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Pedologic Anatomy with special
emphasis on its
Applied Aspects
Presented by:- Dr Nivedita Jain
PG Ist Year
1
CONTENTS
 Definition of Growth & Development
 Introduction
 Prenatal growth changes
 Factors affecting fetal growth
 General Postnatal changes in Dimensions and Proportions
• Neonatal Skeleton
• Weight, Length and Height
• Head Circumference
• Body Proportions
• Posture
• Neck
2
•Chest
•Abdomen
•Extremities
Change in Craniofacial Complex
Oral features at Birth
• General Body reflex
• Facial Reflex
• Oral Reflex
Significance of Pedologic Anatomy in Pedodontics
Reference
3
4 Definition of Growth
It is defined as the physiochemical process of living matter by which
an organism becomes larger. It is largely an anatomic phenomenon.
Krogman defined growth simply as increase in size, change in
proportion and progressive complexity.
Profitt (1986) further simplified and explained growth as an increase
in size or number.
5 Definition of Development:-
It is a physiological and behavioural phenomenon
comprising of changes and complexity in functions.
According to Toss (1931) : Development is defined as
progress towards maturity.
Whereas; Moyers (1988) stated that development consists
of all the naturally occurring unidirectional changes in the
life of an individual from its existence as a single cell to its
elaboration as a multifunctional unit terminating in death.
INTRODUCTION
 A child may appear as a miniature adult but the details of the
anatomy reveal that a child is entirely different from an adult.
 We need to understand normal growth, development,
anatomy and behaviour in order to monitor child's progress,
to identify delays or abnormalities in development, and to
counsel parents.
6
Foetal Growth Changes7
End of Fourth Week (First Month)
 Length of the foetus is around 4mm and begins to curve in c-shape
 Buccopharyngeal membrane ruptures.
 The development of face with the formation of upper lip and nostrils take
place. Palate is incompletely formed.
 The cerebral hemispheres appear as hollow buds
 The eyelids are present in the shape of folds above and below the eye.
8
Enamel organs are developed from dental lamina.
The limbs now appear as oval flattened projections
Kidney begin to form with tubules. Heart forms, starts functioning and
body system begin to form.
The backbone and vertebral canal form small buds that will develop
inner and upper extremities.
Heart forms, start functioning and body systems begin to form.
9
10
END OF SECOND MONTH
 Eyes are far apart with eyelids fused and nose is flat.
 Ossification of bones begins and limbs become
distinct as the upper and lower extremities.
 By the beginning of the fifth week, forelimbs and
hindlimbs appear as paddle-shaped buds
 Formation of digits start appearing by formation of
four radial grooves which are known as rays.
11
Major blood vessels form.
Many internal organs continue to develop.
 By the end of the second month the foetus measures from 28 to 30 mm.
in length
 Counting somites becomes difficult during the second month of
development, the age of the embryo is then indicated as the crown-rump
length (CRL) and expressed in millimetres.
 CRL is the measurement from the vertex of the skull to the midpoint
between the apices of the buttocks
12
13 CLINICAL CORRELATIONS
END OF THIRD MONTH
 The face becomes more human
looking
 Bridge of nose develops and external
ears are formed.
 Ossification begins and continues
 The head flexion increases & the neck
becomes proportionately larger.
 Length of the foetus is about 7 cm,
but if the legs be included it is upto 9
to 10 cm.
14
The umbilical protrusion of the gut is reduced with proportionate
abdominal volume.
Heart beat is detectable.
External genitalia develop to such a degree that the sex of the foetus can
be determined by external examination (ultrasound).
 The eyes, initially directed laterally, move to the ventral aspect of the
face, and the ears come to lie close to their definitive position at the
side of the head .
 The limbs reach their relative length in comparison with the rest of the
body, although the lower limbs are still a little shorter and less well
developed than the upper extremities.
15
END OF FOURTH MONTH
 Face takes on human features and hair appears on the head.
 Bones are ossified and joints begin to form with continued development of the
body system.
 Condyle, coronoid and angle of mandible become distinct.
 The external ear is formed on the side of the head and is no longer in upper part
of the neck.
 The length of the foetus is from 12 to 13 cm.
 Skin is bright pink.
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17
END OF FIFTH
MONTH  Rapid development of body systems take place.
 Skin is bright pink and sebaceous glands
become active forming “Vernix Caseosa” on
skin.
 foetal movement called “Quickening” can be
seen.
 Total length of the foetus, including the legs, is
from 25 to 27 cm.
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END OF SIXTH MONTH
 Head becomes smaller but is still disproportionate to the rest of the body.
 Eyelids separate and eyelashes form.
 Skin is wrinkled and pink because of lack of underlying connective tissue.
 Increase in the growth of the cutaneous and subcutaneous tissue occurs.
 Ameloblast and odontoblast are formed.
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END OF SEVENTH
MONTH
 Head and body become more
proportionate.
 Skin still is wrinkled and pink.
 Eyebrow hair and eyelashes are
developed.
 The pupillary membrane atrophies and
the eyelids are open.
 From vertex to heels the total length at
the end of the seventh month is from 35
to 36 cm.
 The weight is a 1000-1300 gm.
20
END OF EIGHT MONTH
 Subcutaneous fat deposition take place.
 The foetus present is of Plump appearance
 The skin assumes a pink colour
 Testes descend into scrotum.
 There is progressive loss of lanugo except for the hair on eyelids, eyebrow and
scalp.
 The umbilicus is gradually centrally located.
 The total length, i. e., from head to heels, is about 40 cm
 Chances of survival are much greater by this period.
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END OF NINTH
MONTH
 Additional subcutaneous fat accumulates.
 Skull has the largest circumference of all the
parts of the body
 Lanugo sheds.
 Nails extend to the tips of the fingers and even
beyond.
 The umbilicus is almost in the middle of the
body
 Length is 45-50cm
 Weight is 2.5-4.5kg
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MONTHS CROWN-RUMP
LENGTH(cm)
WEIGHT(gm)
3 5-8 10-45
4 9-14 60-200
5 15-19 250-450
6 20-23 500-820
7 24-27 900-1300
8 28-30 1400-2100
9 31-34 2200-2900
24
Developmental horizons
during foetal life
HORIZONS EVENT AGE (WEEKS)
 Taste buds appear 7
 Swallowing 10
 Respiratory Movements 14-16
 Sucking Movements 24
 Some sounds can be heard 24-26
 Eyes sensitive to light 28
25
CLINICAL CO RELATION
Low Birth Weight
 Intrauterine growth restriction (IUGR) is a term applied to infants who are at or
below the 10th percentile for their expected birth weight at a given gestational age.
Sometimes these infants are described as small for dates, small for gestational age
(SGA), foetally malnourished, or dysmature.
 Approximately 1 in 10 babies have IUGR and therefore an increased risk of
neurological deficiencies, congenital malformations, meconium aspiration,
hypoglycaemia, hypocalcaemia, and respiratory distress syndrome (RDS).
 The incidence is higher in blacks than in whites.
26
FACTORS AFFECTING FOETAL GROWTH
Genetic Potential
 The potential traits are usually transmitted to offspring.
 The size of head is more closely related to parents than are the size and
shape of hand and feet
 Structure of chest and fatty tissue has better genetic association than other
somatic characteristics.
27
Foetal Hormones
 Human foetus secretes thyroxin from 12th weeks of gestation period
 Thyroxin and insulin have a role in regulation of tissue acceleration and
differentiation
 Glucocorticoid influence the pre partum maturational events of organs such
as liver, lungs and gastrointestinal tract.
 Growth hormones are present in high level but does not affect the foetal
growth.
28
Placental factors:
 Foetal weight is directly correlated to placental weight
 Foetal growth is highly dependent on structural and functional integrity of
placenta.
 The total villus surface area increases , diffusion distance decreases,
capillaries dilate and the resistance to feto-placental vasculature falls.
 The positive remodelling facilitates the enhanced nutrient transport across
the placenta.
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Maternal factors
 Mother’s diet, nutrient intake and body composition plays an important
 Maternal use of tobacco, cigarettes, drugs, alcohol retards foetal growth.
 Obstetric complications such as pregnancy induced hypertension, pre-
eclampsia, and multiple pregnancy produce foetal growth restriction.
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LAWS OF GROWTH
 Growth and development of children is a continuous and orderly process.
 The foetus grows fast in the first half of gestation, therefore rate of growth is
slowed down until the baby is born
 In early postnatal period velocity of growth is high specially in first few months,
thereafter slower but steady growth during mid childhood
 Second phase of accelerated growth occurs at puberty.
 Growth de-accelerates thereafter for sometime and finally ceases.
32
Different tissues of body grow at
different rates
 General body growth
 Brain growth
 Growth of gonads
 Lymphoid growth
33
Postnatal Growth
A postpartum (or postnatal) period begins immediately
after the birth of a child as the mother's body, including
hormone levels and uterus size, returns to a non-pregnant
state. The terms puerperium or puerperal period, or
immediate postpartum period are commonly used to refer
to the first 6 weeks following childbirth.
34
GENERAL POST NATAL DIMENSIONS AND
PROPORTIONS
Neonate Skeleton
 The neonate has 270 bones as compared to an adult who has 206 bones.
 Skull bones in the neonate are 45 (due to incomplete ossification) & in the adult
22.
 Frontal bone is in two halves separated by metopic suture and fuses by 2 years
 Two Parietal bone are present
35
 Occipital bone has four parts, one squamous, two condylar, and one
basilar which fuses by 4 years of life .
 Each temporal bone has four parts which completely fuses by puberty
 Mastoid process is absent in neonates thus stylomastoid foramen lies
superficially.
36
Body Proportions
 The body proportions are a result of a differential rates of growth of
the cephalic and caudal ends.
Mid point
 the mid point of a 2 month old child is at the chest, while in an adult
it is at the pubic symphysis region.
 At birth- just above umbilicus.
 The length of the head doubles by adulthood.
 There is an axis of increased growth extending from heads towards
the feet. This is called as cephalo caudal gradient.
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38
39
Normal Growth Values
 The infant measures 50cm at birth
 60cm at three months,
 70cm at 9 months,
 75cm at one year
 A normal Indian child is 100cm tall at age of 4 ½ years
 Gains about 6cm in height every year, until age of 12years
 Target height :
o boys (cm) = father’s ht. + mother’s ht. + 6.5
2
o Girls (cm) = father’s ht. + mother’s ht - 6.5
2
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 1cm/month for next three months
 Half cm/month for next 6 months
 By one year of age, circumference is 45-47cm
 Between one to two year 4 inches increase takes place.
 At 10 years
 95%of the total head growth completes with the width of the
head completed by 3 years while the length of the head
completes by 17 to 18 years.
 It increases 2cm/month for first three months.
41
Posture
The new born is usually kept in supine position but can be literally folded in its
most comfortable posture ,i.e. the posture simulating the foetal posture of partial
flexion, mild lordosis and protuberance of abdomen are common finding at 2-3
years of age but disappears by 4 years.
Neck
Neck is relatively short at birth and its muscles are not developed at birth for
supporting the head. Development of these muscle begin from 2 months onwards.
43
Chest
 Chest circumference is measured at level of nipples,
mid way between inspiration and expiration.
 At birth the chest is smaller than the head
circumference. It becomes equal at 2 years and by 15
years its ratio becomes 3:2.
 The final ratio in adults is 5:3.
 The chest is rounded in new born and final shape is
attained by the time of puberty.
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Abdomen
 The umbilicus of the new born sheds off
around the 12th to 15th day after birth.
 The umbilicus is everted and in some cases
umbilical hernia may be present.
 Circumference of the abdomen is equal to
the chest until 2 years.
 After two years it is less than chest.
45
Extremities
At birth:- legs are short and arms are long.
Arms:-
 To measure the mid arm circumference first mark a point midway between
tip of the acromian process of scapula and olecranon of ulna, while the
child hold the left arm by his side.
 birth to 2 years – length increases by 6.75%.
 At 8 years - 50% longer than at 2 years.
 By 16 to 18 years - slow growth, increased development takes place
 Thus an early mature baby has shorter legs than a late matured baby.
46
47
Legs
 At birth-short and curved.
 Birth to 2 years- length increases 40%.
A lot of fat on the mesial aspect of the foot gives the appearance of a
flat foot.
 6 years:- straight, the knock knee and flat foot appearance gets
corrected.
 8 years-50 % longer than at 2 years.
 Adolescence- 4 times longer than at birth.
 Early maturer- shorter legs than the late maturer.
48
Weight
 The weight of the child in nude or
minimal clothing is recorded accurately
on a lever or electronic type of weighing
scale
 The weighing scale should have a
minimum unit of 100gm.
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Length
 Length is recorded under the age of two
years.
 Child is placed on a rigid measuring table or
an infantometer in a supine position
 Length of baby is measured from a scale,
which is set in the measuring table.
50
Standing Height
 For the standing height child stands upright,
heels separated and weight even on both
feet
 Head is so positioned that the child looks
directly forwards with the Frankfurt’s
horizontal plane and biauricular plane being
horizontal.
51
Head Circumference
 Measurement is done using a non stretchable tape
the maximum circumference of the head from the
occipital protuberance to the supraorbital ridges on the
forehead is recorded.
 The head circumference is about 35 cm at birth.
 Head shape is rounded but sometimes it may get
moulded during parturition as over riding of the
parietal bone takes place when the head gets engaged
in birth canal.
52
Changes in Craniofacial Complex
The skeletal portion of the craniofacial complex develops as a blend of morphogenesis
of primary skull components.
1. Neurocranium consists of
 2. Viscerocranium is formed by the bones of facial skeleton which develop
by intramembranous ossification. This is derived from the branchial arches.
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Desmocranium
Chondrocranium
Dimensional Changes in Craniofacial Structures
 These changes can be appreciated even in Intra Uterine Life.
 The entire cranium becomes longer and wider in its relation to height.
 At birth:- Head makes up about a greater part of total body length
whereas in adult it accounts for about one eighth of the total body
height. While the size of the cerebral cranium will increase by about 50%,
the facial skeleton will grow to more than twice the original size.
55
By 4 years:-
 Cranial circumference thus increases from about 33cm (at birth) to 50 cm at
3 years after which it only increases by 6 cm.
4th year onwards:-
 Facial skeleton increase in all dimensions during the post natal growth
period, the increase in height being the greatest (approx. 200%).
 In depth the increase is somewhat smaller(approx 75%).
 Increase in width is the smallest(approx 15%).
56
Fontanelles
They bridge the gap between the bones that limit them. They are made up of the
duramater, the primitive periosteum and the aponeurosis from inside outwards.
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(18 to 24 months after birth)
(2 months after birth)
(3 months after birth)
(Begins to close 1 to 2 months after birth, closed
completely by 12 months)
Clinical importance of fontanelles
1. Enables the foetal skull to modify its size and shape as it passes through the
birth canal and permits rapid growth of the brain during infancy.
2. Helps the physician to gauge the degree of brain development by their state
of closure.
3. Anterior fontanelle serves as a landmark for withdrawal of blood for analysis
from the superior sagittal sinus.
4. Depressed level of fontanelle indicates dehydration and increased level
indicates an increased intracranial pressure.
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59
Encephalitis
 Hydrocephalus
 Meningitis
Fontanels
Bulging
Down syndrome
Premature birth
Congenital rubella
Fontanels
enlarged
• Due to malnutritionShrunken
Craniofacial Synchondroses
It plays an important role in craniofacial development.
 Sphenoccipital: closes by 17-20 years.
 Sphenoethmoidal :closed by 2-4 years; may persist and fuse later in adolescence, but is of little
importance in postnatal growth.
 Mid sphenoidal: closes shortly after birth.
 Other synchondroses:
 1.Intraoccipital
 2.Sphenopetrosal
 3.Petrooccipital
 Craniotabes or soft skull due to paper thin bones is palpable in premature infants.
61
Sutures of Cranium
62
Closes at 24 years to 35 years
(Closes 22 years to 30 years)
(Closes at 29 Years)
Clinical Co Relation
 The shape of the skull depends on which of the sutures closed prematurely.
 Early closure of the sagittal suture (57% of cases) results in frontal and
occipital expansion, and the skull becomes long and narrow (scaphocephaly)
 Premature closure of the coronal suture results in a short, high skull,
known as acrocephaly, or tower skull
63
64
 If the coronal and lambdoid sutures close prematurely on one side only,
asymmetric craniosynostosis, known as plagiocephaly.
 In some cases the cranial vault fails to form (cranioschisis), and brain
tissue exposed to amniotic fluid degenerates, resulting in anencephaly.
 Children with relatively small defects in the skull through which meninges
and/or brain tissue herniate (cranial meningocele and
meningoencephalocele, respectively)
Face
1. At birth, the lower 3rd and middle 3rd of the face are underdeveloped due to
absence of teeth.
2. The forehead is high and bulging.
3. The eyes dominate and owing to the absence of the root of the nose, appear
to be widely separated.
4. After the onset of puberty the forehead flattens and widens, lips thicken and
face acquires an oval shape, mainly due to growth of the jaws
65
66
Nasomaxillary Complex
 The maxilla develops in the membranous tissue at the end of sixth foetal week.
 The maxilla is attached to the neurocranium directly with the fronto maxillary
sutures and indirectly by means of various other facial structures such as the
nasal, lacrimal and ethmoidal bones, nasal septum including vomer, palatine
bone and zygomatic bone. These structures are joined in edge to edge
relation.
 During early phase interrelation between jaws are characterised by mandibular
protrusion, which gradually reversed.
67
68  At birth the maxilla is placed more anteriorly giving class II relationship of
the jaws.
 Later on both maxilla and mandible with their associated soft tissue grows
forward and downward & establish a normal class 1 relationship.
 Maxillary sinuses are not well developed and are present like slits.
 Development of orbital cavities complete at birth.
 The alveolar process can only be faintly discerned and palate has weak
transversal curvature.
 The maxillary body is almost entirely filled with the developing teeth.
69
72
Clinical Co relation
Facial clefts-
a. Cleft lip and palate
b. Median cleft lip
c. Oblique facial clefts
73
Teratogens are likely to cause lip defects if the embryo is exposed to them
during 5th & 6th weeks.
The palate is more susceptible between 7th and 8th week.
Mandible
 At birth, the two rami are short and condylar development is minimal.
 A thin line of fibrocartilage and connective tissue exists at the midline of the
symphysis to separate the right and left mandibular bodies. This symphyseal
cartilage is replaced by bone (between 4 months of age and end of 1stYear)
 The alveolar processes and the muscles are poorly developed at this age, so
that its basal arch mainly determines the shape of the mandible in the
neonate.
 At birth the structure of mandible is shell like with the 10 alveolar sockets for
the developing tooth germs.
74
 During the 1st year of life, appositional growth is specially active at
alveolar border, at the distal and superior surface of ramus, condyle
and lower border of mandible along with lateral surfaces
 After the 1st year , resorption occurs along the anterior border of
ramus lengthening the alveolar border
 Transverse dimensions, after 1 year are mainly due to the growth at
posterior border in an expanding “V” pattern.
 The two rami diverge outwards from below to above so that additive
growth at the coronoid notch, coronoid process and condyle also
increases the superior inter ramus dimensions.
75
 The position of mandibular foramen changes by remodeling, to a more
superior position from occlusal plane as child matures.
 The foramen is below the occlusal plane in a very young child, slightly at the
occlusal plane during the period of primary dentition .
 It averages 7mm above the occlusal plane in the adult.
 Angle of mandible is more obtuse in young children.
 Mental foramen is placed very close to border of mandible in young children
 Forward shift of growing mandibular body changes direction of mental
foramen during infancy & childhood.
76
77
78
79 Inferior Alveolar Nerve Block
Clinical implication-
80 Mental Nerve
 In infants and children, the syringe needle may be applied at right
angles to the body of the mandible to enter the mental foramen
 In the adult, the needle must be applied obliquely from behind to
achieve entry
Temporomandibular Joint
Three phases of development are seen in the intrauterine life period.
1.Blastemic stage:- (7 to 8 weeks of development) corresponds with the
organisation of the condyle, articular disc and capsule.
2.Cavitation stage:- (9 to 11 weeks of development) corresponds to the initial
formation Of inferior joint cavity and then start of condylar chondrogenesis.
3.Maturation stage:- (after 12 weeks of development)
81
Postnatal Changes in TMJ
1. At birth the articular disc is flat and develops an accentuated S-shaped
profile as the articular tubercle develops.
2. Condylar cartilage is approximately 1.5 mm thick at birth, but soon
thins down to about 0.5 mm, by 20 to 30 years of life it is completely
replaced by endochondral ossification.
3. Mandibular condyle grows in a constant posterior, superior and lateral
direction and attains a mature contour by late mixed dentition period.
82
83
Oral features of Neonate
Upper Gum Pad
Gingival Groove Dental Groove
Lateral
Sulcus
Lower Gum Pad84
Relationship of Gum Pads
 There is no definite anteroposterior relationship of the gum pads on occlusion, but the lower gum
pad being smaller, the lateral sulcus of the lower gum pads lies distal to that of the upper.
 Variable overjet with contact only in the first molar segments.
 During function the mandibular movements at this stage are mainly vertical and to a very small
extent in the anteroposterior direction. Lateral movements are absent.
 During the early phases of foetal development the sagittal interrelationship of the jaws is
characterized by a mandibular protrusion ,which is gradually reversed.
 At birth the lower jaw is often situated posteriorly .this relationship has some clinical significance as
disturbed postnatal forward growth of the mandible may result in Malocclusion.
85
86
Growth of Gum Pads
 At birth the width of the gum pads are inadequate to
accommodate all the incisors
 The growth of the gum pads is rapid in the first year after
birth.
 Growth is more in transverse direction and in the labiolingual
direction.
 Due to growth the segments of each gum pads become
prominent.
87
Tongue
 It is comparatively large in relation to the small mouth.
 Tongue is flat, thin and blunt tipped.
 The tongue at this stage performs only one function i.e. acts
as piston while sucking.
 It is formed from 3 swellings, i.e. lingual swelling, tuberculum
impar and hypobrachial eminence.
88
Buccal Pad of Fat
 It is also called as corpus adiposum or bichat”s fat pad.
 It is child’s reserve of energy, it is nothing but the cheek
prominence giving the infant a chubby cheek appearance. It is
formed of a thin encapsulated mass of fat lying between the
subcutaneous fat and the muscles of cheek.
 Exact role in suckling is not known but it regress as suckling
ceases.
89
External Features of a Newly Born Child
Skin
• Colour:- Often reddish
• May have an appearance of cyanosis
• Mongolian Spots
• Vernix Caseosa
• Premature infant has deep red skin with fine, soft, immature lanugo hair.
• Post term infants may show a whitish, peeling, parchment like skin.
• Erythema toxicum
• Pustular melanosis is a similar, benign vesiculo popular rash at birth in some
blacks, around the chin, back, extremities, palms and soles.
90
91
Eyes
Size Cornea Lens
Fundus Retina
92
Nose
 Small and flat with narrow nostrils.
 Bridge of the nose is depressed. Maximal growth of the nasal
cartilage occurs till puberty, after which it attains it’s final form.
 Hair within nose become thicker around puberty.
Lips
 Lips of a new born are reddish pink, soft and supple.
 The midline of the upper lip has a small projection, the labial tubercle
(sucking callus) which is said to disappear after the cessation of
suckling.
 Abrupt separation of the mucosa covering the inner aspect of the lips
from the outer aspect by a thin single line, parallel to the free border of
lip.
 Undergo a slow transformation to form the transition zone between
the outer and inner aspects after one year.
What is reflex?
Definition:-
It is an involuntary, or autonomic , action that the body does in
response to something , without even having to think about it. The
reflexes can be broadly studied under 3 categories:-
1.General body reflex
2.Facial reflex
3.Oral reflex
93
Reflexes present at Birth
i. Moro reflex
ii. Startle reflex
iii. Grasp / Palmar reflex
iv. Walking / Stepping reflex
v. Limb placement reflex
vi. Asymmetric tonic neck reflex
vii. Babinski’s reflex
viii.Parachute reflex
ix. Landau reflex
x. Tendon reflex
xi. Abdominal reflex
95
i. Moro Reflex
 Any sudden movement of the neck initiates this reflex.
 A satisfactory way of eliciting the reflex is to pull the baby
half way of eliciting the reflex is to pull the baby half way
to a sitting position from the supine and suddenly let the
head fall back to a short distance.
 The reflex consists of a rapid abduction and extension of
the arms with the opening of hands. Arms then come
together as in an embrace.
 The Moro reflex is present at birth, peaks in the first
month of life, and begins to disappear around 2-3 months
of age
96
Clinical Importance
 It’s nature gives an indication of muscle tone.
 The response may be asymmetrical if muscle tone in unequal on the two
sides, or if there is weakness of an arm or any injury to the humerus or
clavicle.
 Bilateral absence of the reflex may be linked to damage to the
infant's central nervous system, while a unilateral absence could mean an
injury due to birth trauma.
 In human evolutionary history, the Moro reflex may have helped infants
cling to the mother while being carried around.
97
ii. Startle Reflex
 Similar to Moro reflex but it is initiated by a sudden noise
or any other stimulus.
 The elbows are flexed and the hands remain closed, there
is less of embrace, outward and inward movement of the
arms.
 By the time your baby is 3 to 6 months old, they probably
won't demonstrate the strartle reflex any longer.
98
iii. Palmar/ Grasp reflex
 When the baby’s palm is stimulated, hands closes.
 There is also a corresponding PLANTAR reflex.
 Normally disappears by 24 months.
Clinical Significance
 An exceptionally strong grasp reflex may be found in the spastic form of
cerebral palsy and in kernectirus.
 It may be asymmetrical in hemiplegia and in cases of cerebral damage. It should
have disappear in in 2 or 3 months and persistence may indicate the spastic
form of cerebral palsy.
99
iv. Walking/ Stepping reflex
When the sole of the foot is pressed against the couch, the baby
tries to walk. It persists as voluntary standing.
100
v. Limb Placement Reflex
When the front of the leg below the knee, or the arm below the elbow is
brought into contact with the edge of the table, the child lifts the limbs
over the edge.
Clinical significance-
Reflex is readily demonstrable in newborn and persistent failure to elicit it
at this stage is thought to indicate neurological abnormality.
This reflex disappears by 6 weeks due to increased ratio of leg weight to
strength.
It reappears by 8 month to 1 year when the child starts to walk.
101
vi. Asymmetric tonic neck reflex
102
 When the baby is at rest and not crying, he lies at intervals with his head on one
side, the arms extended to the same side and often with the flexion of the
opposite knee.
 Also called as ‘fencing posture' .
 This reflex is present at one month of age and disappears at around four months
, but may persist in spastic children.
 If the infant is unable to move out of this position or the reflex continues to be
triggered past six months of age, the child may have a disorder of the upper
motor neurons. According to researchers, the tonic neck reflex is a precursor to
the hand/eye coordination of the infant. It also prepares the infant for voluntary
reaching.
vii. Babinski’s reflex
 The Babinski reflex occurs after the sole of the foot has been firmly
stroked. The big toe then moves upward or toward the top surface of
the foot. The other toes fan out.
 It is named after the Russian neurologist Boris Petrovitch Babkin.
103
viii. Parachute Reflex
 It appears at about 6-9 months and persists thereafter. The reflex is
elicited by holding the child in ventral suspension and suddenly
lowering him to the couch. The arms extend as defensive reaction.
 In children with cerebral palsy, the reflex may be absent or abnormal.
104
ix. Landau reflex
 It is seen in vertical suspension, with the head, spine and legs
extended.
 If the head is reflexed, the hips, knees and the elbows also
flex.
 It is normally present from 3 months and is difficult to elicit
after 1 year.
 It is poor in those with floppy infant syndrome and
exaggerated in hypertonic and opisthotonic infants.
105
x. Tendon reflex106
 They are present in neonate.
 They are of great value for the diagnosis of cerebral palsy.
 In spastic children the tendon jerk are exaggerated.
 The pectoralis major was the most readily elicitable reflex in all
infants(100%), regardless of maturity.
xi. Abdominal Reflex
They are also present in most of the new born babies. In these reflex
there contraction of the muscles of the abdominal wall on stimulation
of the skin or tapping on neighboring bony structures.
107
108
Nasal reflex
Stimulation of the face or nasal cavity with water or local irritants produces
apnea in neonates. Breathing stops in expiration with laryngeal closure and
infants exhibit bradycardia and lowering of cardiac output.
Blink reflex
Various stimuli provoke blinking.
Whether the child is awake or asleep, pupils of the eyes react to changes in
the intensity of light.
Facial Reflex
109
Corneal reflex
Consists of blinking when the Cornea is touched.
When the stimulus ,whether sound, light, or touch, has been received .
The reflex occurs at a rapid rate of 0.1 seconds.
Pupil reflex
The pupils react to light, but in the preterm baby and some full term babies the
duration of exposure to light may have to be prolonged to elicit the reflex. The
light should not be bright, for a bright light will cause closure of the eyes.
Doll’s Eye Reflex
Normal response in newborns to keep the eyes stationary as the head is moved to
the right or left.
The reflex disappears as ocular fixation develops.
During the first week they are able to maintain these fixations against passive
Oral Reflexes
Consists of the following types of reflexes:110
Rooting
Reflex
Suckling
Reflex
Swallowin
g
Gag
Reflex
Masticatio
n
i. Rooting Reflex
 When the infants cheek contacts the mother's breast, the baby's mouth results in
vigorous sucking movements resulting in the baby rooting for milk.
 When the corner of the mouth is touched, the lower lip is lowered, the tongue moves
towards the point stimulated. when the finger slides away, the head turns to follow it.
 When the centre of Upper lip is stimulated, the lip elevates.
Onset: 28 weeks IU
Well established: 32-34 weeks IU
Disappears: 3-4 months
111
ii. Suckling Reflex
 Onset – 28 weeks IU
 Well established:32 to 34 weeks IU
 Disappears: starting around 12 months
 Elicited by: the sucking reflex is tested by introducing a finger or teat into the
mouth, when vigorous sucking will occur.
112
iii. Swallowing
Begins around 12.5 weeks of IU life.
Full swallowing and sucking is established by 32-36 weeks of IU life.
 Infantile swallow
Until the primary molars erupt, infant swallow with the jaws separated and the
tongue thrust forward using facial muscles(orbicularis oris and the
buccinator).This is a non conditional congenital reflex.
 Acquired congenital reflex
After eruption of the posterior primary teeth, from 18 months of age onwards,
the child tends to swallow with the teeth brought together by the masticatory
muscle action, without a tongue thrust.
113
114
Cry reflex
 It is a un conditioned reflex which accounts for its lack of
individual character and is of sporadic nature.
 It starts as early as 21-29 weeks intrauterine.
Significance of Pedologic
Anatomy in Pedodontics
 Knowledge of pedologic anatomy is very helpful for a pedodontist. It not only
serves as an adjunct in diagnosis but also helps in treatment planning
 The knowledge of the development of motor skills and language similarly also
helps a pedodontist to gauge whether the development is going on at a proper
rate or not
115
 The anatomical post natal development also aids in a similar way.
 The knowledge of various growth spurts helps in planning treatment
specially in interceptive orthodontic cases, where growth has to be
modified or wherever surgery is involved e.g. in cleft cases, functional jaw
orthopaedics.
116
References
 Tandon S, Introduction to pedodontics, In: Text book of pedodontics, 2nd
edition, hyderabad paras medical publisher, 2008, pg 50-63.
 Inderbir Singh, Alimentary System, In: Human Embryology, 8th edition,
Macmillan Publishers, 2010, pg 126- 166.
 S G Damle, Growth and Development. In:Textbook of Pediatric
Dentistry, 5th Edition, Arya Medi Publishing House, 2017, pg 304-328
 S I Bhalajhi, Growth and Development, General Principles and
Concepts, In Textbook of Orthodontics, 5th Edition, Arya Medi
Publishing House, 2013, pg 9-49
117
Frequently Asked Questions
1. Growth Spurts
2. Scammon’s Curve
3. Gum Pads
4. Reflexes present at birth
118
119
Pupillary Membrane
Persistent pupillary membrane (PPM) is a condition of the eye
involving remnants of a fetal membrane that persist as strands
of tissue crossing the pupil. The pupillary membrane in
mammals exists in the fetus as a source of blood supply for the
lens.
120
Meconium
It is the dark green substance forming the first faeces of a
newborn infant.
Meconium aspiration syndrome (MAS) also known as neonatal
aspiration of meconium is a medical condition affecting newborn
infants. It describes the spectrum of disorders and
pathophysiology of newborns born in meconium-stained amniotic
fluid (MSAF) and have meconium within their lungs.
121
Amniotic Fluid
During pregnancy, your growing baby is cushioned inside a fluid-filled
bag (amniotic sac) in your womb (uterus).
Amniotic fluid protects the developing baby by cushioning against blows
to the mother's abdomen, allowing for easier fetal movement and
promoting muscular/skeletal development. Amniotic fluid swallowed by
the fetus helps in the formation of the gastrointestinal tract.
122
123
Delayed growth puts the baby at risk of certain health problems during pregnancy, delivery, and after birth.
They include:
•Low birth weight
•Difficulty handling the stresses of vaginal delivery
•Decreased oxygen levels
•Hypoglycemia (low blood sugar)
•Low resistance to infection
•Low Apgar scores (a test given immediately after birth to evaluate the newborn's physical condition and
determine need for special medical care)
•Trouble maintaining body temperature
•Abnormally high red blood cell count
In the most severe cases, IUGR can lead to stillbirth. It can also cause long-term growth problems.
Causes of Intrauterine Growth Restriction
IUGR has many possible causes. A common cause is a problem with the placenta. The placenta is the tissue that
joins the mother and fetus, carrying oxygen and nutrients to the baby and permitting the release of waste
products from the baby.
Intra Uterine Growth Restriction
124
The condition can also occur as the result of certain health problems in the mother, such as:
•Advanced diabetes
•High blood pressure or heart disease
•Infections such as rubella, cytomegalovirus, toxoplasmosis, and syphilis
•Kidney disease or lung disease
•Malnutrition or anemia
•Sickle cell anemia
•Smoking, drinking alcohol, or abusing drugs
Other possible fetal causes include chromosomal defects in the baby or multiple gestation
(twins, triplets, or more).
IUGR Symptoms
The main symptom of IUGR is a small for gestational age baby. Specifically, the baby's
estimated weight is below the 10th percentile -- or less than that of 90% of babies of the same
gestational age.
Depending on the cause of IUGR, the baby may be small all over or look malnourished. They
may be thin and pale and have loose, dry skin. The umbilical cord is often thin and dull instead
of thick and shiny.
Not all babies that are born small have IUGR.
125
Indian Population
India with 1.21 billion people constitutes as the second most
populous country in the world, while children
represents 39% of total population of the country. The figures
show that the larger number of about 29 percent constitutes
Children in the age between 0-5 years.
126
Orbit
127
128

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1. pedologic anatomy with special emphasis on its applied

  • 1. Pedologic Anatomy with special emphasis on its Applied Aspects Presented by:- Dr Nivedita Jain PG Ist Year 1
  • 2. CONTENTS  Definition of Growth & Development  Introduction  Prenatal growth changes  Factors affecting fetal growth  General Postnatal changes in Dimensions and Proportions • Neonatal Skeleton • Weight, Length and Height • Head Circumference • Body Proportions • Posture • Neck 2
  • 3. •Chest •Abdomen •Extremities Change in Craniofacial Complex Oral features at Birth • General Body reflex • Facial Reflex • Oral Reflex Significance of Pedologic Anatomy in Pedodontics Reference 3
  • 4. 4 Definition of Growth It is defined as the physiochemical process of living matter by which an organism becomes larger. It is largely an anatomic phenomenon. Krogman defined growth simply as increase in size, change in proportion and progressive complexity. Profitt (1986) further simplified and explained growth as an increase in size or number.
  • 5. 5 Definition of Development:- It is a physiological and behavioural phenomenon comprising of changes and complexity in functions. According to Toss (1931) : Development is defined as progress towards maturity. Whereas; Moyers (1988) stated that development consists of all the naturally occurring unidirectional changes in the life of an individual from its existence as a single cell to its elaboration as a multifunctional unit terminating in death.
  • 6. INTRODUCTION  A child may appear as a miniature adult but the details of the anatomy reveal that a child is entirely different from an adult.  We need to understand normal growth, development, anatomy and behaviour in order to monitor child's progress, to identify delays or abnormalities in development, and to counsel parents. 6
  • 8. End of Fourth Week (First Month)  Length of the foetus is around 4mm and begins to curve in c-shape  Buccopharyngeal membrane ruptures.  The development of face with the formation of upper lip and nostrils take place. Palate is incompletely formed.  The cerebral hemispheres appear as hollow buds  The eyelids are present in the shape of folds above and below the eye. 8
  • 9. Enamel organs are developed from dental lamina. The limbs now appear as oval flattened projections Kidney begin to form with tubules. Heart forms, starts functioning and body system begin to form. The backbone and vertebral canal form small buds that will develop inner and upper extremities. Heart forms, start functioning and body systems begin to form. 9
  • 10. 10
  • 11. END OF SECOND MONTH  Eyes are far apart with eyelids fused and nose is flat.  Ossification of bones begins and limbs become distinct as the upper and lower extremities.  By the beginning of the fifth week, forelimbs and hindlimbs appear as paddle-shaped buds  Formation of digits start appearing by formation of four radial grooves which are known as rays. 11
  • 12. Major blood vessels form. Many internal organs continue to develop.  By the end of the second month the foetus measures from 28 to 30 mm. in length  Counting somites becomes difficult during the second month of development, the age of the embryo is then indicated as the crown-rump length (CRL) and expressed in millimetres.  CRL is the measurement from the vertex of the skull to the midpoint between the apices of the buttocks 12
  • 14. END OF THIRD MONTH  The face becomes more human looking  Bridge of nose develops and external ears are formed.  Ossification begins and continues  The head flexion increases & the neck becomes proportionately larger.  Length of the foetus is about 7 cm, but if the legs be included it is upto 9 to 10 cm. 14
  • 15. The umbilical protrusion of the gut is reduced with proportionate abdominal volume. Heart beat is detectable. External genitalia develop to such a degree that the sex of the foetus can be determined by external examination (ultrasound).  The eyes, initially directed laterally, move to the ventral aspect of the face, and the ears come to lie close to their definitive position at the side of the head .  The limbs reach their relative length in comparison with the rest of the body, although the lower limbs are still a little shorter and less well developed than the upper extremities. 15
  • 16. END OF FOURTH MONTH  Face takes on human features and hair appears on the head.  Bones are ossified and joints begin to form with continued development of the body system.  Condyle, coronoid and angle of mandible become distinct.  The external ear is formed on the side of the head and is no longer in upper part of the neck.  The length of the foetus is from 12 to 13 cm.  Skin is bright pink. 16
  • 17. 17
  • 18. END OF FIFTH MONTH  Rapid development of body systems take place.  Skin is bright pink and sebaceous glands become active forming “Vernix Caseosa” on skin.  foetal movement called “Quickening” can be seen.  Total length of the foetus, including the legs, is from 25 to 27 cm. 18
  • 19. END OF SIXTH MONTH  Head becomes smaller but is still disproportionate to the rest of the body.  Eyelids separate and eyelashes form.  Skin is wrinkled and pink because of lack of underlying connective tissue.  Increase in the growth of the cutaneous and subcutaneous tissue occurs.  Ameloblast and odontoblast are formed. 19
  • 20. END OF SEVENTH MONTH  Head and body become more proportionate.  Skin still is wrinkled and pink.  Eyebrow hair and eyelashes are developed.  The pupillary membrane atrophies and the eyelids are open.  From vertex to heels the total length at the end of the seventh month is from 35 to 36 cm.  The weight is a 1000-1300 gm. 20
  • 21. END OF EIGHT MONTH  Subcutaneous fat deposition take place.  The foetus present is of Plump appearance  The skin assumes a pink colour  Testes descend into scrotum.  There is progressive loss of lanugo except for the hair on eyelids, eyebrow and scalp.  The umbilicus is gradually centrally located.  The total length, i. e., from head to heels, is about 40 cm  Chances of survival are much greater by this period. 21
  • 22. END OF NINTH MONTH  Additional subcutaneous fat accumulates.  Skull has the largest circumference of all the parts of the body  Lanugo sheds.  Nails extend to the tips of the fingers and even beyond.  The umbilicus is almost in the middle of the body  Length is 45-50cm  Weight is 2.5-4.5kg 22
  • 23. MONTHS CROWN-RUMP LENGTH(cm) WEIGHT(gm) 3 5-8 10-45 4 9-14 60-200 5 15-19 250-450 6 20-23 500-820 7 24-27 900-1300 8 28-30 1400-2100 9 31-34 2200-2900 24
  • 24. Developmental horizons during foetal life HORIZONS EVENT AGE (WEEKS)  Taste buds appear 7  Swallowing 10  Respiratory Movements 14-16  Sucking Movements 24  Some sounds can be heard 24-26  Eyes sensitive to light 28 25
  • 25. CLINICAL CO RELATION Low Birth Weight  Intrauterine growth restriction (IUGR) is a term applied to infants who are at or below the 10th percentile for their expected birth weight at a given gestational age. Sometimes these infants are described as small for dates, small for gestational age (SGA), foetally malnourished, or dysmature.  Approximately 1 in 10 babies have IUGR and therefore an increased risk of neurological deficiencies, congenital malformations, meconium aspiration, hypoglycaemia, hypocalcaemia, and respiratory distress syndrome (RDS).  The incidence is higher in blacks than in whites. 26
  • 26. FACTORS AFFECTING FOETAL GROWTH Genetic Potential  The potential traits are usually transmitted to offspring.  The size of head is more closely related to parents than are the size and shape of hand and feet  Structure of chest and fatty tissue has better genetic association than other somatic characteristics. 27
  • 27. Foetal Hormones  Human foetus secretes thyroxin from 12th weeks of gestation period  Thyroxin and insulin have a role in regulation of tissue acceleration and differentiation  Glucocorticoid influence the pre partum maturational events of organs such as liver, lungs and gastrointestinal tract.  Growth hormones are present in high level but does not affect the foetal growth. 28
  • 28. Placental factors:  Foetal weight is directly correlated to placental weight  Foetal growth is highly dependent on structural and functional integrity of placenta.  The total villus surface area increases , diffusion distance decreases, capillaries dilate and the resistance to feto-placental vasculature falls.  The positive remodelling facilitates the enhanced nutrient transport across the placenta. 30
  • 29. Maternal factors  Mother’s diet, nutrient intake and body composition plays an important  Maternal use of tobacco, cigarettes, drugs, alcohol retards foetal growth.  Obstetric complications such as pregnancy induced hypertension, pre- eclampsia, and multiple pregnancy produce foetal growth restriction. 31
  • 30. LAWS OF GROWTH  Growth and development of children is a continuous and orderly process.  The foetus grows fast in the first half of gestation, therefore rate of growth is slowed down until the baby is born  In early postnatal period velocity of growth is high specially in first few months, thereafter slower but steady growth during mid childhood  Second phase of accelerated growth occurs at puberty.  Growth de-accelerates thereafter for sometime and finally ceases. 32
  • 31. Different tissues of body grow at different rates  General body growth  Brain growth  Growth of gonads  Lymphoid growth 33
  • 32. Postnatal Growth A postpartum (or postnatal) period begins immediately after the birth of a child as the mother's body, including hormone levels and uterus size, returns to a non-pregnant state. The terms puerperium or puerperal period, or immediate postpartum period are commonly used to refer to the first 6 weeks following childbirth. 34
  • 33. GENERAL POST NATAL DIMENSIONS AND PROPORTIONS Neonate Skeleton  The neonate has 270 bones as compared to an adult who has 206 bones.  Skull bones in the neonate are 45 (due to incomplete ossification) & in the adult 22.  Frontal bone is in two halves separated by metopic suture and fuses by 2 years  Two Parietal bone are present 35
  • 34.  Occipital bone has four parts, one squamous, two condylar, and one basilar which fuses by 4 years of life .  Each temporal bone has four parts which completely fuses by puberty  Mastoid process is absent in neonates thus stylomastoid foramen lies superficially. 36
  • 35. Body Proportions  The body proportions are a result of a differential rates of growth of the cephalic and caudal ends. Mid point  the mid point of a 2 month old child is at the chest, while in an adult it is at the pubic symphysis region.  At birth- just above umbilicus.  The length of the head doubles by adulthood.  There is an axis of increased growth extending from heads towards the feet. This is called as cephalo caudal gradient. 37
  • 36. 38
  • 37. 39
  • 38. Normal Growth Values  The infant measures 50cm at birth  60cm at three months,  70cm at 9 months,  75cm at one year  A normal Indian child is 100cm tall at age of 4 ½ years  Gains about 6cm in height every year, until age of 12years  Target height : o boys (cm) = father’s ht. + mother’s ht. + 6.5 2 o Girls (cm) = father’s ht. + mother’s ht - 6.5 2 40
  • 39.  1cm/month for next three months  Half cm/month for next 6 months  By one year of age, circumference is 45-47cm  Between one to two year 4 inches increase takes place.  At 10 years  95%of the total head growth completes with the width of the head completed by 3 years while the length of the head completes by 17 to 18 years.  It increases 2cm/month for first three months. 41
  • 40. Posture The new born is usually kept in supine position but can be literally folded in its most comfortable posture ,i.e. the posture simulating the foetal posture of partial flexion, mild lordosis and protuberance of abdomen are common finding at 2-3 years of age but disappears by 4 years. Neck Neck is relatively short at birth and its muscles are not developed at birth for supporting the head. Development of these muscle begin from 2 months onwards. 43
  • 41. Chest  Chest circumference is measured at level of nipples, mid way between inspiration and expiration.  At birth the chest is smaller than the head circumference. It becomes equal at 2 years and by 15 years its ratio becomes 3:2.  The final ratio in adults is 5:3.  The chest is rounded in new born and final shape is attained by the time of puberty. 44
  • 42. Abdomen  The umbilicus of the new born sheds off around the 12th to 15th day after birth.  The umbilicus is everted and in some cases umbilical hernia may be present.  Circumference of the abdomen is equal to the chest until 2 years.  After two years it is less than chest. 45
  • 43. Extremities At birth:- legs are short and arms are long. Arms:-  To measure the mid arm circumference first mark a point midway between tip of the acromian process of scapula and olecranon of ulna, while the child hold the left arm by his side.  birth to 2 years – length increases by 6.75%.  At 8 years - 50% longer than at 2 years.  By 16 to 18 years - slow growth, increased development takes place  Thus an early mature baby has shorter legs than a late matured baby. 46
  • 44. 47
  • 45. Legs  At birth-short and curved.  Birth to 2 years- length increases 40%. A lot of fat on the mesial aspect of the foot gives the appearance of a flat foot.  6 years:- straight, the knock knee and flat foot appearance gets corrected.  8 years-50 % longer than at 2 years.  Adolescence- 4 times longer than at birth.  Early maturer- shorter legs than the late maturer. 48
  • 46. Weight  The weight of the child in nude or minimal clothing is recorded accurately on a lever or electronic type of weighing scale  The weighing scale should have a minimum unit of 100gm. 49
  • 47. Length  Length is recorded under the age of two years.  Child is placed on a rigid measuring table or an infantometer in a supine position  Length of baby is measured from a scale, which is set in the measuring table. 50
  • 48. Standing Height  For the standing height child stands upright, heels separated and weight even on both feet  Head is so positioned that the child looks directly forwards with the Frankfurt’s horizontal plane and biauricular plane being horizontal. 51
  • 49. Head Circumference  Measurement is done using a non stretchable tape the maximum circumference of the head from the occipital protuberance to the supraorbital ridges on the forehead is recorded.  The head circumference is about 35 cm at birth.  Head shape is rounded but sometimes it may get moulded during parturition as over riding of the parietal bone takes place when the head gets engaged in birth canal. 52
  • 50. Changes in Craniofacial Complex The skeletal portion of the craniofacial complex develops as a blend of morphogenesis of primary skull components. 1. Neurocranium consists of  2. Viscerocranium is formed by the bones of facial skeleton which develop by intramembranous ossification. This is derived from the branchial arches. 54 Desmocranium Chondrocranium
  • 51. Dimensional Changes in Craniofacial Structures  These changes can be appreciated even in Intra Uterine Life.  The entire cranium becomes longer and wider in its relation to height.  At birth:- Head makes up about a greater part of total body length whereas in adult it accounts for about one eighth of the total body height. While the size of the cerebral cranium will increase by about 50%, the facial skeleton will grow to more than twice the original size. 55
  • 52. By 4 years:-  Cranial circumference thus increases from about 33cm (at birth) to 50 cm at 3 years after which it only increases by 6 cm. 4th year onwards:-  Facial skeleton increase in all dimensions during the post natal growth period, the increase in height being the greatest (approx. 200%).  In depth the increase is somewhat smaller(approx 75%).  Increase in width is the smallest(approx 15%). 56
  • 53. Fontanelles They bridge the gap between the bones that limit them. They are made up of the duramater, the primitive periosteum and the aponeurosis from inside outwards. 57 (18 to 24 months after birth) (2 months after birth) (3 months after birth) (Begins to close 1 to 2 months after birth, closed completely by 12 months)
  • 54. Clinical importance of fontanelles 1. Enables the foetal skull to modify its size and shape as it passes through the birth canal and permits rapid growth of the brain during infancy. 2. Helps the physician to gauge the degree of brain development by their state of closure. 3. Anterior fontanelle serves as a landmark for withdrawal of blood for analysis from the superior sagittal sinus. 4. Depressed level of fontanelle indicates dehydration and increased level indicates an increased intracranial pressure. 58
  • 55. 59 Encephalitis  Hydrocephalus  Meningitis Fontanels Bulging Down syndrome Premature birth Congenital rubella Fontanels enlarged • Due to malnutritionShrunken
  • 56. Craniofacial Synchondroses It plays an important role in craniofacial development.  Sphenoccipital: closes by 17-20 years.  Sphenoethmoidal :closed by 2-4 years; may persist and fuse later in adolescence, but is of little importance in postnatal growth.  Mid sphenoidal: closes shortly after birth.  Other synchondroses:  1.Intraoccipital  2.Sphenopetrosal  3.Petrooccipital  Craniotabes or soft skull due to paper thin bones is palpable in premature infants. 61
  • 57. Sutures of Cranium 62 Closes at 24 years to 35 years (Closes 22 years to 30 years) (Closes at 29 Years)
  • 58. Clinical Co Relation  The shape of the skull depends on which of the sutures closed prematurely.  Early closure of the sagittal suture (57% of cases) results in frontal and occipital expansion, and the skull becomes long and narrow (scaphocephaly)  Premature closure of the coronal suture results in a short, high skull, known as acrocephaly, or tower skull 63
  • 59. 64  If the coronal and lambdoid sutures close prematurely on one side only, asymmetric craniosynostosis, known as plagiocephaly.  In some cases the cranial vault fails to form (cranioschisis), and brain tissue exposed to amniotic fluid degenerates, resulting in anencephaly.  Children with relatively small defects in the skull through which meninges and/or brain tissue herniate (cranial meningocele and meningoencephalocele, respectively)
  • 60. Face 1. At birth, the lower 3rd and middle 3rd of the face are underdeveloped due to absence of teeth. 2. The forehead is high and bulging. 3. The eyes dominate and owing to the absence of the root of the nose, appear to be widely separated. 4. After the onset of puberty the forehead flattens and widens, lips thicken and face acquires an oval shape, mainly due to growth of the jaws 65
  • 61. 66
  • 62. Nasomaxillary Complex  The maxilla develops in the membranous tissue at the end of sixth foetal week.  The maxilla is attached to the neurocranium directly with the fronto maxillary sutures and indirectly by means of various other facial structures such as the nasal, lacrimal and ethmoidal bones, nasal septum including vomer, palatine bone and zygomatic bone. These structures are joined in edge to edge relation.  During early phase interrelation between jaws are characterised by mandibular protrusion, which gradually reversed. 67
  • 63. 68  At birth the maxilla is placed more anteriorly giving class II relationship of the jaws.  Later on both maxilla and mandible with their associated soft tissue grows forward and downward & establish a normal class 1 relationship.  Maxillary sinuses are not well developed and are present like slits.  Development of orbital cavities complete at birth.  The alveolar process can only be faintly discerned and palate has weak transversal curvature.  The maxillary body is almost entirely filled with the developing teeth.
  • 64. 69
  • 65. 72
  • 66. Clinical Co relation Facial clefts- a. Cleft lip and palate b. Median cleft lip c. Oblique facial clefts 73 Teratogens are likely to cause lip defects if the embryo is exposed to them during 5th & 6th weeks. The palate is more susceptible between 7th and 8th week.
  • 67. Mandible  At birth, the two rami are short and condylar development is minimal.  A thin line of fibrocartilage and connective tissue exists at the midline of the symphysis to separate the right and left mandibular bodies. This symphyseal cartilage is replaced by bone (between 4 months of age and end of 1stYear)  The alveolar processes and the muscles are poorly developed at this age, so that its basal arch mainly determines the shape of the mandible in the neonate.  At birth the structure of mandible is shell like with the 10 alveolar sockets for the developing tooth germs. 74
  • 68.  During the 1st year of life, appositional growth is specially active at alveolar border, at the distal and superior surface of ramus, condyle and lower border of mandible along with lateral surfaces  After the 1st year , resorption occurs along the anterior border of ramus lengthening the alveolar border  Transverse dimensions, after 1 year are mainly due to the growth at posterior border in an expanding “V” pattern.  The two rami diverge outwards from below to above so that additive growth at the coronoid notch, coronoid process and condyle also increases the superior inter ramus dimensions. 75
  • 69.  The position of mandibular foramen changes by remodeling, to a more superior position from occlusal plane as child matures.  The foramen is below the occlusal plane in a very young child, slightly at the occlusal plane during the period of primary dentition .  It averages 7mm above the occlusal plane in the adult.  Angle of mandible is more obtuse in young children.  Mental foramen is placed very close to border of mandible in young children  Forward shift of growing mandibular body changes direction of mental foramen during infancy & childhood. 76
  • 70. 77
  • 71. 78
  • 72. 79 Inferior Alveolar Nerve Block Clinical implication-
  • 73. 80 Mental Nerve  In infants and children, the syringe needle may be applied at right angles to the body of the mandible to enter the mental foramen  In the adult, the needle must be applied obliquely from behind to achieve entry
  • 74. Temporomandibular Joint Three phases of development are seen in the intrauterine life period. 1.Blastemic stage:- (7 to 8 weeks of development) corresponds with the organisation of the condyle, articular disc and capsule. 2.Cavitation stage:- (9 to 11 weeks of development) corresponds to the initial formation Of inferior joint cavity and then start of condylar chondrogenesis. 3.Maturation stage:- (after 12 weeks of development) 81
  • 75. Postnatal Changes in TMJ 1. At birth the articular disc is flat and develops an accentuated S-shaped profile as the articular tubercle develops. 2. Condylar cartilage is approximately 1.5 mm thick at birth, but soon thins down to about 0.5 mm, by 20 to 30 years of life it is completely replaced by endochondral ossification. 3. Mandibular condyle grows in a constant posterior, superior and lateral direction and attains a mature contour by late mixed dentition period. 82
  • 76. 83 Oral features of Neonate Upper Gum Pad Gingival Groove Dental Groove Lateral Sulcus
  • 78. Relationship of Gum Pads  There is no definite anteroposterior relationship of the gum pads on occlusion, but the lower gum pad being smaller, the lateral sulcus of the lower gum pads lies distal to that of the upper.  Variable overjet with contact only in the first molar segments.  During function the mandibular movements at this stage are mainly vertical and to a very small extent in the anteroposterior direction. Lateral movements are absent.  During the early phases of foetal development the sagittal interrelationship of the jaws is characterized by a mandibular protrusion ,which is gradually reversed.  At birth the lower jaw is often situated posteriorly .this relationship has some clinical significance as disturbed postnatal forward growth of the mandible may result in Malocclusion. 85
  • 79. 86
  • 80. Growth of Gum Pads  At birth the width of the gum pads are inadequate to accommodate all the incisors  The growth of the gum pads is rapid in the first year after birth.  Growth is more in transverse direction and in the labiolingual direction.  Due to growth the segments of each gum pads become prominent. 87
  • 81. Tongue  It is comparatively large in relation to the small mouth.  Tongue is flat, thin and blunt tipped.  The tongue at this stage performs only one function i.e. acts as piston while sucking.  It is formed from 3 swellings, i.e. lingual swelling, tuberculum impar and hypobrachial eminence. 88
  • 82. Buccal Pad of Fat  It is also called as corpus adiposum or bichat”s fat pad.  It is child’s reserve of energy, it is nothing but the cheek prominence giving the infant a chubby cheek appearance. It is formed of a thin encapsulated mass of fat lying between the subcutaneous fat and the muscles of cheek.  Exact role in suckling is not known but it regress as suckling ceases. 89
  • 83. External Features of a Newly Born Child Skin • Colour:- Often reddish • May have an appearance of cyanosis • Mongolian Spots • Vernix Caseosa • Premature infant has deep red skin with fine, soft, immature lanugo hair. • Post term infants may show a whitish, peeling, parchment like skin. • Erythema toxicum • Pustular melanosis is a similar, benign vesiculo popular rash at birth in some blacks, around the chin, back, extremities, palms and soles. 90
  • 85. 92 Nose  Small and flat with narrow nostrils.  Bridge of the nose is depressed. Maximal growth of the nasal cartilage occurs till puberty, after which it attains it’s final form.  Hair within nose become thicker around puberty. Lips  Lips of a new born are reddish pink, soft and supple.  The midline of the upper lip has a small projection, the labial tubercle (sucking callus) which is said to disappear after the cessation of suckling.  Abrupt separation of the mucosa covering the inner aspect of the lips from the outer aspect by a thin single line, parallel to the free border of lip.  Undergo a slow transformation to form the transition zone between the outer and inner aspects after one year.
  • 86. What is reflex? Definition:- It is an involuntary, or autonomic , action that the body does in response to something , without even having to think about it. The reflexes can be broadly studied under 3 categories:- 1.General body reflex 2.Facial reflex 3.Oral reflex 93
  • 87. Reflexes present at Birth i. Moro reflex ii. Startle reflex iii. Grasp / Palmar reflex iv. Walking / Stepping reflex v. Limb placement reflex vi. Asymmetric tonic neck reflex vii. Babinski’s reflex viii.Parachute reflex ix. Landau reflex x. Tendon reflex xi. Abdominal reflex 95
  • 88. i. Moro Reflex  Any sudden movement of the neck initiates this reflex.  A satisfactory way of eliciting the reflex is to pull the baby half way of eliciting the reflex is to pull the baby half way to a sitting position from the supine and suddenly let the head fall back to a short distance.  The reflex consists of a rapid abduction and extension of the arms with the opening of hands. Arms then come together as in an embrace.  The Moro reflex is present at birth, peaks in the first month of life, and begins to disappear around 2-3 months of age 96
  • 89. Clinical Importance  It’s nature gives an indication of muscle tone.  The response may be asymmetrical if muscle tone in unequal on the two sides, or if there is weakness of an arm or any injury to the humerus or clavicle.  Bilateral absence of the reflex may be linked to damage to the infant's central nervous system, while a unilateral absence could mean an injury due to birth trauma.  In human evolutionary history, the Moro reflex may have helped infants cling to the mother while being carried around. 97
  • 90. ii. Startle Reflex  Similar to Moro reflex but it is initiated by a sudden noise or any other stimulus.  The elbows are flexed and the hands remain closed, there is less of embrace, outward and inward movement of the arms.  By the time your baby is 3 to 6 months old, they probably won't demonstrate the strartle reflex any longer. 98
  • 91. iii. Palmar/ Grasp reflex  When the baby’s palm is stimulated, hands closes.  There is also a corresponding PLANTAR reflex.  Normally disappears by 24 months. Clinical Significance  An exceptionally strong grasp reflex may be found in the spastic form of cerebral palsy and in kernectirus.  It may be asymmetrical in hemiplegia and in cases of cerebral damage. It should have disappear in in 2 or 3 months and persistence may indicate the spastic form of cerebral palsy. 99
  • 92. iv. Walking/ Stepping reflex When the sole of the foot is pressed against the couch, the baby tries to walk. It persists as voluntary standing. 100
  • 93. v. Limb Placement Reflex When the front of the leg below the knee, or the arm below the elbow is brought into contact with the edge of the table, the child lifts the limbs over the edge. Clinical significance- Reflex is readily demonstrable in newborn and persistent failure to elicit it at this stage is thought to indicate neurological abnormality. This reflex disappears by 6 weeks due to increased ratio of leg weight to strength. It reappears by 8 month to 1 year when the child starts to walk. 101
  • 94. vi. Asymmetric tonic neck reflex 102  When the baby is at rest and not crying, he lies at intervals with his head on one side, the arms extended to the same side and often with the flexion of the opposite knee.  Also called as ‘fencing posture' .  This reflex is present at one month of age and disappears at around four months , but may persist in spastic children.  If the infant is unable to move out of this position or the reflex continues to be triggered past six months of age, the child may have a disorder of the upper motor neurons. According to researchers, the tonic neck reflex is a precursor to the hand/eye coordination of the infant. It also prepares the infant for voluntary reaching.
  • 95. vii. Babinski’s reflex  The Babinski reflex occurs after the sole of the foot has been firmly stroked. The big toe then moves upward or toward the top surface of the foot. The other toes fan out.  It is named after the Russian neurologist Boris Petrovitch Babkin. 103
  • 96. viii. Parachute Reflex  It appears at about 6-9 months and persists thereafter. The reflex is elicited by holding the child in ventral suspension and suddenly lowering him to the couch. The arms extend as defensive reaction.  In children with cerebral palsy, the reflex may be absent or abnormal. 104
  • 97. ix. Landau reflex  It is seen in vertical suspension, with the head, spine and legs extended.  If the head is reflexed, the hips, knees and the elbows also flex.  It is normally present from 3 months and is difficult to elicit after 1 year.  It is poor in those with floppy infant syndrome and exaggerated in hypertonic and opisthotonic infants. 105
  • 98. x. Tendon reflex106  They are present in neonate.  They are of great value for the diagnosis of cerebral palsy.  In spastic children the tendon jerk are exaggerated.  The pectoralis major was the most readily elicitable reflex in all infants(100%), regardless of maturity.
  • 99. xi. Abdominal Reflex They are also present in most of the new born babies. In these reflex there contraction of the muscles of the abdominal wall on stimulation of the skin or tapping on neighboring bony structures. 107
  • 100. 108 Nasal reflex Stimulation of the face or nasal cavity with water or local irritants produces apnea in neonates. Breathing stops in expiration with laryngeal closure and infants exhibit bradycardia and lowering of cardiac output. Blink reflex Various stimuli provoke blinking. Whether the child is awake or asleep, pupils of the eyes react to changes in the intensity of light. Facial Reflex
  • 101. 109 Corneal reflex Consists of blinking when the Cornea is touched. When the stimulus ,whether sound, light, or touch, has been received . The reflex occurs at a rapid rate of 0.1 seconds. Pupil reflex The pupils react to light, but in the preterm baby and some full term babies the duration of exposure to light may have to be prolonged to elicit the reflex. The light should not be bright, for a bright light will cause closure of the eyes. Doll’s Eye Reflex Normal response in newborns to keep the eyes stationary as the head is moved to the right or left. The reflex disappears as ocular fixation develops. During the first week they are able to maintain these fixations against passive
  • 102. Oral Reflexes Consists of the following types of reflexes:110 Rooting Reflex Suckling Reflex Swallowin g Gag Reflex Masticatio n
  • 103. i. Rooting Reflex  When the infants cheek contacts the mother's breast, the baby's mouth results in vigorous sucking movements resulting in the baby rooting for milk.  When the corner of the mouth is touched, the lower lip is lowered, the tongue moves towards the point stimulated. when the finger slides away, the head turns to follow it.  When the centre of Upper lip is stimulated, the lip elevates. Onset: 28 weeks IU Well established: 32-34 weeks IU Disappears: 3-4 months 111
  • 104. ii. Suckling Reflex  Onset – 28 weeks IU  Well established:32 to 34 weeks IU  Disappears: starting around 12 months  Elicited by: the sucking reflex is tested by introducing a finger or teat into the mouth, when vigorous sucking will occur. 112
  • 105. iii. Swallowing Begins around 12.5 weeks of IU life. Full swallowing and sucking is established by 32-36 weeks of IU life.  Infantile swallow Until the primary molars erupt, infant swallow with the jaws separated and the tongue thrust forward using facial muscles(orbicularis oris and the buccinator).This is a non conditional congenital reflex.  Acquired congenital reflex After eruption of the posterior primary teeth, from 18 months of age onwards, the child tends to swallow with the teeth brought together by the masticatory muscle action, without a tongue thrust. 113
  • 106. 114 Cry reflex  It is a un conditioned reflex which accounts for its lack of individual character and is of sporadic nature.  It starts as early as 21-29 weeks intrauterine.
  • 107. Significance of Pedologic Anatomy in Pedodontics  Knowledge of pedologic anatomy is very helpful for a pedodontist. It not only serves as an adjunct in diagnosis but also helps in treatment planning  The knowledge of the development of motor skills and language similarly also helps a pedodontist to gauge whether the development is going on at a proper rate or not 115
  • 108.  The anatomical post natal development also aids in a similar way.  The knowledge of various growth spurts helps in planning treatment specially in interceptive orthodontic cases, where growth has to be modified or wherever surgery is involved e.g. in cleft cases, functional jaw orthopaedics. 116
  • 109. References  Tandon S, Introduction to pedodontics, In: Text book of pedodontics, 2nd edition, hyderabad paras medical publisher, 2008, pg 50-63.  Inderbir Singh, Alimentary System, In: Human Embryology, 8th edition, Macmillan Publishers, 2010, pg 126- 166.  S G Damle, Growth and Development. In:Textbook of Pediatric Dentistry, 5th Edition, Arya Medi Publishing House, 2017, pg 304-328  S I Bhalajhi, Growth and Development, General Principles and Concepts, In Textbook of Orthodontics, 5th Edition, Arya Medi Publishing House, 2013, pg 9-49 117
  • 110. Frequently Asked Questions 1. Growth Spurts 2. Scammon’s Curve 3. Gum Pads 4. Reflexes present at birth 118
  • 111. 119
  • 112. Pupillary Membrane Persistent pupillary membrane (PPM) is a condition of the eye involving remnants of a fetal membrane that persist as strands of tissue crossing the pupil. The pupillary membrane in mammals exists in the fetus as a source of blood supply for the lens. 120
  • 113. Meconium It is the dark green substance forming the first faeces of a newborn infant. Meconium aspiration syndrome (MAS) also known as neonatal aspiration of meconium is a medical condition affecting newborn infants. It describes the spectrum of disorders and pathophysiology of newborns born in meconium-stained amniotic fluid (MSAF) and have meconium within their lungs. 121
  • 114. Amniotic Fluid During pregnancy, your growing baby is cushioned inside a fluid-filled bag (amniotic sac) in your womb (uterus). Amniotic fluid protects the developing baby by cushioning against blows to the mother's abdomen, allowing for easier fetal movement and promoting muscular/skeletal development. Amniotic fluid swallowed by the fetus helps in the formation of the gastrointestinal tract. 122
  • 115. 123 Delayed growth puts the baby at risk of certain health problems during pregnancy, delivery, and after birth. They include: •Low birth weight •Difficulty handling the stresses of vaginal delivery •Decreased oxygen levels •Hypoglycemia (low blood sugar) •Low resistance to infection •Low Apgar scores (a test given immediately after birth to evaluate the newborn's physical condition and determine need for special medical care) •Trouble maintaining body temperature •Abnormally high red blood cell count In the most severe cases, IUGR can lead to stillbirth. It can also cause long-term growth problems. Causes of Intrauterine Growth Restriction IUGR has many possible causes. A common cause is a problem with the placenta. The placenta is the tissue that joins the mother and fetus, carrying oxygen and nutrients to the baby and permitting the release of waste products from the baby. Intra Uterine Growth Restriction
  • 116. 124 The condition can also occur as the result of certain health problems in the mother, such as: •Advanced diabetes •High blood pressure or heart disease •Infections such as rubella, cytomegalovirus, toxoplasmosis, and syphilis •Kidney disease or lung disease •Malnutrition or anemia •Sickle cell anemia •Smoking, drinking alcohol, or abusing drugs Other possible fetal causes include chromosomal defects in the baby or multiple gestation (twins, triplets, or more). IUGR Symptoms The main symptom of IUGR is a small for gestational age baby. Specifically, the baby's estimated weight is below the 10th percentile -- or less than that of 90% of babies of the same gestational age. Depending on the cause of IUGR, the baby may be small all over or look malnourished. They may be thin and pale and have loose, dry skin. The umbilical cord is often thin and dull instead of thick and shiny. Not all babies that are born small have IUGR.
  • 117. 125 Indian Population India with 1.21 billion people constitutes as the second most populous country in the world, while children represents 39% of total population of the country. The figures show that the larger number of about 29 percent constitutes Children in the age between 0-5 years.
  • 119. 127
  • 120. 128

Editor's Notes

  1. I would be discussing under following headings
  2. As a dentist the knowledge of paediatric anatomy is essential for correct diagnosis and to recognise some developing characteristics of child which can be confused with abnormality and pathological condition
  3. An ova consists of 22 + X chromosomes. Cleavage:- The process of subdivision of the ovum into smaller cells. One cell divides first so that we have a 3 cell stage embryo followed by a 4 and then 5 cell stage. As cleavage proceeds, ovum comes to have 16 cells called as morula (looks like mulberry) which is surrounded by zona pellucida. Inner and outer layer cells Outer layer cells are called trophoblast. Inner cell mass give rise to embryo proper called embryoblast. The cells of trophoblast help to provide nutrition to the embryo. Some fluid now passes into the morula from uterine cavity and partially separates the cells of the inner cell mass from those of the trophoblast. As fluid increases, the morula acquires the shape of a cyst. The cells of the trophoblast become flattened and the inner cell mass comes to be attached on the inner side of the trophoblast. The morula has now become blastocyst. The side of the blastocyst to which the inner cell mass is attached is called embryonic or animal pole, while the opposite side is abembryonic pole.
  4. The region where the crescentic masses of the ectoderm and endoderm come into direct contact with each other constitutes a thin membrane, the buccopharyngeal membrane (or oropharyngeal membrane), which forms a septum between the primitive mouth and pharynx.
  5. The external appearance of the embryo is changed by an increase in head size and formation of the limbs, face, ears, nose, and eyes. The former are located dorsal to the pericardial swelling at the level of the fourth cervical to the first thoracic somites, which explains their innervation by the brachial plexus. Hindlimb buds appear slightly later just caudal to attachment of the umbilical stalk at the level of the lumbar and upper sacral somites. With further growth, the terminal portions of the buds flatten and a circular constriction separates them from the proximal, more cylindrical segment. Soon, four radial grooves separating five slightly thicker areas appear on the distal portion of the buds, foreshadowing formation of the digits. These grooves, known as rays, appear in the hand region first and shortly afterward in the foot, as the upper limb is slightly more advanced in development than the lower limb. While fingers and toes are being formed a second constriction divides the proximal portion of the buds into two segments, and the three parts characteristic of the adult extremities can be recognized because counting somites becomes difficult during the second month of development, the age of the embryo is then indicated as the crown-rump length (CRL) and expressed in millimeters CRL is the measurement from the vertex of the skull to the midpoint between the apices of the buttocks.
  6. Clinical Co Relation Somites are bilaterally paired blocks of para axial mesoderm that form along the long axis of developing embryo. Approximate Age (days) - No. of Somites 20 = 1–4 21 =4–7 22 =7–10 23 =10–13 24 =13–17 25 =17–20 26 =20–23 27 =23–26 28 =26–29 30 =34–35
  7. Birth Defects This period is when most gross structural birth defects are induced. If the mother doesn’t avoid harmful influences, such as cigarette smoking and alcohol it may lead to fetal alcohol syndrome.
  8. normal fetal heart rate is about the same heart rate as the mother's: 80 to 85 beats per minute (bpm). By the beginning of the ninth week of pregnancy, the normal fetal heart rate is an average of 175 bpm
  9. Lanugo – hair on fetus
  10. The vernix caseosa is a protective layer on baby’s skin. It appears as a white, cheese-like substance. This coating develops on the baby’s skin while in the womb. Traces of the substance may appear on skin after birth. The vernix caseosa contributes to babies having soft skin after birth. It also protects baby’s skin from infections while in the womb. The amount of vernix caseosa on your baby’s skin decreases the closer you get to your due date. It’s normal for full-term babies to have the substance on their skin. First Fetal Movement: Quickening. Some moms can feel their babies move as early as 13-16 weeks from the start of their last period. These first fetal movements are called quickening and are often described as flutters.
  11. During the sixth month, the skin of the foetus is reddish and has a wrinkled appearance because of the lack of underlying connective tissue. A foetus born early in the sixth month has great difficulty surviving. Although several organ systems are able to function, the respiratory system and the central nervous system have not differentiated sufficiently, and coordination between the two systems is not yet well established. By 6.5to 7 months, the foetus has a length of about 25 cm and weighs approximately 1100 g. If born at this time, the infant has a 90% chance of surviving. Amelogenesis imperfecta is a disorder of tooth development. This condition causes teeth to be unusually small, discolored, pitted or grooved, and prone to rapid wear and breakage.
  12. Atrophy- shrink , wither , deteriorate
  13. Lanugo - fine, soft hair, especially that which covers the body and limbs of a human fetus.
  14. CRL is the measurement from the vertex of the skull to the midpoint between the apices of the buttocks
  15. Meconium aspiration syndrome (MAS) also known as neonatal aspiration of meconium is a medical condition affecting newborn infants. It describes the spectrum of disorders and pathophysiology of newborns born in meconium-stained amniotic fluid (MSAF) and have meconium within their lungs. Neonatal respiratory distress syndrome (NRDS) is more common in premature babies born six weeks or more before their due dates. It usually develops within the first 24 hours after birth. Symptoms include rapid, shallow breathing and a sharp, pulling-in of the chest below and between the ribs with each breath. Treatment includes medication to keep the lungs open, breathing support and oxygen therapy. There is considerable variation in foetal length and weight, and sometimes these values do not correspond with the calculated age of the foetus in months or weeks. Most factors influencing length and weight are genetically determined, but environmental factors also play an important role. Causative factors include chromosomal abnormalities (10%); teratogens; congenital infections (rubella, cytomegalovirus, toxoplasmosis, and syphilis); poor maternal health (hypertension, renal and cardiac disease); the mother’s nutritional status and socioeconomic level; her use of cigarettes, alcohol, and other drugs; placental insufficiency; and multiple births (e.g., twins, triplets). Foetuses that weigh less than 500 g seldom don’t survive, while those that weigh 500 to 1000 g may live if provided with expert care. However, approximately 50% of babies born weighing less than 1000 g who survive will have severe neurological deficits. Infants may be full term, but small because of IUGR or small because they are born prematurely.
  16. Thyroxine is the main hormone secreted into the bloodstream by the thyroid gland. It is the inactive form and most of it is converted to an active form called triiodothyronine by organs such as the liver and kidneys. Levothyroxine, a thyroid hormone, is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. Levothyroxine is also used to treat congenital hypothyroidism (cretinism) and goiter (enlarged thyroid gland Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor, that is present in almost every vertebrate animal cell. A glucocorticoid is a hormone that affects the metabolism of fats and proteins, but especially carbohydrates. Glucocorticoids are produced in the cortex of the adrenal gland and is classified as a steroid
  17. patients with high levels of growth hormone (e.g., acromegaly) have increased serum IGF-1 concentrations. The production of IGF-2 is less dependent on the secretion of growth hormone than is the production of IGF-1, and IGF-2 is much less important in stimulating linear growth. IGF insulin like growth factor, EGF-epidural, TGF-transforming, PDGF-platelet derived, FGF- FIBROBLAST,
  18. Also conditions like chronic renal failure, congestive heart failure and acquired conditions like rubella, syphilis, HIV, CMV, toxoplasmosis. Eclampsia – is a condition in which one or more convulsions occur, in pregnant women suffering from high B.P. Often followed by coma and posing a threat to the mother and the baby.
  19. Growth spurts seem to be period when a sudden acceleration of growth occurs due to hormonal secretion. Just before birth One year after birth Mixed dentition growth spurt Boys (8-11 years); Girls ( 7-9 years) Pre Pubertal growth spurts Boys (14-16 years); Girls (11-13 years)
  20. General tissue or visceral tissue consist of the muscles, bones and other organs. These tissues exhibit an S shaped curve with rapid growth up to 2-3 years of age followed by a slow phase of growth between 3-10 years. After the 10th year a rapid phase of growth occurs terminating by 18-20th year. Neural tissues grows rapidly & almost reaches adult size by 6-7 years of age. Very little growth of neural tissue occurs after 6-7 years. This facilitates intake of further knowledge. Genital tissue consist of reproductive organs and grow rapidly at puberty reaching adult size after which growth ceases. Lymphoid tissue proliferate rapidly in late childhood & reaches almost 200% of adult size. This is an adaptation to protect children from infection, as they are more prone to it. By about 18 years of age, lymphoid tissue undergo involution to reach adult size.
  21. At birth, 22% of body area is covered by head This decreases to 13% at 12 years 10% - adult
  22. Lordosis refers to your natural lordotic curve, which is normal. But if your curve arches too far inward, it's called lordosis, or swayback. Lordosis can affect your lower back and neck. This can lead to excess pressure on the spine, causing pain and discomfort
  23. Frankfort Horizontal Plane : connects the lowest point of the orbit (orbitale) & the superior point of the external auditory meatus (porion)
  24. Desmocranium which comprises the vault of the skull or calvarium. It evolved in response to need for protection of the brain and is formed of the intramembranous bone. Chondrocranium forms the base of the skull, which ossifies as an endochondral bone.
  25. Fontanelles present at birth:- 1.Anterior fontanelle, between the parietal bone and frontal bone. 2.Posterior fontanelle, between the two parietal bones and occipital bone. 3.Sphenoid fontanelle ,between frontal ,parietal, temporal and the sphenoid bone. 4.Mastoid fontanelle. between the parietal ,occipital and temporal bone. Anterior fontanelle(frontal):-18 to 24 months after birth. Posterior fontanelle(occipital):-2 months after birth. Anterolateral fontanelle(sphenoid):-3 months after birth(paired). Posterolateral fontanelle(mastoid):-begins to close 1 to 2 months after birth, closed completely by 12 months (paired). Aponeurosis is a sheet of pearly white fibrous tissue which takes the place of a tendon in sheet-like muscles having a wide area of attachment
  26. Encephalitis is an acute inflammation (swelling) of the brain usually resulting from either a viral infection or due to the body's own immune system mistakenly attacking brain tissue. Hydrocephalus is a condition in which there is an accumulation of cerebrospinal fluid (CSF) within the brain. This typically causes increased pressure inside the skull. Meningitis is an inflammation of the membranes (meninges) surrounding your brain and spinal cord. The swelling from meningitis typically triggers symptoms such as headache, fever and a stiff neck. Down syndrome is a genetic disorder and the most common autosomal chromosome abnormality in humans, where extra genetic material from chromosome 21 is transferred to a newly formed embryo. Congenital rubella syndrome occurs when the rubella virus in the mother affects the developing baby, usually in the first three months of pregnancy. Since the introduction of the rubella vaccine, cases have decreased dramatically. Symptoms include a cloudy or white appearance to the eyes due to cataracts, deafness, heart defects and developmental delay.
  27. Where the connecting medium is hyaline cartilage, a cartilaginous joint is termed a synchondrosis. An example of a synchondrosis joint is the first sternocostal joint (where the first rib meets the manubrium). In this example, the rib articulates with the manubrium via the costal cartilage. (The rest of the sternocostal joints are synovial plane joints.)
  28. Coronal suture: between the frontal and parietal bones: Closes-24 years to 35 years of age. Sagittal suture: between two parietal bone closes: 22 years to 30 years of age. Lambdoidal suture: between two parietal and occipital bones. Starts to close around 29 years of age. Squamous sutures and lateral anteroposterior sutures; between the squamous portion of the temporal bone and the parietal bone. The squamous sutures close later in life.
  29. 5. The child’s convex profile is straightened out, owing to the more anterior position of the jaws. 6. The development of chin prominence and deeper portions of the eyes through growth of orbital ridges and ridge of nose enhances this impression.
  30. Oblique facial cleft:- Non fusion of maxillary and lateral nasal process giving rise to cleft running from the medial angle of the eye to the mouth. Nasolacrimal duct is not formed. Cleft lip:- malfusion of medial nasal prominences Palate is formed by fusion of the maxillary processes with the frontonasal process. Cleft palate:-
  31. In children below 5 years of age, the mandibular foramen lies about 0.5 mm below the occlusal plane, due to the underdeveloped ramus of the mandible. At about age of 6 years, mandibular foramen is at the level of occlusal plane. In children above 6 years, the needle should be placed above the occlusal plane.
  32. Changing direction of the foramen has clinical implications in the administration of local anesthetic to the mental nerve:
  33. It is horse shoe shaped. Gingival groove- it is the groove separating the gum pad from the palate. Dental groove- it originates in the incisive papilla region and extends backwards to touch the gingival groove in the canine region and then laterally to end in the molar region. Lateral sulcus-it is deepened groove separating the canine and deciduous first molar segments.
  34. It is U shaped, with its anterior portion everted labially. It also shows gingival groove that demarcates the lingual extent of the gum pad. Dental groove running from the mandible backwards, laterally to join the gingival groove in the canine region. Lateral sulcus a deepened groove separating the canine and deciduous first molar segments.
  35. Macroglossia is more common than microglossia and can be associated with a number of genetic abnormalities including: trisomy 21 (Down syndrome), acromegaly, Beckwith-Wiedemann syndrome, mucopolysaccharidoses and primary amyloidosis. There is also an association with congenital hypothyroidism and diabetes.
  36. May have an appearance of cyanosis due to thin skin and high content of haemoglobin content of the blood even when CO2 is high, while a deep red purplish appearance may be the result of transient anoxia resulting from a closed glottis prior to a vigorous cry. Mongolian Spots are slate blue coloured, well circumscribed patches of pigmentation over the back, buttocks & sometimes over the other parts occurring in more than 50% of black infants and occasionally in white infants. Vernix Caseosa is a whitish covering over the skin formed by sebaceous secretion and exfoliated epithelial cells around the end of the fifth month of gestation, may persist even after birth or may be stained with the amniotic fluid contaminated with meconium. Erythema toxicum is a rash of whitish, vascular, vesiculo pustuler papules with erythematous base that may appear soon after birth, lasting for 1 week on the trunk, face & extremities.
  37. Size:- Small at birth, being one third of the adult size. Maximum growth occurs in the first year and continues rapidly decelerating rate till three years and further slows down till puberty. Cornea:- At birth, the cornea is relatively more (10mm) and nearly fills the palpebral fissures. It reaches an adult size (12mm) by 2 years, after which the posterior aspect of the eye grows, giving the eyeball in final spherical shape. The lens:- More or less spherical and has greater refracting power The fundus:- Less pigmented than adults, forms by 4-6 months The retina:- Has a fine peppery mottling. The peripheral retina appears pale or greyish since the peripheral vasculature is immature.
  38. Kernectirus:- When severe jaundice goes untreated for too long, it can cause a condition called kernicterus. Kernicterus is a type of brain damage that can result from high levels of bilirubin in a baby's blood. It can cause athetoid cerebral palsy and hearing loss. Hemiplegia:- paralysis of one side of the body.
  39. opisthotonic posturing. Abnormal motor posturing, classified as decorticate, decerebrate or opisthotonic posturing is characterised by generalised extension of the trunk and lower limbs with increased muscular tone
  40. The suckling reflex involves a front to back movement of the tongue. The tongue is deeply cupped and this allows the infant to extract liquid from a breast or bottle. ... The main difference between suckling and sucking is that suckling is a primitive reflex and sucking is a more mature pattern
  41. Vancouver style of referencing
  42. Hydramnios :- Over 1500ml Oligamnios:- too little fluid
  43. Scoliosis is a sideways curvature of the spine that occurs most often during the growth spurt just before puberty. While scoliosis can be caused by conditions such as cerebral palsy and muscular dystrophy, the cause of most scoliosis is unknown. Lordosis:- Too much is referred to as sway-back. It may be inherited or caused by conditions such as arthritis, muscular dystrophy and dwarfism. Lordosis causes an unusually large, inward arch on the lower back, just above the buttocks. The condition may cause lower back pain. Hyperlordosis is when the inward curve of the spine in your lower back is exaggerated.  Hypolordosis (Flatback) More common than hyperlordosis, Hypolordosis means there's less of a curve in the lower back or a flattening of the lower back. This occurs because the vertebrae are oriented toward the back of the spine, stretching the disc towards the back and compressing it in the front  Hunchback (kyphosis) usually refers to an abnormally curved spine. It's most common in older women and often related to osteoporosis. Some people with kyphosis have back pain and stiffness. Others have no symptoms other than an exaggerated forward rounding of the back.