
cells
Striated ducts open into
excretory ducts lined by simple
columnar epithelium
55DR. SAKSHI SHUKLA
CO N N E C T I V E
T I S S U E :
Capsule –demarcate gland
from adjacent structures.
Septa –divide gland into
lobes and lobules -Carry the
nerves and blood vessels and
excretory ducts. Fibroblast,
Macrophages, Dendritic cells,
Mast cells, Plasma Cells,
Adipose tissue
56DR. SAKSHI SHUKLA
EMBYOLOGY
Salivary glands develop as outgrowths of buccal epithelium
• Parotid – ectodermal in origin
• Submandibular & Sublingual – endodermal in origin
Parotid – 4th Wk of gestation
Submandibular – 6th Wk of gestation
Sublingual – 9th Wk of gestation
57DR. SAKSHI SHUKLA
HISTOLOGY
58DR. SAKSHI SHUKLA
Parotid - Serous type
Sublingual –mixed
typr but Mucous cells
predominate
Submandibular -
Mixed type –some
mucous alveoli capped
by serous cresents –
Demilunes
59DR. SAKSHI SHUKLA
SALIVA
60DR. SAKSHI SHUKLA
SALIVA
• Main function of Salivary Gland-secretion of saliva
• Daily secretion -800 to 1500 ml
• pH : 6-7
61DR. SAKSHI SHUKLA
62DR. SAKSHI SHUKLA
Saliva Compositon
Water (99.5%) Solid (0.5%)
Organic Inorganic
Na+ K+ Ca+
Mucin
ptyalin
Lysozyme
IgA
Lactoferrin
63DR. SAKSHI SHUKLA
IONIC
COMPOSITION
Saliva in the acini-isotonic with plasma
Under resting condition ionic composition of
saliva reaching the mouth
Na+ and Cl- 15 mEq/l (1/7 to 1/10 conc of
Plasma)
K+ 30 mEq/l (7 times that of Plasma)
HCO3- 50-70 mEq/l (2-3 times that of
plasma)
During maximal salivation
Na+ and Cl- (1/2 to 2/3 conc of Plasma)
K+ (4 times that of Plasma)
HCO3- 50-70 mEq/l (2-3 times that of
plasma)
64DR. SAKSHI SHUKLA
F U N C T I O N S O F S A L I VA
Keep the mouth moist
Aids in swallowing
Aids in speech
Keeps the mouth and teeth
clean
Antimicrobial action
Digestive function
Bicarbonate acts as buffer
65DR. SAKSHI SHUKLA
66DR. SAKSHI SHUKLA
SALIVA AS A DIAGNOSTIC AID
Oral diseases
High risk caries patient, Patient susceptible to candidiasis
Diagnostic aid for clinical problems
Psychological problems, smoking, poisoning
Systemic diseases affecting saliva
Sjogren’s syndrome, Cystic fibrosis
Steroid hormone determination: Functional efficiency of corpus luteum in case of defect in
hypothalamic-pituitary-ovarian axis, Pregnant status, Ovulation time
Monitoring of certain drugs that exhibit consistent saliva : plasma ratio. e.g., phenytoin,
carbamazine, theophylin
67DR. SAKSHI SHUKLA
SALIVARY GLAND IMAGING
• Plain film radiography
• Sialography
• Computed tomography
• Radionuclide imaging
• Ultrasonography
• Magnetic resonance imaging
68DR. SAKSHI SHUKLA
SIALOGRAPHY
evaluate of the
functional integrity of the
salivary glands
• case of obstructions
• evaluate the ductal
pattern
• facial swellings, to rule
out salivary gland
pathology
• intraglandular
neoplasms
69DR. SAKSHI SHUKLA
CT SCAN
Inflammatory diseases,
calculi, neoplastic disease
70DR. SAKSHI SHUKLA
MRI
Superior contrast
resolution
Better mass
characterisation
Enhanced MRI:
perineural disease if
abscess is suspected
determine the exact
location and extent
of a tumor
71DR. SAKSHI SHUKLA
CLINICAL
CONSIDERATIONS
72DR. SAKSHI SHUKLA
DISORDERS OF SALIVARY GLAND
• Functional disorders
- increased secretion.
- decreased secretion.
• Developmental disorders
• Obstructive disorders
• Inflammatory and infectious disorders
• Immunological disorders
• Neoplastic diseases
73DR. SAKSHI SHUKLA
XEROSTOMIA:
• Drugs- central or peripheral inhibition of salivary secretion.
• Destruction of salivary gland:
-Radiotherapy to H & N region
-Chemotherapy
-Bone marrow transplant
-Autoimmune diseases (sjogren’s syndrome)invasion of lymphocytes & destruction
of epithelial cells.
• Psychological factors
74DR. SAKSHI SHUKLA
• Loss of protective effect of salivary buffers, proteins, and mucins
increased susceptibility to infections.
• Difficulty & pain on eating, speech and swallowing.
• treatment- Temporary saliva
• Oral pharmacosympathomimmetic drugs like Pilocarpine.
75DR. SAKSHI SHUKLA
S I A LO R R H E A :
Refers to excess saliva
production.
Causes:
-Gastrointestinal irritants
-Drugs (Pilocarpine)
-Cerebro vascular
accident -Pt.
with a severe neurologic
deficit
-Pt. who have
undergone extensive oral
surgical procedures.76DR. SAKSHI SHUKLA
DEVELOPMENTAL
DISORDERS
• Aplasia (agenesis)
• Atresia
• Aberrant salivary gland.
(stafne’s cyst)
• Diverticuli
• Darier’s disease (duct dilation
with periodic stricture)
77DR. SAKSHI SHUKLA
S I A LOT H I A S I S
• Common in
submandibular salivary
duct
• Calcium phosphate in
the form of
hydroxyapatite is the
main mineral
component.
78DR. SAKSHI SHUKLA
MUCOCELE
(1) Extravasation
mucocele
(2) Retention
mucocele
79DR. SAKSHI SHUKLA
RANULA
80DR. SAKSHI SHUKLA
SYNDROMES
ASSOCIATED
WITH
SALIVARY
GL AND
DISEASES:
• Hemifacial microsomia
• LADD snydrome
• Treacher collins syndrome
• Sjogren’s syndrome
• Felty’s syndrome
• Aglossia- adactylia
syndrome
• Heerfordt’s syndrom
81DR. SAKSHI SHUKLA
SYSTEMIC
CONDITIONS
WITH SALIVARY
GL AND
INVOLVEMENT
Infectious disorders:
• Actinomycosis
• Granulomatous disease
• Cmv infections
• Hepatits
• HIV
82DR. SAKSHI SHUKLA
METABOLIC
DISORDERS
• Sjogren’ syndrome
• Thyroid disease
• Granulomatous disease
• Alcoholism
• Malnutrition
• Eating disorders
• Diabetes (uncontrolled)
83DR. SAKSHI SHUKLA
84DR. SAKSHI SHUKLA
FAC I A L N E R V E
PA R A LYS I S :
◦Transient FNP
caused by local
anaesthesia into
capsule of the
parotid gland, which
is located at
posterior border of
the mandibular
ramus.
85DR. SAKSHI SHUKLA
HISTOLOGICAL CLASSIFICATION OF
SALIVARY GLAND TUMOURS WHO (1991
• Pleomorphic adenoma
• Myoepithelioma
•Basal cell adenoma
• Warthins tumour
• Oncocytoma
•Canalicular adenoma
•Sebaceous adenoma
• Monomorphic
adenoma
• Ductal papilloma
- inverted ductal papilloma
- intraductal papilloma
- sialadenoma papilliferum
• Cystadenoma
- papillary cystadenoma
- mucinous cystadenoma
86DR. SAKSHI SHUKLA
CARCINOMA
• Acinic cell carcinoma
• Mucoepidermoid carcinoma
• Adenoid cystic carcinoma
• Polymorphous low grade
adenosarcoma
• Epithelial-myoepithelial
carcinoma
• Basal cell adenocarcinoma
• Sebaceous carcinoma
• Papillary cystadenocarcinoma
• Mucinous adenocarcinoma
• Oncocytic carcinoma
• Salivary cell carcinoma
• Adenocarcinoma
• Malignant myoepithelioma
Salivary cell carcinoma
• Adenocarcinoma
• Malignant myoepithelioma
87DR. SAKSHI SHUKLA
NONEPITHELIAL TUMOURS
4. MALIGNANT LYMPHOMAS
5. SECONDARY TUMOURS
6. UNCLASSIFIED TUMOURS
7. TUMOR LIKE LESIONS
- sialadenosis
- oncocytosis
88DR. SAKSHI SHUKLA
PLEOMORPHIC
ADENOMA
Mixed tumour,(Pleos – many
: morphus – form)
Commonest benign salivary
tumour inadult
Common in parotid (80%)
Common in females
Abundant matrix
mucoid,myxoid or chondroid
supporting tissue
Dumb bell tumor –if deep
lobe isinvolved
89DR. SAKSHI SHUKLA
Lobulated , painless
swelling, Long duration
Neither adherent to
skin/ masseter muscle
Generally firm / variable
consistency
Raised ear lobule
Curtain sign – swelling
cannot be moved above
zygomatic bone
90DR. SAKSHI SHUKLA
WARTHINS
TUMOR
Second most common tumor in
the salivary glands.
Slow growing , painless cystic
neoplasm –
exclusively in the parotid gland.
Proliferation of lymphoid tissues
of intra/peri parotid LN
Predisposing factor – smoking,
radiation exp and EBV
Round to oval Swelling , well
circumscribed encapsulated
masses
91DR. SAKSHI SHUKLA
Multicentric or
multifocal disease
Soft ,fluctuant
Fifth to seventh
decades of life
Male : female :: 10:1
Elderly males , smokers
Bilateral 10%
No Malignant potential
92DR. SAKSHI SHUKLA
E FFECTS O F AG I N G :
• decrease in salivary flow
• acinar atrophy
accompanied by fibrosis
• replacement of the
secretory tissue with adipose
tissue.
• structural alterations in the
ducts including intraductal
deposits.
• appearance of oncocytes,
enlarged, inactive secretory
cells with pycnotic nuclei93DR. SAKSHI SHUKLA
CONCLUSION
• Dentists are involved with aspects of salivary gland function in several ways, such as
diagnosing problems involving the major and minor salivary glands, in the
management of oral dryness associated with salivary problems, in the treatment of
caries and periodontal disease resulting from decreased salivary flow, and in
controlling salivation during restorative procedures. Significant abnormality or disease
of the salivary glands, such as that associated with Sjögren syndrome or neoplasm,
necessitates.However, a general dentist may be called upon to provide follow up in
terms of management of the patient’s subsequent oral health.
94DR. SAKSHI SHUKLA
REFERENCES
• Nanci A. Salivary glands, Ten Cate’s Oral histology, Development, Structure, and
function. 8th Ed.Elsevier publications:2012:253-277.
• Kumar GS. Salivary glands,Orban’s Oral Histology and Embryology. Elsevier heath
sciences.10th Ed;2012.
• Malik N. A. Textbook Of Oral And Maxillofacial Surgery,Jaypee Brothers Medical
Publishers Ltd ;( 4th Edition)2015
• Chaurasia B. D. Human Anatomy, CBS publishers and distributers(7th edition)
vol.3,2015
95DR. SAKSHI SHUKLA
THANK YOU
96DR. SAKSHI SHUKLA

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Salivary glands

  • 1. SALIVARY GLANDS BY - D R . S A K S H I S H U K L A 1DR. SAKSHI SHUKLA
  • 2. CONTENTS • Introduction • Definition • Classification • Development • Structure • Histology • Saliva • Clinical considerations • conclusion 2DR. SAKSHI SHUKLA
  • 3. INTRODUCTION • Salivary glands are a group of organs secreting a watery substance that is of utmost importance for several physiological functions ranging from the protection of teeth and surrounding soft tissues to the lubrication of the oral cavity, which is crucial for speech and perception of food taste. • Salivary glands are complex networks of hollow tubes and secretory units that are found in specific locations of the mouth and which, although architecturally similar, exhibit individual specificities according to their location. 3DR. SAKSHI SHUKLA
  • 4. DEFINITIONS • These are compound tubule acinar exocrine glands found in oral cavity that secrete complex fluid known as saliva. Or • any of various glands that discharge a fluid secretion and especially saliva into the mouth cavity and that in humans comprise large compound racemose glands including the parotid glands, the sublingual glands, and the submandibular gland 4DR. SAKSHI SHUKLA
  • 5. CLASSIFICATION OF SALIVARY GLANDS B A S E D O N S I Z E B A S E D O N T Y P E O F S E C R E TO R Y C E L L S 5DR. SAKSHI SHUKLA
  • 6. BASED ON SIZE  Major salivary glands  Minor salivary glands Major salivary glands - Collection of secretory cells aggregated into large bilaterally paired extra oral glands with extended duct system through which the gland secretions reach the mouth. • - Parotid • -Submandibular • - Sublingual 6DR. SAKSHI SHUKLA
  • 7. M I N O R S A L I VA R Y G L A N D S 2. Collection of secretory cells scattered throughout the mucosa & submucosa of the oral cavity with short ducts opening directly onto mucosal surface. -Serous glands of Von Ebner. -Anterior lingual glands. - - Lingual, buccal, labial, palatal glands, glossopalatine and retromolar glands 7DR. SAKSHI SHUKLA
  • 9. BASED ON TYPE OF SECRETORY CELLS 1. Serous : Parotid 2. Mixed (seromucous): Submandibular 3. Mucous: Minor salivary glands 9DR. SAKSHI SHUKLA
  • 11. PAROTID GL AND Largest Average Wt - 15gm Irregular lobulated mass lying mainly below the external acoustic meatus between mandible and sternomastoid. On the surface of the masseter, small detached part lies b/w zygomatic arch and parotid duct accessory parotid gland or ‘socia parotidis’ 11DR. SAKSHI SHUKLA
  • 12. PAROTID CAPSULE Derived from investing layer of deep cervical fascia. Superficial lamina-thick, closely adherent Deep lamina-thin- attached to styloid process, mandible and tympanic plate. Stylomandibular ligament 12DR. SAKSHI SHUKLA
  • 13. REL ATIONS Superficial Temporal vessels. Auriculotemporal n. Cartilaginous part of External Auditory Meatus. Temporal branch of Facial n 13DR. SAKSHI SHUKLA
  • 16. P O S T E R O - M E D I A L S U R FAC E .Mastoid process 2.Sternocleidomastoid 3.Posterior belly of Digastric 4.Styloid process and the muscle & ligaments attached to it. 5.Internal carotid artery & Internal jugular vein. 16DR. SAKSHI SHUKLA
  • 17. APEX Cervical branch of Facial n. 2.Retromandibular vein. 3.Posterior belly of digastric. 4.External Carotid artery SUPERFICIALLY Skin and superficial fascia. 2. Great Auricular nerve. 3. Parotid lymph nodes17DR. SAKSHI SHUKLA
  • 18. A N T E R O M E D I A L S U R FAC E Zygomatic branch of Facial n. • Transverse Facial artery. • Buccal branch of Facial n. • Accessory Parotid gland. • Parotid duct. • Mandibular branch of Facial n. 18DR. SAKSHI SHUKLA
  • 19. PA R OT I D D U C T: Stensons duct Thick walled 5 cm long Emerges from middle of anterior border It opens into the vestibule of mouth opposite to the 2nd upper Molar. 19DR. SAKSHI SHUKLA
  • 20. SURFACE ANATOMY OF PAROTID DUCT Corresponds to middle third of a line drawn from lower border of tragus to a point midway b/w nasal ala and upperlabial margin 20DR. SAKSHI SHUKLA
  • 21. • BLOOD SUPPLY Arterial Branches of Ext . Carotid A Venous Into Ext. Jugular Vein • LYMPHATIC DRAINAGE Upper Deep cervical nodes via Parotid nodes NERVE SUPPLY Sensory: auriculotemporal n for gland, great auricular nerve for the capsule. Sympathetic: plexus around the middle meningeal artery. Parasympathetic: reach the gland through auriculotemporal nerve. 21DR. SAKSHI SHUKLA
  • 23. - Anterior part of digastric triangle - J-shaped - - Walnut size - - 3- surfaces - – lateral, medial, inferior - - Covered by 2 layers of deep cervical fascia. 23DR. SAKSHI SHUKLA
  • 24. PA R T S 1.Superficial part 2.Deep part 3.Submandibular duct 24DR. SAKSHI SHUKLA
  • 25. C A P S U L E Derived from deep cervical fascia Superficial Layer is attached to base of mandible Deep layer attached to mylohyoid line of mandible 25DR. SAKSHI SHUKLA
  • 26. REL ATIONS Inferior- covered by • Skin • Superficial fascia containing platysma and cervical branches of facial N • Deep Fascia • Facial Vein • Submandibular Nodes Lateral surface – Related to submandibluar fossa on the mandible • Madibular attachment of Medial pterygoid • Facial Artery 26DR. SAKSHI SHUKLA
  • 27. Medial surface Anterior part is related to myelohyoid muscle,nerve and vessles Middle part Hyoglossus,,lingual nerve, submandibular ganglion,hypoglossal nerve and deep lingual vein. Posterior Part- Styloglossus,stylohyoid ligament,9th nerve and wall of pharynx 27DR. SAKSHI SHUKLA
  • 28. Deep part Small in size Lies deep to mylohyoid and superficial to hyoglossus and styloglossus Posteriorly continuous with superficial part around the posterior border of mylohyoid 28DR. SAKSHI SHUKLA
  • 29. SUBMANDIBUL AR DUCT Whartons duct 5 cm long Emerges at the anterior end of deep part of the gland Runs forwards on hyoglossus b/w lingual and hypoglossal N At the ant. Border of hyoglossus it is crossed by lingual nerve Opens in the floor of 29DR. SAKSHI SHUKLA
  • 30. BLOOD SUPPLY Facial artery VENOUS DRAINAGE Common facial & lingual vein LYMPHATIC DRAINAGE: Submandibular lymph nodes 30DR. SAKSHI SHUKLA
  • 31. N E R V E S U P P LY Supplied by branches of submandibular ganglion • sensory fibres from lingual nerve. secretomotor fibers. vasomotor sympathetic fibres from the plexus on the facial a 31DR. SAKSHI SHUKLA
  • 33. SUBLINGUAL GL AND smallest of the three glands weighs nearly 3-4 gm Lies beneath the oral mucosa in contact with the sublingual fossa on lingual aspect of mandible 33DR. SAKSHI SHUKLA
  • 34. REL ATIONS Superiorly- Mucosa of oral floor, raised as sublingual fold Inferiorly-Myelohyoid Behind-Deep part of Submandibular gland Lateral -Mandible above the anterior part of mylohyoid line Medial -Genioglossus and separated from it by lingual nerve and 34DR. SAKSHI SHUKLA
  • 35. SUBLINGUAL DUCT Ducts of Rivinus 8-20 ducts Open into oral cavity through series of small ducts (duct of Rivinus) opening along sublingual fold and open through large duct- Bartholin’s duct, that opens with submandibular duct at sublingual caruncle Few of them join the submandibular duct 35DR. SAKSHI SHUKLA
  • 36. Blood supply Arterial from sublingual and submental arteries Venous drainage corresponds to the arteries Nerve Supply Similar to that of submandibular glands( via lingual nerve , chorda tympani and sympathetic fibers36DR. SAKSHI SHUKLA
  • 38. MINOR SALIVARY GLAND: No. between 600 and 1000. Exist as aggregates of secretory tissue present in submucosa throughout most of the oral cavity. Not seen in gingiva & anterior part of hard plate 38DR. SAKSHI SHUKLA
  • 39. V O N E B N E R S ’ S L I N G UA L S E R O U S G L A N D Located in tongue and open into the troughs surrounding circumvallate papillae on the dorsum of tongue and at the foliate papillae on the side of tongue. Secrete digestive enzymes & proteins that are thought to play role in taste process Fluid of their secretion cleanse the trough & prepare the taste receptors for a new stimulus. 39DR. SAKSHI SHUKLA
  • 40. DISTINGUISHING CHARACTERISTICS OF THE MINOR SALIVARY GLANDS: • Produce serous & mucous secretions. • Secretory activity appears to be continuous rather than in response to specific stimuli. • 10% of total salivary secretion. • But approx 70% of mucous secretion. • Empty the secretory products into oral cavity through numerous small ducts. • Are polystomatic (multiple main excretory ducts). • Ducts of minor salivary gland (lips), tend to form cysts(mucocele) 40DR. SAKSHI SHUKLA
  • 42. DEVELOPMENT OF SALIVARY GLANDS Bud formation Formation and growth of epithelial chord. Initiation of branching in terminal parts of epithelial chord. Branching of epithelial chord and lobule formation Canalization Cytodifferentiation 42DR. SAKSHI SHUKLA
  • 45. S T R U C T U R E S O F S A L I VA R Y G L A N D S Comprises of -a series of secretory end piece or acini. -connected to the oral cavity by a system of ducts. 45DR. SAKSHI SHUKLA
  • 46. Secretory end piece or accini: • Consists of secretory cells, which are arranged in a roughly spherical configuration around a central lumen or cavity. • Show a great diversity in size, shape, and cell number. 46DR. SAKSHI SHUKLA
  • 47. S E R O U S C E L L S Secretory end piece consisting of serous cells are typically spherical and consist of 8 to 12 cells surrounding a central lumen. The lumen of serous end piece has small extensions in the form of intercellular canaliculi (found between adjacent serous cells). 47DR. SAKSHI SHUKLA
  • 48. Serous Cells: Parotid & submandibular gland. Serous cells are also present in demilune formations at the blind ends of mucous secretory tubules (submandibular and sublingual glands). Secretions of serous cells are proteinaceous-usually enzymatic, antimicrobial, calcium-binding. 48DR. SAKSHI SHUKLA
  • 50. Plasma membrane exhibits several specializations: The surface of the seromucous cell lining both the central lumen & canaliculi possess a delicate microvilli that extend into luminar and canalicular spaces. Space between basement membrane and basal plasma membrane may be increased by complex foldings (0.5 microns) of the basal plasma membrane. Canaliculus terminates in the form of a classic junctional complex consisting of a tight junction (zona occludens), an adherent junction & a desmosome. 50DR. SAKSHI SHUKLA
  • 51. M U CO U S C E L L S Predominant secretory cell type of the sublingual gland & most of minor salivary glands. Also occur in submandibular gland. Secretion consists of large amount of mucins -lubrication, effective barrier, aggregation of microorganisms. Secretory component of mucous cell accini consists of round or tubular configuration. Larger lumen. Larger than serous cells. Pyramidal in shape. Broader luminal surface 51DR. SAKSHI SHUKLA
  • 53. Serous Stain darkly (zymogen granules) Wedge shaped with round nucleus, lying towards the base Mucous Lightly stained Appears empty Polyhedral Contain mucinogen granules Nucleus flattened ,close to53DR. SAKSHI SHUKLA
  • 54. M YO E P I T H E L I A L C E L L S ( B A S K E T C E L L S ) : Contractile cells located around the terminal secretory units and the first portion of the duct system, intercalated duct. Located between basal lamina and secretory or duct cells and are joined by desmosomes. 54DR. SAKSHI SHUKLA
  • 55. DUCTS Terminal secretory units opens into a small duct called the intercalated duct. Secretions pass through a system of ducts Smallest – intercalated ducts lined by flattened cells Intercalated ducts open into striated ducts lined by cuboidal cells Striated ducts open into excretory ducts lined by simple columnar epithelium 55DR. SAKSHI SHUKLA
  • 56. CO N N E C T I V E T I S S U E : Capsule –demarcate gland from adjacent structures. Septa –divide gland into lobes and lobules -Carry the nerves and blood vessels and excretory ducts. Fibroblast, Macrophages, Dendritic cells, Mast cells, Plasma Cells, Adipose tissue 56DR. SAKSHI SHUKLA
  • 57. EMBYOLOGY Salivary glands develop as outgrowths of buccal epithelium • Parotid – ectodermal in origin • Submandibular & Sublingual – endodermal in origin Parotid – 4th Wk of gestation Submandibular – 6th Wk of gestation Sublingual – 9th Wk of gestation 57DR. SAKSHI SHUKLA
  • 59. Parotid - Serous type Sublingual –mixed typr but Mucous cells predominate Submandibular - Mixed type –some mucous alveoli capped by serous cresents – Demilunes 59DR. SAKSHI SHUKLA
  • 61. SALIVA • Main function of Salivary Gland-secretion of saliva • Daily secretion -800 to 1500 ml • pH : 6-7 61DR. SAKSHI SHUKLA
  • 63. Saliva Compositon Water (99.5%) Solid (0.5%) Organic Inorganic Na+ K+ Ca+ Mucin ptyalin Lysozyme IgA Lactoferrin 63DR. SAKSHI SHUKLA
  • 64. IONIC COMPOSITION Saliva in the acini-isotonic with plasma Under resting condition ionic composition of saliva reaching the mouth Na+ and Cl- 15 mEq/l (1/7 to 1/10 conc of Plasma) K+ 30 mEq/l (7 times that of Plasma) HCO3- 50-70 mEq/l (2-3 times that of plasma) During maximal salivation Na+ and Cl- (1/2 to 2/3 conc of Plasma) K+ (4 times that of Plasma) HCO3- 50-70 mEq/l (2-3 times that of plasma) 64DR. SAKSHI SHUKLA
  • 65. F U N C T I O N S O F S A L I VA Keep the mouth moist Aids in swallowing Aids in speech Keeps the mouth and teeth clean Antimicrobial action Digestive function Bicarbonate acts as buffer 65DR. SAKSHI SHUKLA
  • 67. SALIVA AS A DIAGNOSTIC AID Oral diseases High risk caries patient, Patient susceptible to candidiasis Diagnostic aid for clinical problems Psychological problems, smoking, poisoning Systemic diseases affecting saliva Sjogren’s syndrome, Cystic fibrosis Steroid hormone determination: Functional efficiency of corpus luteum in case of defect in hypothalamic-pituitary-ovarian axis, Pregnant status, Ovulation time Monitoring of certain drugs that exhibit consistent saliva : plasma ratio. e.g., phenytoin, carbamazine, theophylin 67DR. SAKSHI SHUKLA
  • 68. SALIVARY GLAND IMAGING • Plain film radiography • Sialography • Computed tomography • Radionuclide imaging • Ultrasonography • Magnetic resonance imaging 68DR. SAKSHI SHUKLA
  • 69. SIALOGRAPHY evaluate of the functional integrity of the salivary glands • case of obstructions • evaluate the ductal pattern • facial swellings, to rule out salivary gland pathology • intraglandular neoplasms 69DR. SAKSHI SHUKLA
  • 70. CT SCAN Inflammatory diseases, calculi, neoplastic disease 70DR. SAKSHI SHUKLA
  • 71. MRI Superior contrast resolution Better mass characterisation Enhanced MRI: perineural disease if abscess is suspected determine the exact location and extent of a tumor 71DR. SAKSHI SHUKLA
  • 73. DISORDERS OF SALIVARY GLAND • Functional disorders - increased secretion. - decreased secretion. • Developmental disorders • Obstructive disorders • Inflammatory and infectious disorders • Immunological disorders • Neoplastic diseases 73DR. SAKSHI SHUKLA
  • 74. XEROSTOMIA: • Drugs- central or peripheral inhibition of salivary secretion. • Destruction of salivary gland: -Radiotherapy to H & N region -Chemotherapy -Bone marrow transplant -Autoimmune diseases (sjogren’s syndrome)invasion of lymphocytes & destruction of epithelial cells. • Psychological factors 74DR. SAKSHI SHUKLA
  • 75. • Loss of protective effect of salivary buffers, proteins, and mucins increased susceptibility to infections. • Difficulty & pain on eating, speech and swallowing. • treatment- Temporary saliva • Oral pharmacosympathomimmetic drugs like Pilocarpine. 75DR. SAKSHI SHUKLA
  • 76. S I A LO R R H E A : Refers to excess saliva production. Causes: -Gastrointestinal irritants -Drugs (Pilocarpine) -Cerebro vascular accident -Pt. with a severe neurologic deficit -Pt. who have undergone extensive oral surgical procedures.76DR. SAKSHI SHUKLA
  • 77. DEVELOPMENTAL DISORDERS • Aplasia (agenesis) • Atresia • Aberrant salivary gland. (stafne’s cyst) • Diverticuli • Darier’s disease (duct dilation with periodic stricture) 77DR. SAKSHI SHUKLA
  • 78. S I A LOT H I A S I S • Common in submandibular salivary duct • Calcium phosphate in the form of hydroxyapatite is the main mineral component. 78DR. SAKSHI SHUKLA
  • 81. SYNDROMES ASSOCIATED WITH SALIVARY GL AND DISEASES: • Hemifacial microsomia • LADD snydrome • Treacher collins syndrome • Sjogren’s syndrome • Felty’s syndrome • Aglossia- adactylia syndrome • Heerfordt’s syndrom 81DR. SAKSHI SHUKLA
  • 82. SYSTEMIC CONDITIONS WITH SALIVARY GL AND INVOLVEMENT Infectious disorders: • Actinomycosis • Granulomatous disease • Cmv infections • Hepatits • HIV 82DR. SAKSHI SHUKLA
  • 83. METABOLIC DISORDERS • Sjogren’ syndrome • Thyroid disease • Granulomatous disease • Alcoholism • Malnutrition • Eating disorders • Diabetes (uncontrolled) 83DR. SAKSHI SHUKLA
  • 85. FAC I A L N E R V E PA R A LYS I S : ◦Transient FNP caused by local anaesthesia into capsule of the parotid gland, which is located at posterior border of the mandibular ramus. 85DR. SAKSHI SHUKLA
  • 86. HISTOLOGICAL CLASSIFICATION OF SALIVARY GLAND TUMOURS WHO (1991 • Pleomorphic adenoma • Myoepithelioma •Basal cell adenoma • Warthins tumour • Oncocytoma •Canalicular adenoma •Sebaceous adenoma • Monomorphic adenoma • Ductal papilloma - inverted ductal papilloma - intraductal papilloma - sialadenoma papilliferum • Cystadenoma - papillary cystadenoma - mucinous cystadenoma 86DR. SAKSHI SHUKLA
  • 87. CARCINOMA • Acinic cell carcinoma • Mucoepidermoid carcinoma • Adenoid cystic carcinoma • Polymorphous low grade adenosarcoma • Epithelial-myoepithelial carcinoma • Basal cell adenocarcinoma • Sebaceous carcinoma • Papillary cystadenocarcinoma • Mucinous adenocarcinoma • Oncocytic carcinoma • Salivary cell carcinoma • Adenocarcinoma • Malignant myoepithelioma Salivary cell carcinoma • Adenocarcinoma • Malignant myoepithelioma 87DR. SAKSHI SHUKLA
  • 88. NONEPITHELIAL TUMOURS 4. MALIGNANT LYMPHOMAS 5. SECONDARY TUMOURS 6. UNCLASSIFIED TUMOURS 7. TUMOR LIKE LESIONS - sialadenosis - oncocytosis 88DR. SAKSHI SHUKLA
  • 89. PLEOMORPHIC ADENOMA Mixed tumour,(Pleos – many : morphus – form) Commonest benign salivary tumour inadult Common in parotid (80%) Common in females Abundant matrix mucoid,myxoid or chondroid supporting tissue Dumb bell tumor –if deep lobe isinvolved 89DR. SAKSHI SHUKLA
  • 90. Lobulated , painless swelling, Long duration Neither adherent to skin/ masseter muscle Generally firm / variable consistency Raised ear lobule Curtain sign – swelling cannot be moved above zygomatic bone 90DR. SAKSHI SHUKLA
  • 91. WARTHINS TUMOR Second most common tumor in the salivary glands. Slow growing , painless cystic neoplasm – exclusively in the parotid gland. Proliferation of lymphoid tissues of intra/peri parotid LN Predisposing factor – smoking, radiation exp and EBV Round to oval Swelling , well circumscribed encapsulated masses 91DR. SAKSHI SHUKLA
  • 92. Multicentric or multifocal disease Soft ,fluctuant Fifth to seventh decades of life Male : female :: 10:1 Elderly males , smokers Bilateral 10% No Malignant potential 92DR. SAKSHI SHUKLA
  • 93. E FFECTS O F AG I N G : • decrease in salivary flow • acinar atrophy accompanied by fibrosis • replacement of the secretory tissue with adipose tissue. • structural alterations in the ducts including intraductal deposits. • appearance of oncocytes, enlarged, inactive secretory cells with pycnotic nuclei93DR. SAKSHI SHUKLA
  • 94. CONCLUSION • Dentists are involved with aspects of salivary gland function in several ways, such as diagnosing problems involving the major and minor salivary glands, in the management of oral dryness associated with salivary problems, in the treatment of caries and periodontal disease resulting from decreased salivary flow, and in controlling salivation during restorative procedures. Significant abnormality or disease of the salivary glands, such as that associated with Sjögren syndrome or neoplasm, necessitates.However, a general dentist may be called upon to provide follow up in terms of management of the patient’s subsequent oral health. 94DR. SAKSHI SHUKLA
  • 95. REFERENCES • Nanci A. Salivary glands, Ten Cate’s Oral histology, Development, Structure, and function. 8th Ed.Elsevier publications:2012:253-277. • Kumar GS. Salivary glands,Orban’s Oral Histology and Embryology. Elsevier heath sciences.10th Ed;2012. • Malik N. A. Textbook Of Oral And Maxillofacial Surgery,Jaypee Brothers Medical Publishers Ltd ;( 4th Edition)2015 • Chaurasia B. D. Human Anatomy, CBS publishers and distributers(7th edition) vol.3,2015 95DR. SAKSHI SHUKLA

Editor's Notes

  1. Acinar cells bery like lobule shaped, clustr of cells, exocrine- secrete their products on to epithelium rather than blood, racemose is form of cluster
  2. The main difference in mucous and serous is the presence pf more proteinous substances in serous secretion and serous protein hasn linked oligosaccharide and their consistency
  3. 60 65 prcnt of total saliva
  4. Investinng layer is most superficial layer, cervical fascia covers neck it is divided into deep or superficial etc, superficial lmain ais layer covering epithelial cell
  5. Tragus is the small eminence
  6. Bartholin is the largest major duct of salivary gland, CARuncle ir on either side of frenulum linguae on the sublingual surface of tongue
  7. Chorda is a abranch of facial nerve carries taste message to brain
  8. More protein content with added sugar n all
  9. Imp feature is that mucus is present more apically heance nucleua and cytoplsasm etc move towards basement me
  10. MAIN DIIFERENCE IS PRESENCE OF MUCIN CONTAINING CELLS TOWARDA APICAL AREA THAT MOVES THE NUCLEUA AND EMAINIG APPARATUS TOWARDS BASAL LAYER
  11. Polyhedral many points
  12. Myo is muscle By contraction it maintains the patency of he cell
  13. Mast cells release histamine during inflammatory cells Fibroblast produces collagen and other fibres Plasma cells cells of b lymphocytes produces antibody
  14. Ectoderm outer layer of germ cells
  15. FORMATION OF SALIVA occurs in 2 stages in ducts Ist in intercalated forms isotonic whereas in execretory and secretory duct there is there are resorption and secretion og components like na cl etc to form hypotonic
  16. Meq mili equilant of solute per litre
  17. Extravasation is leakage of fluid out of its duct Ruptured saliary duct usuaaly by trauma Seromucous gland obstruction mucous retention cyst
  18. Mucocele in floor of mouth
  19. LADD lacrimo auriculodental digital anomalies of ear, multiple congenital anamoly, hypoplasia atresia, dental malformation, narrowing of passage of body atresia Treacher syndrome- facial deformty micrognasia, bird , dryness of face as pathologic appearance dysplasia or aplasia Felty autoimmune diseaseand few neutrophils in blood trid it is artritis ,enlargement of spleen Adactylia- congenital loss of finges Heerfordt parotid gland enlargement facial alsy fever
  20. Hepatitis cgranulomatous immunodeficiency disease , granulomas are masses of immune cells that are formed at site of infection
  21. Myxoid containing mucous or gelatinous tissue Chondrioi- cartilage