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2016.03.15 neurophysiology-intro

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NEUROPHYSIOLOGY INTRODUCTION
100 billion neurons 10 – 50 times glial cells, CNS is a complex organ, 40% genes participate in its formation Neurons have evolved from primitive neuroeffector cells Functional unit Normal brain function :- synaptic activity, ECF homeostasis, energy metabolism, & n.protect cerebral ischaemia, seizures, neurodegenerative disorders, c. edema GLIAL CELLS
Ξ±-motor neuron Neuromuscular junction – Ach M E P EPP Action potential Ca Excitation – contraction coupling Polio virus Lower motor neuron paralysis
Upper motor neuron lesion – cortico-spinal tract – spinal animal Association areas – frontal cortex – ideation Spinal shock Reflex arc – monosynaptic reflex / polysynaptic reflex – stretch reflex – Ξ³. Efferent discharge – muscle spindle contractile part Reticular formation – vital centres – area for consciousness – G.A. Decerebrate rigidity Midline space occupying lesion & thalamus Cerebral conning
4S suppressor strip – stretch reflex – mental retardation Sensory/motor ataxia Speech Hypothalamus LESIONS: -peripheral nerve injury -polio -LMN/UMN lesion -ataxia -aphasia -hypothalamic obesity
2016.03.15 neurophysiology-intro
2016.03.15 neurophysiology-intro

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2016.03.15 neurophysiology-intro

  • 2. 100 billion neurons 10 – 50 times glial cells, CNS is a complex organ, 40% genes participate in its formation Neurons have evolved from primitive neuroeffector cells Functional unit Normal brain function :- synaptic activity, ECF homeostasis, energy metabolism, & n.protect cerebral ischaemia, seizures, neurodegenerative disorders, c. edema GLIAL CELLS
  • 3. Ξ±-motor neuron Neuromuscular junction – Ach M E P EPP Action potential Ca Excitation – contraction coupling Polio virus Lower motor neuron paralysis
  • 4. Upper motor neuron lesion – cortico-spinal tract – spinal animal Association areas – frontal cortex – ideation Spinal shock Reflex arc – monosynaptic reflex / polysynaptic reflex – stretch reflex – Ξ³. Efferent discharge – muscle spindle contractile part Reticular formation – vital centres – area for consciousness – G.A. Decerebrate rigidity Midline space occupying lesion & thalamus Cerebral conning
  • 5. 4S suppressor strip – stretch reflex – mental retardation Sensory/motor ataxia Speech Hypothalamus LESIONS: -peripheral nerve injury -polio -LMN/UMN lesion -ataxia -aphasia -hypothalamic obesity