If compound inhibits cilia growth, what is the molecular mechanism?
Solution
Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles
on the surface of most eukaryotic cells. They play important roles in coordinating a variety of
signaling pathways during growth, development, cell mobility, and tissue homeostasis. Defects
in ciliary structure or function are associated with multiple human disorders called
ciliopathies.Ciliary assembly and maintenance requires a precise balance between two
indispensable processes; so called assembly and disassembly. The interplay between them
determines the length of the resulting cilia. These processes require a highly conserved transport
system to provide the necessary substances at the tips of the cilia and to recycle ciliary turnover
products to the base using a based microtubule intraflagellar transport (IFT) system.
Cilia are specialized surface regions of eukaryotic cells that serve a variety of functions, ranging
from motility to sensation and to regulation of cell growth and differentiation. is the possibility
that the cilium is a secretory organelle in addition to being a motility and sensory organelle and
T. cruzi FCaBP can be found in vesicles shed from the cell..
If compound inhibits cilia growth, what is the molecular mechanism.pdf
1. If compound inhibits cilia growth, what is the molecular mechanism?
Solution
Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles
on the surface of most eukaryotic cells. They play important roles in coordinating a variety of
signaling pathways during growth, development, cell mobility, and tissue homeostasis. Defects
in ciliary structure or function are associated with multiple human disorders called
ciliopathies.Ciliary assembly and maintenance requires a precise balance between two
indispensable processes; so called assembly and disassembly. The interplay between them
determines the length of the resulting cilia. These processes require a highly conserved transport
system to provide the necessary substances at the tips of the cilia and to recycle ciliary turnover
products to the base using a based microtubule intraflagellar transport (IFT) system.
Cilia are specialized surface regions of eukaryotic cells that serve a variety of functions, ranging
from motility to sensation and to regulation of cell growth and differentiation. is the possibility
that the cilium is a secretory organelle in addition to being a motility and sensory organelle and
T. cruzi FCaBP can be found in vesicles shed from the cell.
