PowerPoint Presentation Advanced Pharmacology

1. Jeremy Sanders
MSNE 5356 Section 3N, Advanced Pharmacology
April 3, 2016

2. Risperidone
 Treatment of schizophrenia and
bipolar mania
 2nd generation antipsychotic

3. Reelin expression deficit
- Chromosome 22
Serotonin transporter (5-HT-T) either short allele or
long allele
- Reuptake of serotonin moderates serotonin
response to stress
 Mood Alterations (depression/mania)
- Neurochemical dysregulation
- Neuroendocrine dysregulation

4.  Decreased excitation
 Decreased functional impairment
 Decreased paranoia (fear & mistrust)
 Increased appropriate socialization
 Decreased risk-taking behavior
- promiscuity
- drug abuse
- reckless driving
 Calm demeanor

5.  Levedopa- decrease antiparkinsonian effects
 Paxil, Prozac, Tegretol- cytochrome adjustment
 Additive hypotension with acute ETOH,
antihypertensives, nitrates ingestion
 Additive central nervous system (CNS) depression
with other CNS depressants
 Enzyme inducers> increase metabolism, decrease
effectiveness
 Clozapine decreases metabolism increasing
risperidone effects

6.  Neuroleptic malignant syndrome
 Aggressive behavior
 Dizziness
 Extrapyramidal reactions
 Cough
 Constipation, diarrhea, dry mouth, nausea
 Itching/skin rash
 Weight Gain

7.  Fatigue, impaired temperature regulation,
nervousness, tardive dyskinesia (TD)
 Dyspnea
 Arrhythmias, orthostatic hypotension
 Abdominal pain, anorexia, dyspepsia, increased
salivation, vomiting
 Difficulty urinating, polyuria
 Dry skin, increased pigmentation, increased
sweating, photosensitivity, seborrhea

8.  Rapid absorption (70% after
administration of tablets,
solution or orally disintegrating)
 Excreted primarily in urine
 Effective half-life 24 hours
 Prolonged half-life with hepatic
or renal dysfunction

9.  Phenytoin and other enzyme inducers
- Increase metabolism of risperidone

10. Electronic Health Record (EHR)
- Warning detectors for duplicate medications
- Drug-drug interactions
- Prevention of drug abuse from doctor shopping
Nurses question prescribers to decrease medication
errors
- Decrease patient harm from med errors
- Improve patient outcomes

11.  Educate patients/caregivers in home health
- Adverse reactions/side effects
- Drug interactions
 Nurses spearhead movement- nurses as patient
advocates (no exceptions)
- Question potential erroneous medication orders
 Patient safety increased through open and honest
communication across disciplines