A brief overview of ROSALIND - a smart data platform designed to provide better personalized treatment options to cancer patients based on their genetic profile.

1. Defining Personalized
Cancer Care
© 2016 Critical Outcome Technologies Inc. All rights reserved.

2. When it comes to
cancer chemotherapy,
“one size does not fit all.”
Ideally, an individual’s
chemotherapy should be
tailored to the gene mutation
of the tumor in question

3. There are billions of
mutation profiles

4. There are hundreds of cancer drugs
and hundreds of thousands of drug
combinations
Too much for any doctor, or
team of doctors, to consider

5. Developed to determine better
personalized treatment options
based on a patient’s genetic profile
ROSALINDTM
 a smart
data
platform

6. The ROSALINDTM
platform is powered by
a dynamic computer
simulation of human
cancer cell signaling

7. Our vision
More personalized
cancer treatments
Higher remission
rates + lower cost
of cancer therapy

8. ROSALIND’s scientific premise
 Gene mutations found in a tumor
lead to mutations in proteins
 Mutated proteins result in abnormal
cell signaling and can lead to cancer
 To be effective cancer therapy must
aim to restore normal cell signaling

9. ROSALIND evaluates data
from a tumor’s gene
mutation profile and
recommends treatments
most likely to restore
normal cell signaling

10. 1
2
3
An input vector composed of the genetic
profile of the tumor to be simulated
A dynamic representation of positive &
negative interactions between cell
signaling proteins
An output vector identifying potential
remission inducing drug combinations
3 basic components to ROSALIND

11. Step 1: Obtain a gene mutation
profile from a biopsy of the patient’s
tumor
Step 2: A physician must send a
confidential copy of the gene
mutation profile to COTI*
Our 5 step process
* Critical Outcome Technologies Inc.

12. Step 3: COTI programs ROSALIND
with the gene mutation profile and
runs the simulation

13. Step 4: COTI reviews and interprets
the simulation output
Step 5: COTI sends the simulation
output to the ordering physician for
treatment consideration
NOTE: The simulation output drug combinations
only include drugs currently approved or in
clinical trials

14. If you have cancer, you want the best
treatment for your specific tumor.
Ask your doctor about
ROSALIND today

15. Visit our website
www.ROSALINDonline.com
Share our story online:
Follow ROSALINDonline
on Facebook and
Twitter
#ROSALIND
#Personalized
CancerCare

16. Disclaimer:
 ROSALIND is a patent pending computational research and personalized cancer care
tool that continues to undergo development and real world validation.
 ROSALIND is not intended to replace or supersede the assessments or decisions of
any experienced physician or group of physicians.
 The ROSALIND information is NOT a prescription for any treatment(s) and in no way
obligates any physician or group of physicians to use any part of the information
provided in any way.
 The sole purpose of ROSALIND is to provide information only regarding treatment
options that might otherwise not have been considered.
 ROSALIND only considers drugs that have been approved for the treatment of cancer.
 ROSALIND should not be used without the express and informed consent of the
patient. By using ROSALIND, the physician acknowledges that he or she has obtained
this consent.
 ROSALIND does not warrant or guarantee the effectiveness of its informational output
to the physician.

17. Defining Personalized
Cancer Care
© 2016 Critical Outcome Technologies Inc. All rights reserved.