complete description in osteoporosis with video of bone formation and bone destruction

1. Molecular Mechanism of Osteoporosis
Presented by:- SHOUVIK KUMAR NANDY
SHIKHA THAKUR
Department of Pharmacology

2. CONTENTS:-
1. Introduction
2. Component of bones
3. Pathophysiology of osteoporosis
4. Molecular signaling of osteoporosis
5. Treatment
6. Bone remodeling
7. Reference
Fig:- Osteoporosis bone damage

3. Introduction(1):-
 Definition of Osteoporosis:- A medical condition in which the bones brittle and fragile from loss of
tissue, typically as a results of hormonal changes or deficiency of calcium or vitamin D.
 Low bone density.
 Increase the risk of fracture.
Osteoporosis bones Normal bones

4. Composition Of Bone(1)
Matrix Cells
Organic Inorganic
Osteocyte
Phosphorus
Calcium
Non collagenous
protein
Collagen
Osteoclast
Osteoblast
Fig:- Human Bones

5. • Osteocytes:-
Are mono nuclear cells in mineralized matrix.
• Osteoblast:-
Responsible for mineralization of bone matrix.
Responsible for secretion of type 1 collagen and large number of collagenous bone
protein.
• Osteoclast:-
Excusably bone resorbing cell.
Appears at site of high bone turn over.

6. Fig:- Pathophysiology of Osteoporosis(3)

7. Pathophysiology of glucocorticoids- induced osteoporosis

8. Fig:- Molecular signaling of osteoporosis

9. Treatment(2)
 Anti body therapy:-
Selerostin inhibitor- Romosozumab
RANKL inhibitor- Denosumab
DKK- 1 Inhibitor
 Anti- serotonin therapy
 Stem cell therapy

10. RANKL inhibitor

11. Bone remodeling(4):-
Bone remodeling is a lifelong process where mature bone tissue is
removed from the skeleton and new bone tissue is formed.
Sex hormone at puberty contributes in modeling.
Also nutrition, life styles and genetic factor.
Vit D receptor type 1 collagen, ER, IL-6 IGF-I.

12. Bone remodeling(4)

13. Hormones &growth factor regulating bone formation:-

15. Bone remodeling(4)

16. Reference:-
1. https://www.youtube.com/watch?v=0dV1Bwe2v6c&t=55ss
2. https://pmj.bmj.com/content/78/923/526
3. https://www.sciencedirect.com/science/article/pii/S1297319X18303476
4. https://www.redalyc.org/jatsRepo/3313/331359393004/html/index.html
5. https://www.youtube.com/watch?v=0dV1Bwe2v6c&t=55s

17. Thank you