for educational purpose only..

1. VII. Pathophysiology
Modifiable
 Lifestyle
 SMOKING
Non- Modifiable
 Age
Decrease secretionof
HCO3 from the pancreas
Increase secretionof HCL
& pepsinfromthe
pancreasintothe
gastrodoudenal.
Increase concentration/
activityof the acid-pepsin
Decrease interference
withHCL secretionfrom
the pancreasinto
duodenum
Mucosal damaged occurs
Duodenal mucosa cannot withstand
the digestive action of the HCL and
pepsin
Damagedmucosa cannot
secrete enoughmucusto
act as a barrieragainstHCL

2. Duodenal Ulcer
Decrease resistance of
mucosa
Destruction of blood vessels
Further mucosal erosion Increase acid in duodenum,
Erodes the lesions and
stimulates the exposed nerve
endings.
Bile / pancreatic enzymes
reflux from duodenum
Abdominal pain
Mucosal bleeding