In laboratory animals, maintaining the health status in very alarming situations very difficult. Both SPF and Gnotobiotic animals have laboratory significance for which their management is a valid aspect.

3.  Free of particular pathogens
Example.
The animal should not have any
respiratory diseases while testing the
effects of drugs on lungs.

4.  High monitoring system
 During purchasing, the buyer should
make query about the list of the
diseases affecting the animals and the
recent history of health screening with
the type of health programme
monitoring so as to decide whether
that particular item is matching up to
the expermental purpose or not.

5.  Special care during caesarian section.
 Use of sterile isolation units with
positive pressure potential build up so
as to prevent the entry of pathogen
from outside.

6.  Entry of sterilized food and water
through the isolation unit.
 Airlock should be disinfected prior to
the entry of above items.

8.  Only certain strains of bacteria are
present.
 They are only carrying the organisms
on which researchers want to do
experiment.
 Used to study the symbiotic
relationship between the animal and
the inhabiting organisms.

9.  Important for microbiologist as it
establishes some specific symbiotic
relationship between animal and
micro-organisms