Cushing's syndrome

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Cushing's syndrome

  1. 1. Cushing’s Syndrome By: Laura Brown, Sarah Afiz and Nick Olson
  2. 2. What is Cushing’sSyndrome?  Cushing’s syndrome is caused by prolonged exposure of the bodies’ tissue to high levels of the hormone cortisol  Cushing syndrome is also called hypercortisolism
  3. 3. What is Cortisol?  Cortisol is a hormone secreted by the adrenal glands  Helps maintain proper glucose metabolism, regulation of blood pressure, insulin released for blood sugar control, immune function and inflammatory response  Most importantly cortisol helps the body respond to stress (called the “stress hormone”)
  4. 4. Causes of Cushing’s  Majority of the people who suffer from Cushing’s syndrome have had prior use of glucocorticoid hormones -Glucocorticoid hormones are used to prevent transplant rejection as well as treat inflammatory diseases such as asthma, rheumatoid arthritis and lupus
  5. 5. Causes of Cushing’s(cont.) Other causes:  Pituitary Adenomas: tumors of pituitary gland  Adrenal gland overgrowth or adrenal tumors  Too much stress put on the body (ex. Athletes under intense training, pregnant women- carrying fetus)
  6. 6. Who’s affected?  Can affect anyone but the disease is extremely rare  Affects 10-15 people out of every million  Most commonly occurs in females ages 25-50  Any ethnicity
  7. 7. Symptoms Upper body obesity (rounded face, increased neck fat) Thinning around the arms and legs Delayed growth Easy bruising of skin Purplish-pink stretch marks on the abdomen, thigh, buttocks, arms, and breasts
  8. 8. Symptoms (cont.)  High blood sugar, high blood pressure  Depression and anxiety  Increased hair growth in women  Irregular menstrual cycles  Bones are fragile, susceptible to fractures easily
  9. 9. Treatments  Depending on the reason for cortisol excess, treatments include: 1. Surgery 2. Radiation 3. Chemotherapy 4. Cortisol inhibiting drug such as mitotane
  10. 10. New Treatment  Corcept Therapeutics Inc won U.S. approval for a drug known as Korlym that uses the active ingredient of the abortion pill RU-486
  11. 11. Korlym  Korlym blocks the binding of cortisol to its receptor  Korlym inhibits or reduces the effects of excess cortisol  Orphan drug status: Given to drugs discovered for rare diseases. Allows Corcept to have exclusive rights.
  12. 12. Other Facts  This disease is not inherited  People who are more prone to developing tumors are at greater risk  If the disease is not treated, it can be lethal  Cushing’s can also lead to heart attacks and strokes  70% of patients with Cushing’s suffer from diabetes.
  13. 13. Works Cited 1. Medecinenet. (2008, May 12). Retrieved from http://www.medicinenet.com/cushings_syndrome/article.ht m 2. Mayo Clinic Staff. (2010, September 11). Retrieved from http://www.mayoclinic.com/health/cushings- syndrome/DS00470 3. http://endocrine.niddk.nih.gov. (july, 2008). Retrieved from http://endocrine.niddk.nih.gov/pubs/cushings/cushings.as px 4. Scott, E. (2011, September 22). Cortisol and stress: How to stay healthy. Retrieved from http://stress.about.com/od/stresshealth/a/cortisol.htm 5. (n.d.). Cushing syndrome. [0]. Retrieved from http://flipper.diff.org/app/items/info/418
  14. 14. Works cited cont. 6. Keil, M. (2004). Cushing. Retrieved from http://csrf.net/page/cushings_syndrome_in_children.php 7. Adler, G. (2011, October 21). Cushing. Retrieved from http://emedicine.medscape.com/article/117365-overview 8. Cushing. (1996, June). Retrieved from http://pituitary.mgh.harvard.edu/cushings.htm 9. Margulies, D. P. (n.d.). National adrenal diseases foundation: Adrenal diseases - cushing. Retrieved from http://www.nadf.us/diseases/cushings.htm 10. Adrenal glands. (2009, November 23). Retrieved from http://www.nlm.nih.gov/medlineplus/ency/article/002219.htm 11. (05/1). Retrieved from http://www.endocrineweb.com/endocrinology/your-adrenal- glands

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