itx a summarized introduction of sodium cromoglycate which is a mast cell stablizer drug

3. INTRODUCTION:
Sodium Cromoglycate also known as Sodium
Cromoglicate. a synthetic non-steroidal anti-
inflammatory drug, inhaled to prevent asthmatic
attacks and allergic reactions.
Sodium cromoglycate is traditionally described as a
mast cell stabilizer, and is commonly marketed as
the sodium salt, sodium cromoglycate or cromolyn
sodium

4. Sodium cromoglycate (SCG) was discovered
in1965 by the late Dr. Roger Altounyan (who was
himself a lifelong asthma sufferer)
developed by Fisons Pharmaceuticals for use as
an inhaled drug in asthma, primarily of allergic
origin. The drug was selected after over 200
compounds had been tested by Altounyan

5. Sodium cromoglycate acts by inhibiting the release of
chemical mediators from sensitized mast cells. It is used in
the prophylactic treatment of both allergic and exercise-
induced asthma, but does not affect an established
asthmatic attack.
Cromolyn sodium probably interferes with the antigen-
stimulated calcium transport across the mast cell
membrane, thereby inhibiting mast cell release of
histamine, leukotrienes, and other substances that cause
hypersensitivity reactions.

6. BRONCHIAL ASTHMA
ALLERGIC RHINITIS
ALLERGIC CONGUCTIVITUS

7. AS AN INHALER: (Fintal inhaler)
PREPARATION: 1mg metered dose inhaler.
DOSE: 2 puffs (Q.I.D)
AS A NASAL SPRAY : (Fintal nasal spray)
PREPARATION: 2% aqueous solution
DOSE: 2 squeezes in each nostrils (Q.I.D)
AS EYE DROPS: (Fintal eye drops)
PREPARATION: 2% aqueous solution
DOSE: 1 drop in each eye (Q.I.D)

8. Skin rashes
Bronchospasm
Throat irritation
dizziness
Flare up of skin
Arthralgia
Sometime urticaria

9. ABSORPTION: poorly absorbed orally i.e. 0.5% but in
the form of aerosol its absorption rate increased up
to 1.5%
ELIMINATION: most of absorbed drug is excreted
unchanged by liver & kidneys within a few days &
none appears to undergo metabolic degradation.