Benign connective tissue tumors 4/certified fixed orthodontic courses by Indian dental academy

INDIAN DENTAL ACADEMYINDIAN DENTAL ACADEMY
Leader in continuing DentalLeader in continuing Dental
EducationEducation
www.indiandentalacademy.com

 At the end of the lecture students should be able to
 Describe clinical features , histopathological features
and treatment of –
1. Myxoma
2. Neurofibroma
3. Neurilemoma

 Abundant myxoid ground substance
(mucopolysaccharides, mainly hyaluronic acid)
 True neoplasm made of tissue resembling primitive
mesenchyme
 Benign lesion, does not metastasize
 Frequently infiltrates adjacent tissues
 Intraoral soft tissue myxoma- extremely rare
 Cases occurring in jaw bones- commonly are
odontogenic myxomas
Myxoma

Histopathlogical Features-
 Loose-textured tissue with delicate reticulin fibers
 Mucoid material probably hyaluronic acid
 Varying nos. of stellate cells & occasional spindle
cells interspersed throughout
 No encapsulation
 May invade into surrounding tissue
Myxoma

Myxoma
Loose-textured tissue with delicate reticulin fibers

Treatment & Prognosis-
 Surgical excision
 Recurrence common

 Benign tumor of nerve tissue origin
 derived from cells that form nerve sheath
 Seen either
◦ As a solitary lesion- similar except absence of
hereditary factors, unknown etiology
◦ As a part of Neurofibromatosis- Autosomal
Dominant trait
Neurofibroma

Clinical Features-
 Hereditary disease, Autosomal dominant trait,
 No gender predilection, cosmetic problems,
 Risk of malignant transformation
 Discrete, non-ulcerated nodules or Diffuse masses of
tissue
 Buccal mucosa, palate, alveolar ridge, tongue
 Macroglossia due to diffuse involvement of tongue
 Occasionally located centrally within jaw bones
Neurofibroma

Discrete, non-ulcerated nodules or Diffuse masses of tissue

Histopathological Features-
 May or may not be well circumscribed
 Interlacing bundles of spindle-shaped cells often with
wavy nuclei
 Cells are associated with delicate collagen bundles
 variable amounts of myxoid matrix
 Numerous mast cells
 In plexiform neurofibroma- distorted masses of
myxomatous peripheral nerve tissue still within
perineural sheath
Neurofibroma

Treatment-
 Solitary neurofibroma- surgical excision
 For neurofibromas associated with
Neurofibromatosis- surgical removal only for
functional or cosmetic purpose
Neurofibroma

 Benign neural neoplasm of Schwann cell origin
 Neurites are not a component of tumor as in
neurofibroma
Clinical Features-
 Occurs at any age, no gender predilection
 Slow growing lesion, arises in association with a
nerve trunk
 Usually painless unless causes pressure on adjacent
nerve
 Few mm to several cm in size
Neurilemoma

Oral Manifestations-
 Tongue- most common site for oral neurilemomas
 Can occur anywhere in mouth
 Single circumscribed nodule of varying size
 Can occur centrally within jaw bones
◦ commonly in mandible- arising from mandibular
nerve
◦ May cause destruction of bone with cortical plate
expansion
Neurilemoma

Histopathological Features-
 Usually encapsulated
 2 microscopic patterns in varying amounts
 Antoni type A
◦ Streaming fascicles of spindle-shaped Schwann
cells
◦ Cells often form a palisaded arrangement around
central acellular,
◦ eosinophilic areas called verocay bodies
◦ Verocay bodies consist of reduplicated basement
membrane & cytoplasmic processes
Neurilemoma

 Antoni type B-
◦ Less cellular & less organized
◦ Spindle cells arranged randomly within a loose
myxomatous stroma
 No neurites, but degenerative changes can be seen
Treatment & Prognosis-
 Surgical excision
 Recurrence uncommon
 No malignant transformation
Neurilemoma

 Clinical features , histopathological features and
treatment of –
Myxoma
Neurofibroma
Neurilemoma

Benign connective tissue tumors 4/certified fixed orthodontic courses by Indian dental academy

Recommended

Recommended

More Related Content

What's hot

What's hot (19)

Viewers also liked

Viewers also liked (13)

Similar to Benign connective tissue tumors 4/certified fixed orthodontic courses by Indian dental academy

Similar to Benign connective tissue tumors 4/certified fixed orthodontic courses by Indian dental academy (20)

More from Indian dental academy

More from Indian dental academy (20)

Recently uploaded

Recently uploaded (20)

Benign connective tissue tumors 4/certified fixed orthodontic courses by Indian dental academy