This document summarizes evidence-based treatment recommendations for uremic bleeding. Uremic bleeding is a complication of renal failure caused by multiple factors including dysfunctional von Willebrand factor, accumulation of uremic toxins, anemia, and platelet dysfunction. Treatment options aim to address specific pathophysiological mechanisms and may include erythropoietin to increase red blood cell count, cryoprecipitate to provide clotting factors, desmopressin to release von Willebrand factor and factor VIII, and estrogens to decrease nitric oxide levels and increase platelet aggregation. Early prevention and treatment that targets multiple disease mechanisms may most effectively manage uremic bleeding.
