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Designer Drug Tests Solutions for Employers
SYNTHETIC MARIJUANA UPDATE
K2/Spice
K2/Spice
Marijuana Most popular recreational drug after alcohol and tobacco. Main psychoactive component THC #1 Drug in the DRE pro...
K2/Spice <ul><li>What is K2/Spice? </li></ul><ul><li>Synthetic chemicals that look to the brain like marijuana. </li></ul>...
K2/Spice <ul><li>Chemicals used change frequently. </li></ul><ul><li>Different products with same name contain different c...
K2/Spice
Synthetic Cannabinoids 2010 <ul><li>JWH-018 </li></ul><ul><li>JWH-073 </li></ul><ul><li>CP 47, 497 (C7) </li></ul><ul><li>...
Synthetic Cannabinoid 2012 JWH-007 JWH-015 JWH-018 JWH-018 methyl hexyl homolog JWH-019 JWH-073 JWH-073 methyl butyl homol...
Legal Status - Federal <ul><ul><li>Temporary Scheduling </li></ul></ul><ul><ul><li>3/1/2011 – Synthetic Cannabinoids </li>...
Marijuana/K2 Effects Red eyes / bloodshot Burning of the eyes  Xerostomia (dry mouth)  Tachycardia Changes in perception/m...
K2/Spice Prevalence NFLIS, Oct 2011 Calls to Poison Control Centers
K2/Spice Behavioral Effects
K2/Spice and Lethality
<ul><li>Synthetic Cannabinoid Metabolites Screen - Expanded, Urine (Forensic) Test (9562U) </li></ul><ul><li>JWH-018 N-(4-...
Urine K2/Spice - Positivity
Blood  K2/Spice - Positivity
“ BATH SALTS” UPDATE
Designer Drugs <ul><ul><li>1980’s </li></ul></ul><ul><ul><li> -methylfentanyl, MPPP, MDMA,  </li></ul></ul><ul><ul><li>19...
Designer Stimulants and Hallucinogens <ul><ul><li>2008-2012 </li></ul></ul><ul><ul><li>Benzylpiperazines (6+) </li></ul></...
Designer Stimulants and Hallucinogens <ul><ul><li>Bath Salts Products </li></ul></ul>
Bath Salts Effects Meth Ecstasy Bath Salts Excitement Euphoria Tachycardia Increased pupil size Rapid Speech Motor Restles...
Bath Salts - Prevalence NFLIS, Oct 2011 Calls to Poison Control Centers
Legal Status - Federal <ul><ul><li>Temporary Scheduling </li></ul></ul><ul><ul><li>10/21/2011  “Bath Salts” </li></ul></ul...
Bath Salts and Depression
Bath Salts and Violence
Bath Salts Lethality
Designer Drugs - Salvia
ANABOLIC STEROIDS UPDATE
Designer Drugs
Designer Drugs
Anabolic Steroids Mimic Effects of Testosterone and Dihydrotestosterone Increase protein synthesis Buildup of muscle Stimu...
9305U  Anabolic Steroid Assay <ul><li>Bolasterone  </li></ul><ul><li>Boldenone  </li></ul><ul><li>Clenbuterol  </li></ul><...
Urine Detection Times for Steroids Various internet sources including user input* Compound Detection Clenbuterol ~4 days T...
Most Frequently Encountered - 9305U Compound Abnormal Testosterone/Epi Ratio Nandrolone Metabolite Nandrolone Norandrosten...
Testosterone:Epitestosterone   Ratio Normal Range, less than 4.0 ~3% have concentrations greater than 4.0 Range:  4.1 – 420
Designer Drugs
NMS Labs Philosophy <ul><li>NMS Labs is the  industry leader  in its ability to identify and stay current in an evolving a...
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Designer Drugs Testing Solutions for Employers

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Designer Drugs Testing Solutions for Employers
Presented February 1, 2012
by Dr. Barry K. Logan, PhD, DABFT
NMS Labs National Director of Forensic Services

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Designer Drugs Testing Solutions for Employers

  1. 1. Designer Drug Tests Solutions for Employers
  2. 2. SYNTHETIC MARIJUANA UPDATE
  3. 3. K2/Spice
  4. 4. K2/Spice
  5. 5. Marijuana Most popular recreational drug after alcohol and tobacco. Main psychoactive component THC #1 Drug in the DRE program Some 25 million Americans have smoked marijuana in the past year, and more than 14 million do so regularly. Possession and use illegal under federal law, but states have variable policies on enforcement and prosecution. 6.8% of Friday and Saturday evening drivers test positive for use.
  6. 6. K2/Spice <ul><li>What is K2/Spice? </li></ul><ul><li>Synthetic chemicals that look to the brain like marijuana. </li></ul><ul><li>Sprayed onto plant material for smoking. </li></ul><ul><li>Give marijuana-like high </li></ul><ul><li>Sold online and in headshops </li></ul><ul><li>Legal grey area </li></ul>
  7. 7. K2/Spice <ul><li>Chemicals used change frequently. </li></ul><ul><li>Different products with same name contain different chemicals. </li></ul><ul><li>The same product from the same manufacturer contains different drug, lot to lot. </li></ul>
  8. 8. K2/Spice
  9. 9. Synthetic Cannabinoids 2010 <ul><li>JWH-018 </li></ul><ul><li>JWH-073 </li></ul><ul><li>CP 47, 497 (C7) </li></ul><ul><li>CP 47,497 (C8) </li></ul><ul><li>HU-210 </li></ul>
  10. 10. Synthetic Cannabinoid 2012 JWH-007 JWH-015 JWH-018 JWH-018 methyl hexyl homolog JWH-019 JWH-073 JWH-073 methyl butyl homolog JWH-081 JWH-122 JWH-133 JWH-175 JWH-200 JWH-201 JWH-203 JWH-210 JWH-250 JWH-251 JWH-302 JWH-398 CP 47, 497 (C7) CP 47,497 (C8) CP 55,940 AM-694 AM-1220 AM-1241 AM-2201 AM-2233 RCS-4 RCS-8 WIN 48,098 (Pravadoline) WIN 55,212-2 WIN 55,212-3 CB-25 CB-52 HU-210 HU-211 HU-308 HU-331 JT-7770
  11. 11. Legal Status - Federal <ul><ul><li>Temporary Scheduling </li></ul></ul><ul><ul><li>3/1/2011 – Synthetic Cannabinoids </li></ul></ul><ul><ul><li>JWH-018 </li></ul></ul><ul><ul><li>JWH-073 </li></ul></ul><ul><ul><li>JWH-200 </li></ul></ul><ul><ul><li>CP47,497 (C7) </li></ul></ul><ul><ul><li>CP47,497 (C8) </li></ul></ul>
  12. 12. Marijuana/K2 Effects Red eyes / bloodshot Burning of the eyes Xerostomia (dry mouth) Tachycardia Changes in perception/mood Balance and Coordination Hallucinations Sedation Subjective thought disruption/loss of concentration Impaired sense of time Self assessed impairment Arrhythmias Seizures/Convulsions Panic Attacks Paranoia and Anxiety Sickness
  13. 13. K2/Spice Prevalence NFLIS, Oct 2011 Calls to Poison Control Centers
  14. 14. K2/Spice Behavioral Effects
  15. 15. K2/Spice and Lethality
  16. 16. <ul><li>Synthetic Cannabinoid Metabolites Screen - Expanded, Urine (Forensic) Test (9562U) </li></ul><ul><li>JWH-018 N-(4-hydroxypentyl) metabolite </li></ul><ul><li>JWH-018 N-(5-hydroxypentyl) metabolite </li></ul><ul><li>JWH-019 N-(5-hydroxyhexyl) metabolite </li></ul><ul><li>JWH-073 N-(3-hydroxybutyl) metabolite </li></ul><ul><li>JWH-073 N-(4-hydroxybutyl) metabolite </li></ul><ul><li>JWH-250 N-(4-hydroxypentyl) metabolite </li></ul><ul><li>AM-2201 N-(4-hydroxypentyl) metabolite </li></ul>Urine K2/Spice – Expanded Scope
  17. 17. Urine K2/Spice - Positivity
  18. 18. Blood K2/Spice - Positivity
  19. 19. “ BATH SALTS” UPDATE
  20. 20. Designer Drugs <ul><ul><li>1980’s </li></ul></ul><ul><ul><li> -methylfentanyl, MPPP, MDMA, </li></ul></ul><ul><ul><li>1990’s, early 2000’s </li></ul></ul><ul><ul><li>PMA, rise of methamphetamine </li></ul></ul><ul><ul><li>Growth of the Internet </li></ul></ul><ul><ul><li>Beginnings of the “Research Chemicals” or “New Psychedelic” Movement. </li></ul></ul><ul><ul><li>Mid 2000’s </li></ul></ul><ul><ul><li>AMT, DMT, 5-MeO-DiPT </li></ul></ul><ul><ul><li>Khat, cathinone, methcathinone </li></ul></ul>
  21. 21. Designer Stimulants and Hallucinogens <ul><ul><li>2008-2012 </li></ul></ul><ul><ul><li>Benzylpiperazines (6+) </li></ul></ul><ul><ul><li>BZP, TFMPP, m-CPP </li></ul></ul><ul><ul><li>“ Bath Salts” </li></ul></ul><ul><ul><li> -Keto amphetamines (30+) </li></ul></ul><ul><ul><li>Ephedrone, mephedrone, methylone, methedrone… </li></ul></ul><ul><ul><li>Phenethylamines (2C suite) (15+) </li></ul></ul><ul><ul><li>2C-B, 2C-E, 2C-I, 2C-B, 2C-T-7,… </li></ul></ul><ul><ul><li>Pyrrolidophenones (pyrovalerones) (20+) </li></ul></ul><ul><ul><li> -PVP, MDPV, PPP,… </li></ul></ul>
  22. 22. Designer Stimulants and Hallucinogens <ul><ul><li>Bath Salts Products </li></ul></ul>
  23. 23. Bath Salts Effects Meth Ecstasy Bath Salts Excitement Euphoria Tachycardia Increased pupil size Rapid Speech Motor Restlessness Anxiety Paranoia Mood Changes Withdrawal/Depression Delusions Hallucinations Seizures/Convulsions Death
  24. 24. Bath Salts - Prevalence NFLIS, Oct 2011 Calls to Poison Control Centers
  25. 25. Legal Status - Federal <ul><ul><li>Temporary Scheduling </li></ul></ul><ul><ul><li>10/21/2011 “Bath Salts” </li></ul></ul><ul><ul><li>MDPV </li></ul></ul><ul><ul><li>Mephedrone </li></ul></ul><ul><ul><li>Methylone </li></ul></ul>
  26. 26. Bath Salts and Depression
  27. 27. Bath Salts and Violence
  28. 28. Bath Salts Lethality
  29. 29. Designer Drugs - Salvia
  30. 30. ANABOLIC STEROIDS UPDATE
  31. 31. Designer Drugs
  32. 32. Designer Drugs
  33. 33. Anabolic Steroids Mimic Effects of Testosterone and Dihydrotestosterone Increase protein synthesis Buildup of muscle Stimulate bone growth Stimulate Appetite Treat Chronic Wasting Cause acne Elevate cholesterol Hypertension Heart and Liver damage Gynecomastia Testicular atrophy Mood changes/Depression Anger Violence
  34. 34. 9305U Anabolic Steroid Assay <ul><li>Bolasterone </li></ul><ul><li>Boldenone </li></ul><ul><li>Clenbuterol </li></ul><ul><li>Clostebol Metabolite </li></ul><ul><li>Clostebol </li></ul><ul><li>Creatinine </li></ul><ul><li>Drostanolone Metabolite </li></ul><ul><li>Epitestosterone </li></ul><ul><li>Fluoxymesterone </li></ul><ul><li>Methandienone Metabolite </li></ul><ul><li>Methandienone </li></ul><ul><li>Methenolone </li></ul><ul><li>Methyltestosterone </li></ul><ul><li>Nandrolone Metabolite </li></ul><ul><li>Nandrolone </li></ul><ul><li>Nandrolone </li></ul><ul><li>Norandrostenedione </li></ul><ul><li>Norethandrolone Metabolite </li></ul><ul><li>Norethandrolone </li></ul><ul><li>Norethindrone </li></ul><ul><li>Oxandrolone </li></ul><ul><li>Oxymetholone Metabolite </li></ul><ul><li>Probenecid </li></ul><ul><li>Stanozolol Metabolite </li></ul><ul><li>Stanozolol </li></ul><ul><li>Testosterone/Epitestosterone Ratio </li></ul><ul><li>Testosterone </li></ul><ul><li>Tetrahydrogestrinone </li></ul><ul><li>Trenbolone Metabolite </li></ul><ul><li>Turinabol </li></ul>
  35. 35. Urine Detection Times for Steroids Various internet sources including user input* Compound Detection Clenbuterol ~4 days Testosterone Undecanoate ~1 Week Testosterone Propionate ~ 2weeks Oxandrolone ~ 3 Weeks Oral Stanozolol ~ 3 Weeks methandienone ~ 3 Weeks Noretadrolone ~ 3 Weeks Oxymetholone ~2 months Injectable Stanozolol ~2 months Boldenone ~ 5 months Trenbolone ~ 5 months Nandrolone ~12-18 months
  36. 36. Most Frequently Encountered - 9305U Compound Abnormal Testosterone/Epi Ratio Nandrolone Metabolite Nandrolone Norandrostenedione Boldenone Methenolone Trenbolone Metabolite Methandienone Metabolite Stanozolol Methyltestosterone Stanozolol Metabolite Methandienone
  37. 37. Testosterone:Epitestosterone Ratio Normal Range, less than 4.0 ~3% have concentrations greater than 4.0 Range: 4.1 – 420
  38. 38. Designer Drugs
  39. 39. NMS Labs Philosophy <ul><li>NMS Labs is the industry leader in its ability to identify and stay current in an evolving and challenging designer drug market offering testing established and new and emerging drugs of abuse. </li></ul>

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