Salivary glands are a group of organs secreting a watery substance that is of utmost importance for several physiological functions ranging from the protection of teeth and surrounding soft tissues to the lubrication of the oral cavity.
3. INTRODUCTION
• Salivary glands are a group of organs secreting a watery substance that
is of utmost importance for several physiological functions ranging from
the protection of teeth and surrounding soft tissues to the lubrication of
the oral cavity, which is crucial for speech and perception of food taste.
• Salivary glands are complex networks of hollow tubes and secretory
units that are found in specific locations of the mouth and which,
although architecturally similar, exhibit individual specificities according
to their location.
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4. DEFINITIONS
• These are compound tubule acinar exocrine glands found in oral cavity
that secrete complex fluid known as saliva.
Or
• any of various glands that discharge a fluid secretion and especially
saliva into the mouth cavity and that in humans comprise large
compound racemose glands including the parotid glands, the sublingual
glands, and the submandibular gland
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6. BASED ON
SIZE
Major salivary glands
Minor salivary glands
Major salivary glands -
Collection of secretory cells
aggregated into large
bilaterally paired extra oral
glands with extended duct
system through which the
gland secretions reach the
mouth.
• - Parotid
• -Submandibular
• - Sublingual
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7. M I N O R S A L I VA R Y
G L A N D S
2. Collection of secretory cells
scattered throughout the mucosa
& submucosa of the oral cavity
with short ducts opening directly
onto mucosal surface.
-Serous glands of Von Ebner.
-Anterior lingual glands.
- - Lingual, buccal, labial, palatal
glands, glossopalatine and
retromolar glands
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11. PAROTID
GL AND
Largest
Average Wt - 15gm
Irregular lobulated
mass lying mainly below
the external acoustic
meatus between
mandible and
sternomastoid.
On the surface of the
masseter, small detached
part lies b/w zygomatic
arch and parotid duct
accessory parotid gland
or ‘socia parotidis’
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12. PAROTID
CAPSULE
Derived from investing
layer of deep cervical
fascia.
Superficial lamina-thick,
closely adherent
Deep lamina-thin-
attached to styloid
process, mandible and
tympanic plate.
Stylomandibular
ligament
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16. P O S T E R O - M E D I A L
S U R FAC E
.Mastoid process
2.Sternocleidomastoid
3.Posterior belly of
Digastric
4.Styloid process and the
muscle & ligaments
attached to it.
5.Internal carotid artery
& Internal jugular vein.
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17. APEX
Cervical branch of Facial
n.
2.Retromandibular vein.
3.Posterior belly of
digastric.
4.External Carotid artery
SUPERFICIALLY
Skin and superficial
fascia.
2. Great Auricular nerve.
3. Parotid lymph nodes17DR. SAKSHI SHUKLA
18. A N T E R O M E D I A L
S U R FAC E
Zygomatic branch of Facial n.
• Transverse Facial artery.
• Buccal branch of Facial n.
• Accessory Parotid gland.
• Parotid duct.
• Mandibular branch of Facial n.
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19. PA R OT I D D U C T:
Stensons duct
Thick walled
5 cm long
Emerges from middle
of anterior border
It opens into the
vestibule of mouth
opposite to the 2nd
upper Molar.
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20. SURFACE
ANATOMY OF
PAROTID DUCT
Corresponds to middle
third of a line drawn from
lower border of tragus to
a point midway b/w
nasal ala and upperlabial
margin
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21. • BLOOD
SUPPLY
Arterial
Branches of Ext .
Carotid A
Venous
Into Ext. Jugular
Vein
• LYMPHATIC
DRAINAGE
Upper Deep
cervical nodes via
Parotid nodes
NERVE SUPPLY
Sensory: auriculotemporal n for
gland, great auricular nerve for the
capsule.
Sympathetic: plexus around the
middle meningeal artery.
Parasympathetic: reach the gland
through auriculotemporal nerve.
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23. - Anterior part of digastric
triangle - J-shaped
- - Walnut size
- - 3- surfaces
- – lateral, medial, inferior
- - Covered by 2 layers of
deep cervical fascia.
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24. PA R T S
1.Superficial part
2.Deep part
3.Submandibular duct
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25. C A P S U L E
Derived from deep
cervical fascia
Superficial Layer is
attached to base of
mandible
Deep layer attached
to mylohyoid line of
mandible
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26. REL ATIONS
Inferior- covered by
• Skin
• Superficial fascia containing
platysma and cervical branches of
facial N
• Deep Fascia
• Facial Vein
• Submandibular Nodes
Lateral surface – Related to
submandibluar fossa on the mandible
• Madibular attachment of Medial
pterygoid
• Facial Artery
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27. Medial surface
Anterior part is related to
myelohyoid muscle,nerve
and vessles
Middle part
Hyoglossus,,lingual nerve,
submandibular
ganglion,hypoglossal nerve
and deep lingual vein.
Posterior Part-
Styloglossus,stylohyoid
ligament,9th nerve and wall
of pharynx
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28. Deep part
Small in size
Lies deep to mylohyoid
and superficial to
hyoglossus and
styloglossus
Posteriorly continuous
with superficial part
around the posterior
border of mylohyoid
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29. SUBMANDIBUL AR
DUCT
Whartons duct
5 cm long
Emerges at the anterior
end of deep part of the
gland
Runs forwards on
hyoglossus b/w lingual and
hypoglossal N
At the ant. Border of
hyoglossus it is crossed by
lingual nerve
Opens in the floor of
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31. N E R V E S U P P LY
Supplied by branches
of submandibular
ganglion
• sensory fibres from
lingual nerve.
secretomotor fibers.
vasomotor
sympathetic fibres
from the plexus on
the facial a
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33. SUBLINGUAL GL AND
smallest of the three glands
weighs nearly 3-4 gm
Lies beneath the oral
mucosa in contact with the
sublingual fossa on lingual
aspect of mandible
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34. REL ATIONS
Superiorly- Mucosa of oral
floor, raised as sublingual
fold
Inferiorly-Myelohyoid
Behind-Deep part of
Submandibular gland
Lateral -Mandible above
the anterior part of
mylohyoid line
Medial -Genioglossus and
separated from it by
lingual nerve and
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35. SUBLINGUAL
DUCT
Ducts of Rivinus
8-20 ducts
Open into oral cavity through
series of small ducts (duct of
Rivinus) opening along
sublingual fold and
open through large duct-
Bartholin’s duct, that opens with
submandibular duct at
sublingual caruncle
Few of them join the
submandibular duct
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36. Blood supply
Arterial from
sublingual and
submental arteries
Venous drainage
corresponds to the
arteries
Nerve Supply
Similar to that of
submandibular glands(
via lingual nerve ,
chorda tympani and
sympathetic fibers36DR. SAKSHI SHUKLA
38. MINOR SALIVARY GLAND:
No. between 600 and 1000.
Exist as aggregates of secretory tissue present in submucosa throughout
most of the oral cavity.
Not seen in gingiva & anterior part of hard plate
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39. V O N E B N E R S ’ S
L I N G UA L S E R O U S
G L A N D
Located in tongue and open
into the troughs surrounding
circumvallate papillae on the
dorsum of tongue and at the
foliate papillae on the side of
tongue.
Secrete digestive enzymes &
proteins that are thought to
play role in taste process
Fluid of their secretion
cleanse the trough & prepare
the taste receptors for a new
stimulus.
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40. DISTINGUISHING CHARACTERISTICS OF
THE MINOR SALIVARY GLANDS:
• Produce serous & mucous secretions.
• Secretory activity appears to be continuous rather than in response to
specific stimuli.
• 10% of total salivary secretion.
• But approx 70% of mucous secretion.
• Empty the secretory products into oral cavity through numerous small
ducts. • Are polystomatic (multiple main excretory ducts). • Ducts of minor
salivary gland (lips), tend to form cysts(mucocele)
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42. DEVELOPMENT OF SALIVARY GLANDS
Bud formation
Formation and growth of epithelial chord.
Initiation of branching in terminal parts of epithelial chord.
Branching of epithelial chord and lobule formation
Canalization Cytodifferentiation
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45. S T R U C T U R E S O F
S A L I VA R Y G L A N D S
Comprises of
-a series of secretory end piece
or acini.
-connected to the oral cavity
by a system of ducts.
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46. Secretory end piece or accini:
• Consists of secretory cells,
which are arranged in a roughly
spherical configuration around a
central lumen or cavity.
• Show a great diversity in size,
shape, and cell number.
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47. S E R O U S C E L L S
Secretory end piece
consisting of serous cells
are typically spherical
and consist of 8 to 12
cells surrounding a
central lumen.
The lumen of serous end
piece has small
extensions in the form of
intercellular canaliculi
(found between adjacent
serous cells).
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48. Serous Cells:
Parotid & submandibular
gland.
Serous cells are also
present in demilune
formations at the blind ends
of mucous secretory tubules
(submandibular and
sublingual glands).
Secretions of serous cells
are proteinaceous-usually
enzymatic, antimicrobial,
calcium-binding.
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50. Plasma membrane exhibits several specializations:
The surface of the seromucous cell lining both the central lumen & canaliculi possess a
delicate microvilli that extend into luminar and canalicular spaces.
Space between basement membrane and basal plasma membrane may be increased
by complex foldings (0.5 microns) of the basal plasma membrane.
Canaliculus terminates in the form of a classic junctional complex consisting of a tight
junction (zona occludens), an adherent junction & a desmosome.
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51. M U CO U S C E L L S
Predominant secretory cell type of
the sublingual gland & most of
minor salivary glands.
Also occur in submandibular
gland.
Secretion consists of large
amount of mucins -lubrication,
effective barrier, aggregation of
microorganisms.
Secretory component of
mucous cell accini consists of
round or tubular configuration.
Larger lumen. Larger than
serous cells. Pyramidal in shape.
Broader luminal surface
51DR. SAKSHI SHUKLA
53. Serous
Stain darkly (zymogen
granules)
Wedge shaped with
round nucleus, lying towards
the base
Mucous
Lightly stained
Appears empty
Polyhedral
Contain mucinogen
granules
Nucleus flattened ,close to53DR. SAKSHI SHUKLA
54. M YO E P I T H E L I A L
C E L L S ( B A S K E T
C E L L S ) :
Contractile cells located
around the terminal secretory
units and the first portion of
the duct system, intercalated
duct.
Located between basal
lamina and secretory or duct
cells and are joined by
desmosomes.
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55. DUCTS
Terminal secretory units opens
into a small duct called the
intercalated duct.
Secretions pass through a
system of ducts
Smallest – intercalated ducts
lined by flattened cells
Intercalated ducts open into
striated ducts lined by cuboidal
cells
Striated ducts open into
excretory ducts lined by simple
columnar epithelium
55DR. SAKSHI SHUKLA
56. CO N N E C T I V E
T I S S U E :
Capsule –demarcate gland
from adjacent structures.
Septa –divide gland into
lobes and lobules -Carry the
nerves and blood vessels and
excretory ducts. Fibroblast,
Macrophages, Dendritic cells,
Mast cells, Plasma Cells,
Adipose tissue
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57. EMBYOLOGY
Salivary glands develop as outgrowths of buccal epithelium
• Parotid – ectodermal in origin
• Submandibular & Sublingual – endodermal in origin
Parotid – 4th Wk of gestation
Submandibular – 6th Wk of gestation
Sublingual – 9th Wk of gestation
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63. Saliva Compositon
Water (99.5%) Solid (0.5%)
Organic Inorganic
Na+ K+ Ca+
Mucin
ptyalin
Lysozyme
IgA
Lactoferrin
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64. IONIC
COMPOSITION
Saliva in the acini-isotonic with plasma
Under resting condition ionic composition of
saliva reaching the mouth
Na+ and Cl- 15 mEq/l (1/7 to 1/10 conc of
Plasma)
K+ 30 mEq/l (7 times that of Plasma)
HCO3- 50-70 mEq/l (2-3 times that of
plasma)
During maximal salivation
Na+ and Cl- (1/2 to 2/3 conc of Plasma)
K+ (4 times that of Plasma)
HCO3- 50-70 mEq/l (2-3 times that of
plasma)
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65. F U N C T I O N S O F S A L I VA
Keep the mouth moist
Aids in swallowing
Aids in speech
Keeps the mouth and teeth
clean
Antimicrobial action
Digestive function
Bicarbonate acts as buffer
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67. SALIVA AS A DIAGNOSTIC AID
Oral diseases
High risk caries patient, Patient susceptible to candidiasis
Diagnostic aid for clinical problems
Psychological problems, smoking, poisoning
Systemic diseases affecting saliva
Sjogren’s syndrome, Cystic fibrosis
Steroid hormone determination: Functional efficiency of corpus luteum in case of defect in
hypothalamic-pituitary-ovarian axis, Pregnant status, Ovulation time
Monitoring of certain drugs that exhibit consistent saliva : plasma ratio. e.g., phenytoin,
carbamazine, theophylin
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69. SIALOGRAPHY
evaluate of the
functional integrity of the
salivary glands
• case of obstructions
• evaluate the ductal
pattern
• facial swellings, to rule
out salivary gland
pathology
• intraglandular
neoplasms
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74. XEROSTOMIA:
• Drugs- central or peripheral inhibition of salivary secretion.
• Destruction of salivary gland:
-Radiotherapy to H & N region
-Chemotherapy
-Bone marrow transplant
-Autoimmune diseases (sjogren’s syndrome)invasion of lymphocytes & destruction
of epithelial cells.
• Psychological factors
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75. • Loss of protective effect of salivary buffers, proteins, and mucins
increased susceptibility to infections.
• Difficulty & pain on eating, speech and swallowing.
• treatment- Temporary saliva
• Oral pharmacosympathomimmetic drugs like Pilocarpine.
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76. S I A LO R R H E A :
Refers to excess saliva
production.
Causes:
-Gastrointestinal irritants
-Drugs (Pilocarpine)
-Cerebro vascular
accident -Pt.
with a severe neurologic
deficit
-Pt. who have
undergone extensive oral
surgical procedures.76DR. SAKSHI SHUKLA
78. S I A LOT H I A S I S
• Common in
submandibular salivary
duct
• Calcium phosphate in
the form of
hydroxyapatite is the
main mineral
component.
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85. FAC I A L N E R V E
PA R A LYS I S :
◦Transient FNP
caused by local
anaesthesia into
capsule of the
parotid gland, which
is located at
posterior border of
the mandibular
ramus.
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89. PLEOMORPHIC
ADENOMA
Mixed tumour,(Pleos – many
: morphus – form)
Commonest benign salivary
tumour inadult
Common in parotid (80%)
Common in females
Abundant matrix
mucoid,myxoid or chondroid
supporting tissue
Dumb bell tumor –if deep
lobe isinvolved
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90. Lobulated , painless
swelling, Long duration
Neither adherent to
skin/ masseter muscle
Generally firm / variable
consistency
Raised ear lobule
Curtain sign – swelling
cannot be moved above
zygomatic bone
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91. WARTHINS
TUMOR
Second most common tumor in
the salivary glands.
Slow growing , painless cystic
neoplasm –
exclusively in the parotid gland.
Proliferation of lymphoid tissues
of intra/peri parotid LN
Predisposing factor – smoking,
radiation exp and EBV
Round to oval Swelling , well
circumscribed encapsulated
masses
91DR. SAKSHI SHUKLA
92. Multicentric or
multifocal disease
Soft ,fluctuant
Fifth to seventh
decades of life
Male : female :: 10:1
Elderly males , smokers
Bilateral 10%
No Malignant potential
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93. E FFECTS O F AG I N G :
• decrease in salivary flow
• acinar atrophy
accompanied by fibrosis
• replacement of the
secretory tissue with adipose
tissue.
• structural alterations in the
ducts including intraductal
deposits.
• appearance of oncocytes,
enlarged, inactive secretory
cells with pycnotic nuclei93DR. SAKSHI SHUKLA
94. CONCLUSION
• Dentists are involved with aspects of salivary gland function in several ways, such as
diagnosing problems involving the major and minor salivary glands, in the
management of oral dryness associated with salivary problems, in the treatment of
caries and periodontal disease resulting from decreased salivary flow, and in
controlling salivation during restorative procedures. Significant abnormality or disease
of the salivary glands, such as that associated with Sjögren syndrome or neoplasm,
necessitates.However, a general dentist may be called upon to provide follow up in
terms of management of the patient’s subsequent oral health.
94DR. SAKSHI SHUKLA
95. REFERENCES
• Nanci A. Salivary glands, Ten Cate’s Oral histology, Development, Structure, and
function. 8th Ed.Elsevier publications:2012:253-277.
• Kumar GS. Salivary glands,Orban’s Oral Histology and Embryology. Elsevier heath
sciences.10th Ed;2012.
• Malik N. A. Textbook Of Oral And Maxillofacial Surgery,Jaypee Brothers Medical
Publishers Ltd ;( 4th Edition)2015
• Chaurasia B. D. Human Anatomy, CBS publishers and distributers(7th edition)
vol.3,2015
95DR. SAKSHI SHUKLA
Acinar cells bery like lobule shaped, clustr of cells, exocrine- secrete their products on to epithelium rather than blood, racemose is form of cluster
The main difference in mucous and serous is the presence pf more proteinous substances in serous secretion and serous protein hasn linked oligosaccharide and their consistency
60 65 prcnt of total saliva
Investinng layer is most superficial layer, cervical fascia covers neck it is divided into deep or superficial etc, superficial lmain ais layer covering epithelial cell
Tragus is the small eminence
Bartholin is the largest major duct of salivary gland, CARuncle ir on either side of frenulum linguae on the sublingual surface of tongue
Chorda is a abranch of facial nerve carries taste message to brain
More protein content with added sugar n all
Imp feature is that mucus is present more apically heance nucleua and cytoplsasm etc move towards basement me
MAIN DIIFERENCE IS PRESENCE OF MUCIN CONTAINING CELLS TOWARDA APICAL AREA THAT MOVES THE NUCLEUA AND EMAINIG APPARATUS TOWARDS BASAL LAYER
Polyhedral many points
Myo is muscle
By contraction it maintains the patency of he cell
Mast cells release histamine during inflammatory cells
Fibroblast produces collagen and other fibres
Plasma cells cells of b lymphocytes produces antibody
Ectoderm outer layer of germ cells
FORMATION OF SALIVA occurs in 2 stages in ducts
Ist in intercalated forms isotonic whereas in execretory and secretory duct there is there are resorption and secretion og components like na cl etc to form hypotonic
Meq mili equilant of solute per litre
Extravasation is leakage of fluid out of its duct Ruptured saliary duct usuaaly by trauma
Seromucous gland obstruction mucous retention cyst
Mucocele in floor of mouth
LADD lacrimo auriculodental digital anomalies of ear, multiple congenital anamoly, hypoplasia atresia, dental malformation, narrowing of passage of body atresia
Treacher syndrome- facial deformty micrognasia, bird , dryness of face as pathologic appearance dysplasia or aplasia
Felty autoimmune diseaseand few neutrophils in blood trid it is artritis ,enlargement of spleen
Adactylia- congenital loss of finges
Heerfordt parotid gland enlargement facial alsy fever
Hepatitis cgranulomatous immunodeficiency disease , granulomas are masses of immune cells that are formed at site of infection
Myxoid containing mucous or gelatinous tissue
Chondrioi- cartilage