1. Salmonellesis Shigellosis E.Coli Staph
intox-n
Botulism Intestinal
Yersiniosis
Entero
patogenic
Entero
toxigenic
Entero
hemorragic
Entero
aggregative
Entero
invasive
Etiology
- Toxigenity
-
-
-ve, motile
Sal.entiritidis
Sal.
Typhymurium
,….
Endotoxin:
fever,
microcirculation
failure, septic
shock.
Enterotoxin
(cholera like
toxin): act
adenylatcyclase
….
-ve, non
motile, non
capsulated
Sh.Dysentr.
Sh.Sonney
Sh.Flexneri
Epidemiology
- Mechanism of
transmission
Anthropo-
zoonotic disease
F/O, contamin.
food,
Close contact
Anthropo-
zoonotic
disease
F/O,
contamin.
food,
Close
contact
- Sourse of
transmission
Human with
manifestation
Carriers
Animals,
Birds(raw eggs)
Human
with
manifestati
on
Carriers
Animals,
- Season Warm more
common, but
can be any
season
Warm
more
common,
but can be
any season
2. Pathogenesis Endotoxin:
fever,
microcirculation
failure, septic
shock.
Enterotoxin
(cholera like
toxin): act-n
adenylatcyclase,
increase c-AMF,
2
mechanism
:
colonisatio
n, invasion.
Incubation Period
(IP)
2-5 days,
3 d
4-7
5 d
Clinic picture Gastroenteritis
Nousea,
vomiting,
watery green
diarrhea, no
pain, no mucos,
blood………
Enterocolitis-
abd pain,
Green stool nd
mucos nd blood
SIGMOID
COLITIS
INVASIVE
DIARHEA
BLOOD
MUCUS
HEMOCOLI
TIS
HIGH
INTOX
Complication Dehydratation
Septic shock
Diagnosis CBC-
Stool
microscopy
Stool culture
Treatment Gastroenteritis
– self limited
Supportive,
ors/iv
Enterocolilitis –
AB(cypro, azitro,
cef3)
Rehydratation
