IoT Driver Smart Packaging

2. Outline of presentation
• INTRODUCTION
• LITERATURE REVIEW
• PROPOSED METHODOLOGY
• RESULTS AND DISCUSSIONS
• CONCLUSION
• REFERENCES

3. INTRODUCTION
• The pharmaceutical business is crucial to the healthcare system because it provides
people all over the globe with access to life-saving drugs and treatments.
• Several areas of the pharmaceutical industry, including research and development,
production, distribution, and patient care, stand to benefit greatly from the use of
IoT technology [1].
• There are several challenges that the pharmaceutical sector must overcome to
guarantee the quality, safety, and authenticity of its products.
• The integrity and stability of pharmaceutical medicines may be severely
compromised by environmental conditions such as temperature, humidity, light, and
maltreatment during transit. Furthermore, patient safety and brand image are at risk
from counterfeiting and tampering [2].
• Sensors, wireless networks, and analytic software are all part of what's known as
"smart packaging," which is increasingly used in the pharmaceutical industry to
monitor the product's conditions in real time [3].
• Pharmaceutical businesses may protect the efficacy of their products by delivering
them to patients in optimal condition using smart packaging equipped with
temperature sensors [4].

4. • Light sensors are another crucial part of smart packaging for pharmaceuticals that
might be damaged by exposure to light. These sensors can determine how much
light has reached the package and sound an alarm if the product's security has been
breached [5].
• Medication purity and effectiveness may be protected against the introduction of
unwanted substances by monitoring the gas environment within the package [6].
• Smart packaging with GPS tracking capability may provide more transparency
throughout the pharmaceutical supply chain, protect product integrity, and
discourage counterfeiting.
• Pharmaceutical shipments may be tracked in real-time, reducing the possibility of
loss, theft, or misuse and making the information available to manufacturers,
distributors, and patients [7].
• Smart packaging may also identify instances of harsh handling by including
accelerometers and shock/vibration sensors. The pharmaceutical items are protected
from possible danger to patients thanks to these sensors' ability to detect any
impacts or physical shocks that might cause damage to the products.
• Improving patient safety and simplifying pharmaceutical operations helps with
inventory management, supply chain optimization, and authenticating genuine
pharmaceuticals [8]

5. LITERATURE SURVEY
• IoT-enabled telemedicine has emerged as a game-changing method in healthcare
delivery, notably for disease prevention and health promotion.
• Such IoT-driven telemedicine technologies show potential in expanding access to
healthcare for those living in rural or underserved locations [9]. The literature also
examines how mobility in IoT devices affects healthcare.
• Adding mobility to IoT devices improves real-time monitoring and response, which
means the senior population will get help faster and have better health results [10].
• Many uses, such as remote healthcare monitoring, health data analytics, and
individualized health treatments, have been revealed in a state-of-the-art assessment
of IoT-based telemedicine systems.
• IoT integration in telemedicine may lead to better patient participation, earlier
diagnosis of health problems, and preventative care [11]
• Healthcare delivery may be more efficient and effective if these technologies are
integrated into telemedicine systems to improve data storage, processing, and
accessibility [12].

6. • The investigation of monitoring systems for senior healthcare showed how IoT
technology, in combination with cloud computing, promotes remote monitoring,
individualized treatment, and seamless data exchange among healthcare
practitioners, carers, and patients [13].
• This Internet of Things-based strategy provides real-time data insights, letting
stakeholders make educated choices and allowing for prompt actions to lessen
risks and ensure the authenticity of pharmaceutical products [14].
• Opportunities for more effective and patient-centric healthcare systems are being
created as telemedicine and healthcare solutions advance via cutting-edge
technologies like cloud computing, data engineering, and mobility [15].
• Real-time monitoring, tracking, and information sharing are all made possible by
this technology, which entails the incorporation of sensors, communication
devices, and data analytics capabilities into the packaging of pharmaceutical
items.
• Sensors have the ability to detect exposure to light, which may assist in
preventing light-sensitive drugs from deteriorating.

7. • IoT-enabled packaging offers real-time insight into the whereabouts of
pharmaceutical items across the supply chain, from the point of manufacture to the
point of distribution and sale.
• Smart packaging assists in combating counterfeiting by combining elements such as
tamper-evident seals and authentication technology. This enhances the level of
security and anti-counterfeiting that smart packaging provides.
• IoT sensors have the ability to offer information on the patterns of medicine
consumption, which assists medical professionals in monitoring and modifying
treatment regimens as required.
• By using advanced analytics, it is possible to anticipate probable problems in the
supply chain, which enables preventive actions to be implemented in order to avoid
problems with product integrity.
• Software updates and security patches may be remotely deployed to Internet of
Things devices that are integrated in smart packaging.
• As a result, this guarantees that the systems will continue to function properly and
safeguards them against any new dangers that may arise.

8. PROPOSED METHODOLOGY
Working Principle
• Intelligence packaging solutions in the pharmaceutical business are being
driven by the IoT.
• In order to provide intelligent packaging solutions that are capable of
monitoring and optimizing the circumstances under which drugs are kept,
transported, and delivered, these solutions are meant to be intelligent
packaging solutions.
• Temperature sensors, humidity sensors, light sensors, tamper detection
sensors, gas sensors, accelerometers, shock/vibration sensors, moisture
indicator tags, and RFID tags are strategically placed within the packaging to
collect real-time data about the environmental conditions and handling status
of the pharmaceutical products.
• The sensors maintain a continual vigil over the inside and outside
environments of the package. For instance, temperature sensors maintain track
of temperature fluctuations and ensure that pharmaceuticals stay within the
recommended temperature range by ensuring the medications are kept within
the appropriate temperature range.
• When the data from the sensors are uploaded to the cloud platform, more
complex algorithms for data analysis may begin to run.

9. • The cloud-based technology would provide immediate warnings and notifications
to important parties, such as pharmaceutical firms, distributors, and healthcare
practitioners if any irregularities or significant deviations from the ideal conditions
occur.
• The pharmaceutical supply chain may be seen in its entirety with the use of smart
packaging equipped with capabilities for GPS monitoring.
• The use of GPS data gives stakeholders the ability to monitor the position and
movement of pharmaceutical shipments while they are in transit.
• In addition, patient involvement and medication adherence may be improved with
the use of IoT-driven smart packaging.
• For instance, intelligent packaging that includes integrated electronics may send
patients dose-related reminders, which increases the likelihood that the user will
follow their treatment plans as directed.
• The pharmaceutical business is well-positioned to revolutionize drug management
by adopting IoT technology. This will allow for the safest, most effective, and most
genuine pharmaceuticals to be sent to patients all over the globe.

10. Methods and Materials
• Pharmaceutical smart packaging relies on the temperature sensor. It continually monitors
the packing temperature to ensure pharmaceuticals are kept and delivered within the
authorized temperature range.
• Real-time temperature monitoring keeps pharmaceutical items efficacious and stable
throughout their lifespan.
• Figure 1 shows the proposed smart packaging system for pharmaceuticals for ensuring
product integrity and patient safety.
Fig.1 Workflow of the system
Products and package
IoT sensors
Controller
Communication module
Data Analytics
User interface
Stakeholders

11. • Smart packaging senses light exposure and evaluates its effects on medicine. If the
package is damaged and light exposure threatens product stability, the sensor warns
to guarantee prompt action. Pharmaceutical tampering and counterfeiting are major
hazards.
• Accelerometers detect movement and impact. It helps evaluate pharmaceutical
product handling during shipping.
• The accelerometer warns about hard handling or extreme vibrations to avoid drug
harm. RFID tags identify medicine packages.
• IoT-driven pharmaceutical smart packaging integrates sensors, GPS, RFID tags, and
smart electronics.
• These components monitor, evaluate, and optimize pharmaceutical product storage,
transit, and delivery.
• Smart packaging uses IoT to assure product integrity, combat counterfeiting,
increase supply chain visibility, and improve patient safety and healthcare results.

12. RESULT AND DISCUSSION
• The use of IoT technology in smart packaging in the pharmaceutical business
resulted in positive effects, including a revolution in medication management,
guaranteeing product integrity, and increased patient safety.
• The effectiveness of smart packaging in terms of monitoring and optimizing the
circumstances of pharmaceutical product storage, transportation, and delivery was
proved by incorporating a variety of sensors, communication technologies, and data
analytics within the package itself.
• Monitoring the product's temperature was necessary to ensure the effectiveness of
the product. The temperature sensors monitored temperature changes in real-time,
guaranteeing that the temperature of the drugs stayed within the acceptable range.
• Humidity sensors were able to effectively manage the amount of moisture that was
contained inside the package.
• The intelligent packaging preserved the ideal humidity levels, shielding moisture-
sensitive drugs from the potential for chemical reactions and the development of
microorganisms.

13. • The intelligent packaging was able to effectively identify illegal openings and
attempts at tampering, which made it possible for prompt steps to be taken to
prevent the distribution of counterfeit pharmaceuticals and ensure the safety of
patients.
• The presence of gas sensors allowed for monitoring and managing certain gas
environments inside the packaging.
• The findings showed a significant decrease in the amount of pharmaceutical
product contamination caused by gas exposure, which contributed to an
improvement in the overall quality and safety of drugs.
• Improved inventory management and authentication were both made possible by
the use of RFID tags.
• The supply chains of pharmaceutical businesses have become more transparent,
reducing the number of instances of fake drugs being sold and increasing the
likelihood that patients will be protected.

14. • Table 1 shows the packing-sensors data
TABLE I IOT-DRIVEN SMART PACKAGING SENSORS DATA
• The smart packaging system gave stakeholders actionable insights and timely
warnings using real-time data collecting, analytics, and remote communication. This
made it possible for stakeholders to make proactive interventions and decisions.
Sensor Type
Parameter
Monitored
Measurement
Units
Data
Sample
1
Data
Sample
2
Temperature
Sensor
Temperatur
e
°C 25.6 26.1
Humidity
Sensor
Humidity %RH 45.2 47.8
Light Sensor
Light
Exposure
Lux 120 130
Tamper
Detection
Tampering
Events
Count 0 1
Gas Sensor
Gas
Concentrati
on
ppm 10.2 11.5
GPS
(Location)
GPS
Coordinate
s
Latitude,
Longitude
37.7749,
-
122.419
4
40.7128
, -
74.0060
Accelerometer
Motion and
Impact
g 0.1 0.2
Shock/Vibratio
n
Vibration
Intensity
g 0.5 0.3
RFID Tags
Alphanumeric
Code
ABC12
3
XYZ78
9
Moisture
Indicator
Moisture
Presence
Binary Yes No

15. • As a result, the danger of product deterioration and spoiling was greatly reduced while
stored and transported.
• Light sensors are very helpful in maintaining the stability of light-sensitive medication.
• Patients were given legitimate and risk-free drugs thanks to the tamper detection
capacity, which offered effective security against selling counterfeit medications.
• The use of gas sensors provided pharmaceutical makers with the ability to handle
specific gas-related difficulties, ultimately improving the product quality and safety of
particularly sensitive pharmaceuticals.
• The use of GPS monitoring made it possible to optimize the supply chain.
• The accelerometer and the shock and vibration sensors contributed substantially to
preventing product damage while it was in transit, lowering the possibility of losses and
waste.
• RFID tags were used, resulting in improved inventory management and authentication
procedures. These expedited operations offered additional protection against product
piracy and circulation that was not permitted.
• In the pharmaceutical business, the findings and debates highlight the transformational
potential of IoT-driven smart packaging.
• Smart packaging enables enhanced product quality, more visibility across the supply
chain, and increased patient safety for pharmaceutical firms..

16. CONCLUSION
• Regarding drug management and patient safety, smart packaging powered by the
IoT has emerged as a game-changer. Monitoring and improving pharmaceutical
items' storage, transit, and delivery circumstances are now possible because of the
smart packaging's integration of numerous sensors, communication technologies,
and data analytics.
• Improved product integrity, less waste, more supply chain visibility, and improved
patient outcomes have all resulted from the widespread use of temperature,
humidity, light, tamper detection, gas, GPS, accelerometer, shock/vibration, and
RFID tags and indications.
• As a result of the real-time data insights provided by smart packaging solutions,
stakeholders are better able to make educated choices, and prompt interventions
may be made to reduce risks and ensure product authenticity.
• Smart packaging enabled by the Internet of Things has unquestionable advantages,
notwithstanding the persistence of obstacles and expenses.
• To fully realize the promise of emerging technologies and develop a pharmaceutical
ecosystem that is safer, more efficient, and patient-centric, further study,
standardization, and industry cooperation are required.

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