Oral Fluid as a Chemical Test for the DRE Program
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History, the Future, and Practical Considerations. Presented by Barry K Logan PhD, DABFT, National Director of Forensic Services, NMS Labs, Willow Grove, PA at the 2011 IACP-DRE Conference in Montreal, Canada.
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Oral Fluid as a Chemical Test for the DRE Program
- 1. ORAL FLUID AS A CHEMICAL TEST FOR THE DRE PROGRAM : HISTORY, THE FUTURE, AND PRACTICAL CONSIDERATIONS Barry K Logan PhD, DABFT National Director of Forensic Services, NMS Labs Willow Grove PA
- 3. Current Options in Drug Testing
- 7. Drugs in Oral Fluid
- 9. Cocaine in Oral Fluid 150 mg/70 kg sc cocaine, (N=14 oral fluid) (N=13 plasma) Courtesy, Marilyn Huestis, NIDA
- 10. THC in Oral Fluid Courtesy, Marilyn Huestis, NIDA Hours 0.01 0.1 1 10 100 1000 10000 0 1 10 100 Oral Fluid Plasma 3.55%THC GC-MS ng/mL or ng/mg
- 11. Methamphetamine in Oral Fluid 0 20 40 60 80 Low Dose High Dose Hours Oral fluid (cutoffs 50 Meth/2.5 Amp) Urine (cutoffs 500Meth/200 Amp) Courtesy, Marilyn Huestis, NIDA
- 12. History of OF Drug Testing
- 15. DUID Oral Fluid Use Belgium: saliva screening, blood/saliva confirmation Australia: saliva screening (2x), saliva confirmation Germany: saliva/urine testing, blood confirmation UK: FST, blood sampling; no device being used France: saliva screening, blood confirmation Switzerland: Approved for use
- 18. DUID Oral Fluid Use United States: OF Specifically Approved in: Alabama Arizona Colorado Indiana Kansas Louisiana Missouri New York North Carolina North Dakota Ohio Oregon South Dakota Utah Canada: OF Approved in Federal Legislation
- 21. US National Roadside Survey 2007
- 27. 2007 NRS - OF Positivity
- 30. Most common exact matches
Editor's Notes
- Lipophilicity of drug Non-polar analytes (THC) partition into oral fluid more readily than polar metabolites (11-nor-9-carboxy-THC) Usually more parent drug than metabolites pKa of drug Non-ionized basic drugs in blood partition into more acidic oral fluid, become ionized & accumulate, “ion trapping of basic drugs” Molecular size of drug
- Median and interquartile ranges presented on log axis. Dasehed lines indicate LOQ (2.5ug/L), SAMHSA (8ug/L) and DRUID (10ug/L) oral fluid cutoffs.
- Time To Last Positive Methamphetamine oral fluid positive at 50 ng/mL requires 2.5 ng/mL amphetamine presence Methamphetamine urine positive at 500 ng/mL requires 200 ng/mL amphetamine presence After how many doses? After the last?