Cushing's syndrome


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Cushing's syndrome

  1. 1. Cushing’s Syndrome By: Laura Brown, Sarah Afiz and Nick Olson
  2. 2. What is Cushing’sSyndrome?  Cushing’s syndrome is caused by prolonged exposure of the bodies’ tissue to high levels of the hormone cortisol  Cushing syndrome is also called hypercortisolism
  3. 3. What is Cortisol?  Cortisol is a hormone secreted by the adrenal glands  Helps maintain proper glucose metabolism, regulation of blood pressure, insulin released for blood sugar control, immune function and inflammatory response  Most importantly cortisol helps the body respond to stress (called the “stress hormone”)
  4. 4. Causes of Cushing’s  Majority of the people who suffer from Cushing’s syndrome have had prior use of glucocorticoid hormones -Glucocorticoid hormones are used to prevent transplant rejection as well as treat inflammatory diseases such as asthma, rheumatoid arthritis and lupus
  5. 5. Causes of Cushing’s(cont.) Other causes:  Pituitary Adenomas: tumors of pituitary gland  Adrenal gland overgrowth or adrenal tumors  Too much stress put on the body (ex. Athletes under intense training, pregnant women- carrying fetus)
  6. 6. Who’s affected?  Can affect anyone but the disease is extremely rare  Affects 10-15 people out of every million  Most commonly occurs in females ages 25-50  Any ethnicity
  7. 7. Symptoms Upper body obesity (rounded face, increased neck fat) Thinning around the arms and legs Delayed growth Easy bruising of skin Purplish-pink stretch marks on the abdomen, thigh, buttocks, arms, and breasts
  8. 8. Symptoms (cont.)  High blood sugar, high blood pressure  Depression and anxiety  Increased hair growth in women  Irregular menstrual cycles  Bones are fragile, susceptible to fractures easily
  9. 9. Treatments  Depending on the reason for cortisol excess, treatments include: 1. Surgery 2. Radiation 3. Chemotherapy 4. Cortisol inhibiting drug such as mitotane
  10. 10. New Treatment  Corcept Therapeutics Inc won U.S. approval for a drug known as Korlym that uses the active ingredient of the abortion pill RU-486
  11. 11. Korlym  Korlym blocks the binding of cortisol to its receptor  Korlym inhibits or reduces the effects of excess cortisol  Orphan drug status: Given to drugs discovered for rare diseases. Allows Corcept to have exclusive rights.
  12. 12. Other Facts  This disease is not inherited  People who are more prone to developing tumors are at greater risk  If the disease is not treated, it can be lethal  Cushing’s can also lead to heart attacks and strokes  70% of patients with Cushing’s suffer from diabetes.
  13. 13. Works Cited 1. Medecinenet. (2008, May 12). Retrieved from m 2. Mayo Clinic Staff. (2010, September 11). Retrieved from syndrome/DS00470 3. (july, 2008). Retrieved from px 4. Scott, E. (2011, September 22). Cortisol and stress: How to stay healthy. Retrieved from 5. (n.d.). Cushing syndrome. [0]. Retrieved from
  14. 14. Works cited cont. 6. Keil, M. (2004). Cushing. Retrieved from 7. Adler, G. (2011, October 21). Cushing. Retrieved from 8. Cushing. (1996, June). Retrieved from 9. Margulies, D. P. (n.d.). National adrenal diseases foundation: Adrenal diseases - cushing. Retrieved from 10. Adrenal glands. (2009, November 23). Retrieved from 11. (05/1). Retrieved from glands