2. INTRODUCTION
Anesthesia is a temporary state consisting
of unconsciousness, loss of memory, lack of
pain, and muscle relaxation.
It can be divided into 3 parts:
Local
Regional (spinal and epidural) and;
General anesthesia
3. HISTORY
The first documented general anesthetic was
performed by Crawford W. Long in 1842
The first public demonstration of general
anesthesia was in 1846 by William T.G.
Morton
John Snow (1813–1858) made science out of
the art of anesthesia
4. EPIDURAL ANESTHESIA
It is a form of regional anesthesia where an
anesthetic agent is introduced directly to the
epidural space between the fourth and fifth
lumbar vertebra
Esters: chloroprocaine, procaine, cocaine and
tetracaine
Amines: lidocaine, mepivacaine, prilocaine,
bupivacaine, ropivacaine
7. DIFFERENCES
SPINAL EPIDURAL
Involved space is smaller
Injected dose is less 1,5-3,5 ml
Usually one-shot only
Onset of analgesia is 5
minutes
cause neuromuscular block
performed below the
second lumbar vertebral
body to avoid piercing and
consequently damaging the
spinal cord.
Involved space is larger
Injected dose is larger 10-
20ml
Additional injections are
available
Onset of analgesia is 15-30
minutes
Doesn’t cause neuromuscular
block
may be performed anywhere
along the vertebral column
8. DIFFERENCES
Below the anesthesia
all segments are
blocked
Extension of block is
depended on the
density of solution and
the position of patient
Possible to create
segmental block
Extension of block is
depended on the
volume and rate of
injections and the
position of patient has
no impact
9. ADVERSE EFFECTS
Hypotension and bradycardia through
blockade of the sympathetic nervous system.
Limb damage from sensory and motor block.
Epidural bleed
Post-dural puncture headache
Hypotension
10. Respiratory failure if block is 'too high'.
Direct nerve damage.
Hypothermia.
Damage to the spinal cord - may be transient or permanent.
Spinal infection.
Aseptic meningitis.
Hematoma of the spinal cord - enhanced by use of LMWH
pre-operatively.
Anaphylaxis.
Urinary retention.
Spinal cord infarction.
Anesthetic intoxication
11. CONTRAINDICATION
Patient’s refusal
Coagulopathy
Infection at the site of epidural injection
Abnormal anatomy of the spinal column
Septicemia
Neurological disease
Severe aortic or mitral stenosis