Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Anti depressant and its classifications


Published on

  • Stop getting scammed by online, programs that don't even work! ★★★
    Are you sure you want to  Yes  No
    Your message goes here

Anti depressant and its classifications

  1. 1. Anti-Depressant and itsClassificationByNatasha PuriM.Sc Forensic Science(3rdSem.)
  2. 2. What is Depression ??? Serious disorder of mood, ranges from mild tovery serious condition Most serious mental problem which people facingtoday Most common Psychological Disorder Some people referred depression as “CommonCold” of mental illness Can affect people of all ages,religion and race Twice common in female as compared to male Risk of suicide is high
  3. 3. Type of Depression Depression are of Following types :a. Uni-polar - Mind of subject swing in somedirectionb. Bi-polar - Depression associated withmania some times called asmanic depressionc. Endogenous – Depression due to shock orstressful life events
  4. 4. CausesFollowing are the main causes : Family History Positive and negative events Certain medication Use of alcohol Imbalance of certain chemicals in the brain
  5. 5. Symptoms Vary from subject to subject but having to keysigns are: a. loss of interest in thingslike to dob. sadness or irritability Divided into followingBiological EmotionalPhysical
  6. 6. Biochemical TheoryIn 1950, Reserpine induce Depressionand study shows that it depletes thestorage of NE and 5-HT Then Biochemical or monoaminetheory was Proposed in 1965 bySchildkrant Theory state that there is decreased orfunctional deficiency inmonoamine i.e NE , 5-HT, DAtransmission in the CNS
  7. 7. TreatmentPsychotherapy Electroconvulsive Therapy Natural alternatives MedicationThe drug which is used for therelieve or prevention of depression and itssymptoms known as Anti-depressant Drugs
  8. 8. Anti Depressant DrugsDrugs which are used to relieve or preventdepression known as Anti depressant Anti depressant was first developed in1950’s Work by stabilize and normalize the level ofneurotransmitter in brain.Neurotransmitterlike NE,5-HT,DA play an important role inregulating the mood Practically all antidepressants affectmonoaminergic transmission in the brain
  9. 9. Classification Tricyclic Antidepressants (TCAs)i. NA+5-HT reuptake inhibitor- Imipramine- Trimipramine- Amitriptyline- Doxepinii. Predominantly NA reuptake inhibitors- Desipramine- Nortriptyline- Reboxetine
  10. 10.  Selective Serotonin reuptake inhibitors(SSRIs)- Citalopram- Escitalopram- Fluoxetine- Paroxetine- Sertraline5-HT / NE Reuptake Inhibitors (SNRIs)- Duloxetine- Venlafaxine
  11. 11. Atypical Antidepressants- Buproprion- Mirtazapine- Nefazodone- Trazodone Monoamine Oxidase Inhibitors- Phenelzine- Selegiline- Tranylcypromine
  12. 12. Mechanism of TCAs Drugs
  13. 13. Mechanism of SSRIs Drugs
  14. 14. Mechanism of monoamineoxidase Inhibitors
  15. 15. Side EffectClassification Side effects PharmacokineticsTCAs Blurred Vision ,xerostomia , constipation,Increased appetite, Nausea,cardiac arrhythmiaWell absorbed OrallyPass BBBMetabolised in liverSSRIs Nausea, anxiety, insomnia,sexual dysfunction, gastricupsetWell absorbed OrallyFood effect absorptionMetabolised in LiverSNRIs Nausea,anxiety,insomnia,sexualdysfunction, gastric upsetWell absorbed OrallyMetabolised in LiverAtypical Antidepressant Dry mouth , nervousness,seizures at high doseWell absorbed orallyMAOIs Nausea, Headache, Stiffneck, dry mouth, DruginteractionWell absorbed orally
  16. 16. References Tripathi K.D “Essential of Medical Pharmacology” 6thEdition , JaypeeBrothers Medical Publishers(P)ltd. Goodman and Gilman’s “Manual of Pharmacology and Therapeutics”10thEdition, McGraw Hill Companies Finkel Richard, “Pharmacolgy”,4thEdition, Lippincott Williamsand Wilkin Hollinger A. Mannfred, “ Introduction to Pharmacology” ,2ndEdition ,Taylor & Francis Group Dipiro T. Joseph, “ Pharmacotherapy” ,7thEdition , McGraw HillCompanies Stahl SM. Essential Psychopharmacology,2ndEdition, CambridgeUniversity Press, New York Foye O.William, Principles of Medicinal Chemistry,3rdEdition,Varghese Publishing House