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OLIGOHYDRAMNIOS

Dr Mona Shroff
www.obgyntoday.info

*
PHYSIOLOGY OF AMNIOTIC
FLUID

*
INFLOW

OUTFLOW

(1000 ml/d)

1.FETAL URINE
2.LUNG LIQUID

(1000 ml/d)

1.FETAL
SWALLOWING

INTRAMEMBRANOUS (placenta,cord)
TRANSMEMBRANOUS(amniotic membranes)
RECYCLING – 3hrs

Dr Mona Shroff
www.obgyntoday.info

*
*

Dr

MonaDr Mona Shroff
Shroff
www.obgyntoday.info
Amniotic fluid volume
●8

weeks : 15 ml,increases 10 ml/wk
● 17 wks :250 ml ,increases 50 ml/wk
● 28-38 wks :750-1000ml (decreases
after 34 wks)
● 42 wks<500ml

Dr Mona Shroff
www.obgyntoday.info

*
FUNCTIONS OF AMNIOTIC FLUID
●
●
●
●
●
●
●
●

Shock absorber – protects from external trauma.
Protects cord from compression.
Permits fetal movements – development of
musculoskeletal system, prevents adhesions.
Swallowing of AF enhances growth & development
of GIT.
AF volume maintains AF pressure – reduces loss of
lung liquid – pulmonary development.
Maintenance of fetal body temperature.
Some fetal nutrition, water supply.
Bacteriostatic properties – decreases potential for
infection
Dr Mona Shroff
www.obgyntoday.info

*
DEFINITION
●

AMNIOTIC FLUID VOLUME < 5 th
percentile for gestational age

●

AMNIOTIC FLUID INDEX < 5

●

SINGLE VERTICAL POCKET < 2 cms

●

Amniotic fluid volume of less than 500 mL at
32-36 weeks' gestation

Dr Mona Shroff
www.obgyntoday.info

*
Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
INCIDENCE
0.5 – 5%

Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
AETIOLOGY
FETAL
●

●
●
●
●
●

PROM (50%)
CHROMOSOMAL ANOMALIES
CONGENITAL ANOMALIES
IUGR
IUFD
POSTTERM PREGNANCY

MATERNAL
●
●
●

DRUGS
●

PLACENTAL
●

●
●

CHRONIC ABRUPTION
TTTS
CVS

Dr Mona Shroff
www.obgyntoday.info

PREECLAMPSIA
APLA SYNDROME
CHRONIC HT

●

PG SYNTHETASE
INHIBITORS
ACE INHIBITORS

IDIOPATHIC
Dr Mona Shroff
www.obgyntoday.info

*
DIAGNOSIS
SYMPTOMS

SIGNS

NO SPECIFIC
SYMPTOMS
H/O leaking p/v
Postterm
s/o preeclampsia
Drugs
Less fetal movements

Dr

Uterus – small for
date
Feels full of fetus
Malpresentations
IUGR

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
USG
METHODS
MVP
AFI

<2 cms
(<1 severe)
<5 cms
(5-8 borderline)

2D pocket

Dr Mona Shroff
www.obgyntoday.info

<15 sq cms

Dr Mona Shroff
www.obgyntoday.info

*
Technique of AFI
●

●
●

●
●

Uterus divided into 4 quadrants
Transducer in vertical plane
Sum of 4 quadrants max pocket depth
excluding cord & limbs.
Prior to 20 wks 2 halves
Twins: composite AFI or individual
vertical pockets

Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
Authors' conclusions
●

The single deepest vertical pocket measurement in
the assessment of amniotic fluid volume during fetal
surveillance seems a better choice since the use of
the amniotic fluid index increases the rate of
diagnosis of oligohydramnios and the rate of induction
of labor without improvement in peripartum outcomes.
A systematic review of the diagnostic accuracy of
both methods in detecting decreased amniotic fluid
volume is required.
Nabhan AF, Abdelmoula YA. Amniotic fluid index versus single deepest
vertical pocket as a screening test for preventing adverse pregnancy
outcome. Cochrane Database of Systematic Reviews 2008, Issue 3

Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
COMPLICATIONS

FETAL

MATERNAL

Abortion
Increased morbidity
Prematurity
Prolonged labour:
IUFD
uterine inertia
Deformities –
CTEV,contractures,amputation Increased operative
intervention
Potters syndrome- pulmonary
(malformations,
hypoplasia
distres)
Malpresentations
Fetal distress
MSAF – MAS
Dr Mona Shroff
Low APGAR
*

www.obgyntoday.info
Dr Mona Shroff
MANAGEMENT
DEPENDS UPON
●
●
●
●

AETIOLOGY
GESTATIONAL AGE
SEVERITY
FETAL STATUS & WELL BEING

Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
DETERMINE AETIOLOGY
●
●
●
●
●

R/O PROM, h/o medical illness
TARGETED USG FOR ANOMALIES
R/O IUGR ,IUFD when suspected
Amniocentesis if chromosomal anomalies
suspected – early symmetric IUGR
Tests for APLA Syndrome , if suspected

Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
Dr Mona Shroff
www.obgyntoday.info

Dr Mona Shroff

*
Techniques for Monitoring
●
●
●

Single pocket without cord
AFI = sum of deepest pocket in each of 4 quadrants without
cord
BPP =
1.
2.
3.
4.
5.
●

●

NST
breathing 30sec in 30min
move 3 limb/body in 30min
extension of extremity with flexion or open/close hand
single vertical non-cord pocket of 2 cm
Scoring: 0 or 2 for each, 10 is normal, 6 equivocal, 4 abnormal

Modified BPP = NST, +/- acoustic stimulation, AFI
●
●
●

AFI > 5 ok
AFI < 5 or non-reactive NST not ok
modified BPP equally useful as BPP for monitoring, per ACOG
TREATMENT
●
●

●
●

●

ADEQUATE REST – decreases dehydration
HYDRATION – Oral/IV Hypotonic fluids(2 Lit/d)
temperory increase
helpful during labour,prior
to ECV, USG
SERIAL USG – Monitor growth,AFI,BPP
INDUCTION OF LABOUR/ LSCS
Lung maturity attained
Lethal malformation
Fetal jeopardy
Sev IUGR
Severe oligo
DDAVP: ? Research settings
Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
Hofmeyr GJ, Gülmezoglu AM. Maternal hydration for increasing amniotic fluid
volume in oligohydramnios and normal amniotic fluid volume. Cochrane Database of
Systematic Reviews 2002, Issue 1.

Authors' conclusions
●

Simple maternal hydration /IV Hypotonic fluid (2 lit)
appears to increase amniotic fluid volume and may be
beneficial in the management of oligohydramnios and
prevention of oligohydramnios during labour or prior
to external cephalic version. Controlled trials are
needed to assess the clinical benefits and possible
risks of maternal hydration for specific clinical
purposes.

Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
●

● AMNIOINFUSION
INDICATIONS
1.Diagnostic
2.Prophylactic
3.Therapeutic
Decreases cord
compression
Dilutes meconium

Dr Mona Shroff
www.obgyntoday.info

Dr Mona Shroff
www.obgyntoday.info

*
Hofmeyr GJ. Prophylactic versus therapeutic amnioinfusion for oligohydramnios in

labour. Cochrane Database of Systematic Reviews 1996,Issue 1

.

Authors' conclusions
● There appears to be no advantage of
prophylactic amnioinfusion over
therapeutic amnioinfusion carried out
only when fetal heart rate decelerations
or thick meconium-staining of the liquor
occur.
Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
DDAVP
●

Oral hydration + DDAVP :Prevents diuresis

●

Results in maternal plasma hypotonicity –fetal plasma hypotonicity—increased fetal
urine production—reduced fetal
swallowing—increased AFI

Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
DDAVP : concerns
● Effect

on maternal & fetal bld

volume
● Long term effects on AFI
● Prophylactic or chronic use
● Mask oligohydramnios ??

Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
Therapeutic Interventions:
Oligohydramnios
TREATMENT ACC. TO CAUSE
●

●
●
●

Drug induced – OMIT DRUG
PROM – INDUCTION
PPROM – Antibiotics,steroid – Induction
FETAL SURGERY
VESICO AMNIOTIC SHUNT-PUV
Laser photocoagulation for TTTS

Dr

Dr Mona Shroff
www.obgyntoday.info
Mona Shroff

*
Posterior urethral valves
●

Sonographic findings:
●

Keyhole sign
Posterior urethral valves
●

Management:
Karyotyping
● Perform serial bladder drainage every 3-4
days
● Use sample of 3rd drainage
● Isotonic urine indicate poor function
●
Posterior urethral valves
●

Good prognostic biochemical markers:
Na < 100meq/L
● Cl < 90meq/L
● Osmolarity <210mOsm/L
● B2 microglobulin < 4mg/L
● Ca < 8mg/dl
●

●

Indication for vesico amniotic shunts
Dr Mona Shroff
www.obgyntoday.info

Dr Mona Shroff
www.obgyntoday.info

*

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Oligohydramnios

  • 3. INFLOW OUTFLOW (1000 ml/d) 1.FETAL URINE 2.LUNG LIQUID (1000 ml/d) 1.FETAL SWALLOWING INTRAMEMBRANOUS (placenta,cord) TRANSMEMBRANOUS(amniotic membranes) RECYCLING – 3hrs Dr Mona Shroff www.obgyntoday.info *
  • 5.
  • 6. Amniotic fluid volume ●8 weeks : 15 ml,increases 10 ml/wk ● 17 wks :250 ml ,increases 50 ml/wk ● 28-38 wks :750-1000ml (decreases after 34 wks) ● 42 wks<500ml Dr Mona Shroff www.obgyntoday.info *
  • 7. FUNCTIONS OF AMNIOTIC FLUID ● ● ● ● ● ● ● ● Shock absorber – protects from external trauma. Protects cord from compression. Permits fetal movements – development of musculoskeletal system, prevents adhesions. Swallowing of AF enhances growth & development of GIT. AF volume maintains AF pressure – reduces loss of lung liquid – pulmonary development. Maintenance of fetal body temperature. Some fetal nutrition, water supply. Bacteriostatic properties – decreases potential for infection Dr Mona Shroff www.obgyntoday.info *
  • 8. DEFINITION ● AMNIOTIC FLUID VOLUME < 5 th percentile for gestational age ● AMNIOTIC FLUID INDEX < 5 ● SINGLE VERTICAL POCKET < 2 cms ● Amniotic fluid volume of less than 500 mL at 32-36 weeks' gestation Dr Mona Shroff www.obgyntoday.info *
  • 10. INCIDENCE 0.5 – 5% Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 11. AETIOLOGY FETAL ● ● ● ● ● ● PROM (50%) CHROMOSOMAL ANOMALIES CONGENITAL ANOMALIES IUGR IUFD POSTTERM PREGNANCY MATERNAL ● ● ● DRUGS ● PLACENTAL ● ● ● CHRONIC ABRUPTION TTTS CVS Dr Mona Shroff www.obgyntoday.info PREECLAMPSIA APLA SYNDROME CHRONIC HT ● PG SYNTHETASE INHIBITORS ACE INHIBITORS IDIOPATHIC Dr Mona Shroff www.obgyntoday.info *
  • 12. DIAGNOSIS SYMPTOMS SIGNS NO SPECIFIC SYMPTOMS H/O leaking p/v Postterm s/o preeclampsia Drugs Less fetal movements Dr Uterus – small for date Feels full of fetus Malpresentations IUGR Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 13. USG METHODS MVP AFI <2 cms (<1 severe) <5 cms (5-8 borderline) 2D pocket Dr Mona Shroff www.obgyntoday.info <15 sq cms Dr Mona Shroff www.obgyntoday.info *
  • 14. Technique of AFI ● ● ● ● ● Uterus divided into 4 quadrants Transducer in vertical plane Sum of 4 quadrants max pocket depth excluding cord & limbs. Prior to 20 wks 2 halves Twins: composite AFI or individual vertical pockets Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 15. Authors' conclusions ● The single deepest vertical pocket measurement in the assessment of amniotic fluid volume during fetal surveillance seems a better choice since the use of the amniotic fluid index increases the rate of diagnosis of oligohydramnios and the rate of induction of labor without improvement in peripartum outcomes. A systematic review of the diagnostic accuracy of both methods in detecting decreased amniotic fluid volume is required. Nabhan AF, Abdelmoula YA. Amniotic fluid index versus single deepest vertical pocket as a screening test for preventing adverse pregnancy outcome. Cochrane Database of Systematic Reviews 2008, Issue 3 Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 16. COMPLICATIONS FETAL MATERNAL Abortion Increased morbidity Prematurity Prolonged labour: IUFD uterine inertia Deformities – CTEV,contractures,amputation Increased operative intervention Potters syndrome- pulmonary (malformations, hypoplasia distres) Malpresentations Fetal distress MSAF – MAS Dr Mona Shroff Low APGAR * www.obgyntoday.info Dr Mona Shroff
  • 17. MANAGEMENT DEPENDS UPON ● ● ● ● AETIOLOGY GESTATIONAL AGE SEVERITY FETAL STATUS & WELL BEING Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 18. DETERMINE AETIOLOGY ● ● ● ● ● R/O PROM, h/o medical illness TARGETED USG FOR ANOMALIES R/O IUGR ,IUFD when suspected Amniocentesis if chromosomal anomalies suspected – early symmetric IUGR Tests for APLA Syndrome , if suspected Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 20. Techniques for Monitoring ● ● ● Single pocket without cord AFI = sum of deepest pocket in each of 4 quadrants without cord BPP = 1. 2. 3. 4. 5. ● ● NST breathing 30sec in 30min move 3 limb/body in 30min extension of extremity with flexion or open/close hand single vertical non-cord pocket of 2 cm Scoring: 0 or 2 for each, 10 is normal, 6 equivocal, 4 abnormal Modified BPP = NST, +/- acoustic stimulation, AFI ● ● ● AFI > 5 ok AFI < 5 or non-reactive NST not ok modified BPP equally useful as BPP for monitoring, per ACOG
  • 21. TREATMENT ● ● ● ● ● ADEQUATE REST – decreases dehydration HYDRATION – Oral/IV Hypotonic fluids(2 Lit/d) temperory increase helpful during labour,prior to ECV, USG SERIAL USG – Monitor growth,AFI,BPP INDUCTION OF LABOUR/ LSCS Lung maturity attained Lethal malformation Fetal jeopardy Sev IUGR Severe oligo DDAVP: ? Research settings Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 22. Hofmeyr GJ, Gülmezoglu AM. Maternal hydration for increasing amniotic fluid volume in oligohydramnios and normal amniotic fluid volume. Cochrane Database of Systematic Reviews 2002, Issue 1. Authors' conclusions ● Simple maternal hydration /IV Hypotonic fluid (2 lit) appears to increase amniotic fluid volume and may be beneficial in the management of oligohydramnios and prevention of oligohydramnios during labour or prior to external cephalic version. Controlled trials are needed to assess the clinical benefits and possible risks of maternal hydration for specific clinical purposes. Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 23. ● ● AMNIOINFUSION INDICATIONS 1.Diagnostic 2.Prophylactic 3.Therapeutic Decreases cord compression Dilutes meconium Dr Mona Shroff www.obgyntoday.info Dr Mona Shroff www.obgyntoday.info *
  • 24. Hofmeyr GJ. Prophylactic versus therapeutic amnioinfusion for oligohydramnios in labour. Cochrane Database of Systematic Reviews 1996,Issue 1 . Authors' conclusions ● There appears to be no advantage of prophylactic amnioinfusion over therapeutic amnioinfusion carried out only when fetal heart rate decelerations or thick meconium-staining of the liquor occur. Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 25. DDAVP ● Oral hydration + DDAVP :Prevents diuresis ● Results in maternal plasma hypotonicity –fetal plasma hypotonicity—increased fetal urine production—reduced fetal swallowing—increased AFI Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 26. DDAVP : concerns ● Effect on maternal & fetal bld volume ● Long term effects on AFI ● Prophylactic or chronic use ● Mask oligohydramnios ?? Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 28. TREATMENT ACC. TO CAUSE ● ● ● ● Drug induced – OMIT DRUG PROM – INDUCTION PPROM – Antibiotics,steroid – Induction FETAL SURGERY VESICO AMNIOTIC SHUNT-PUV Laser photocoagulation for TTTS Dr Dr Mona Shroff www.obgyntoday.info Mona Shroff *
  • 29. Posterior urethral valves ● Sonographic findings: ● Keyhole sign
  • 30. Posterior urethral valves ● Management: Karyotyping ● Perform serial bladder drainage every 3-4 days ● Use sample of 3rd drainage ● Isotonic urine indicate poor function ●
  • 31. Posterior urethral valves ● Good prognostic biochemical markers: Na < 100meq/L ● Cl < 90meq/L ● Osmolarity <210mOsm/L ● B2 microglobulin < 4mg/L ● Ca < 8mg/dl ● ● Indication for vesico amniotic shunts
  • 32. Dr Mona Shroff www.obgyntoday.info Dr Mona Shroff www.obgyntoday.info *