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2. LEARNING OBJECTIVES
At the end of the lecture student should be able
to
• Describe etiology, clinical features, treatment
& prognosis of squamous cell carcinoma of lip,
buccal mucosa, floor of mouth, tongue, gingiva,
palate, maxillary sinus.
• Describe histopathology-well &moderately
differentiated sqamous cell carcinoma
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3. Carcinoma of Lip
Etiology
1. Tobacco (Pipe
Smoking)
Heat, Trauma from pipe
stem
2. Sunlight
3. Poor oral hygiene
4. Sharp cusps of teeth
5. Leukoplakia
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4. Clinical features
• Elderly males
• Lower lip > Upper lip
• Begins on vermillion border on one side of the
midline
• Commences as either
– Small area of thickening
– Induration & ulceration
– Irregularity of the surface
• Becomes crater like/ proliferative growth
• Slow to metastatize. Submental & Submaxillary
nodes www.indiandentalacademy.com
5. Treatment & Prognosis
• Surgical excision
• X-Ray radiation
• Success of treatment depends on
- Size of the lesion
- Duration
- Presence of metastatic lymph nodes
- Histologic grade of the tumor
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6. Carcinoma Of Tongue
Etiology
• Syphilis
• Plummer Vinson
syndrome
• Chronic irritation/
Trauma
• Leukoplakia
• Poor oral hygiene
• Use of alcohol/
tobacco www.indiandentalacademy.com
7. Clinical features
• Males more than females
• Painless mass/ ulcer
• Begins as indurated ulcer/ exophytic mass
• Proceed to fungating mass
• Infiltrate deeper layers
• Lateral border/ ventral surface of tongue
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8. •Lesions near base are insidious
•May present as dysphagia, sore throat
•High grade, metastatize early
•Metastasis ipsilateral, contralateral.
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11. Clinical features
• Indurated painful
ulcer on one side of
the midline
• Anterior area
• Early extension into
lingual mucosa of
mandible, tongue
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12. •Extends into submandibular & sublingual
glands
•Limitation of tongue movements
•Metastasis to submaxillary group of
lymph nodes
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13. Treatment & Prognosis
• Difficult & Unscessful
• Surgery & Radiations
• Recurrence common
• Fair prognosis
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15. Clinical features
• Elderly
• Lesions along/inferior
line of occlusion
• Painful ulcer
• Infiltration common
• High metastasis to
submaxillary lymph
nodes.
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16. Treatment & Prognosis
• Surgery
• Radiation
• 50% survival rate over a period of 5 years
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23. Treatment & Prognosis
• Surgery
• Radiation
• Prognosis similar to gingival carcinoma
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24. Carcinoma Of Maxillary Sinus
Etiology
• Extremely dangerous
• Chronic sinusitis not related
• Exact etiology unknown
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25. Clinical features
• Elderly males
• Bulging of alveolar ridge
• Loosening of molars
• Swelling of the face
• Unilateral stuffiness
• Invasion of floor of sinus results in oral features
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26. • Medial wall invasion leads to nasal symptoms
• Superior wall invasion leads to ocular lesions
• Ulceration is delayed feature
• Metastasis to submaxillary & cervical nodes
Treatment & Prognosis
• Surgery
• Radiation
• Poor prognosis
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