2. It occurs when the body is exposed to high
levels of the hormone cortisol for a long
time.
also called hypercortisolism.
3. Cushing disease is caused by a pituitary
gland tumor (usually benign) that over-
secretes the hormone ACTH, thus
overstimulating the adrenal glands' cortisol
production.
Cushing syndrome refers to the signs and
symptoms associated with excess cortisol in
the body, regardless of the cause.
4. high stress levels, including stress related to
an acute illness, surgery, injury, or
pregnancy, especially in the final trimester
athletic training
malnutrition
alcoholism
depression, panic disorders, or high levels of
emotional stress
The most common cause of Cushing
syndrome is the use of corticosteroid
medications, such as prednisone, in high
doses for a long period.
5. a pituitary gland tumor in which the pituitary
gland releases too much adrenocorticotropic
hormone, which is also known as Cushing’s
disease
ectopic ACTH syndrome, which causes tumors
that usually occur in the lung, pancreas,
thyroid, or thymus gland
an adrenal gland abnormality or tumor
6. Weight gain and fatty tissue deposits,
particularly around the midsection and upper
back, in the face (moon face), and between
the shoulders (buffalo hump)
Pink or purple stretch marks (striae) on the
skin of the abdomen, thighs, breasts and
arms
Thinning, fragile skin that bruises easily
Slow healing of cuts, insect bites and
infections
Acne
7. Women with Cushing syndrome may
experience:
Thicker or more visible body and facial hair
(hirsutism)
Irregular or absent menstrual periods
Men with Cushing syndrome may experience:
Decreased fertility
Erectile dysfunction
8. Severe fatigue
Muscle weakness
Depression, anxiety and irritability
Loss of emotional control
Cognitive difficulties
New or worsened high blood pressure
Headache
Bone loss, leading to fractures over time
In children, impaired growth
9.
10.
11.
12. urine & blood test
saliva test
imaging test
petrosal sinus
sampling
reducing
corticosteroid use
surgery
radiation therapy
medications