TMA

1. HSCT related
TMA
Elevated BP AKI + proteinuria
Hemolysis( LDH, haptoglobin)
Anemia
Thromobocytopenia
Causes
Treatment
Small vessels, big trouble in the kidney and beyond:
hematopoietic stem cell transplantation -associated
thrombotic microangiopathy.
Laskin B et al.

2. HSCT related
TMA
Elevated BP AKI + proteinuria
Hemolysis( LDH, haptoglobin)
Anemia
Thromobocytopenia
Causes
BK, CMV, Adenovirus,
HHV6,8, parvovirus b19
CNI, sirolimus
Chemotherapy , radiation,
Complement disorders,
GVHD, cytokines, coagulation
pathways
Treatment
Small vessels, big trouble in the kidney and beyond:
hematopoietic stem cell transplantation -associated
thrombotic microangiopathy.
Laskin B et al.

3. HSCT related
TMA
Elevated BP AKI + proteinuria
Hemolysis( LDH, haptoglobin)
Anemia
Thromobocytopenia
Causes
BK, CMV, Adenovirus,
HHV6,8, parvovirus b19
CNI, sirolimus
Chemotherapy , radiation,
Complement disorders,
GVHD, cytokines, coagulation
pathways
Treatment
Alter GVHD treatment
No data on TPE.
Newer complement based
therapies
Small vessels, big trouble in the kidney and beyond:
hematopoietic stem cell transplantation -associated
thrombotic microangiopathy.
Laskin B et al.

4. HSCT related
TMA
Elevated BP AKI + proteinuria
Hemolysis( LDH, haptoglobin)
Anemia
Thromobocytopenia
Causes
BK, CMV, Adenovirus,
HHV6,8, parvovirus b19
CNI, sirolimus
Chemotherapy , radiation,
Complement disorders,
GVHD, cytokines, coagulation
pathways
Treatment
Alter GVHD treatment
No data on TPE.
Newer complement based
therapies
Small vessels, big trouble in the kidney and beyond:
hematopoietic stem cell transplantation -associated
thrombotic microangiopathy.
Laskin B et al.