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Global Journal of Biotechnology
and Biomaterial Science
Peertechz Journals
Short Communication
A Protocol for the Computational Design of
High Affinity Molecularly Imprinted Polymer
Synthetic Receptors
 Kal Karim*, Todd Cowen, Antonio Guerreiro, Elena Piletska, Michael J
Whitcombe and Sergey A Piletsky
 *Corresponding author: Kal Karim, Department of Chemistry,
University of Leicester, Leicester, LE1 7RH, UK, Tel: +44 116 294
4668; Fax: +44 116 252 3789;
 Dates: Received: 13 March, 2017; Accepted: 2 13 April, 2017;
Published: 14 April, 2017
 Citation: Karim K, Cowen T, Guerreiro A, Piletska E, Whitcombe MJ,
et al. (2017) A Protocol for the Computational Design of High Affinity
Molecularly Imprinted Polymer Synthetic Receptors. Glob J
Biotechnol Biomater Sci 3(1): 001-007.
Abstract
 Molecularly imprinted polymer (MIP) nanoparticles, commonly
referred to as ‘plastic antibodies’ or synthetic receptors, are
polymeric materials with strong affinity and selectivity for a
particular chemical target. MIPs are regularly produced for use
in sensors for monitoring food quality and environmental
pollutants, and in the design of robust and affordable
replacements for biological receptors, enzymes and antibodies
in drug testing and assays. More recently the easy production of
MIP nanoparticles has also permitted research relating to
possible in vivo applications, primarily in drug delivery systems,
toxin sequestration and pathogen inhibition. The strength of the
interaction between the target and the polymer binding site is
dependent on the particular monomers selected in synthesis of
the MIP, and the relative concentrations of these in the pre-
polymerization mixture.
Thank you
For more information Read Online Article…
https://www.peertechz.com/articles/a-protocol-for-the-computational-design-of-
high-affi-nity-molecularly-imprinted-polymer-synthetic-receptors.pdf
For
Full
Article
PDF

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a-protocol-for-the-computational-design-of-high-affinity-molecularly-imprinted-polymer-synthetic-receptors-global-journal-of-biotechnology-and-biomaterial-science-peertech-journals

  • 1. Global Journal of Biotechnology and Biomaterial Science Peertechz Journals
  • 2. Short Communication A Protocol for the Computational Design of High Affinity Molecularly Imprinted Polymer Synthetic Receptors  Kal Karim*, Todd Cowen, Antonio Guerreiro, Elena Piletska, Michael J Whitcombe and Sergey A Piletsky  *Corresponding author: Kal Karim, Department of Chemistry, University of Leicester, Leicester, LE1 7RH, UK, Tel: +44 116 294 4668; Fax: +44 116 252 3789;  Dates: Received: 13 March, 2017; Accepted: 2 13 April, 2017; Published: 14 April, 2017  Citation: Karim K, Cowen T, Guerreiro A, Piletska E, Whitcombe MJ, et al. (2017) A Protocol for the Computational Design of High Affinity Molecularly Imprinted Polymer Synthetic Receptors. Glob J Biotechnol Biomater Sci 3(1): 001-007.
  • 3. Abstract  Molecularly imprinted polymer (MIP) nanoparticles, commonly referred to as ‘plastic antibodies’ or synthetic receptors, are polymeric materials with strong affinity and selectivity for a particular chemical target. MIPs are regularly produced for use in sensors for monitoring food quality and environmental pollutants, and in the design of robust and affordable replacements for biological receptors, enzymes and antibodies in drug testing and assays. More recently the easy production of MIP nanoparticles has also permitted research relating to possible in vivo applications, primarily in drug delivery systems, toxin sequestration and pathogen inhibition. The strength of the interaction between the target and the polymer binding site is dependent on the particular monomers selected in synthesis of the MIP, and the relative concentrations of these in the pre- polymerization mixture.
  • 4. Thank you For more information Read Online Article… https://www.peertechz.com/articles/a-protocol-for-the-computational-design-of- high-affi-nity-molecularly-imprinted-polymer-synthetic-receptors.pdf For Full Article PDF