RCISE Friedrich her showed in 1868 that chromosomes could be broken down to elements found in pro- Miesc teins: carbon, nitrog and hydrogen. However, chromosomes also contained phosphorus, an ele- ment not found in proteins. This suggested that a different type of molecule comprised chromosomes that contained not only the elements found in proteins, but also phosphorus. Miescher suggested this molecule be called nuclein, named for the nucleus in which chromosomes are found. walter Sutton showed in 1903 that Mendel\'s\"factors\" were physically located on chromosomes. 1. With this information, generate two hypotheses to address the question \"What type of molecule makes up the genetic material\" Construct your response in this format: H The genetic material is In 1927, Frederick Griffith experimented with two strains of pneumonia: smooth, virulent pneumonia, which always caused illness and death in mice: and rough, non-virulent pneumonia, which did not cause ness (Figure 8.1). Using heat, Griffith killed the smooth virulent pneumonia and found that when killed, it did not cause illness in mice. He then mixed the heat-killed virulent pneumonia with live, non-virulent pneumonia and injected it into a mouse. To hi surprise, this mouse died. Griffith concluded thar the is virulent strain of pneumonia, even when killed, could somehow pass its deadly characteristics to the non- virulent strain known to be harmless. He called the material that transferred the virulence from one strain to the other the \"transforming factor Heat-kiled virulent virulent strain (S) non-virulent strain (R) strain (S) and wing Mouse is healthy Mouse is healthy Living Soels found Figure 8.1. Griffith\'s experiment Solution 1. DNA is the genetic material. it is responsible for the heredity characters. here the two hypothesis are - 1. DNA of a individual cell can act as its genetic determinant which is more common of all. DNA is present in the nucleus. 2. in griffith experiment we see the \'transformation\' phenomena. it is due to the presence of plasmid which is an extrachromosomal portion that upon integration in celll can code for several other characters. this is seen mostly in bacteria. a plasmid may carry information for antibiotic resistance, toxin production or may have several other type of effects. 2. several contribution by various scientists led to the conclution that DNA is the genetic material. HARSHRY and CHASE proved that DNA is the genetic material experimentally. they proved this by radiolabeled experiment on lambda phage which have double stranded DNA..

1. RCISE Friedrich her showed in 1868 that chromosomes could be broken down to elements
found in pro- Miesc teins: carbon, nitrog and hydrogen. However, chromosomes also contained
phosphorus, an ele- ment not found in proteins. This suggested that a different type of molecule
comprised chromosomes that contained not only the elements found in proteins, but also
phosphorus. Miescher suggested this molecule be called nuclein, named for the nucleus in which
chromosomes are found. walter Sutton showed in 1903 that Mendel's"factors" were physically
located on chromosomes. 1. With this information, generate two hypotheses to address the
question "What type of molecule makes up the genetic material" Construct your response in
this format: H The genetic material is In 1927, Frederick Griffith experimented with two strains
of pneumonia: smooth, virulent pneumonia, which always caused illness and death in mice: and
rough, non-virulent pneumonia, which did not cause ness (Figure 8.1). Using heat, Griffith killed
the smooth virulent pneumonia and found that when killed, it did not cause illness in mice. He
then mixed the heat-killed virulent pneumonia with live, non-virulent pneumonia and injected it
into a mouse. To hi surprise, this mouse died. Griffith concluded thar the is virulent strain of
pneumonia, even when killed, could somehow pass its deadly characteristics to the non- virulent
strain known to be harmless. He called the material that transferred the virulence from one strain
to the other the "transforming factor Heat-kiled virulent virulent strain (S) non-virulent strain
(R) strain (S) and wing Mouse is healthy Mouse is healthy Living Soels found Figure 8.1.
Griffith's experiment
Solution
1. DNA is the genetic material. it is responsible for the heredity characters.
here the two hypothesis are - 1. DNA of a individual cell can act as its genetic determinant which
is more common of all. DNA is present in the nucleus.
2. in griffith experiment we see the 'transformation' phenomena. it is due to the presence of
plasmid which is an extrachromosomal portion that upon integration in celll can code for several
other characters. this is seen mostly in bacteria. a plasmid may carry information for antibiotic
resistance, toxin production or may have several other type of effects.
2. several contribution by various scientists led to the conclution that DNA is the genetic
material. HARSHRY and CHASE proved that DNA is the genetic material experimentally. they
proved this by radiolabeled experiment on lambda phage which have double stranded DNA.