A genetic chimerism or chimera is a single organism composed of cells with more than one distinct genotype

1. CHIMERA (Genetics)
Melvin Alex

2. Hybrid vs Chimera
X
Horse Donkey
Mule

3. Chimera (Genetics)
A chimera is a mixture of two separate
organisms, with discrete parts of each.

4. Sheep-Goat Chimeras

5. Chimeras in mythology

6. Naturally occurring chimeras are rare,
usually found only in same species
Free martin fetus with conjoined circulation:
The key to understanding immunological tolerance

7. Fetal-Maternal chimerism in humans
Dr. Lee Nelson

8. Humanzee
• Human STEM cells are
injected into a chimp
blastocysts
• It will help us to find how cells
grow and interact inside an
animal.
By, Mriganka

9. Humans and Chimps share a LOT of DNA!

10. Procedure
Delete
specific
piece of
animal DNA
Inject
embryo with
human
STEM cells
Embryo is
then put
back inside
animal

11. Applications
• Xenotransplantation
• To understand how our cells grow and interact inside an animal.
• To make functional human tissues
• Immunological tolerance

12. ETHICAL ISSUES
• Because it involves research on human embryos.
• It disregards the welfare of animals and animal species
involved.
• More specifically, because it disregards the welfare of higher
primates involved.

13. Conclusion
• “Chimps share 98% of the human genome, and a fully mature chimp
has the equivalent mental abilities and consciousness of a four-year-
old human. Fusing a human and chimpanzee embryo—which
researchers say is feasible—could produce a creature so human that
questions regarding its moral and legal status would throw 4,000
years of ethics into chaos. Would such a creature enjoy human
rights? Would it have to pass some kind of ‘humanness' test to win
its freedom? Would it be forced into doing menial labor or be used to
perform dangerous activities?”