Describe how partial diploids can be produced in E. coli. Solution Patial diploids can be produced by the transfer of genetic material of Hfr cell to an F- cell through conjugation.When Hfr mates with F- cell through conjugation the chromosome acts as a rolling circle transferring part of its genetic material across a conjugation bridge.Very rarely whole portion of DNA is transferred,resulting very low chance of passing of F factor to the F- cell.After that F- cell will contain part of Hfr,the exogene and its own genomic material the endogene,at this stage the cell is called partial diploid..