Simple Explanation Meconium Ileus

1. MECONIUM ILEUS
Mohd Fazrul. 122854

2. • Neonatal intestinal obstruction secondary to
• Meconium within the lumen of the bowel
that has become thickened
INCIDENCE
can occur in approximately 20% of patients with
cystic fibrosis
RISK FACTORS
1. Family history of
• cystic fibrosis
• meconium ileus
2. low birth weight
PATHOGENESIS
1. Accumulated thickened meconium leads to
obstruction in the bowel lumen resulting in
• dilation of the proximal ileum wall and
• narrowing of the distal intestine

3. PRESENTATION
• Symptoms
• failure to rectally pass meconium
• Physical exam
• abdominal distension
• palpable bowel loops
• may have visible peristaltic waves
DIFFERENTIAL DIAGNOSIS
1. Intestinal atresia
2. Hirschsprung disease
3. Volvulu

5. TREATMENT
1. Non-operative
Hyperosmolar enema (e.g., Gastrografin)
 indication
• this is a non-operative approach to treat meconium ileus as this leads to
 breakdown of the thickened meconium which clears the obstruction
• this is typically performed in simple meconium ileus but
 can be used in complicated meconium ileus
2. Operative
Resection with enterostomy or primary anastomosis
 indication
• can be used in cases of simple meconium ileus that does not clear with
hyperosmolar enema
• this is typically performed in complicated meconium ileus

6. REFERENCE