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Prepared by:
BSN, Level II
Sarah Jane A. Cristobal
MONITORING TECHNOLOGY
Telemetry
 is the monitoring and analyzing
of data that are received at a distance
from their source. It usually refers to a
certain way of monitoring a hospital
patient's heart activity
MONITORING TECHNOLOGY
Telemetry
It allows the patient to get up
and move around, at least within the
device's transmitting range.
MONITORING TECHNOLOGY
Telemetry
To provide skilled cardiac
monitoring to patients who require
cardiac monitoring, but other wise do not
warrant ICU placement.
MONITORING TECHNOLOGY
The ICU environment should focus on
these therapeutic elements:
 Windows and art that provide natural
views; views of naturecan reduce
stress, hasten recovery, lower blood
pressure andlower pain medication
needs
MONITORING TECHNOLOGY
3. Post cardiothoracic surgery.
4. Drug toxicities limited to potential
arrhythmogenic compounds such as digitalis
and tricyclics.
5. New onset supraventricular arrhythmias
(atrial fibrillation or flutter, PSVT, etc.)
6. Suspected pacemaker malfunction.
7. Observation post pacemaker or defibrillator
placement or post ablation.
MONITORING TECHNOLOGY
8. Syncope when an arrhythmia or other cardiac disorder is
a suspected etiology.
9. Suspected defibrillator discharge.
10. Unstable angina of low or intermediate grade (new
onset angina without EKG or enzymatic changes,
crescendo angina in patient with history of coronary
disease).
11. Study drug protocols requiring cardiac monitoring as a
part of the protocol.
MONITORING TECHNOLOGY
Prior to discharge from the Telemetry Unit,
patients shall meet the following criteria:
1. Physician shall order the discontinuation of
Telemetry monitoring.
2. Patient shall be free of chest pain for 24 hours
prior to discharge.
3. Patient's vital signs shall be stable
MONITORING TECHNOLOGY
4. Patient does not require intravenous
vasoactive medications.
5. Patient shall be able to perform minimal
ADLs without shortness of breath.
6. Patient shall have normal sinus rhythm,
stable rhythm, or controlled arrhythmia for
thepast 24 hours
DIAGNOSTIC INFORMATION
SYSTEM
Today's physicians and other
caregivers have access to more than
5,000 different patient tests to help them
evaluate, diagnose, and treat patients.
The problem is that physicians receive
these test results from a wide range of
disparate sources that use vastly
different reporting formats
DIAGNOSTIC INFORMATION
SYSTEM
Displaying test results in fragmented,
variable and incomplete formats
prevents physicians fromefficiently
reviewing and analyzing vital patient
information. This can lead to:
 Clinicians spending far too much time
(an estimated 30%) gathering and
organizing data
DIAGNOSTIC INFORMATION
SYSTEM
 Critical information being missed which
can cause medical errors
 Redundant testing (an estimated 14%
to 30% of the 30 billion diagnostic tests
done annually in the US are non-
contributory and avoidable)
DIAGNOSTIC INFORMATION
SYSTEM
 The inability to share or exchange vital
clinical information among providers
 Underutilization of EHRs and other
health IT applications and an
unnecessary reliance on paper,
telephones, and fax machines
In order to provide cost-
effective, high quality care, physicians
and other caregivers need immediate
access to accurate, timely, and
comprehensive clinical information.
THE PATENTED DIS SOLUTION
The patented DIS solution
provides rapid access to cumulative
patient information in an easy to read and
analyze format that increases the accuracy
and efficiency of patient care and improves
the productivity of physicians, nurses and
others at all points of care.
THE PATENTED DIS SOLUTION
DIS can aggregate and collate
more than 5,000 different patient test
results and display them all in one place in
the same user-friendly format. Its ease of
access and use adds immediate value to
the health care delivery process:
 Converts raw patient test results data into
organized, meaningful information for
easy access,viewing, and analysis
THE PATENTED DIS SOLUTION
 Provides a standardized reporting
format that unifies test results from all
data sources for usersat all points of
care3.
 Integrates test results data on all levels
(data, application, system and network)
increasing efficiency, accuracy and
productivity
THE PATENTED DIS SOLUTION
 Reduces the number of pages and
screens on which results are displayed
by an average of 80percent5.
 Saves time and helps physicians
minimize duplicate and non-
contributory testing
THE PATENTED DIS SOLUTION
The DIS technology solution was
specifically designed for immediate use by
all test results data users in physician
offices, hospital inpatient facilities and
outpatient clinics and community health
centers. Its implementation will depend on
collaborative innovation among a number
of interdependent stakeholders.
THE PATENTED DIS SOLUTION
These include all the test
results data providers in hospital and
community-based clinical laboratories
and in imaging and other testing
facilities and the vendors of EHRs and
PHRs, as well as the vendors of HIE data
integration and exchange platforms and
the HIOs/HIEs that they serve
MECHANICAL VENTILATOR
Is a machine that generates a
controlled flow of gas into a patients
airways. Oxygen and air are received from
cylinders or wall outlets, the gas is
pressure reduced and blended according
to the prescribed inspired oxygen tension
(FiO2), accumulated in a receptacle within
the machine, and delivered to the patient
using one of many available modes of
ventilation.
MECHANICAL VENTILATOR
The mechanics of inspiratory support
are more complex than previously
considered. It has been established that
cyclical inflation and deflation injures
lung parenchyma and worsens outcome:
(1). Large tidal volume ventilation, to
normalize blood gases has been shown
to worsen outcome in lung injury
MECHANICAL VENTILATOR
(2), presumably due to excessive
pressure induced stretch injury of the
parenchyma. Modernventilation strategy
involves attempting to achieve an
adequate minute volume with the lowest
possibleairway pressure (as this relates
to the degree of alveolar distension).
The pressure that we areinterested in
minimizing is at the level of the alveolus,
the plateau pressure.
MECHANICAL VENTILATOR
Ventilator cycling refers to the
mechanism by which the phase of the
breath switches from inspiration to
expiration. Modes of ventilation are time
cycled, volume cycled or flow cycled. Time
cycling refers to the application of a set
controlled breath rate. In controlled
ventilation a number of mandatory breaths
are delivered to the patient at a
predetermined interval.
MECHANICAL VENTILATOR
The respiratory rate may be
controlled by the operator or the patient.
The patient may breathe spontaneously,
and with modern ventilators these
breaths are supported either by
delivering facsimiles of the controlled
breaths synchronously with the patient’s
effort or by allowing the patient more
subjective control.
MECHANICAL VENTILATOR
Pressure support is a form of
flow cycled ventilation in which the
patient triggers the ventilator and a
pressure limited flow of gas is delivered.
The patient determines the duration of
the breath and the tidal volume, which
may vary from breath to breath
CT SCAN
CT scans are a specialized type
of x-ray. The patient lies down on a
couch which slides into a large circular
opening. The x-ray tube rotates
around the patient and a computer
collects the results. These results are
translated into images that look like a
"slice" of the person.
CT SCAN
Sometimes a radiologist will
decide that contrast agents should be
used. Contrast agents are iodine based
and are absorbed by abnormal
tissues. They make it easier for the
doctor to see tumors within the brain
tissue. There are some (rare) risks
associated with contrast agents and you
should make sure that you discuss this
with the doctor before arriving for the
CT SCAN
CT is very good for imaging
bone structures. In fact, it's usually the
imaging mode of choice when looking at
the inner ears. It can easily detect
tumors within the auditory canals and
can demonstrate the entire cochlea on
most patients.
MRI
MRI is a completely different
animal! Unlike CT it uses magnets and
radio waves to create the images. No x-
rays are used in an MRI scanner.
MRI
The patient lies on a couch that
looks very similar the ones used for
CT. They are then placed in a very long
cylinder and asked to remain perfectly
still. The machine will produce a lot of
noise and examinations typically run
about 30 minutes.
MRI
The cylinder that you are lying in
is actually a very large magnet. The
computer will send radio waves through
your body and collect the signal that is
emitted from the hydrogen atoms in your
cells. This information is collected by an
antenna and fed into a sophisticated
computer that produces the images. These
images look similar to a CAT scan but they
have much higher detail in the soft tissues.
Unfortunately, MRI does not do a very good
job with bones.
MRI
One of the great advantages of
MRI is the ability to change the contrast
of the images. Small changes in the
radio waves and the magnetic fields can
completely change the contrast of the
image. Different contrast settings will
highlight different types of tissue.
MRI
Another advantage of MRI is the
ability to change the imaging plane
without moving the patient. If you look at
the images to the left you should notice
that they look very different. The top two
images are what we call axial
images. This is what you would see if
you cut the patient in half and looked at
them from the top.
MRI
The image on the bottom is a
coronal image. This slices the patient
from front to back. Most MRI machines
can produce images in any plane. CT
can not do this.
MRI
Contrast agents are also used
in MRI but they are not made of iodine.
There are fewer documented cases of
reactions to MRI contrast and it is
considered to be safer than x-ray dye.
Once again, you should discuss
contrast agents with your physician
before you arrive for the examination.
ICU
The ICU environment should focus on
the set herapeutic elements:
 Windows and art that provide natural
views; views of nature can reduce
stress, hasten recovery, lower blood
pressure and lower pain medication
needs
ICU
 Family participation, including
facilities for overnight stay and
comfortable waiting rooms
 Providing familiarity in the ICU
environment through personalization,
warmer colors, natural materials, and
artwork
ICU
 Providing a measure of privacy and
personal control through adjustable
lighting, adjustable curtains and blinds,
accessible bed controls, and TV, VCR
and CD players
 Noise reduction through computerized
pagers and silent alarms
 Medical team continuity that allows one
team to follow the patient through his or
her entire stay
ICU
A tele-ICU system involves a
command center with the technological
capability to remotely monitor patients in
off-site intensive care units. The command
center is staffed with intensivist physicians
and critical care nurses who use two-way
audio-visual monitoring systems to provide
support and guidance to the bedside staff
in those ICUs.
ICU
And critical care nurses play a
major role in the success of a tele-ICU.
They have a great deal of potential when
it comes to bridging distance barriers,
influencing patient safety and even
mentoring bedside nurses, noted Karen
Harvey, MSN, RN, certification programs
specialist for the corporation
LABORATORY TESTING
 What are the indicators of test reliability?
Four indicators are most
commonly used to determine the reliability
of a clinical laboratory test. Two of these,
accuracy and precision, reflect how well the
test method performs day to day in a
laboratory. The other two, sensitivity and
specificity, deal with how well the test is
able to distinguish disease from absence of
disease.
LABORATORY TESTING
The accuracy and precision of each
test method are established and are
frequently monitored by the professional
laboratory personnel. Sensitivity and
specificity data are determined by
research studies and are generally
found in medical literature.
LABORATORY TESTING
Although each test has its own
performance measures and appropriate
uses, laboratory tests are designed to be
as precise, accurate, specific, and
sensitive as possible. These basic
concepts are the corner stonesof
reliability of your test results and
provide the confidence your health care
provider has in using the clinical
laboratory.
LABORATORY TESTING
 Accuracy and Precision
Statistical measurements
of accuracy and precision reveal a lab
test's basic reliability. These terms,
which describe sources of variability, are
not interchangeable. A test method can
be precise (reliable reproducibility)
without being accurate (measuring what
it is supposed to measure and its true
value) or vice versa.
LABORATORY TESTING
 Precision (Repeatability)
A test method is said to be precise
when repeated analyses on the same
sample give similar results. When a test
method is precise, the amount of random
variation is small. The test method can be
trusted because results are reliably
reproduced time after time.
LABORATORY TESTING
 Accuracy (Trueness)
A test method is said to be accurate
when the test value approaches the
absolute ³true´ value of the
substance(analyte) being measured.
Results from every test performed are
compared to known "control specimens"
that have undergone multiple evaluations
and compared to the "gold" standard for
that assay, thus analyzed to the best testing
standards available
LABORATORY TESTING
Accuracy (Trueness)
Although a test that is 100% accurate and
100% precise is ideal, in practice, test
methodology, instrumentation, and laboratory
operations all contribute to small but
measurable variations in results. The small
amount of variability that typically occurs does
not usually detract from the test ¶s value and
statistically is insignificant. The level of
precision and accuracy that can be obtained is
specific to each test method but is constantly
monitored for reliability through comprehensive
quality control and quality assurance
procedures.
LABORATORY TESTING
Accuracy (Trueness)
Therefore, when your blood is
tested more than once by the same
laboratory, your test results should not
change much unless your condition has
changed. There may be some differences
between laboratories in precision and
accuracy due to different analytical
instrumentation or methodologies,
however, the test results are reported with
standardized reference intervals specific
for that laboratory.
LABORATORY TESTING
 Sensitivity and Specificity
The tests that a provider chooses
in order to diagnose or monitor a medical
condition are based on their in
herentability to distinguish whether you
have the condition or do not have the
condition. Depending on the symptoms
and medical history, a provider will order
tests to confirm a condition (tests with high
sensitivity) or tests to rule out the
condition (tests with high specificity).
LABORATORY TESTING
 Sensitivity
Sensitivity is the ability of a test to
correctly identify individuals who have a given
disease or condition.
For example, ascertain test may have proven to
be 90% sensitive. If 100 people are known to
have a certain disease, the test that identifies
that disease will correctly do so for 90 of those
100 cases (90%). The other 10 people (10%)
tested will not show the expected result for this
test.
For that 10%, the finding of a "normal" result can
be misleading and is termed false-negative
LABORATORY TESTING
 Sensitivity
A test's sensitivity becomes
particularly important when you are
seeking to exclude a dangerous disease,
such astesting for the presence of the
HIV antibody. Screening for HIV antibody
often utilizes an ELISA test method,
whichhas sensitivity over 99%. However,
a person may get a false-negative if
tested too soon after the initial infection
(lessthan 6 weeks).
LABORATORY TESTING
 Sensitivity
Thus, the result of a false-
negative gives a person the sense of
being disease-free when in fact theyare
not. The more sensitive a test, the fewer
false-negative results will be produced.
LABORATORY TESTING
 Specificity
Specificity is the ability of a test
to correctly exclude individuals who do
not have a given disease or condition.
For example, a certain test may have
proven to be 90% specific. If 100 healthy
individuals are tested with that
method,only 90 of those 100 healthy
people (90%) will be found "normal"
(disease-free) by the test.
LABORATORY TESTING
 Specificity
The other 10 people (who do
not have the disease) will appear to be
positive for that test.
For that 10%, their "abnormal" findings
are a misleading false-positive result.
When it is necessary to confirm a
diagnosis that requires dangerous
therapy, a test's specificity is one of the
crucial indicators.
LABORATORY TESTING
 Specificity
A patient who has been told
that he is positive for a specific test yet
truly does not have that disease may be
subjected to potentially painful or
dangerous treatment, additional expense,
and unwarranted anxiety. The more
specific a test, the fewer false-positive
results it produces.
LABORATORY TESTING
The FDA requires that developers
and manufacturers of a new test provide
target values for test results and provide
evidence for the expected ranges as well
as information on test limitations and other
factors that could generate false results.
Thus it is critical for the health care
provider to correlate the laboratory results
with an individual's clinical condition to
determine if repeat testing would be
needed.
Elec ii

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Elec ii

  • 1.
  • 2. Prepared by: BSN, Level II Sarah Jane A. Cristobal
  • 3. MONITORING TECHNOLOGY Telemetry  is the monitoring and analyzing of data that are received at a distance from their source. It usually refers to a certain way of monitoring a hospital patient's heart activity
  • 4. MONITORING TECHNOLOGY Telemetry It allows the patient to get up and move around, at least within the device's transmitting range.
  • 5. MONITORING TECHNOLOGY Telemetry To provide skilled cardiac monitoring to patients who require cardiac monitoring, but other wise do not warrant ICU placement.
  • 6. MONITORING TECHNOLOGY The ICU environment should focus on these therapeutic elements:  Windows and art that provide natural views; views of naturecan reduce stress, hasten recovery, lower blood pressure andlower pain medication needs
  • 7. MONITORING TECHNOLOGY 3. Post cardiothoracic surgery. 4. Drug toxicities limited to potential arrhythmogenic compounds such as digitalis and tricyclics. 5. New onset supraventricular arrhythmias (atrial fibrillation or flutter, PSVT, etc.) 6. Suspected pacemaker malfunction. 7. Observation post pacemaker or defibrillator placement or post ablation.
  • 8. MONITORING TECHNOLOGY 8. Syncope when an arrhythmia or other cardiac disorder is a suspected etiology. 9. Suspected defibrillator discharge. 10. Unstable angina of low or intermediate grade (new onset angina without EKG or enzymatic changes, crescendo angina in patient with history of coronary disease). 11. Study drug protocols requiring cardiac monitoring as a part of the protocol.
  • 9. MONITORING TECHNOLOGY Prior to discharge from the Telemetry Unit, patients shall meet the following criteria: 1. Physician shall order the discontinuation of Telemetry monitoring. 2. Patient shall be free of chest pain for 24 hours prior to discharge. 3. Patient's vital signs shall be stable
  • 10. MONITORING TECHNOLOGY 4. Patient does not require intravenous vasoactive medications. 5. Patient shall be able to perform minimal ADLs without shortness of breath. 6. Patient shall have normal sinus rhythm, stable rhythm, or controlled arrhythmia for thepast 24 hours
  • 11. DIAGNOSTIC INFORMATION SYSTEM Today's physicians and other caregivers have access to more than 5,000 different patient tests to help them evaluate, diagnose, and treat patients. The problem is that physicians receive these test results from a wide range of disparate sources that use vastly different reporting formats
  • 12. DIAGNOSTIC INFORMATION SYSTEM Displaying test results in fragmented, variable and incomplete formats prevents physicians fromefficiently reviewing and analyzing vital patient information. This can lead to:  Clinicians spending far too much time (an estimated 30%) gathering and organizing data
  • 13. DIAGNOSTIC INFORMATION SYSTEM  Critical information being missed which can cause medical errors  Redundant testing (an estimated 14% to 30% of the 30 billion diagnostic tests done annually in the US are non- contributory and avoidable)
  • 14. DIAGNOSTIC INFORMATION SYSTEM  The inability to share or exchange vital clinical information among providers  Underutilization of EHRs and other health IT applications and an unnecessary reliance on paper, telephones, and fax machines
  • 15. In order to provide cost- effective, high quality care, physicians and other caregivers need immediate access to accurate, timely, and comprehensive clinical information.
  • 16. THE PATENTED DIS SOLUTION The patented DIS solution provides rapid access to cumulative patient information in an easy to read and analyze format that increases the accuracy and efficiency of patient care and improves the productivity of physicians, nurses and others at all points of care.
  • 17. THE PATENTED DIS SOLUTION DIS can aggregate and collate more than 5,000 different patient test results and display them all in one place in the same user-friendly format. Its ease of access and use adds immediate value to the health care delivery process:  Converts raw patient test results data into organized, meaningful information for easy access,viewing, and analysis
  • 18. THE PATENTED DIS SOLUTION  Provides a standardized reporting format that unifies test results from all data sources for usersat all points of care3.  Integrates test results data on all levels (data, application, system and network) increasing efficiency, accuracy and productivity
  • 19. THE PATENTED DIS SOLUTION  Reduces the number of pages and screens on which results are displayed by an average of 80percent5.  Saves time and helps physicians minimize duplicate and non- contributory testing
  • 20. THE PATENTED DIS SOLUTION The DIS technology solution was specifically designed for immediate use by all test results data users in physician offices, hospital inpatient facilities and outpatient clinics and community health centers. Its implementation will depend on collaborative innovation among a number of interdependent stakeholders.
  • 21. THE PATENTED DIS SOLUTION These include all the test results data providers in hospital and community-based clinical laboratories and in imaging and other testing facilities and the vendors of EHRs and PHRs, as well as the vendors of HIE data integration and exchange platforms and the HIOs/HIEs that they serve
  • 22. MECHANICAL VENTILATOR Is a machine that generates a controlled flow of gas into a patients airways. Oxygen and air are received from cylinders or wall outlets, the gas is pressure reduced and blended according to the prescribed inspired oxygen tension (FiO2), accumulated in a receptacle within the machine, and delivered to the patient using one of many available modes of ventilation.
  • 23. MECHANICAL VENTILATOR The mechanics of inspiratory support are more complex than previously considered. It has been established that cyclical inflation and deflation injures lung parenchyma and worsens outcome: (1). Large tidal volume ventilation, to normalize blood gases has been shown to worsen outcome in lung injury
  • 24. MECHANICAL VENTILATOR (2), presumably due to excessive pressure induced stretch injury of the parenchyma. Modernventilation strategy involves attempting to achieve an adequate minute volume with the lowest possibleairway pressure (as this relates to the degree of alveolar distension). The pressure that we areinterested in minimizing is at the level of the alveolus, the plateau pressure.
  • 25. MECHANICAL VENTILATOR Ventilator cycling refers to the mechanism by which the phase of the breath switches from inspiration to expiration. Modes of ventilation are time cycled, volume cycled or flow cycled. Time cycling refers to the application of a set controlled breath rate. In controlled ventilation a number of mandatory breaths are delivered to the patient at a predetermined interval.
  • 26. MECHANICAL VENTILATOR The respiratory rate may be controlled by the operator or the patient. The patient may breathe spontaneously, and with modern ventilators these breaths are supported either by delivering facsimiles of the controlled breaths synchronously with the patient’s effort or by allowing the patient more subjective control.
  • 27. MECHANICAL VENTILATOR Pressure support is a form of flow cycled ventilation in which the patient triggers the ventilator and a pressure limited flow of gas is delivered. The patient determines the duration of the breath and the tidal volume, which may vary from breath to breath
  • 28. CT SCAN CT scans are a specialized type of x-ray. The patient lies down on a couch which slides into a large circular opening. The x-ray tube rotates around the patient and a computer collects the results. These results are translated into images that look like a "slice" of the person.
  • 29. CT SCAN Sometimes a radiologist will decide that contrast agents should be used. Contrast agents are iodine based and are absorbed by abnormal tissues. They make it easier for the doctor to see tumors within the brain tissue. There are some (rare) risks associated with contrast agents and you should make sure that you discuss this with the doctor before arriving for the
  • 30. CT SCAN CT is very good for imaging bone structures. In fact, it's usually the imaging mode of choice when looking at the inner ears. It can easily detect tumors within the auditory canals and can demonstrate the entire cochlea on most patients.
  • 31. MRI MRI is a completely different animal! Unlike CT it uses magnets and radio waves to create the images. No x- rays are used in an MRI scanner.
  • 32. MRI The patient lies on a couch that looks very similar the ones used for CT. They are then placed in a very long cylinder and asked to remain perfectly still. The machine will produce a lot of noise and examinations typically run about 30 minutes.
  • 33. MRI The cylinder that you are lying in is actually a very large magnet. The computer will send radio waves through your body and collect the signal that is emitted from the hydrogen atoms in your cells. This information is collected by an antenna and fed into a sophisticated computer that produces the images. These images look similar to a CAT scan but they have much higher detail in the soft tissues. Unfortunately, MRI does not do a very good job with bones.
  • 34. MRI One of the great advantages of MRI is the ability to change the contrast of the images. Small changes in the radio waves and the magnetic fields can completely change the contrast of the image. Different contrast settings will highlight different types of tissue.
  • 35. MRI Another advantage of MRI is the ability to change the imaging plane without moving the patient. If you look at the images to the left you should notice that they look very different. The top two images are what we call axial images. This is what you would see if you cut the patient in half and looked at them from the top.
  • 36. MRI The image on the bottom is a coronal image. This slices the patient from front to back. Most MRI machines can produce images in any plane. CT can not do this.
  • 37. MRI Contrast agents are also used in MRI but they are not made of iodine. There are fewer documented cases of reactions to MRI contrast and it is considered to be safer than x-ray dye. Once again, you should discuss contrast agents with your physician before you arrive for the examination.
  • 38. ICU The ICU environment should focus on the set herapeutic elements:  Windows and art that provide natural views; views of nature can reduce stress, hasten recovery, lower blood pressure and lower pain medication needs
  • 39. ICU  Family participation, including facilities for overnight stay and comfortable waiting rooms  Providing familiarity in the ICU environment through personalization, warmer colors, natural materials, and artwork
  • 40. ICU  Providing a measure of privacy and personal control through adjustable lighting, adjustable curtains and blinds, accessible bed controls, and TV, VCR and CD players  Noise reduction through computerized pagers and silent alarms  Medical team continuity that allows one team to follow the patient through his or her entire stay
  • 41. ICU A tele-ICU system involves a command center with the technological capability to remotely monitor patients in off-site intensive care units. The command center is staffed with intensivist physicians and critical care nurses who use two-way audio-visual monitoring systems to provide support and guidance to the bedside staff in those ICUs.
  • 42. ICU And critical care nurses play a major role in the success of a tele-ICU. They have a great deal of potential when it comes to bridging distance barriers, influencing patient safety and even mentoring bedside nurses, noted Karen Harvey, MSN, RN, certification programs specialist for the corporation
  • 43. LABORATORY TESTING  What are the indicators of test reliability? Four indicators are most commonly used to determine the reliability of a clinical laboratory test. Two of these, accuracy and precision, reflect how well the test method performs day to day in a laboratory. The other two, sensitivity and specificity, deal with how well the test is able to distinguish disease from absence of disease.
  • 44. LABORATORY TESTING The accuracy and precision of each test method are established and are frequently monitored by the professional laboratory personnel. Sensitivity and specificity data are determined by research studies and are generally found in medical literature.
  • 45. LABORATORY TESTING Although each test has its own performance measures and appropriate uses, laboratory tests are designed to be as precise, accurate, specific, and sensitive as possible. These basic concepts are the corner stonesof reliability of your test results and provide the confidence your health care provider has in using the clinical laboratory.
  • 46. LABORATORY TESTING  Accuracy and Precision Statistical measurements of accuracy and precision reveal a lab test's basic reliability. These terms, which describe sources of variability, are not interchangeable. A test method can be precise (reliable reproducibility) without being accurate (measuring what it is supposed to measure and its true value) or vice versa.
  • 47. LABORATORY TESTING  Precision (Repeatability) A test method is said to be precise when repeated analyses on the same sample give similar results. When a test method is precise, the amount of random variation is small. The test method can be trusted because results are reliably reproduced time after time.
  • 48. LABORATORY TESTING  Accuracy (Trueness) A test method is said to be accurate when the test value approaches the absolute ³true´ value of the substance(analyte) being measured. Results from every test performed are compared to known "control specimens" that have undergone multiple evaluations and compared to the "gold" standard for that assay, thus analyzed to the best testing standards available
  • 49. LABORATORY TESTING Accuracy (Trueness) Although a test that is 100% accurate and 100% precise is ideal, in practice, test methodology, instrumentation, and laboratory operations all contribute to small but measurable variations in results. The small amount of variability that typically occurs does not usually detract from the test ¶s value and statistically is insignificant. The level of precision and accuracy that can be obtained is specific to each test method but is constantly monitored for reliability through comprehensive quality control and quality assurance procedures.
  • 50. LABORATORY TESTING Accuracy (Trueness) Therefore, when your blood is tested more than once by the same laboratory, your test results should not change much unless your condition has changed. There may be some differences between laboratories in precision and accuracy due to different analytical instrumentation or methodologies, however, the test results are reported with standardized reference intervals specific for that laboratory.
  • 51. LABORATORY TESTING  Sensitivity and Specificity The tests that a provider chooses in order to diagnose or monitor a medical condition are based on their in herentability to distinguish whether you have the condition or do not have the condition. Depending on the symptoms and medical history, a provider will order tests to confirm a condition (tests with high sensitivity) or tests to rule out the condition (tests with high specificity).
  • 52. LABORATORY TESTING  Sensitivity Sensitivity is the ability of a test to correctly identify individuals who have a given disease or condition. For example, ascertain test may have proven to be 90% sensitive. If 100 people are known to have a certain disease, the test that identifies that disease will correctly do so for 90 of those 100 cases (90%). The other 10 people (10%) tested will not show the expected result for this test. For that 10%, the finding of a "normal" result can be misleading and is termed false-negative
  • 53. LABORATORY TESTING  Sensitivity A test's sensitivity becomes particularly important when you are seeking to exclude a dangerous disease, such astesting for the presence of the HIV antibody. Screening for HIV antibody often utilizes an ELISA test method, whichhas sensitivity over 99%. However, a person may get a false-negative if tested too soon after the initial infection (lessthan 6 weeks).
  • 54. LABORATORY TESTING  Sensitivity Thus, the result of a false- negative gives a person the sense of being disease-free when in fact theyare not. The more sensitive a test, the fewer false-negative results will be produced.
  • 55. LABORATORY TESTING  Specificity Specificity is the ability of a test to correctly exclude individuals who do not have a given disease or condition. For example, a certain test may have proven to be 90% specific. If 100 healthy individuals are tested with that method,only 90 of those 100 healthy people (90%) will be found "normal" (disease-free) by the test.
  • 56. LABORATORY TESTING  Specificity The other 10 people (who do not have the disease) will appear to be positive for that test. For that 10%, their "abnormal" findings are a misleading false-positive result. When it is necessary to confirm a diagnosis that requires dangerous therapy, a test's specificity is one of the crucial indicators.
  • 57. LABORATORY TESTING  Specificity A patient who has been told that he is positive for a specific test yet truly does not have that disease may be subjected to potentially painful or dangerous treatment, additional expense, and unwarranted anxiety. The more specific a test, the fewer false-positive results it produces.
  • 58. LABORATORY TESTING The FDA requires that developers and manufacturers of a new test provide target values for test results and provide evidence for the expected ranges as well as information on test limitations and other factors that could generate false results. Thus it is critical for the health care provider to correlate the laboratory results with an individual's clinical condition to determine if repeat testing would be needed.