ALL ABOUT DR YIMON AYE-Field of Biochemistry, Molecular and Cell Biology Cornell University

8/2/2017 Yimon Aye | Chemistry & Chemical Biology Cornell Arts & Sciences
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Home » Yimon Aye
Yimon Aye
Howard Milstein Faculty Fellow and Assistant Professor
ya222@cornell.edu
607-254-4519
EDUCATIONAL BACKGROUND
Damon Runyon Postdoc Fellow,
Massachusetts Institute of Technology
PhD, Harvard University
M.Chem, University of Oxford
B.Chem, University of Oxford
WEBSITE(S)
Aye Lab
Chemistry & Chemical Biology
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Overview
Methods development in deconstructing redox-dependent signal transduction; Molecular
regulation of proteins/pathways involved in mammalian genome surveillance. Please visit
our lab website for more information.
KEYWORDS
Selected Honors: Beckman Young Investigator (2014); NSF CAREER (2014); NIH Director's
New Innovator (2014); Sloan Fellowship (2016); American Chemical Society CRT Young
Investigator (2016); American Chemical Society WCC Rising Star Chemist (2016);
International Chemical Biology Society Rising Star Chemical Biologist (2016); O ce of Naval
Research Young Investigator (2017); Pershing Square Sohn Prize in Cancer Research (2017)
DEPARTMENTS/PROGRAMS
Chemistry and Chemical Biology
GRADUATE FIELDS
Biochemistry, Molecular and Cell Biology
Biophysics
Chemistry and Chemical Biology
AFFILIATIONS
Weill Cornell Medicine, Department of Biochemistry
Research
The Aye Lab (established: July 2012) exploits a unique blend of synthetic methodology,
mechanistic biochemistry, mammalian cell biology as in vitro research toolkit and worm and
sh as in vivo models.
Courses

CHEM 4500 - Principles of Chemical Biology
CHEM 4610 - Introduction to Organic Chemistry Research
Publications
Selected Publications: Aye Lab (est. July 2012) (
*
correspondence author)
Original Research
Marcus J. C. Long, Hong-Yu Lin, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, and
Yimon Aye* "β-TrCP1 is a Vacillatory Regulator of Wnt Signaling, Either Degrading β-Catenin
or Preventing Nrf2 Inhibition of Wnt"
Cell Chemical Biology 2017 Just Accepted
Perspective
Marcus J. C. Long, and Yimon Aye* "Privileged Electrophile Sensors: a Resource for
Covalent Drug Development"
Cell Chemical Biology 2017 In Press
Original Research
Marcus J. C. Long, Saba Parvez, Yi Zhao, Yiran Wang, Sanjna L. Surya, and Yimon Aye*
"Akt3 is a Privileged First Responder in Isozyme-Speci c Electrophile Response"
Nature Chemical Biology 2017 13, 333–338
*Highlighted for “News & Views”: Nature Chemical Biology 2017 13, 244–245
Review Article
Marcus J. C. Long, Souradyuti Ghosh, Jesse R. Poganik, and Yimon Aye* “Subcellular Redox
Targeting: Bridging in Vitro and in Vivo Chemical Biology.”
ACS Chemical Biology 2017 12, 586–600
Original Research

Saba Parvez, Marcus J. C. Long, Hong-Yu Lin, Yi Zhao, Joseph A. Haegele, Vanha N. Pham,
Dustin K. Lee, and Yimon Aye* “T-REX™ On-Demand Redox Targeting in Live Cells”
Nature Protocols 2016 11, 2328–2356
Perspective
Marcus J. C. Long, and Yimon Aye* “The Die is Cast: Precision Electrophilic Modi cations
Contribute to Cellular Decision Making”
ACS Chem Res Toxicol 2016 29, 1575–1582
* Contributed as part of 2016 ACS CRT Young Investigator Award to Y.A.
* Selected as an ACS Editors' Choice article.
* Selected for Journal Cover Art.
Original Research
Somsinee Wisitpatthaya, Yi Zhao, Marcus J. C. Long, Minxing Li, William A. Blessing, Elaine
A. Fletcher, Robert S. Weiss, and Yimon Aye* “Antileukemic Nucleotides Induce
Conformationally Distinct Hexamers De ning a Common Mode of Reversible RNR
Inhibition”
ACS Chemical Biology 2016 11, 2021–2032
Perspective
Marcus J. C. Long, Jesse R. Poganik, and Yimon Aye* “On-Demand Targeting: Investigating
Biology with Proximity-Directed Chemistry”
J Am Chem Soc 2016, 138, 3610–3622
*JACS Spotlights Article – 2016, 138, 4269
* The ACS LiveSlides Open Access Article
Original Research

Hong-Yu Lin, Joseph A. Haegele, Michael T. Disare, and Yimon Aye* “A Generalizable
Platform for Interrogating Target- and Signal-Speci c Consequences of Electrophilic
Modi cations in Redox-Dependent Cell Signaling”
J Am Chem Soc (Full Article) 2015, 137, 6232–6244
Original Research
Saba Parvez, Yuan Fu, Jiayang Li, Marcus J. C. Long, Hong-Yu Lin, Dustin K. Lee, Gene S. Hu
and Yimon Aye* “Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates
Whole-Cell-Stimulated Antioxidant Response”
J Am Chem Soc (Communication) 2015, 137, 10–13
Mini Review
Yimon Aye*, Minxing Li, Marcus J. C. Long and Robert Weiss* (*, co-corresponding
authors) “Ribonucleotide Reductase & Cancer: Biological Mechanisms & Targeted
Therapies”
Oncogene (Mini Review) 2015, 34, 2011
Original Research
Yuan Fu, Hong-Yu Lin, Somsinee Wisitpitthaya, William A. Blessing and Yimon Aye* “A
Fluorimetric Readout Reporting the Inhibitor-Induced Human Ribonucleotide Reductase
Oligomerization”
ChemBioChem (Full Article) 2014, 15, 2598–2604
Original Research
Yuan Fu, Marcus J. C. Long, Mike Rigney, Saba Parvez, William A. Blessing and Yimon Aye*
“Uncoupling of Allosteric and Oligomeric Regulation in a Functional Hybrid Enzyme
Constructed from Escherichia coli and Human Ribonucleotide Reductase”
Biochemistry (Full Article) 2013, 52, 7050–7059
Original Research

Xinqiang Fang, Yuan Fu, Marcus J. C. Long, Joseph A. Haegele, Eva J. Ge, Saba Parvez and
Yimon Aye* “Temporally Controlled Targeting of 4-Hydroxynonenal to Speci c Proteins in
Living Cells”
J Am Chem Soc (Communication) 2013, 135, 14496–14499
Postdoctoral (Aug 2009 - June 2012)
Original research:
“Mechanistic Studies of Semicarbazone Triapine
®
Targeting on Ribonucleotide
Reductase in Vitro and in Mammalian Cells: Tyrosyl Radical Quenching Not
Involving Reactive Oxygen Species” Yimon Aye, Marcus J. C. Long and JoAnne
Stubbe* J Biol Chem 2012, 287, 35768.
“Clofarabine Targets the Large Subunit (a) of Human Ribonucleotide Reductase in
Live Cells by Assembly into Persistent Hexamers” Yimon Aye, Edward J. Brignole,
Marcus J. C. Long, Johnathan Chitturulu, Catherine L. Drennan, Francisco J. Asturias,
and JoAnne Stubbe* Chem Biol 2012, 19, 799.
“Clofarabine 5´-Di and –Triphosphates Inhibit Human Ribonucleotide Reductase by
Altering the Quaternary Structure of its Large Subunit” Yimon Aye and JoAnne
Stubbe* Proc Natl Acad Sci USA 2011 direct submission, 108, 9815.
Predoctoral ( Jan 2005 - Jun 2009)
Independent review article:
“Vinyl-, Propargyl- and Allenylsilicon Reagents in Asymmetric Synthesis: Relatively
Untapped Resource of Environmentally-Benign Reagents” Marcus J. Curtis-¬Long
and Yimon Aye*; Chemistry, A European Journal 2009, 15, 5402.
Original research:
“Structural Report for Sc[(R,R)-norephedrine-pybox](OTf )3 Dimeric Complex” Richard
J. Staples* and Yimon Aye; Journal of Chemical Crystallography 2008, 38, 49.
“Aluminum-catalyzed Enantio- and Diastereoselective Carbonyl Addition of
Propargylsilanes. A New Approach to Enantioenriched Vinyl Epoxides” David A.
Evans* and Yimon Aye; Journal of the American Chemical Society 2007, 129,
9606.

“Enantioselective Scandium-catalyzed Vinylsilane Additions: A New Approach to the
Synthesis of β,γ-Unsaturated α-Amino Acid Derivatives” David A. Evans* and Yimon
Aye; Journal of the American Chemical Society 2006, 128, 11034.
“Asymmetric, Anti–selective Scandium-catalyzed Sakurai Additions to Glyoxamide.
Applications to the Syntheses of N-Boc- D-Alloisoleucine and D-Isoleucine” David A.
Evans*, Yimon Aye and Jimmy Wu; Organic Letters 2006, 8, 2071.
“Copper-catalyzed Asymmetric Conjugate Reduction as a Route to Novel β-
Azaheterocyclic Acid Derivatives” Matthew P. Rainka, Yimon Aye and Stephen L.
Buchwald*; Proceedings to the National Academy of Sciences USA, 2004, 101,
5821.
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CCB Special Seminar Series
Department of Chemistry and Chemical Biology
Dr. Yimon Aye
Cornell University
Wednesday, April 20th
11:00AM, WL 260
Host: Professor Daniel Seidel
"On-Demand Redox Targeting"
Chemical redox signals are an emerging class of small-molecule messengers
believed to be essential for nearly all aspects of life. However, the
mechanisms by which regulated redox events on a specific target elicit specific
gain-of-function signaling responses is unknown because there had not been a
method to selectively interrogate precise consequences of redox
modifications that occur on specific targets at specific times. Our laboratory
has developed a unique platform—T-REX (targetable reactive electrophiles
and oxidants), with which specific sensor proteins can be selectively modified
with a choice of >10 specific redox signal on demand, against an otherwise
unperturbed proteome. T-REX is validated to (1) pinpoint the precise impacts
of reactive small-molecule messengers on specific signaling nodes, and (2)
identify bona fide redox-sensor targets of disease relevance. This talk
highlights some of our latest findings underpinning the specific chemical redox
signaling events of fundamental and therapeutic significance, using
approaches that combine organic chemistry, biochemistry, cell biology and
nematode models.
~Coffee/tea will be served prior to lecture~
If you would like to schedule a meeting with Dr. Aye please
contact Kristin Render at 848-445-8602 or kristin.render@rutgers.edu

8/2/2017 WCC Newsletter: 2017 WCC Rising Star Dr. Yimon ... | ACS Network
https://communities.acs.org/groups/wcc-newsletter/blog/2017/07/27/2017-wcc-rising-star-dr-yimon-aye-cornell-university 1/1
By Ann Weber

As a child growing up in Burma, Yimon Aye, Assistant Professor of Chemistry at Cornell University, was always
fascinated by tools, engines, electronics, and fixing things. But due to political unrest, receiving a proper
higher education in science in her homeland was simply impossible. Doing well on internationally-accredited
exams enabled Yimon to win a full scholarship to study for sixth-form (high school equivalent) in the UK. She
then studied chemistry at Somerville College, Oxford University. Yimon notes that Somerville is historically a
very special home for nurturing women leaders such as Margaret Thatcher, Indira Gandhi, and Dorothy
Hodgkin.

Yimon moved to the United States to study synthetic organic chemistry with Professor David A. Evans at
Harvard University, where she earned her Ph.D. degree in 2009. Her hunger for learning led her to pursue a
post-doctoral fellowship in another field, biological chemistry. As a Damon Runyon Cancer Research
postdoctoral fellow at MIT in Prof. JoAnne Stubbe’s lab, she learned a completely new field, having never
studied biology before, even at the high-school level. Looking back, Yimon credits this dual training at the
frontiers of small-molecule chemistry and mechanistic biology with endowing her lab with a unique, cross-
disciplinary vision. “I feel these challenges have allowed me to go beyond my comfort zone and tackle the
biggest challenges in the complex chemical processes of life during my independent career,” says Yimon. “My
background is unconventional compared to those trained in mainstream oncology and biochemistry/chemical
biology. I think that helps my lab at Cornell in two unique ways: first, we tend to see solutions to problems in
different ways. Second, because I’ve made this pretty drastic switch in my training, I’m not afraid of failure,
and my lab has been fearless in taking new directions in research and successfully implementing new
techniques.”

At Cornell, Yimon’s lab is pioneering new methods to deconvolute unconventional cell signaling paradigms.
For example, they developed T-REX™ (targetable reactive electrophiles and oxidants), which allows them to
link specific upstream protein modifications to downstream responses. This technique can be applied in vitro
and in vivo in zebrafish embryos to study reactive electrophile and oxygen signaling pathways which are
believed to be important in neuroprotection, stress defense, and immune responses.

Aside from solving disease-related problems, another key driving force for Yimon is closely tied to her
personal background. “Education is a real privilege, and being educated at world-class institutions like Oxford
and Harvard, and being taught by inspirational teachers, are true privileges that one cannot take for granted,”
she explains. “I am here today because many individuals, including my family who supported and believed in
me, have helped me directly and indirectly along the way, and I want to continue working hard to actively pay
it forward.” Yimon is keen to nurture aspiring students from disadvantaged backgrounds and do for them
what her teachers, mentors and philanthropic foundations have done for her to help her get to where she is
today.

8/2/2017 Aye Lab Recognized by an ONR Young Investigator Award | Chemistry & Chemical Biology Cornell Arts & Sciences
http://chemistry.cornell.edu/aye-lab-recognized-onr-young-investigator-award 1/7
Aye Lab Recognized by an ONR Young
Investigator Award


February 22, 2017
Congratulations to Prof. Yimon Aye, who has recently received a 2017 ONR Young
Investigator Award! The O ce of Naval Research (ONR) Young Investigator Program
(YIP) identi es and supports academic scientists and engineers who show exceptional
promise for doing creative research. The program's objectives are to attract
outstanding faculty members from Institutions of Higher Education to the Department
of Navy's research program, support their research, and encourage their teaching and
research careers. As covered in the Cornell Chronicle this week
(http://www.news.cornell.edu/stories/2017/02/aye-shepherd-win-young-
investigator-awards-navy), Aye is among the 33 scientists who have been selected to
receive a 2017 YIP grant from 360 applicants nationwide (the full list of awardees can
be found at https://www.onr.navy.mil/Science-Technology/Directorates/o ce-
research-discovery-invention/Sponsored-Research/YIP/2017-young-investigators).
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For more information about the research in Prof. Aye's laboratory, please visit
www.ayelab.org.
Other News

Ukrainian hometown celebrates Nobel prize-winning professor
Learn More ›

Co-founder of chemical ecology celebrates 90 years
Learn More ›

Aye group discovers avenue for precision cancer treatment
Learn More ›

Lancaster group reports how nature uses ammonia as cellular fuel
Learn More ›
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8/2/2017 Graduate Field of Biochemistry, Molecular and Cell Biology | Cornell University
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Fall 2018
Application
Deadline
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BMCB-GGD
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Graduate Field of
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Faculty list in Alphabetical Order | Faculty list According to Research Theme | Faculty list According to
Department | Shared Facilities & Collaborations
Yimon Aye
Assistant Professor
Phone 607-254-4519
Address Department of Chemistry & Chemical
Biology
Cornell University
224A Baker Laboratory
Ithaca, NY 14853
Email ya222@cornell.edu
Web Sites Lab Web Site
Department Profile
Background Yimon Aye received a B.S. degree in 2003 and a Master’s degree in 2004 in
Chemistry from the University of Oxford, and a Ph.D. in Synthetic Methodology
from Harvard University in 2009. She became an Assistant Professor in the
Department of Chemistry & Chemical Biology at Cornell University in July 2012.
Research
Description
The Aye group is working on important biological problems in a multidisciplinary
setting in the realms of synthetic organic research chemistry & new reaction
discovery, chemical biology, mechanistic biochemistry and mammalian cell biology.
Specific Aims:
1) We are developing a new chemical perturbation technology to deconvolute
mammalian redox regulatory matrix in vivo.
2) We are seeking to understand small-molecule-modulated perturbation of protein
oligomeric equilibria and how it can be harnessed to control in vivo activities and
functions of mammalian regulatory enzymes.
3) We are striving to establish a new chemical platform for directed protein
trafficking in mammalian cells.
Selected
Publications
Fang, X., Fu, Y., Long, M.J.C., Haegele, J.A., Ge, E.J., Parvez, S., and Aye, Y.
(2013) Temporally controlled targeting of 4-hydroxynonenal to specific proteins in
living cells. J. Amer. Chem. Soc., accepted for publication ASAP (doi:
10.1021/ja405400k) (http://pubs.acs.org/doi/abs/10.1021/ja405400k) .
Fu, Y., Long, M.J.C., Rigney, M., Parvez, S., Blessing, W.A., and Aye, Y. (2013)
Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme
constructed from Escherichia coli and human ribonucleotide reductase.
Biochemistry, accepted for publication
(http://pubs.acs.org/doi/abs/10.1021/bi400781z).
Aye, Y., Long, M.J.C., and Stubbe, J. (2012) Mechanistic studies of semicarbazone
triapine targeting ribonucleotide reductase in vitro and in mammalian cells: tyrosyl
radical quenching not involving reactive oxygen species. J. Biol. Chem. 287, 35768.
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8/2/2017 Graduate Field of Biochemistry, Molecular and Cell Biology | Cornell University
http://bmcb.cornell.edu/faculty/aye.html 2/2
Aye, Y., Brignole, E.J., Long, M.J.C., Chitturulu, J., Drennan, C.L., Asturias, F.J., and
Stubbe, J. (2012) Clofarabine targets the large subunit (α) of human ribonucleotide
reductase in live cells by assembly into persistent hexamers. Chem. & Biol. 19, 799.
Aye, Y. and Stubbe, J. (2011) Clofarabine 5´-Di and –Triphosphates inhibit human
ribonucleotide reductase by altering the quaternary structure of its large subunit.
Proc. Natl. Acad. Sci. USA 108, 9815.
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Curriculum Vitae
Yimon Aye
Howard Milstein Assistant Professor (since July 2012)
244A Baker Laboratory, Cornell University, Ithaca, NY 14853, ya222@cornell.edu, www.ayelab.org

Positions and Employment
2012 July– Assistant Professor, Cornell University, Department of Chemistry & Chemical Biology
2012 July– Assistant Professor, Weill Cornell Medicine, Department of Biochemistry
2012 July– Lecturer of undergraduate and graduate courses at Cornell University College of Arts & Sciences
2012 July– Lecturer of the Essential Principles of Medicine curriculum at Weill Cornell Medicine
2009–2012 Damon Runyon Cancer Research postdoctoral fellow, Mentor: Prof. JoAnne Stubbe, MIT
Education and Training
Honors
2017 May Pershing Square Sohn Prize for Young Investigators in Cancer Research
2017 Feb Office of Naval Research (ONR) Young Investigator Award
2016 Sept ICBS Rising Star Chemical Biologist Award sponsored by ACS Chemical Biology
2016 Sept American Chemical Society WCC Rising Star Chemist Award
2016 Mar American Chemical Society CRT Young Investigator Award
2016 Feb Sloan Research Fellowship
2015 May Burroughs Wellcome Fund (BWF) Collaborative Research Award
2014 Oct National Institutes of Health (NIH) Director’s New Innovator Award
2014 July Beckman Young Investigator Award, The Arnold and Mabel Beckman Foundation
2014 June National Science Foundation (NSF) CAREER Award
2013 Jan Affinito-Stewart Fellow of the President Council of Cornell Women
2012 Sept Milstein New Faculty Fellowship, Howard & Abby Milstein Foundation
2012 Mar Cornell University-ADVANCE Faculty Development Grantee
2009–2012 Damon Runyon Cancer Research Postdoctoral Fellowship (DRG-2015-09)
2010 Apr International Union of Pure & Applied Chemistry (IUPAC) Book Prize for Young Chemists
2009 May Levenson Memorial Teaching Prize, Harvard University
2008–2009 Dudley R. Herschbach Award for Outstanding Teaching & Departmental Service, Harvard University
2008–2009 Bristol-Myers Squibb Graduate Fellowship for Excellence in Synthetic Organic Chemistry
2007,2008 Harvard College Excellence in Teaching Award (awarded twice)
2006–2007 American Association of University Women (AAUW) International Fellowship
2006 Sept Christensen Travel Award, Harvard University
2005–2006 Eli Lilly Graduate Fellowship
2004 Aug Christensen Prize, Department of Chemistry & Chemical Biology, Harvard University
2004 July Mary Somerville Prize, Somerville College, Oxford University, UK
2004 Feb Representative to Her Majesty Queen Elizabeth II during her visit to Oxford, UK
2003 July Exxon Mobil Practical Work Prize, Physical and Theoretical Chemistry Lab, Oxford, UK
2003 June Gibbs Book Prize, Department of Chemistry, Oxford University, UK
2003 May International Student of the Year Award: Gold Medal, The British Council, UK
2002 Mar Kirkildy Prize, Somerville College, Oxford University, UK
2001 Sept Beilbey Scholar in Chemistry, Somerville College, Oxford University, UK
2001 June British Petroleum Chemicals Ltd. Prize in Physical Sciences, UK.
2000–2004 Waverley Scholarship, Oxford University, UK
2000 Sept Conference for Independent Further Education Award, UK
2000 July Royal Society of Chemistry National Prize, UK
Institution and country Degree Month/Year Field of Study (Research Mentor)
MIT, USA
Harvard University, USA
University of Oxford, UK
University of Oxford, UK
Postdoc
Ph.D.
M. Chem
B. Chem
08/09-06/12
06/09
06/04
06/03
Biology (with Prof. JoAnne Stubbe)
Chemistry (with Prof. David A. Evans)
Chemistry (with Prof. Stephen G. Davies)
Chemistry

Yimon Aye Curriculum Vitae Page 2 of 4

Selected Publications at Cornell (as a senior correspondence author) -- last updated June 2017
Published (from the Aye Lab, established July 2012):
1) Original Research
Xinqiang Fang, Yuan Fu, Marcus J. C. Long, Joseph A. Haegele, Eva J. Ge, Saba Parvez and Yimon Aye* “Temporally
Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells” J Am Chem Soc (Communication) 2013,
135, 14496.
Yuan Fu, Marcus J. C. Long, Mike Rigney, Saba Parvez, William A. Blessing and Yimon Aye* “Uncoupling of Allosteric
and Oligomeric Regulation in a Functional Hybrid Enzyme Constructed from Escherichia coli and Human
Ribonucleotide Reductase” Biochemistry (Full Article) 2013, 52, 7050.
Yuan Fu, Hong-Yu Lin, Somsinee Wisitpitthaya, William A. Blessing and Yimon Aye* “A Fluorimetric Readout
Reporting the Inhibitor-Induced Human Ribonucleotide Reductase Oligomerization” ChemBioChem (Full Article)
2014, 15, 2598.
4) Mini Review
Yimon Aye*, Minxing Li, Marcus J. C. Long and Robert Weiss* (*, co-corresponding authors) “Ribonucleotide
Reductase & Cancer: Biological Mechanisms & Targeted Therapies” Oncogene (Mini Review) 2015, 34, 2011.
Saba Parvez, Yuan Fu, Jiayang Li, Marcus J. C. Long, Hong-Yu Lin, Dustin K. Lee, Gene S. Hu and Yimon Aye*
“Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant
Response” J Am Chem Soc (Communication) 2015, 137, 10.
Hong-Yu Lin, Joseph A. Haegele, Michael T. Disare, and Yimon Aye* “A Generalizable Platform for Interrogating
Target- and Signal-Specific Consequences of Electrophilic Modifications in Redox-Dependent Cell Signaling” J Am
Chem Soc (Full Article) 2015, 137, 6232.
7) Perspective
Marcus J. C. Long, Jesse R. Poganik, and Yimon Aye* “On-Demand Targeting: Investigating Biology with Proximity-
Directed Chemistry” J Am Chem Soc (Perspective) 2016, 138, 3610. JACS Spotlights Article – 2016, 138, 4269.
Somsinee Wisitpatthaya, Yi Zhao, Marcus J. C. Long, Minxing Li, William A. Blessing, Elaine A. Fletcher, Robert S.
Weiss, and Yimon Aye* “Cladribine and Fludarabine Nucleotides Induce Conformationally Distinct Hexamers
Defining a Common Mode of Reversible RNR Inhibition” ACS Chemical Biology (Research Article) 2016, 11, 2021
9) Perspective
Marcus J. C. Long, and Yimon Aye* “The Die is Cast: Precision Electrophilic Modifications Contribute to Cellular
Decision Making” ACS Chem Res Toxicol (Perspective) 2016 In Press (contributed in honor of 2016 ACS CRT Young
Investigator Award (to Y.A.) Selected as an ACS Editors’ Choice Article and for journal Cover Art
10) Review Article
Marcus J. C. Long, Souradyuti Ghosh, Jesse R. Poganik, and Yimon Aye* “Subcellular Redox Targeting: Bridging in
Vitro and in Vivo Chemical Biology.” ACS Chemical Biology 2017 ASAP doi: 10.1021/acschembio.6b01148.
Saba Parvez, Marcus J. C. Long, Hong-Yu Lin, Yi Zhao, Joseph A. Haegele, Vanha N. Pham, Dustin K. Lee, and Yimon
Aye* “T-REX™
On-Demand Redox Targeting in Live Cells” Nature Protocols 2016 11 2328.
Marcus J. C. Long, Saba Parvez, Yi Zhao, Sanjna Surya, Yiran Wang, Sheng Zhang, and Yimon Aye* “Akt3 is a
Privileged First Responder in Isozyme-Specific Electrophile Response” Nature Chemical Biology 2017 13 333.
Highlighted for “News & Views” in the same journal: “Redox regulation: Taking AKTion on HNEs”.
13) Perspective
Marcus J. C. Long, and Yimon Aye* “Privileged Electrophile Sensors: a Resource for Covalent Drug Development”
Cell Chemical Biology 2017 (Perspective) Just Accepted

Hong-Yu Lin, Marcus J. C. Long, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, and Yimon Aye* “β-TrCP1 is a
vacillatory regulator of Wnt signaling, either degrading β-catenin or preventing Nrf2 inhibition of Wnt” Cell Chemical
Biology 2017 (Article) Just Accepted

In Revision/Under Review (from the Aye Lab only, established July 2012):

Yuan Fu, Marcus J. C. Long, Somsinee Wisitpatthaya, Huma Inayat, Timothy M. Pierpont, Jordana C. Bloom, Joaquin
Ortega, Robert S. Weiss, and Yimon Aye*
“Nuclear RNR-α Antagonizes Cell Proliferation” 2017 (Article) In Revision
Marcus J. C. Long, Saba Parvez, Jesse R. Poganik, Brian Miller, Joseph R. Fetcho, and Yimon Aye* “Z-REX:
Shepherding Reactive Electrophiles to Specific Proteins and Recording the Resultant Functional Redox Responses in
Larval Fish” 2017 In Revision
Yi Zhao, Yiran Wang, and Yimon Aye* “A Ubiquitin-Ligase Adaptor Serves as a Rosetta Stone Bridging Redox and
Ubiquitin Codes, Coordinating DDR Responses”
2017 Under Peer Review

Publications Prior to Cornell (first and second author publications only)

Postdoctoral Research At MIT
3) Yimon Aye, Marcus J. C. Long and JoAnne Stubbe* “Mechanistic Studies of Semicarbazone Triapine®
Targeting on
Ribonucleotide Reductase in Vitro and in Mammalian Cells: Tyrosyl Radical Quenching Not Involving Reactive Oxygen
Species” J Biol Chem 2012, 287, 35768.
2) Yimon Aye, Edward J. Brignole, Marcus J. C. Long, Johnathan Chitturulu, Catherine L. Drennan, Francisco J. Asturias,
and JoAnne Stubbe* “Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by
Assembly into Persistent Hexamers” Chem Biol 2012, 19, 799.
1) Yimon Aye and JoAnne Stubbe* “Clofarabine 5´-Di and –Triphosphates Inhibit Human Ribonucleotide Reductase by
Altering the Quaternary Structure of its Large Subunit” Proc Natl Acad Sci USA (direct submission) 2011, 108, 9815.

Predoctoral Research At Harvard
5) Marcus J. C. Long and Yimon Aye* “Vinyl-, Propargyl- and Allenylsilicon Reagents in Asymmetric Synthesis: Relatively
Untapped Resource of Environmentally-Benign Reagents” Chem Euro J 2009, 15, 5402.
4) Richard Staples* and Yimon Aye “Structural Report for Sc[(R,R)-norephedrine-pybox](OTf)3 Dimeric Complex” J
Chem Crystallogr 2008, 38, 49.
3) David A. Evans* and Yimon Aye “Aluminum-catalyzed Enantio- and Diastereoselective Carbonyl Addition of
Propargylsilanes. A New Approach to Enantioenriched Vinyl Epoxides” J Am Chem Soc 2007, 129, 9606.
2) David A. Evans* and Yimon Aye “Enantioselective Scandium-catalyzed Vinylsilane Additions: A New Approach to the
Synthesis of β,γ- Unsaturated α-Amino Acid Derivatives” J Am Chem Soc 2006, 128, 11034.
1) David A. Evans*, Yimon Aye and Jimmy Wu “Asymmetric, Anti–selective Scandium-catalyzed Sakurai Additions to
Glyoxamide” Org Lett 2006, 8, 2071.

Undergraduate Research At Oxford University And Junior-Year Summer Research At MIT:
2) Yimon Aye, Stephen G. Davies*, Christopher A. Garner, Paul M. Roberts and Andrew D. Smith “Parallel Kinetic
Resolution Of Tert-Butyl (RS)-3-Oxy-Substituted Cyclopent-1-Ene Carboxylates For The Asymmetric Synthesis Of 3-
Oxy- Substituted Cispentacin And Transpentacin Derivatives” Org Biomol Chem, 2008, 6, 2195.
1) Matthew P. Rainka, Yimon Aye and Stephen L. Buchwald* “Copper-catalyzed Asymmetric Conjugate Reduction as a
Route to Novel β-Azaheterocyclic Acid Derivatives” Proc Natl Acad Sci USA 2004, 101, 5821.

Current Research Support
7) Pershing Square Sohn Cancer Research Alliance Grant Award
Targeting Novel Moonlighting Functions of RNR-α in B-Cell Lymphomas
07/01/17 – 08/31/20 PI: Yimon Aye

6) Office of Naval Research (ONR) Young Investigator Award
Gene Activation by Innate Nucleophilicity (GAIN)
07/01/17 – 06/30/20 PI: Yimon Aye

5) Sloan Research Fellowship, The Alfred P. Sloan Foundation
Regulated Chemical Signals in Redox Communications
09/01/16 – 08/31/18 PI: Yimon Aye

4) NIH Director’s New Innovator Award Grant (1DP2GM114850)
Deconvoluting Redox Biology with Targeted Chemistry
09/30/14 – 06/30/19 PI: Yimon Aye

3) Beckman Young Investigator Award Grant, The Arnold and Mabel Beckman Foundation
A Chemical Technology for Target-Specific Redox Perturbation
09/01/14 – 8/31/18 PI: Yimon Aye

2) NSF CAREER Award Grant (CHE-1351400)
CAREER: A Chemical Technology to Define Target-Specific Bioreactivity: Integrating Research & Education at the
Crossroads of Chemistry & Biology
07/01/14 – 06/30/19 PI: Yimon Aye

1) NSF MRI (CHE-1531632) (instrumentation only)
MRI: Acquisition of a Cryogenic Probe and Modern Console for Outstanding NMR Sensitivity to Benefit Research and
Education at Cornell University
09/01/15 – 8/31/18 PI: Yimon Aye, Co-PIs: Profs. William Dichtel and Linda Nicholson

Completed Research Support

5) Burroughs Wellcome Fund (BWF) Collaborative Research Travel Grant Award (CRTG)
Precise Targeting of Stress Signaling in Zebrafish Cardiogenesis
05/21/15 – 12/31/16 PI: Yimon Aye, Host: Prof. Todd Evans (Weill Cornell Medicine)
4) Lung Cancer Seed Grant, The Meyer Cancer Center at Weill Cornell Medicine, New York, NY
Oligomeric Regulation Underlying Gemcitabine Sensitivity, Resistance And The Discovery Of RNR-Targeted Lung
Cancer Drugs
07/01/15-06/30/16 PI: Prof. Robert Weiss, Co-PI: Yimon Aye
3) Cornell University and Weill Medicine “High-risk Transformative Research” intercampus seed grant
Redox-linked Mechanisms of HuR Protein Regulation in Angiogenesis
07/01/14 – 06/30/15 PI: Yimon Aye; Co-PI: Prof. Timothy Hla (Weill Cornell Medicine)
2) Affinito-Stewart Fellowship Grant, the President Council of Cornell Women
RNR Inhibitors For Targeted Cancer Therapy
05/21/13 – 06/30/14 PI: Yimon Aye
1) NSF: Cornell University-NSF ADVANCE Faculty Development Grant (SBE-0547373)
Small-Molecule Driven Approaches To Dissect Biological Cell Signaling Networks
07/01/13-06/30/14 PI: Provost Kent Fuchs

https://www.facebook.com/permalink.php?story_fbid=3411758163
35488&id=100013292160588
Naing Tun-·
ကင္ဆာကုထံုံေဆနဲ႔္တက္က္ုနု႔ ဆံေဆနုဲ႔႔ုတ္ဲသံထၸံထူးေ္ဆုနုဆ ေ္ ာ
ဆ ေ္ ာာ း္ံတ မံု႔ူဆဲက္ဲ႔႔ ာကာုDr. နည္ ူေ္႔ ာံ
==============================
"..Oxford ႔ကၠတု္က္က္ုုာဲ္ကု႔
႔က္ထဆဲ့န႔ဆဲ့ာ႔ ၾကာင္ံာနင္ံကကည္ံုကး ႔္ုနုု႔ ္ုင္ငံ
ု႔ ္ုင္ငံနဆံ႔ ထ႔င္ံ႔ ဆာင္ု႔ င႔ ာာင္ဆေ္ံ ုၾကည္ုက္ုုာာံကးထဆဲ့က္ုနဲ႔လိိိပါ။..."
ကင္ဆာေဆနုဲ႔္တက္႔ဆဲ့ုကး်ဴ ာုာႀက္႔္႔ ႔ူက္ုုာနင္က္ုုဲ႔
ဲ႔႔္ကင္ နာ က္ုဲဆုာဆထာံေည္ံက ္ံေဆနု႔ ဲးာက္ကင္ံုတက္တာ
တက္တာ႔ ု႔ ္ုင္ ငဲ့္ုဆဲ ္ု႔ ္ုင္႔ ထးေည္ံက ္ံ႔ ႔ူက္ုုနလာ႔ ဲူ႔ ႔ူံနလ္
နလာ႔ ဲူ႔ ႔ူံနလ္ိဲမံုတု႔တေကုဲ္႔ ေ႔ ၾကာင္ံုာ႔ န္ကေ္တ္ဲသံပာတာနဲ္ လာုထ္ဲ္႔
ထ္ဲ္႔ေ္ံဲညာနလင္႔တံဆဲ ္႔ဆဲ့ုဆ ေ္ ာာ း္ံတ မံုကင္ဆာ
ကင္ဆာဇမ၀႔ ဗ ဲညာနလင္ု႔ ႔က္႔ာနည္ ူေ္႔ ာံကုဗမူာ္ု႔ ာက္ုု႔ ဆဲာဲ႔
႔ ဆဲာဲ႔႔င္လ
ာထုက္ုုကင္ဆာ႔ နာာ႔ေဆနုဲ႔္တက္ိဲမံု႔ ဲးာက္ကင္ံု႔ ္ုင္ ငဲ့္ုေည္ံက ္ံ႔ ႔ူ
ေည္ံက ္ံ႔ ႔ူက္ုုနလာ႔ ဲူ႔ ဲငထု႔္ုတု႔ ႔တေဆဲ႔ ေ႔ဆဲ့ာ႔ူက္ုအ၀ြကုထုေလ ္ု
Pershing Square Shon ဆုနလင္ု၆ုတံထဆ လာု႔တံာဆဲ ္ု
ထးမံဆ လငဲ့္ထံထဆဲ့နဲ႔႔င္လုကင္ဆာုတု႔ ႔တေုေဆနုဲ႔္တင္နင္ုထၸံ
ထၸံထၸံထူးေ္ထူးေ္ကုဲ္႔ ဆာင္႔ ေ႔ဆဲ့ုာ႔ န္ကေ္ုကၸငင္ုတ္ဲသံဲညာနလင္႔ ႔ူက္ုု

Pershing Square Shon ကင္ဆာုတု႔တောဲဆူနကု႔ နူံထးင္ိဲမံုထးမံ
ထးမံဆ လင္႔ဆဲ့ုဆု လာုဆု႔ ၾကံ႔ ငူာဆဲ ္ုကင္ဆာုတု႔ ႔
တု႔ ႔တေကုဲ္ငေ္ံာ႔ူက္ု႔ု႔ လ ္က္ုုာ႔ န္ကေ္ု႔ ငကာုအုတ္ေ္ံေဆနုးုု႔ လ ္ု
းုု႔ လ ္ုဆက္႔္ုက္ထးမံဆ လငဲ့္႔ာဆဲ ္ဲ႔႔င္လု႔ ႔က္႔ာုနည္ ူေ္
နည္ ူေ္႔ ာံးာုော ည္႔ ကးာ္ုCornell ႔ကၠတု္က္နဆံုဲာ
ဲာ႔ု႔ ဗ ေဆနုလဇမဇဲာ႔ု႔ ဗ ုဗာေ လာု႔ူဆဲက္ဲ႔႔ ာကာာဆဲ ္ေဆံကည္ံု႔ာ၀ေ္ထ
႔ာ၀ေ္ထ ္ံ႔ ဆာင္႔ ေဲ႔႔င္လ
ကက္နလ္ုကင္ဆာတု႔ ႔တေဆဲကုဲ္ထးက္က႔ ေုပာ
ပာ႔ ႔ူာ႔ ထာက္ာကၸဆဲု႔ ္ုင္တကဆဆ္ု႔ာက္ုု႔ ႔က္႔ာ
႔ ႔က္႔ာနည္ ူေ္႔ ာံကုာထုက္ုု ႔ ဆဲာဲ႔႔င္လယ ာင္ၾကင္ံု႔ ္ုင္ု႔ ံဆ ေ္ံတည္
႔ ံဆ ေ္ံတည္သည္)
“ကး်ဴ ာာႀက္႔္က္ုု႔ ဲးာက္ကင္ံ႔ ု႔ ္ုင္ ငဲ့္ုဆဲ ္ု႔ ္ုင္ နာုက ္ံ႔ ၾကာင္ံက္ု
က ္ံ႔ ၾကာင္ံက္ုုကး ႔္ုန႔ ႔ူံထာံဲ႔႔င္လု ႔႔ ၾကာငဲ့္ုကင္ဆာေဆနုတက္ဆ္ု
တက္ဆ္ုင္႔ာဲဆဆဲ ္ဆဲ ္စုကး်ဴ ာေဆနုတက္ဆ္ုင္႔ာဲဆဆဲ ္ဆဲ ္ု႔ ဲးာက္က
႔ ဲးာက္ကင္ံတက္တာ႔ ု႔ ္ုင္႔ဆဲ့ုက ္ံ႔ ၾကာင္ံဆဲ ္ကာ လာဲ႔လ
ကင္ဆာ႔ နာာ႔႔ ဲးာက္ကင္ံု႔ ္ုင္ ငဲ့္ု႔ ဆံ၀႔ံ႔ ဲငထု႔္ု႔ ္ုင္ဲ္ုနုကး ႔္ုနုတု႔ ႔တ
ကး ႔္ုနုတု႔ ႔တေဆဲထးက္ကနကာ ငဲ့္ုေည္
ေည္ံက ္ံ႔ ႔ူကာ႔ ထာက္ာကၸ႔ ဲံ လာဆဲ ္႔ာ႔ ၾကာငဲ့္ုSohn ဆုကုကး ႔္ုနု
တု႔ ႔တေဲ႔႔္ထဆူထေ္ံာ႔ူက္ု႔ ထာက္ဲံဲ့႔ာဆဲ ္ဲ႔႔င္လ
ာင္ၾကင္ံေ္ုင္လုလုာဆ မဆု လာု႔ု႔ လ ္က္ုုာ႔ န္ကေ္႔ ငကာုအုတ္ေ္ံု႔ ထာက္ဲံဲ့
႔ ထာက္ဲံဲ့ လာဆ္ု႔ ႔ာဲ့ုတု႔ ႔တေကုဲ္ငေ္ံာ႔ူက္ုာ႔ န္ကေ္ လာုပာက္ု
ပာက္ုနုာဆ မ႔ ကာက္႔ ႔ာင္ုာကုေ္ာကးထံ႔ာကဆနလငဲ့္လ

႔ ႔က္႔ာနည္ ူေ္႔ ာံလုလုတု႔ ႔တေကုဲ္ငေ္ံ႔ ႔ူကုကၸနာတ္ု
ကၸနာတ္ုင္ံာ၀္ုင္ံု႔္ုံ႔က္ဲ္ုနာ႔ူက္ာ႔ နံႀကမံ႔င္လုဲံူိဲ္ံ႔ဆဲ့ုု႔ ္ုင္ငံ
ု႔ ္ုင္ငံ႔ ႔ူ လာဆ္ုုတု႔ ႔တေကုဲ္ငေ္ံ႔ ႔ူနဆံုာ႔ နံႀကမံ းက္ုုာထၸံုာတ္ာ လ႔္
ာတ္ာ လ႔္ဆဲ႔င္လုဆ ေ္ ာု႔ ္ုင္ငံ လာုဲံူိဲ္ံဆဆု႔ ္ုင္ငံ လာ႔ ႔ာဲ့ုတု႔ ႔တေကုဲ္င
တု႔ ႔တေကုဲ္ငေ္ံက္ုုာတ္ာ လ႔္ဆဲဲ္ုနကုာထက္ာ
ာထက္ာထဆာ းာံႀကမံနလ္႔ ေ႔င္လု ႔႔ ဲ ငဲ့္ုတု႔ ႔
တု႔ ႔တေကုဲ္ငေ္ံ႔ ၾကာငဲ့္ုာကး်ဴ္ံ႔ ကးံဇၸံ႔ ႔ူက႔ ႔ာဲ့ု႔က ာာကံ
႔က ာာကံုံက္ုုထ္႔ နာက္ လာဲဆဆဲ ္ဲ႔႔င္လ
ာင္ၾကင္ံု႔ ္ုင္လလုဆုနနလ္ထဆဲ့ဲံုက္ုု႔ ဆဲာဆဲဲ႔ကာံနလငဲ့္လ
႔ ႔က္႔ာနည္ ူေ္႔ ာံလလု မဆုန႔ာက႔ ႔ာဲ့ုာန ္ံက္ုထၸံဆထာံဲ႔႔င္လု မဆု
မဆုက္ု႔ ဲံဲ္ုနုာင္႔ာဗး်ဴံ ငဲ့္ုတၸ႔ ႔ူးာု႔ကငဲ့္က္ုုထ္ဲ္႔
ထ္ဲ္႔ေ္ံုု႔ ္ုပင္က္ဆုနုတ္ဲံသဲညာနလင္႔ ႔ူဆဲ ္ဆဲမံ႔ ႔ာဲ့ု ကာံကက္ဆံ
ကာံကက္ဆံု႔ ဆဲာဲ္ုန ႔ ဆဲာေဆနု႔ ႔ူံဲ္ုနာထူငဲ့္ာ႔ နံနဲ္ုန႔ ႔ာင္ု႔ကင္ ကူ
႔ကင္ ကူင္႔ဆဲ့ုတၸ႔ ႔ူဲ႔လု မ႔ ႔ာဲ့ုကး က္ုုာင္႔ာဗး်ဴံ႔ ထင႔ ႔ာဲ့ုတၸ႔္ု
တၸ႔္ုနေဆနု႔ ႔ူနနဲ္ုနုာန ္ံက္ုု ္႔္ကးဲ္နလာံထဆဲ့နဲ႔႔င္လု႔ ောက္ိဲမံုကး
ကး ႔႔္ထာံ႔ဆဲ့ုဲ႔႔ု႔ ဗ ဲညာနဲ္က္ုု႔ ဆံဲညာ႔ ကာကာ႔ူက္ုာတံ
ာတံုံထးဲ္ုနု ္႔္၀င္ ာံထဆဲ့႔ာဲ႔လ
ာင္ၾကင္ံု႔ ္ုင္လုလု႔ ႔က္႔ာနည္ ူေ္႔ ာံာ႔ ေေဆနုာထုက္ုုာ႔ န္က
ာ႔ န္ကေ္ု႔ ္ုင္ငံ လာုထ္ဲ္႔ေ္ံတ္ဲသံဲညာနလင္႔တံဆဲ ္ကာဲ္ုနုပင္က္ု
ပင္က္ုႀက္ံ ာံထဆဲ့ကဆနလငဲ့္လ
႔ ႔က္႔ာနည္ ူေ္႔ ာံလလုကး ုဆင္႔ေ္ံုက္ုုဆ ေ္ ာ
ဆ ေ္ ာ႔ ္ု႔ ု္င္ငံကံုံု႔႔္ငုနန္လထဆဲ့တၸဆဲ ္ဆဲမံုြဖဖ္ု လုအ၀၀၀ုထုု႔ လ ္ာထ္ု
ထုု႔ လ ္ာထ္ုာာဂကေ္ု႔ ု္င္ငံုနဆံုCambridge Tutors College (CTC) လာု
႔က္႔ နာက္ဲ္ုနုဲညာုတင္ဆုနန္လထဆဲ့တၸကဆဆဲ ္ဲ႔႔င္လုအ၀၀၀ုထုု႔ လ ္ုဇူေ္က

ဇူေ္က လာ႔ ဆဲဆ္ုထဆဲ့႔ဆဲ့ုA-level ာ႔ ံဲူဆ လာုဲာ႔ု႔ ဗ ဲညာနဲ္ေဆနာာဂကေ္ု႔ေ္ု
႔ေ္ုင္ငံကံုံ လာုာ လ႔္ာ းာံဆံုံုနန္လထဆဲ့ဆဲမံုRoyal Society of Chemistry’s
National ဆုက္ုုနန္လထဆဲ့ဲ႔႔င္လုာဆ မ႔ ောက္ လာ႔ ႔ာဲ့ုOxford ႔ကၠတု္က္ လာုဲာ
ဲာ႔ု႔ ဗ ေဆနုပူဆံငၸထဆဲ့ဲ႔႔င္လုOxford ႔ကၠတု္က္က္ုုာဲ္ကု႔
႔က္ထဆဲ့န႔ဆဲ့ာ႔ ၾကာင္ံာနင္ံကကည္ံုကး ႔္ုနုု႔ ္ုင္ငံ
ု႔ ္ုင္ငံနဆံ႔ ထ႔င္ံ႔ ဆာင္ု႔ င႔ ာာင္ဆေ္ံ ုၾကည္ုက္ုုာာံကးထဆဲ့က္ုနဲ႔လ
ာဆ မ႔ ောက္ုာ႔ န္ကေ္ဆဲည္႔ ထာင္ ုုHarvard ႔ကၠတ္ုက္ လာု
ပူဆနကူေ္ဆက္႔က္ဆဲမံုPhD ပူဆံက္ုုအ၀၀ဖုထုု႔ လ ္ လာုနန္လထဆဲ့ဲ႔႔င္လုHarvard
က႔ ေု႔ ကးာင္ံဆဲမံ႔ဆဲ့ာထ႔ုMassachusetts Institute of Technology (MIT)ု
႔ ကးာင္ံ လာုDamon Runyun Cancer Research Postdoctoral Fellow
႔ ္တံာဆဲ ္႔ ေထဆဲ့ဆဲမံုCellular and Biochemical regulatory mechanisms
of the enzyme ribonucleotide reductase (RNR) တု႔ ႔တေ႔ ႔ူုကု
ကုဲ္႔ ဆာင္ထဆဲ့ဲ႔႔င္လုအ၀ြအုထုု႔ လ ္ုဇၸက္ုင္ကကု ဆဲမံုCornell ႔ကၠတု္က္နဆံုဲာ
ဲာ႔ု႔ ဗ ေဆနုလဇမဇဲာ႔ု႔ ဗ ုဗာေ လာု႔ူဆဲက္ဲ႔႔ ာကာာဆဲ ္ု႔ာဇေ္ထ
႔ာဇေ္ထ ္ံ႔ ဆာင္ထဆဲ့ဆဲမံုအ၀ြ၂ုထုု႔ လ ္ လာုာ႔ န္
ာ႔ န္ကေ္ာ း္ံတာံကးေ္ံ ာ႔ နံု႔ကၠတ္ုက္ကုထးမံဆ လငဲ့္႔ဆဲ့ုNew Innovator
Award ဆုက္ုုတၸနနဆံုDeconvoluting redox biology with targeted
chemistry project ေဆနုနန္လထဆဲ့ဲ႔႔င္လ
ဆ ေ္ ာု႔ ္ုင္ငံာ႔ူက္ကည္ံုဆဲေ္ိဲမံာကး္ံဆဲု႔ ္ုင္႔ ာာင္ုႀက္ံဲ ္ံ႔ ေ႔
ႀက္ံဲ ္ံ႔ ေ႔ ၾကာင္ံု႔ ႔က္႔ာနည္ ူေ္႔ ာံကု႔ ဆဲာတူာံဲ႔႔င္
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ALL ABOUT DR YIMON AYE-Field of Biochemistry, Molecular and Cell Biology Cornell University

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