2. Introduction:
• TCIM protein
• Official symbol: TCIM
• Official full name : Transcriptional and immune response regulator
• Transcriptional And Immune Response Regulator
• Thyroid Cancer Protein 1
• Human Thyroid Cancer.
• Plays a role in the regulation of hematopoiesis even if the mechanisms are
unknown (By similarity).
• In cancers such as thyroid or lung cancer, it has been described as promoter of
cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis.
• Involved in the regulation of heat shock response
• Amino acid composition:106 amino acid.
3. How to drug design in Bioinformatics?
COMPUTER-AIDED DRUG DESIGN (CADD) is a specialized discipline that uses
computational methods to simulate drug-receptor interactions.
CADD methods are heavily dependent on bioinformatics tools, applications and
databases.
Pharmaceutical companies are always searching for new leads to develop
into drug compounds.
In the most basic sense, drug design involves the design of molecules that are
complementary in shape and charge to the bio-molecular target with which they
interact and therefore will bind to it.
Drug design frequently but not necessarily relies on computer modeling techniques
8. Conclusion:
In conclusion, the in silico analyses o have higher probability and efficacy on
the basis of binding energy and other used parameters. The uniform results
clearly described the 3D structure. The docking studies have been
conducted with the purpose of ligand based, to predict the binding mode of a
ligand with selected 3D protein structure.