application of nanotechnology in veterinary science

1. Submitted to:
Dr. ADITYA MISHRA
Officer- In-charge
Seminar/Synopsis
Major Advisor
Dr. Y. P. SAHNI
Director Research Services
Presented by:
NARENDRA SINGH
M.V.Sc. Scholar
J/V/M/ 22/2016
DEPARTMENT OF VETERINARY PHARMACOLOGY AND TOXICOLOGY
COLLEGE OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY
JABALPUR (M.P.)

2. (Boulaiz et al., 2011)
Nanotechnology

3. http://www.terressentials.com/exposure.html
This is one
nanometer!
Man is 1.62 meter
tall or 2 billion nm
2 µm wide
2 nm wide

4. Polymeric
nanoparticles
Liposomes
Nanotubes
Solid lipid
nanoparticles
(SLNs)
Micelles

5. Quantum
dots
Nanoemulsion
Respirocytes
Microbivores

6. (Yang, 2000)
• Natural and synthetic
polymers
• The active components
are entrapped

7. • An aqueous core
phospholipid bilayer
• Suitable for topical,
intravenous and intra
muscular administration
(Bakker-Woudenberg et al., 2005)

8. • Sequence of nanoscale C60
atoms
• Potent and selective
antibacterial agent
buckytubes
(Fernandez-lopez et al., 2001)

9. • SLN are composed of
lipids that are solid at
room temperature
• Adhering to mucosal
surfaces
(Muller and Keck, 2004)

10. • Self-assembly of
amphiphiles in water
• Hydrophilic shell is
highly water soluble
(Koo et al., 2005)

11. • In veterinary, quantum
dots are used in blood
sample to screen for
proteins
• Quantum dots are
used as a probe and in
immune assays
(Mohanty et al., 2014)

12. • Nanoemulsions are
dispersion of oil and
water
• Ability to solubilise
lipophilic substances
and to protect them
from degradation
(Vandamme and Anton, 2011)

13. • Higher capacity to
deliver 236 times
more oxygen per unit
volume than natural
red blood cells
(Mohanty et al., 2014)

14. Functions
• Destroy pathogens
found in animal
bloodstream
• Clear the bloodstream
in septicaemia
(Freitas et al., 2005)

15. (Derfus et al., 2004)
Nanoparticles
Generation ROS
Release of ions
Interruption of
electron transport
DNA Damage

16. Disease
diagnosis
Treatment
of diseases
Drug delivery system
Animal Reproduction
Animal Breeding
Livestock Products
Food safety
through identity
preservation

17. Applications
• Detection of gene
mutation
• Detection of cystic
fibrosis
• To locate source of
pathogen such as
avian flu and mad
cow disease
DNA BIOCHIP
(Hirsch et al., 2003)

18. Quantum dot
for cancer cell
diagnosis
Immunoassay
(HCGH)
(Chakravathi and Balaji, 2010)

19. S.
No.
Nanocarriers Veterinary
Application
Animal species
under
trial/evaluated/
approved
1 Iron oxide
nanoparticles
MRI imaging and
Drug delivery
Cat.
(Underwood et al.,
2012)
2 Gold
nanoparticles
In-vitro diagnosis
• Anthrax detection
• T.B.
• Influenza virus
Cat.
(Underwood et al.,
2012)
3 Quantum dot Fluorescent
contrast,
In-vitro diagnostics
(cancer cells).
Cat.
(Underwood et al.,
2012)

20. • Nanoshells and quantum
dots injected into the
bloodstream
• Kills the tumour cells
(Dilbaghi et al., 2013)

21. S.
No.
Nanocarriers Veterinary
Application
Animal species under
trial/evaluated/approv
ed
1 Dendrimers Tumors Sheep, bird, horse.
(Underwood et al., 2012)
2 Liposomes Cancer therapy Cattle, dog, horse, Cat,
bird, sheep. (Underwood
et al., 2012)
3 Aluminosilicate Reduce bleeding Dog, Cat
(Underwood et al., 2012)
4 Silver nano
particles
Antibacterial
agent
-

22. • Magnetic Nanoparticles
– Carry drug to
malignant sites with
magnetic fields
– Release the drug by
enzymatic activity
(Tomanek and Enbody, 2000)

23. S.
No.
Nanocarriers Veterinary
Application
Animal species
under trial/evaluated/
approved
1 Dendrimers and
Nanosphere
Vaccine delivery Pig
(Underwood et al., 2012)
2 Carbon
nanotubes
Orthopaedic
implant
Dog, Cat
(Underwood et al., 2012)
3 Silver and zinc
Nps
Drug
bioavailability
Horse
(Underwood et al., 2012)
4 SLNs Promote
absorption of
orally adm drugs
Horse
(Underwood et al., 2012)

24. (Muktar et al., 2015)
 Nanobiosensor for Detection of Reproductive
Status
• Detection of oestrus
• Detection of hormonal concentration
 Nanosystem for Cryopreservation of Gametes
and Embryos
• Metallic nanoparticles for cryopreservation

25. Breeding Management
• Tracking oestrus
animals
• Microfluidics in vitro
fertilisation in animal
• Detect the quality of
sperm and eggs
(Patil et al., 2009)
NANOTECHNOLOGY IN ANIMAL BREEDING

26. • Enhances taste and
reduces the use of
preservatives
• Cost effective nano-meat
• Keeps food fresh
(Muktar et al., 2015)

27. • Information regarding
origin, protocol for
production and food safety
• Quality assurance of food
• Increases shelf life of food
product
(Patil et al., 2009)