pH of the solution is 2.52 .pdf

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pH of the solution is 2.52 Solution pH of the solution is 2.52.

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Tannins are naturally occurring plant polyphenols and they have the property to bind and precipitate proteins. Tannins are extensively distributed throughout the plant kingdom. They are commonly found in both Gymnosperms and Angiosperms. Properties and uses of product Tanning of hides: Collagen present in the aniaml skin can be readily degraded by bacteria and fungi. Tannins as the propert to bindthe collagen and form crosslinked fibers which are no longer susceptible to attack Tannins has styptic and astringent properties and can be used to treat tonsillitis, pharyngitis, hemorrhoids, and skin eruptions. They are soluble in water forming dark blue or dark green solutions with iron salts and this property of tannin is utilized in the manufacture of inks and dyes.PlantCountry of OriginAcacia sp. (wattle)Found in tropical and subtropical regions of the world particurly in south-eastern Australia and AfricaSchinopsis sp.Argentina, Paraguay, and BrazilQuercus spNorth America, MexicoEucalyptus spAustralia Solution Tannins are naturally occurring plant polyphenols and they have the property to bind and precipitate proteins. Tannins are extensively distributed throughout the plant kingdom. They are commonly found in both Gymnosperms and Angiosperms. Properties and uses of product Tanning of hides: Collagen present in the aniaml skin can be readily degraded by bacteria and fungi. Tannins as the propert to bindthe collagen and form crosslinked fibers which are no longer susceptible to attack Tannins has styptic and astringent properties and can be used to treat tonsillitis, pharyngitis, hemorrhoids, and skin eruptions. They are soluble in water forming dark blue or dark green solutions with iron salts and this property of tannin is utilized in the manufacture of inks and dyes.PlantCountry of OriginAcacia sp. (wattle)Found in tropical and subtropical regions of the world particurly in south-eastern Australia and AfricaSchinopsis sp.Argentina, Paraguay, and BrazilQuercus spNorth America, MexicoEucalyptus spAustralia.

Tannins are naturally occurring plant polyphenols and they have the .pdf

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Such damage never happens during first pregnancy as there is no transference of blood during the 1st pregnancy. During the delivery of the first fetus(Rh+), Rh antigens from the fetus can enter into the mother’s(Rh-) circulation. As a response to this, the mother’s body would produce antibodies. These antibodies would harm the second child if the child is Rh+. There is no chance for this to occur in the first pregnancy Solution Such damage never happens during first pregnancy as there is no transference of blood during the 1st pregnancy. During the delivery of the first fetus(Rh+), Rh antigens from the fetus can enter into the mother’s(Rh-) circulation. As a response to this, the mother’s body would produce antibodies. These antibodies would harm the second child if the child is Rh+. There is no chance for this to occur in the first pregnancy.

Such damage never happens during first pregnancy as there is no tran.pdf

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Option 4 an abstract class can have ordinary methods but an interfac.pdf

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Please follow the data and description : Doubly linked list : In the filed of computer science, a doubly linked list is a linked data structure that consists of a set of sequentially linked records called nodes. Each node contains two fields, called links, that are references to the previous and to the next node in the sequence of nodes. The example that has been provides is the : 3(head)-----> 7 ----->5-----> 9-----> 1(tail) Now that we have a node defining the head and the tail of the list. And because they are double referenced this means we can easily add or remove items from the head and the tail. As there are given some lines of code that has to been predicted we follow it as : a) current = head; : This clearly indicates that the current position of the element is the head element which is the element 3 in the present case. So the current node element after the execution of the line is 3. b) current = current.next; : Now that the current element is the 3 which is the head so that the pointer is in the head element and the command now says that current position of the element is the next element to the current element. So by moving to the next element as this is possible in the linked list, we get the element as 7. So the current node element after the execution of the line is 7. c) current = current.next; : Now that the current element is the 7 which is the element next to head so that the pointer is in the node element and the command now says that current position of the element is the next element to the current element. So by moving to the next element as this is possible in the linked list, we get the element as 9. So the current node element after the execution of the line is 9. d) current = current.previous; : Now that the current element is the 9 and the command now says that current position of the element is the previous element to the current element. So by moving to the previous element as this is possible in the doubly linked list to move forth and backwards, we get the element as 7. So the current node element after the execution of the line is 7. e) current = current.next; : Now that the current element is the 7 which is the element next to head so that the pointer is in the node element and the command now says that current position of the element is the next element to the current element. So by moving to the next element as this is possible in the linked list, we get the element as 9. So the current node element after the execution of the line is 9. f) current = current.next; : Now that the current element is the 9 and the command now says that current position of the element is the next element to the current element. So by moving to the next element as this is possible in the linked list, we get the element as 5. So the current node element after the execution of the line is 5. g) current = current.previous; : Now that the current element is the 5 and the command now says that current position of the element is the p.

Please follow the data and description Doubly linked list In t.pdf

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Pictures are not legible. plz post it again.SolutionPictures a.pdf

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No. Redox reactions can occur between two nonmetals as well: Example: H2 and O2 are both nonmetals, but they can undergo a redox reaction to give H2O: 2 H2 + O2 => 2 H2O H2 is oxidized as its oxidation state increases from 0 (in H2) to +1 (in H2O). O2 is reduced as it oxidation state decreases from 0 (in O2) to -2 (in H2O). Solution No. Redox reactions can occur between two nonmetals as well: Example: H2 and O2 are both nonmetals, but they can undergo a redox reaction to give H2O: 2 H2 + O2 => 2 H2O H2 is oxidized as its oxidation state increases from 0 (in H2) to +1 (in H2O). O2 is reduced as it oxidation state decreases from 0 (in O2) to -2 (in H2O)..

No. Redox reactions can occur between two nonmetals as wellExampl.pdf

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Moles of Cu atoms = massmolar mass= 2.1563.55 = 0.03383 molNo..pdf

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D XeF2 only 2 electrons are shared with F AND .pdf

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co2Solution co2.pdf

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Generally the formula for an acid is a hydrogen atom bonded with either another atom that is an anion, such as Cl- (chlorine anion) or another molecule that is an anion, such as SO42- (sulfate anion). What makes an acid an acid is that the hydrogen cation can fall off the molecule, known as protonation, leaving behind a relatively stable anion. This anion is known as the acid\'s conjugate base. A strong acid, such as HCl, has a weak conjugate base. A weak acid, such as HF, would have a strong conjugate base. A strong acid is dictated by how much it protonates in water, that is, how much the H+ cation dissociates from the anion in water. In HCl\'s case, the acid protonates almost completely, making it a strong acid. The acidity of an acid is measured by the well known pH scale. As you go upwards in difficulty of chemistry, molecules with multiple hydrogens can have different acidities because when different hydrogens leave, they can form a more or less stable anion behind. I hope this helps! Solution Generally the formula for an acid is a hydrogen atom bonded with either another atom that is an anion, such as Cl- (chlorine anion) or another molecule that is an anion, such as SO42- (sulfate anion). What makes an acid an acid is that the hydrogen cation can fall off the molecule, known as protonation, leaving behind a relatively stable anion. This anion is known as the acid\'s conjugate base. A strong acid, such as HCl, has a weak conjugate base. A weak acid, such as HF, would have a strong conjugate base. A strong acid is dictated by how much it protonates in water, that is, how much the H+ cation dissociates from the anion in water. In HCl\'s case, the acid protonates almost completely, making it a strong acid. The acidity of an acid is measured by the well known pH scale. As you go upwards in difficulty of chemistry, molecules with multiple hydrogens can have different acidities because when different hydrogens leave, they can form a more or less stable anion behind. I hope this helps!.

Generally the formula for an acid is a hydrogen atom bonded with eit.pdf

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Directives are JavaScript functions that manipulate and add behaviours to HTML DOM elements. Directives can be very simplistic or extremely complicated. Therefore, getting a solid grasp on their many options and functions that manipulate them is critical. There are many options that can be configured and how those options are related to each other is important. Each directive undergoes something similar to a life cycle as AngularJS compiles and links the DOM. The directive lifecycle begins and ends within the AngularJS bootstrapping process, before the page is rendered. In a directive’s life cycle, there are four distinct functions that can execute if they are defined. Each enables the developer to control and customize the directive at different points of the life cycle. The four functions are: compile, controller, pre-link and post-Link. The compile function allows the directive to manipulate the DOM before it is compiled and linked thereby allowing it to add/remove/change directives, as well as, add/remove/change other DOM elements. The controller function facilitates directive communication. Sibling and child directives can request the controller of their siblings and parents to communicate information. The pre-link function allows for private $scope manipulation before the post-link process begins. The post-link method is the primary workhorse method of the directive. In the directive, post-compilation DOM manipulation takes place, event handlers are configured, and so are watches and other things. In the declaration of the directive, the four functions are defined like this. .directive(\"directiveName\",function() { return{ controller:function() { // controller code here... }, link:function() { // post-link code here... } } }) Social policies are policies which are designed to address social issues, ranging from poverty to racism. Many governments have agencies which formulate and administrate social policies, and governments approach social issues in a variety of ways. Some countries often regarded as a very progressive model when it comes to social policy, with a number of far-reaching programs which are designed to promote equality in the European Union. Social policy reform can also take place outside the government, as seen when community organizations work to support disadvantaged citizens. Social policies include: government pensions, welfare for the poor, food stamps, affordable housing initiatives, health care, unemployment benefits, equal opportunityemployment laws, antidiscrimination laws, and policy initiatives which are designed to benefit disadvantaged people in society. For instance, many nations encourage their colleges and universities to accept students regardless of need, with the goal of giving people at an economic disadvantage the chance to go to college, improving their opportunities. Solution Directives are JavaScript functions that manipulate and add behaviours to HTML DOM elements. Directives can be very simpli.

Directives are JavaScript functions that manipulate and add behaviou.pdf

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Answer: A. Dyslexia The word dyslexia comes from the Greek language and means difficulty with words. Individuals with dyslexia have trouble with reading and spelling despite having the ability to learn. Solution Answer: A. Dyslexia The word dyslexia comes from the Greek language and means difficulty with words. Individuals with dyslexia have trouble with reading and spelling despite having the ability to learn..

AnswerA. DyslexiaThe word dyslexia comes from the Greek languag.pdf

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Answer: Option E IFN-Gamma is th most likely candidate for cytokinin x Cellular immunity mediated by T-cells, macrophages, and activity of Type-1 cytokines (interleukin-12 [IL-12] and interferon [INF] gamma) is necessary for maintaining the quiescence of chronic T. gondii infection. The production of IL-12 and INF gamma is stimulated by CD154 (also known as CD40 ligand) in human models of T. gondii infection. CD154 acts by triggering dendritic cells and macrophages to secrete IL-12, which in turn enhances the production of INF gamma by T-cells.In HIV infection due to immunosuppression opportunistic infection occurs withT. gondiidue to depletion of CD4 T-cells, impaired production of IL-12 and INF gamma and impaired cytotoxic T-lymphocyte activity. There is decreasedin vitroproduction of IL-12, INF gamma, and decreased expression of CD154 in response toT. gondii Solution Answer: Option E IFN-Gamma is th most likely candidate for cytokinin x Cellular immunity mediated by T-cells, macrophages, and activity of Type-1 cytokines (interleukin-12 [IL-12] and interferon [INF] gamma) is necessary for maintaining the quiescence of chronic T. gondii infection. The production of IL-12 and INF gamma is stimulated by CD154 (also known as CD40 ligand) in human models of T. gondii infection. CD154 acts by triggering dendritic cells and macrophages to secrete IL-12, which in turn enhances the production of INF gamma by T-cells.In HIV infection due to immunosuppression opportunistic infection occurs withT. gondiidue to depletion of CD4 T-cells, impaired production of IL-12 and INF gamma and impaired cytotoxic T-lymphocyte activity. There is decreasedin vitroproduction of IL-12, INF gamma, and decreased expression of CD154 in response toT. gondii.

Answer Option E IFN-Gamma is th most likely candidate for cytokinin.pdf

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a). m = 0 kg (b). Let S representing the amount of sugar (in kg) at time t (in minutes). Then dS/dt = (rate of salt going in) (rate of salt going out) dS/dt = (0.01)(3) - (3/1320)S dS/dt +(3/1320)S = 0.03 (c) integrating factor : IF = e( (3/1320) dt) = e^((3/1320)t) Multiply both sides of ODE: e^((3/1320)t) dS/dt +e^((3/1320)t) (3/1320)S = 0.03e^((3/1320)t) d/dt(e^((3/1320)t)*S) = 0.03e^((3/1320)t) iNTEGRATE BOTH SIDES: e^((3/1320)t)*S = 0.03e^((3/1320)t)*(1320/3) + C S = 0.03(1320/3) + Ce^(-(3/1320)t) S(t) = 13.2 + Ce^(-(3/1320)t) initial condition S(0) = 0 0 = 13.2 + Ce^(-(3/1320)*0) = 0.00007 + C C = -13.2 general solution is S(t) = 13.2 - 13.2e^(-(3/1320)t) S(t) = 13.2(1 - e^(-(3/1320)t) ) (c). then S(75) = 13.2(1 - e^(-(3/1320)*75) ) = 2.06869 kg Solution a). m = 0 kg (b). Let S representing the amount of sugar (in kg) at time t (in minutes). Then dS/dt = (rate of salt going in) (rate of salt going out) dS/dt = (0.01)(3) - (3/1320)S dS/dt +(3/1320)S = 0.03 (c) integrating factor : IF = e( (3/1320) dt) = e^((3/1320)t) Multiply both sides of ODE: e^((3/1320)t) dS/dt +e^((3/1320)t) (3/1320)S = 0.03e^((3/1320)t) d/dt(e^((3/1320)t)*S) = 0.03e^((3/1320)t) iNTEGRATE BOTH SIDES: e^((3/1320)t)*S = 0.03e^((3/1320)t)*(1320/3) + C S = 0.03(1320/3) + Ce^(-(3/1320)t) S(t) = 13.2 + Ce^(-(3/1320)t) initial condition S(0) = 0 0 = 13.2 + Ce^(-(3/1320)*0) = 0.00007 + C C = -13.2 general solution is S(t) = 13.2 - 13.2e^(-(3/1320)t) S(t) = 13.2(1 - e^(-(3/1320)t) ) (c). then S(75) = 13.2(1 - e^(-(3/1320)*75) ) = 2.06869 kg.

a). m = 0 kg (b). Let S representing the amount of sugar (in kg).pdf

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According to Henderson\'s Equation pOH = pKb + log ([salt] / [base] ) = - log Kb + log ( [NH4Cl] / [ NH3] ) = - log ( 1.8*10^-5) + log [( 1.5mol/5L) / ( 1.0 mol / 5.oL) ] = 5 - log 1.8 + log 1.5 = 4.92 pH = 14 - pOH = 14 - 4.92 = 9.08 Solution According to Henderson\'s Equation pOH = pKb + log ([salt] / [base] ) = - log Kb + log ( [NH4Cl] / [ NH3] ) = - log ( 1.8*10^-5) + log [( 1.5mol/5L) / ( 1.0 mol / 5.oL) ] = 5 - log 1.8 + log 1.5 = 4.92 pH = 14 - pOH = 14 - 4.92 = 9.08.

According to Hendersons Equation pOH = pKb + lo.pdf

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1.) The Occupational Safety and Health Administration, or OSHA, was established in 1970 to encourage employees and employers to decrease workplace hazards. OSHA recommends that both parties cooperatively establish workplace-specific safety standards. The agency also establishes training programs for occupational safety and health personnel. Finally, OSHA oversees research to find new approaches to workplace safety and health issues, according to Princeton University Environmental Health and Safety Department. OSHA has had significant effects on workplace safety. Although U.S. employment has almost doubled, workplace fatalities have gone down by more than 65 percent since OSHA’s inception. There were about 38 worker deaths a day in 1970 as compared to 13 per day in 2011. Occupational injury and illness rates have also lowered noticeably. In 1972 the workforce experienced about 10.9 incidents per 100 workers as compared to fewer than 4 per 100 in 2010. Compliance with OSHA regulations along with implementing your own well-designed safety program can save your business money. Accidents and injuries occurring on the job can result in major medical and legal expenses. Training your employees and having a program in place can prevent these costly incidents from occurring. Maintaining a safe environment for your workers rewards you with increased productivity and higher morale as well. 2.) Industrial safety expert, H.W. Heinrich’s 10 axioms of industrial safety stem from his domino theory. He said injuries occur due to a series of preventable incidents or factors. An accident occurs as the last step or last falling domino. \"Heinrich Revisited: Truisms or Myths\" by Fred A. Manuele, CSP, PE [2002, ISBN 0-87912- 245-5 published by National Safety Council offers the following in the last chapter. \"The intent of this book is to present a review of the origin of certain of Heinrich\'s premises that became accepted as truisms, how they evolved and changed over time, and to determine their validity. A summary of the observations made in this book follows. 1. Files pertaining to Heinrich\'s research do not exist. Thus, there is no material to review as the quality of research, or the analytical system used to arrive at his premises or their validity. 2. Heinrich\'s studies were made of accidents that occurred in the 1920s. Safety at work and the workplace itself have changed substantively since then, as evidenced by noteworthy reductions in accident experience in the past 70 years. Therefore, the current value and applicability of his conclusions should be questioned and researched. 3. Although psychology has a place in safety management, the emphasis Heinrich gave to it as being \"a fundamental of great importance in accident causation\" was disproportionate, and that overemphasis influenced his work considerably. 4. Heinrich\'s 88-10-2 ratios indicate that among the direct and proximate causes, 88 percent are unsafe acts, 10 percent are unsafe mechanica.

1.)The Occupational Safety and Health Administration, or OSHA, was.pdf

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1. three examples of life-critical software applications are: a) ISO 26262 b) IEC 62304 (medical) c) IEC 61513 (nuclear) 2. component from a text-editor GUI and the methods that it encapsulate. a) Find and replace – Text editors provide extensive facilities for searching and replacing text, either on groups of files or interactively. Advanced editors can use regular expressions to search and edit text or code. b) Cut, copy, and paste – most text editors provide methods to duplicate and move text within the file, or between files. c) Ability to handle UTF-8 encoded text. d) Text formatting – Text editors often provide basic formatting features like line wrap, auto- indentation, bullet list formatting using ASCII characters, comment formatting, syntax highlighting and so on. e) Undo and redo – As with word processors, text editors provide a way to undo and redo the last edit. Often—especially with older text editors—there is only one level of edit history remembered and successively issuing the undo command will only \"toggle\" the last change. Modern or more complex editors usually provide a multiple level history such that issuing the undo command repeatedly will revert the document to successively older edits. A separate redo command will cycle the edits \"forward\" toward the most recent changes. The number of changes remembered depends upon the editor and is often configurable by the user. f) Data transformation – Reading or merging the contents of another text file into the file currently being edited. Some text editors provide a way to insert the output of a command issued to the operating system\'s shell. g) Filtering – Some advanced text editors allow the editor to send all or sections of the file being edited to another utility and read the result back into the file in place of the lines being \"filtered\". This, for example, is useful for sorting a series of lines alphabetically or numerically, doing mathematical computations, indenting source code, and so on. h) Syntax highlighting – contextually highlights source code, markup languages, config files and other text that appears in an organized or predictable format. Editors generally allow users to customize the colors or styles used for each language element. Some text editors also allow users to install and use themesto change the look and feel of the editor\'s entire user interface. i) Extensibility - a text editor intended for use by programmers must provide some plugin mechanism, or be scriptable, so a programmer can customize the editor with features needed to manage individual software projects, customize functionality or key bindings for specific programming languages or version control systems, or conform to specific coding styles. 3. Python programs that uses the following functions: i. minmax(data), that takes a sequence of one or more numbers, and returns the smallest and largestnumbers. ii. takes a positive integer n and returns the sum of the squares of all the positiv.

1. three examples of life-critical software applications area) IS.pdf

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1) Yes, Turkey was required to adopt certain monetary policies as a condition for IMF aid. These include: - Promoting short term foreign capital flows - High interest rates - Appreciation of the local currency 2) Yes, the crisis in Turkey affects its entry in European union. Its economic situation will be a matter of concern for the other EU nations. The main reason for this is that most of Turkey\'s trade links are within Europe. However, Germany will be a strong support for Turkey. 3) When Turkish Lira did not devaluate as it was expected to, then the currency was pegged to US Dollar. 4) No, the Turkish crisis did not spread to other countries of that area. Instead it might affect the other weak economies of the world. Solution 1) Yes, Turkey was required to adopt certain monetary policies as a condition for IMF aid. These include: - Promoting short term foreign capital flows - High interest rates - Appreciation of the local currency 2) Yes, the crisis in Turkey affects its entry in European union. Its economic situation will be a matter of concern for the other EU nations. The main reason for this is that most of Turkey\'s trade links are within Europe. However, Germany will be a strong support for Turkey. 3) When Turkish Lira did not devaluate as it was expected to, then the currency was pegged to US Dollar. 4) No, the Turkish crisis did not spread to other countries of that area. Instead it might affect the other weak economies of the world..

1) Yes, Turkey was required to adopt certain monetary policies as a .pdf

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A molecular formula (or chemical formula) is a notation used by chemists to describe a molecule. Lewis structures are diagrams that show the bonding between atoms of a molecule and the lone pairs of electrons that may exist in the molecule. In early organic- chemistry publications, where use of graphics was strongly limited, a typographic system arose to describe organic structures in a line of text. Hence condensed formulas The skeletal formula of an organic compound is a shorthand representation of its molecular structure. Solution A molecular formula (or chemical formula) is a notation used by chemists to describe a molecule. Lewis structures are diagrams that show the bonding between atoms of a molecule and the lone pairs of electrons that may exist in the molecule. In early organic- chemistry publications, where use of graphics was strongly limited, a typographic system arose to describe organic structures in a line of text. Hence condensed formulas The skeletal formula of an organic compound is a shorthand representation of its molecular structure..

A molecular formula (or chemical formula) is a no.pdf

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Match the following Question Correct answer Explanation 1 f. Transovum transmission The transmission of pathogen from one generation to the next through the egg. The pathogen on the surface of the egg can infect the neonate host upon hatching or it can cause infection within the host embryo 2 d. Transovarial transmission The transmission of pathogen from one generation to the next through the egg within the ovary of the infected female and usually found in the embryo cells. 3 a. Mechanical transmission Foot and Mouth disease virus is present in excretions and secretions of infected host and is tramsmitted mechanically by direct or indirect contact 4 c. Biological transmission The pathogen enters the vector from an infected host, undergoes a development phase and transmitted to the susceptible main host. 5 g. Vertical transmission The pathogen is transmitted from mother to child either before or after the birth. 6 j. Pool feeding The ticks injures the host tissues and create a pool of blood in pits (Telmophagy). 7 m. Vessel feeding Mosquitoes suck blood directly from blood vessel/ capillaries (Solenophagy) 8 h. Resistant infection The pathogen gains entry into the host system. Due to some specific conditions within the host , it cannot complete the life cycle. 9 k.Accidental infection The Bubonic plague by Yerwinis pestis is transmitted accidentally to humans from bites of infected fleas. 10 b. Productive infection The pathogen enter the host system and get established by completing its life cycle. 11 e. abortive infection The pathogen dies once entered the host system 12 i. Reservoir host Reservoir hosts serve as source of infections without developing themselves any symptoms. 13 l. Extrinsic incubation period The time gap between entry of pathogen and occurance of symptom of disease. Solution Match the following Question Correct answer Explanation 1 f. Transovum transmission The transmission of pathogen from one generation to the next through the egg. The pathogen on the surface of the egg can infect the neonate host upon hatching or it can cause infection within the host embryo 2 d. Transovarial transmission The transmission of pathogen from one generation to the next through the egg within the ovary of the infected female and usually found in the embryo cells. 3 a. Mechanical transmission Foot and Mouth disease virus is present in excretions and secretions of infected host and is tramsmitted mechanically by direct or indirect contact 4 c. Biological transmission The pathogen enters the vector from an infected host, undergoes a development phase and transmitted to the susceptible main host. 5 g. Vertical transmission The pathogen is transmitted from mother to child either before or after the birth. 6 j. Pool feeding The ticks injures the host tissues and create a pool of blood in pits (Telmophagy). 7 m. Vessel feeding Mosquitoes suck blood directly from blood vessel/ capillaries (Solenophagy) 8 h. Resistant infection The pathogen gains entr.

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In an age where generative AI is becoming increasingly sophisticated, the potential for fraud and misinformation has reached unprecedented levels. This keynote will begin with a personal case study exploring how the speaker became the target of a generative AI scam, highlighting the convincing nature of these deceptions. Building upon this experience, the talk will delve into the broader implications of generative AI for the spread of misinformation and the erosion of trust in online spaces. As the line between truth and falsehood becomes increasingly blurred, the role of education in equipping individuals with the critical thinking skills needed to navigate this complex landscape becomes paramount. The keynote will argue that empowering postgraduate social science researchers with the tools to critically engage with generative AI is not only essential for their own work but also for the wider fight against misinformation.

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Progress in understanding the molecular basis of primary neurulation has occurred on two fronts: neural induction and shaping and bending of the neural plate. In regard to the former, the neural plate is now known to be the default state of the ectoderm, and induction of the neural plate actually involves suppressing the formation of the epidermal ectoderm (neural induction is not considered further herein). In regard to shaping and bending of the neural plate, about 100 mutations in the mouse have been identified that result in defective shaping and/or bending and, consequently, result in neural tube defects (NTDs); thus, these mutations provide insight into which genes are involved in both normal and abnormal neurulation. Because these form-shaping events of neurulation are driven by changes in cell behavior, as discussed earlier, it is not surprising that mutation of cytoskeletal, extracellular matrix/cell adhesion, cell cycle, and cell death genes results in NTDs. Neurulation is a highly choreographed morphogenetic series of events that must be precisely timed and coordinated across multiple tissues. This presumably involves signaling among tissues. It is the hope of studies using mouse mutations that such signaling pathways will be identified, ultimately leading to an understanding of the molecular basis of neurulation and the formation of NTDs in both animal models and ultimately in humans. In the following sections, we discuss what has been learned about the molecular basis of shaping and bending of the neural plate.Embryology Neurulation is the critical morphogenetic event occurring during the fourth week of human gestation, converting the previously developed neural plate into the ectoderm covered neural tube that will eventually differentiate into the brain and spinal cord. Genetic regulation of the events involved in mammalian neural tube morphogenesis is a complicated process that involves a multitude of genes. These genes have vital functions in a range of biological activities that are thought to include signaling molecules, transcription proteins and factors, cytoskeletal and gap junction proteins, growth factors, and tumor suppressor genes (Copp et al., 2003; Ewart et al., 1997; Sah et al., 1995; Zhang et al., 1996). The neural tube, formed by the cell shape changes and movements, ultimately fuses at several discrete points.Neurulation (or primary neurulation) starts in the fourth week of gestation and is the process that leads to the formation of the neural tube from the neural plate, the rudiment of the CNS [34]. It encompasses four essential and overlapping events: (1) neural induction, (2) shaping, (3) bending of the neural plate, and (4) closure of the neural tube. Neural induction (1) is the process of neural plate formation, that is, the beginning of the development of the CNS. It occurs during gastrulation starting on day 18. As described earlier, cells of the ectoderm differentiate into the neuroectoderm, a pseudostratif.

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