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1. Vitamins _ Positive Homeopathy
Vitamin A
Vitamin A can be obtained in two forms:
• preformed retinol (retinyl esters) found in animal derived foods
• carotenoids which are mainly plant derived (beta carotene being the most abundant carotenoid),
some of which can be converted to retinol in the body; 6mg of beta carotene is equivalent to 1mg
of retinol.
The total vitamin A content of the diet (from both animal and plant sources) is normally
expressed as retinol equivalents (RE).
Vitamin A is essential to the normal structure and function of the skin and mucous membranes
such as in the eyes, lungs and digestive system. Therefore, it is vital for vision, embryonic
development, growth and cellular differentiation, and the immune system.
Deficiency
Vitamin A deficiency is a serious public health problem worldwide,. It can lead to night
blindness (impaired adaptation to low-intensity light) and an eye condition called xerophthalmia
(dryness of the conjunctiva and cornea) and eventually total blindness. Marginal deficiency
contributes to childhood susceptibility to infection, and therefore morbidity and mortality, in
both developing and developed countries. Vitamin A deficiency is common in many developing
countries especially among young children.
In the UK, frank deficiency is rare but low intakes are relatively common. For example,
depending on age and sex between 6% and 20% of children have intakes that are unlikely to be
adequate (below the Lower Reference Nutrient intake, LRNI). In adults, intakes tend to be higher
although 16% of men aged 19-24 have intakes below the LRNI. In the UK, supplements
containing 233µg of vitamin A are recommended for infants and young children from age 1 to 5
years (from 6 months for infants that receive breast milk as their main drink).
Toxicity

2. Excess retinol during pregnancy can increase the risk of birth defects. As a precautionary
measure, women who are pregnant, or who might become pregnant, are advised not to consume
high dose vitamin A supplements (>2800-3300 μg/day). Liver and liver products may contain a
large amount of vitamin A, so these should also be avoided in pregnancy.
Large amounts of retinol can also cause liver and bone damage. To prevent adverse effects on
bones, intakes above 1500 µgrams of retinol equivalents from food or supplements should be
avoided. The Food Standards Agency advises that, as a precaution, regular consumers of liver
(once a week or more) should not increase their intake of liver or take supplements containing
retinol (for example, cod liver oil).
Food sources
Liver, whole milk, cheese, butter, margarine and many reduced fat spreads are dietary sources of
retinol. Carrots, dark green leafy vegetables and orange-coloured fruits, e.g. mangoes and
apricots are dietary sources of carotenoids. In the UK, the law states that margarine must be
fortified with vitamin A (and vitamin D). Vitamin A is also often voluntarily added to reduced
fat spreads, as is vitamin D.
Vitamin D
Dietary vitamin D exists as either ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3).
Ergocalciferol (D2) is derived from the UV irradiation of the plant sterol ergosterol, which is
widely distributed in plants and fungi. (D3 ) is formed from the action of UV irradiation on 7-
dehydrocholesterol in the skin of animals including humans.
Dietary sources are relatively insignificant, compared with the synthesis in the skin from
exposure to sunlight or ultraviolet rays, because there are not many rich food sources of vitamin
D.
Vitamin D is not classically a vitamin but a pro-hormone, acting as a precursor to one of the
hormones involved in calcium homeostasis. Cholecalciferol is metabolised to the active steroid
hormone 1,25-dihydroxyvitamin D3 in the liver and kidney. In this form it works as a hormone
regulating the amount of calcium absorbed in the intestine. It is also essential for the absorption
of phosphorus and for normal bone mineralisation. Vitamin D is also involved in the regulation
of cell proliferation and differentiation. Vitamin D is also an activator of insulin-like growth
factor (IGF-1) and, associated with this, poor vitamin D status is linked to sarcopenia (age
related loss of skeletal muscle) which affects up to 25% of those over the age of 65 years and
more than half of those over 85.
Deficiency
Deficiency of vitamin D results in poor calcification of the skeleton and hence skeletal deformity
in children (rickets) and it leads to pain and bone fragility in adults (osteomalacia). Osteoporosis
is not due to vitamin D deficiency but vitamin D may be beneficial in treatment. In the UK some
groups of people such as Asian, black, older, institutionalised and housebound people and those

3. who habitually cover the skin are vulnerable to vitamin D deficiency as a result of limited
exposure to sunlight. Poor vitamin D status and rickets in children used to be commonplace in
the UK but fortification and supplementation policies following the Second World War made
rickets a thing of the past. However, in recent years, cases are again being reported, particularly
in some ethnic minority groups from the Middle East and Indian subcontinent. Poor vitamin D
status (a blood level of 25hydroxyitaminD below 25nmol/L – judged to be sufficient to prevent
rickets) is also commonplace in the white population of the UK, emphasising the importance of
balancing the need for sun exposure with the use of sun screen. For example, 36% of men and
38% of women aged 65-84 and living in institutions had low status in the NDNS for this age
group. Amongst other age groups, the worst statistics were for young adults aged 19-24 years;
24% males and 28% of females. As sunlight is the major source, status tends to be lower in the
winter/ spring than summer/autumn. Many young women enter pregnancy with poor stores of the
vitamin.
It is recommended that pregnant and lactating women and people aged 65 years and over take
vitamin D supplements (10µg per day). For other ‘at risk’ groups, for example ethnic groups that
have limited sun exposure because of their style of dress, supplements may also be necessary.
Infants are recommended to receive supplements containing 7.5µg of vitamin D; and these are
available under the Healthy Start Scheme.
Toxicity
Excessive dietary vitamin D intake may lead to hypercalaemia (high calcium level in the blood),
and some infants are especially sensitive to hypercalcaemia resulting from vitamin D toxicity. It
is thought that skin synthesis is self-regulating.
Sources
Oily fish, eggs, fortified cereals and margarine are the main dietary sources of vitamin D. In the
UK, the law states that margarine must be fortified with vitamin D (and vitamin A). Vitamin D is
also often voluntarily added to reduced fat spreads, as is vitamin A. Human milk contains low
levels of vitamin D, but infant formula is fortified with 0.001-0.0025 mg/100kcal.
Most vitamin D is obtained through the action of sunlight on our skin during the summer
months. The latitude and strength of the sun in the UK means that the skin can only make
vitamin D between 11am and 3pm, during the months of April to October.
Vitamin E
Vitamin E is a group of eight lipid-soluble compounds synthesised by plants, tocopherols and
tocotrienols. Alpha-tocopherol accounts for 90% of the vitamin E in human tissues. Vitamin E
acts as an antioxidant and is required to protect cells against oxidative damage from free radicals,
for example oxidation of the lipids in cell membranes. Vitamin E content in food is expressed in
terms of mg equivalents based on the biological activities of the tocopherols present.
Deficiency

4. Existence of dietary vitamin E deficiency is not considered to be a problem even in people
consuming a relatively poor diet. Deficiency only occurs in people with severe fat malabsorption
and rare genetic disorders.
Toxicity
Vitamin E has very low toxicity and humans appear to be able to tolerate high levels of the
vitamin without untoward effects (e.g. between 540-970 mg/day). However, at very high doses
vitamin E may have negative effects on other fat-soluble vitamins; it exacerbates the effects of
vitamin K deficiency and interferes with the absorption of vitamin A.
Food sources
Foods containing large amount of polyunsaturated fatty acids will generally contain large
amounts of vitamin E, therefore the richest sources of vitamin E are vegetable oils, nuts and
seeds. Since vegetable oils are the richest source, deficiency is rare.
Vitamin K
Vitamin K is required for the synthesis of several of proteins required for normal blood clotting
and bone structure. Vitamin K is synthesised by bacteria in the large bowel and is also present in
both plant and animal foods.
Deficiency
Deficiency is rare as vitamin K is widely available from the diet and is also provided by gut
bacteria. Thus, deficiency is generally secondary to conditions such as malabsorption or impaired
gut synthesis. However, there is growing interest in the role of vitamin K in optimising bone
health. Newborn babies up to six weeks old have low levels of vitamin K, which puts them at
risk of potentially fatal ‘haemorrhage disease of the newborn’, and is known as vitamin K
deficiency bleeding in infancy. Therefore, is it usual to give all newborn infants prophylactic
vitamin K.
Toxicity
Few toxic reactions to Vitamin K have been identified.
Food sources

5. Dietary vitamin K is obtained from green leafy vegetables, dairy products and meat.
Water soluble vitamins
The B vitamins
Thiamin (vitamin B1)
Thiamin is a co-enzyme for several central energy-yielding metabolic pathways, and therefore is
required to release energy from carbohydrate. As a result thiamin requirement is related to the
amount of energy consumed. Thiamin is also involved in the normal function of the nervous
system and other excitable tissues, such as skeletal muscles and the heart.
Deficiency
Deficiency of thiamin causes the peripheral nervous system disease beri-beri. This became a
public health issue in the Far East in the nineteenth century with the introduction of highly milled
(polished) rice. While beriberi is now rare, it remains a problem in some parts of the world where
rice is the staple food. A different condition due to thiamin deficiency, affecting the central
nervous system rather than the peripheral is sometimes seen in alcoholics and people with HIV,
known as Wernicke-Korsakoff syndrome. This is caused by a combination of low intake and
impairment of absorption and utilisation of the vitamin.
Toxicity
There is no evidence of any toxic effect of high doses of thiamin as the body excretes any excess.
Food sources
Whole grains, nuts, meat (especially pork), fruit and vegetables and fortified breakfast cereals are
sources of thiamin in the diet. In the UK, white and brown bread flour are fortified with thiamin
by law (and also with calcium, iron and niacin).
Riboflavin (vitamin B2)
Riboflavin functions as a coenzyme in a wide variety of reactions that take place in the body.
Riboflavin is required to release energy from protein, carbohydrate and fat. It is also involved in

6. the transport and metabolism of iron in the body and is needed for the normal structure and
function of mucous membranes and the skin.
Deficiency
According to UK surveys, intakes of riboflavin are low in a number of population subgroups, in
particular teenage girls (over 20% have intakes below the LRNI), young women (15% of 19-24
year olds below the LRNI) and women over 65 years living at home (10% of those 65-84, 15%
of those over 85 years with intakes below the LRNI). A low status of riboflavin is also common
but there is no clear deficiency disease because there is very efficient conservation and
reutilisation of riboflavin in tissues; therefore deficiency is never fatal. Deficiency is
characterised by dryness and cracking of the skin around the mouth and nose and a painful
tongue that is red and dry (magenta tongue).
Toxicity
No toxic or adverse reactions to riboflavin in humans have been reported. The body excretes
excess riboflavin in urine.
Food sources
Milk, eggs, fortified breakfast cereals, liver, legumes, mushrooms and green vegetables are all
sources of riboflavin.
Niacin (nicotinic acid)
Niacin is required for the release of energy from food (it is the precursor to the coezymes NAD
and NADP which are fundamental to key reactions in carbohydrate metabolism). As a result
niacin requirement is related to the amount of energy consumed. Niacin is also required for the
normal function of the skin and mucous membranes and for normal functioning of the nervous
system.
Niacin can be synthesised from the essential amino acid tryptophan to meet daily requirements
and dietary intake is only necessary when tryptophan metabolism is disturbed or intake of this
amino acid is inadequate.
Deficiency
Deficiency of niacin results in the disease pellagra. It is characterized by sun-sensitive skin
producing effects similar to severe sunburn. Advanced pellagra also results in dementia and if
untreated is fatal. Pellagra is now rare but was a major public health problem in the early part of
the last century up until the 1980s in some parts of the world. It was usually seen in communities
where maize forms the staple diet as maize contains little tryptophan and the niacin that is
present is in an unavailable form.
Toxicity

7. Reports of niacin/nicotinic acid toxicity in humans have been observed from its use as a
treatment of hyperlipidaemia (high blood lipid levels). Adverse effects are dose related and
generally subside with a reduction in dose or the cessation of treatment. Acute toxic symptoms
include flushing, itching of the skin, nausea and gastrointestinal disturbances.
Food sources
Meat, wheat and maize flour, eggs, dairy products and yeast are all dietary sources of niacin.
Vitamin B6 (Pyridoxine)
Vitamin B6 comprises 3 forms (vitamers): pyridoxine, pyridoxal and pyridoxamine, and has a
central role in the metabolism of amino acids. It is involved in breaking down glycogen and has a
role in the modification of steroid hormone action. It is also essential for the formation of red
blood cells and the metabolism and transport of iron. Together with folate and vitamin B12,
vitamin B6 is required for maintenance of normal blood homocysteine levels. Raised
homocysteine is a risk factor for cardiovascular disease.
Deficiency
Deficiency of vitamin B6 is rare because it is widely distributed in foods and is synthesised by
the body’s gut flora. Deficiency may only occur as a complication of disease or prolonged
administration of certain drugs.
Toxicity
Long-term intake of high dose vitamin B6 from supplements (typically >200mg/day) has been
reported to result in sensory nerve damage.
Food sources
Poultry, white fish, milk, eggs, whole grains, soya beans, peanuts and some vegetables are
sources of vitamin B6.
Vitamin B12 (Cyanocobalamin)

8. Vitamin B12 serves as a cofactor for enzymes involved in the normal function of the nervous
system, the formation of red blood cells and for the metabolism of folate. It is also involved in
energy production. Together with folate and vitamin B6, vitamin B12 is required for maintenance
of normal blood homocysteine levels. Raised homocysteine is a risk factor for cardiovascular
disease.
Deficiency
Dietary deficiency is rare in younger people and only occurs among strict vegans. It is more
common in older people as a result of impaired absorption, usually due to chronic inflammation
of the stomach lining (atrophic gastritis) or lack of intrinsic factor (the substance required for
vitamin B12 absorption). Deficiency results in the development of pernicious anaemia, in which
red blood cells are enlarged (megaloblastic), and peripheral neurological damage develops.
Toxicity
There are few reports of any adverse effects of high intakes of vitamin B12.
Food sources
Vitamin B12 is found in almost all foods of animal origin. Green plants provide none but it can be
synthesized by some algae and bacteria, although the bioavailability of such forms has been
disputed. Meat, fish, milk, cheese, eggs, yeast extract and fortified breakfast cereals are all
dietary sources.
Folate/folic acid
The term folate describes a group of derivatives of pteryl glutamic acid. Folic acid is the
synthetic form of folate. It is used in supplements and for food fortification.
Folate functions together with vitamin B12 to form healthy red blood cells. It is also required for
normal cell division, the normal structure of the nervous system and specifically in the
development of the neural tube (which develops into the spinal cord and skull) in the embryo.
There is conclusive evidence that supplements of 400μg/day of folic acid taken before
conception and during the first 12 weeks of pregnancy prevent the majority of neural tube
defects (e.g. spina bifida) in babies. It is recommended that all women of childbearing age who

9. are planning a pregnancy take a daily supplement as it is difficult to achieve 400μg/day from diet
alone.
Together with vitamins B6 and B12, folate is involved with the maintenance of normal blood
homocysteine levels. The amino acid homocysteine is an intermediate in folate metabolism and
evidence suggests that raised blood homocysteine (hyperhomocysteinemia) is an independent
risk factor for cardiovascular disease. High intakes of folate have been found to lower the blood
concentration of homocysteine in people genetically at risk of hyperhomocysteinemia and, as a
result it has been proposed that folic acid supplementation might reduce the risk of
cardiovascular disease. However, a recent meta-analysis of a number of large trials failed to
demonstrate an effect of folic acid on either coronary heart disease or stroke risk.
Deficiency
Deficiency results in megaloblastic anaemia and may be due to poor diet or increased
requirement, for example in pregnancy, from prolonged drug use or malabsorption.
Megaloblastic anaemia is characterized by the release of immature red blood cell precursors into
the circulation due to impairment of the normal process of maturation in the bone marrow. There
may also be a low white cell and platelet count in the blood. Deficiency is often accompanied by
insomnia, depression, forgetfulness and irritability.
Toxicity
Few adverse effects have been reported although high intakes may mask vitamin B12 deficiency
and excessive intakes can cause complications if taken with certain drugs, for example
anticonvulsants used in the treatment of epilepsy.
Food sources
Green leafy vegetables, brown rice, peas, oranges, bananas and fortified breakfast cereals are
sources of folate.
In various parts of the world folic acid is added by law to flour and bread e.g. USA, Canada and
Chile. The UK is yet to commit to this fortification, largely because of concerns that high intakes
of folic acid mask vitamin B12 deficiency in older people who are particularly susceptible, and
some concerns regarding the relationship between folic acid and cancer. In 2005 the Scientific
Advisory Committee on Nutrition (SACN) reviewed the research to underpin potential folic acid
fortification in the UK and recommended that ‘mandatory fortification’ with folic acid should be
implemented. Their conclusions were considered by the Food Standards Agency’s Board and it
was agreed by the Board that mandatory fortification should go ahead. But before the
recommendations were finalized, it was agreed to wait for the findings of ongoing trials
investigating the relationship between folic acid and cancer. These trials have now finished and
have been considered by SACN: an outcome is awaited.
Vitamin C (ascorbic acid)

10. Vitamin C has antioxidant properties, potentially protecting cells from oxidative damage caused
by free radicals. Vitamin C is also involved in the synthesis of collagen which is required for the
normal structure and function of connective tissues such as skin, cartilage and bones. It is
therefore an important nutrient for the healing process. It is also involved in the normal structure
and function of blood vessels and neurological function. Vitamin C also increases the absorption
of non-haem iron (iron from plant sources) in the gut.
Deficiency
Severe deficiency of vitamin C leads to scurvy. Signs of deficiency do not manifest until
previously adequately nourished individuals have been deprived of vitamin C for 4-6 months.
Deficiency is associated with fatigue, weakness, aching joints and muscles. Most of the other
symptoms of scurvy are due to impaired collagen synthesis and are characterized by bleeding
gums, poor wound healing and damage to bone and other tissues.
Toxicity
Acute high doses of vitamin C are occasionally associated with diarrhoea and intestinal
discomfort. A significant number of people take high dose (1000mg) vitamin C supplements (the
RNI for adults is 40mg/day); however there is no evidence that this either confers any benefit or
presents negative health consequences.
Food sources
Fresh fruits especially citrus fruits and berries; green vegetables, peppers and tomatoes are all
sources of vitamin C. It is also found in potatoes (especially new potatoes).
The bioavailability and absorption of vitamins
The bioavailability of a vitamin (i.e. how readily it can be absorbed and used by the body) may
be influenced by a variety of factors. The proportion of a vitamin absorbed from the diet
following consumption can vary, and will depend upon the individual person’s needs, their
ability to absorb nutrients, the amount available to them and other components of the diet. For
example, vitamin C can enhance the absorption of non-haem iron when foods or drink containing
both vitamin C and non-haem iron are consumed in the same meal. Some vitamins, e.g. vitamin
C and riboflavin, are labile and susceptible to damage by heat, light, oxygen, enzymes and
minerals and these losses may occur during food processing, preparation and storage.
Vitamin supplements
Although most people are able to meet their requirements for vitamins by eating a varied diet,
there are certain groups of the population who have higher than normal requirements for some
nutrients, e.g. ill people, those taking certain drugs and pregnant women. Such people need to
ensure they eat foods rich in particular vitamins and sometimes supplements are advised. Infants
and young children are recommended to have supplements of vitamins A, C and D up to age 5
years. Vitamin D supplements are also recommended for older people and pregnant and lactating

11. women. Some women may require additional iron if menstrual losses are high and folic acid is
advised for women planning a pregnancy and for pregnant women in the first 12 weeks of
pregnancy.
- See more at: http://www.positivehomeopathy.com/vitamins